KR930010009A - 벤조퀴녹살린류 화합물 - Google Patents
벤조퀴녹살린류 화합물 Download PDFInfo
- Publication number
- KR930010009A KR930010009A KR1019920022422A KR920022422A KR930010009A KR 930010009 A KR930010009 A KR 930010009A KR 1019920022422 A KR1019920022422 A KR 1019920022422A KR 920022422 A KR920022422 A KR 920022422A KR 930010009 A KR930010009 A KR 930010009A
- Authority
- KR
- South Korea
- Prior art keywords
- compound
- formula
- alkoxy
- acid addition
- prepare
- Prior art date
Links
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D241/00—Heterocyclic compounds containing 1,4-diazine or hydrogenated 1,4-diazine rings
- C07D241/36—Heterocyclic compounds containing 1,4-diazine or hydrogenated 1,4-diazine rings condensed with carbocyclic rings or ring systems
- C07D241/38—Heterocyclic compounds containing 1,4-diazine or hydrogenated 1,4-diazine rings condensed with carbocyclic rings or ring systems with only hydrogen or carbon atoms directly attached to the ring nitrogen atoms
- C07D241/46—Phenazines
- C07D241/48—Phenazines with hydrocarbon radicals, substituted by nitrogen atoms, directly attached to the ring nitrogen atoms
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D241/00—Heterocyclic compounds containing 1,4-diazine or hydrogenated 1,4-diazine rings
- C07D241/36—Heterocyclic compounds containing 1,4-diazine or hydrogenated 1,4-diazine rings condensed with carbocyclic rings or ring systems
- C07D241/38—Heterocyclic compounds containing 1,4-diazine or hydrogenated 1,4-diazine rings condensed with carbocyclic rings or ring systems with only hydrogen or carbon atoms directly attached to the ring nitrogen atoms
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/20—Hypnotics; Sedatives
Landscapes
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Health & Medical Sciences (AREA)
- Medicinal Chemistry (AREA)
- General Health & Medical Sciences (AREA)
- Neurology (AREA)
- Neurosurgery (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Chemical Kinetics & Catalysis (AREA)
- General Chemical & Material Sciences (AREA)
- Engineering & Computer Science (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Veterinary Medicine (AREA)
- Pharmacology & Pharmacy (AREA)
- Life Sciences & Earth Sciences (AREA)
- Animal Behavior & Ethology (AREA)
- Biomedical Technology (AREA)
- Public Health (AREA)
- Anesthesiology (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Plural Heterocyclic Compounds (AREA)
Abstract
4위치에 임의로 치환된 페닐기를 갖는 6-히드록시 또는 6-알콕시-1,2,3,4,4a,5,10,10a-옥타히드로벤조[g]퀴녹살린은 정신분열증, 약물남용 또는 자가-손상 행동을 치료하는데 사용될 수 있다.
Description
본 내용은 요부공개 건이므로 전문내용을 수록하지 않았음
Claims (6)
- 4위치에 임의로 치환된 페닐기를 가지며, 유리 염기 또는 산 부가 염의 형태인 6-히드록시-또는 6-알콕시-1,2,3,4,4a,5,10,10a-옥타히드로벤조[g]퀴녹살린.
- 제1항에 있어서, 하기 일반식(I)을 가지며 유리염기 또는 산부가 염의 형태인 화합물:상기식에서 R1은 (C1-4)알킬이고 R2는 원자번호 9 내지 53의 할로겐, (C1-4)알킬 및/또는 (C1-4)알콕시로 임의로 일, 이, 또는 삼치환된 페닐이고, R3는 히드록시 또는 (C1-4)알콕시이다.
- 제1항에 있어서, 유리염기 또는 산 부가염의 형태인, (-)-[4aR, 10aR]-1,2,3,4,4a,5,10,10a-옥타히드로-4-(4'-클로로-2'-메틸-페닐-1-메틸-1-벤조[g]퀴녹살린-6-올 인 것을 특징으로 하는 화합물.
- a)하기 일반식(Ia)화합물을 제조하기 위하여 하기 일반식(Ib)의 화합물의 에테르기를 분해하고, 또는 b)일반식 (Ib)의 화합물을 제조하기 위하여, 하기 일반식(Ⅱ)의 화합물을 알킬화시키고, 또는 c)하기 일반식 (I'b)의 화합물을 제조하기 위하여, 하기 일반식(Ⅲ)의 화합물을 환원시킴으로써, 제2항에서 정의된 것과 같은 일반식( I)의 화합물을 제조하고, 원한다면, 상기에서 수득된 일반식(I)의 화합물을 그들의 산부가 염으로 전환시키는 것을 특징으로 하는 방법.상기식에서, R1및 R2는 제2항에서 정의된 것과 같고, R1 3은 (C1-4)를 갖는 알콕시이고, R4는 메틸기로 환원될 수 있는 라디칼이다.
- 약제로서 사용하기 위한, 생리학적으로 허용가능한 형태의 제1내지 3항중 임의의 한 항의 화합물.
