KR930008148A - 변이 인간 프로우로키나아제 - Google Patents
변이 인간 프로우로키나아제 Download PDFInfo
- Publication number
- KR930008148A KR930008148A KR1019920018372A KR920018372A KR930008148A KR 930008148 A KR930008148 A KR 930008148A KR 1019920018372 A KR1019920018372 A KR 1019920018372A KR 920018372 A KR920018372 A KR 920018372A KR 930008148 A KR930008148 A KR 930008148A
- Authority
- KR
- South Korea
- Prior art keywords
- amino acid
- human prourokinase
- prourokinase
- plasmid
- human
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Withdrawn
Links
- 108010073863 saruplase Proteins 0.000 title claims abstract 10
- 150000001413 amino acids Chemical class 0.000 claims abstract 13
- 230000002378 acidificating effect Effects 0.000 claims abstract 6
- 239000013612 plasmid Substances 0.000 claims abstract 5
- 230000007935 neutral effect Effects 0.000 claims abstract 3
- VBEQCZHXXJYVRD-GACYYNSASA-N uroanthelone Chemical compound C([C@@H](C(=O)N[C@H](C(=O)N[C@@H](CS)C(=O)N[C@@H](CC(N)=O)C(=O)N[C@@H](CS)C(=O)N[C@H](C(=O)N[C@@H]([C@@H](C)CC)C(=O)NCC(=O)N[C@@H](CC=1C=CC(O)=CC=1)C(=O)N[C@@H](CO)C(=O)NCC(=O)N[C@@H](CC(O)=O)C(=O)N[C@@H](CCCNC(N)=N)C(=O)N[C@@H](CS)C(=O)N[C@@H](CCC(N)=O)C(=O)N[C@@H]([C@@H](C)O)C(=O)N[C@@H](CCCNC(N)=N)C(=O)N[C@@H](CC(O)=O)C(=O)N[C@@H](CC(C)C)C(=O)N[C@@H](CCCNC(N)=N)C(=O)N[C@@H](CC=1C2=CC=CC=C2NC=1)C(=O)N[C@@H](CC=1C2=CC=CC=C2NC=1)C(=O)N[C@@H](CCC(O)=O)C(=O)N[C@@H](CC(C)C)C(=O)N[C@@H](CCCNC(N)=N)C(O)=O)C(C)C)[C@@H](C)O)NC(=O)[C@H](CO)NC(=O)[C@H](CC(O)=O)NC(=O)[C@H](CC(C)C)NC(=O)[C@H](CO)NC(=O)[C@H](CCC(O)=O)NC(=O)[C@@H](NC(=O)[C@H](CC=1NC=NC=1)NC(=O)[C@H](CCSC)NC(=O)[C@H](CS)NC(=O)[C@@H](NC(=O)CNC(=O)CNC(=O)[C@H](CC(N)=O)NC(=O)[C@H](CC(C)C)NC(=O)[C@H](CS)NC(=O)[C@H](CC=1C=CC(O)=CC=1)NC(=O)CNC(=O)[C@H](CC(O)=O)NC(=O)[C@H](CC=1C=CC(O)=CC=1)NC(=O)[C@H](CO)NC(=O)[C@H](CO)NC(=O)[C@H]1N(CCC1)C(=O)[C@H](CS)NC(=O)CNC(=O)[C@H]1N(CCC1)C(=O)[C@H](CC=1C=CC(O)=CC=1)NC(=O)[C@H](CO)NC(=O)[C@@H](N)CC(N)=O)C(C)C)[C@@H](C)CC)C1=CC=C(O)C=C1 VBEQCZHXXJYVRD-GACYYNSASA-N 0.000 claims abstract 3
- 102000009024 Epidermal Growth Factor Human genes 0.000 claims abstract 2
- 101800003838 Epidermal growth factor Proteins 0.000 claims abstract 2
- 238000012258 culturing Methods 0.000 claims abstract 2
- 229940116977 epidermal growth factor Drugs 0.000 claims abstract 2
- 238000004519 manufacturing process Methods 0.000 claims abstract 2
- 108091028043 Nucleic acid sequence Proteins 0.000 claims 3
- 238000011144 upstream manufacturing Methods 0.000 claims 2
- 108020004414 DNA Proteins 0.000 claims 1
- 102000004316 Oxidoreductases Human genes 0.000 claims 1
- 108010022394 Threonine synthase Proteins 0.000 claims 1
- 108090000435 Urokinase-type plasminogen activator Proteins 0.000 claims 1
- 102000003990 Urokinase-type plasminogen activator Human genes 0.000 claims 1
- 210000004102 animal cell Anatomy 0.000 claims 1
- 210000004027 cell Anatomy 0.000 claims 1
- 230000002950 deficient Effects 0.000 claims 1
- 102000004419 dihydrofolate reductase Human genes 0.000 claims 1
- 229940014144 folate Drugs 0.000 claims 1
- OVBPIULPVIDEAO-LBPRGKRZSA-N folic acid Chemical compound C=1N=C2NC(N)=NC(=O)C2=NC=1CNC1=CC=C(C(=O)N[C@@H](CCC(O)=O)C(O)=O)C=C1 OVBPIULPVIDEAO-LBPRGKRZSA-N 0.000 claims 1
- 235000019152 folic acid Nutrition 0.000 claims 1
- 239000011724 folic acid Substances 0.000 claims 1
- 238000000034 method Methods 0.000 claims 1
- 230000001105 regulatory effect Effects 0.000 claims 1
- 238000006467 substitution reaction Methods 0.000 claims 1
- 229960005356 urokinase Drugs 0.000 claims 1
- 108091026890 Coding region Proteins 0.000 abstract 1