- 약제 담체 또는 희석제와 함께 생리학적으로 허용가능한 형태로 제1내지 3항중 임의의 한항에 따른 화합물을 함유하는 약제 조성물.※ 참고사항 : 최초출원 내용에 의하여 공개하는 것임.
Applications Claiming Priority (2)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
DE4139143A DE4139143A1 (de) | 1991-11-28 | 1991-11-28 | Neue benzochinoxaline, ihre herstellung und verwendung |
DEP4139143.8 | 1991-11-28 |
Publications (1)
Publication Number | Publication Date |
---|---|
KR930010009A true KR930010009A (ko) | 1993-06-21 |
Family
ID=6445784
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
KR1019920022422A KR930010009A (ko) | 1991-11-28 | 1992-11-26 | 벤조퀴녹살린류 화합물 |
Country Status (17)
Country | Link |
---|---|
EP (1) | EP0544240A1 (ko) |
JP (1) | JPH05194427A (ko) |
KR (1) | KR930010009A (ko) |
AU (1) | AU659250B2 (ko) |
CA (1) | CA2083914A1 (ko) |
CZ (1) | CZ350492A3 (ko) |
DE (1) | DE4139143A1 (ko) |
FI (1) | FI925389A (ko) |
HU (1) | HUT62567A (ko) |
IL (1) | IL103894A (ko) |
MX (1) | MX9206820A (ko) |
NO (1) | NO179907C (ko) |
NZ (1) | NZ245284A (ko) |
PH (1) | PH30999A (ko) |
RO (1) | RO110487B1 (ko) |
TW (1) | TW258734B (ko) |
ZA (1) | ZA929236B (ko) |
Families Citing this family (2)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
US5538971A (en) * | 1991-11-28 | 1996-07-23 | Sandoz Ltd. | Benzoquinoxalines, pharmaceutical compositions containing them and their use in treating schizophrenia |
CN102245625A (zh) | 2008-10-17 | 2011-11-16 | 威斯康星旧生研究基金会 | 制备有生物活性的α-β肽的方法 |
-
1991
- 1991-11-28 DE DE4139143A patent/DE4139143A1/de not_active Withdrawn
-
1992
- 1992-11-13 HU HU9203562A patent/HUT62567A/hu unknown
- 1992-11-25 EP EP92120025A patent/EP0544240A1/en not_active Withdrawn
- 1992-11-26 CZ CS923504A patent/CZ350492A3/cs unknown
- 1992-11-26 FI FI925389A patent/FI925389A/fi not_active Application Discontinuation
- 1992-11-26 CA CA002083914A patent/CA2083914A1/en not_active Abandoned
- 1992-11-26 AU AU29650/92A patent/AU659250B2/en not_active Ceased
- 1992-11-26 NO NO924563A patent/NO179907C/no unknown
- 1992-11-26 IL IL10389492A patent/IL103894A/en not_active IP Right Cessation
- 1992-11-26 KR KR1019920022422A patent/KR930010009A/ko not_active Application Discontinuation
- 1992-11-26 NZ NZ245284A patent/NZ245284A/en unknown
- 1992-11-26 MX MX9206820A patent/MX9206820A/es unknown
- 1992-11-26 RO RO92-01475A patent/RO110487B1/ro unknown
- 1992-11-27 JP JP4318258A patent/JPH05194427A/ja active Pending
- 1992-11-27 ZA ZA929236A patent/ZA929236B/xx unknown
- 1992-11-27 PH PH45350A patent/PH30999A/en unknown
- 1992-11-30 TW TW081109579A patent/TW258734B/zh active
Also Published As
Publication number | Publication date |
---|---|
ZA929236B (en) | 1994-05-27 |
CA2083914A1 (en) | 1993-05-29 |
IL103894A0 (en) | 1993-04-04 |
NO179907B (no) | 1996-09-30 |
TW258734B (ko) | 1995-10-01 |
MX9206820A (es) | 1993-05-01 |
HUT62567A (en) | 1993-05-28 |
DE4139143A1 (de) | 1993-06-03 |
NO924563D0 (no) | 1992-11-26 |
CZ350492A3 (en) | 1993-09-15 |
NZ245284A (en) | 1995-07-26 |
AU2965092A (en) | 1993-06-03 |
FI925389A (fi) | 1993-05-29 |
PH30999A (en) | 1997-12-23 |
EP0544240A1 (en) | 1993-06-02 |
RO110487B1 (ro) | 1996-01-30 |
FI925389A0 (fi) | 1992-11-26 |
JPH05194427A (ja) | 1993-08-03 |
NO179907C (no) | 1997-01-08 |
NO924563L (no) | 1993-06-01 |
HU9203562D0 (en) | 1993-01-28 |
AU659250B2 (en) | 1995-05-11 |
IL103894A (en) | 1996-10-16 |
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Legal Events
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WITN | Application deemed withdrawn, e.g. because no request for examination was filed or no examination fee was paid |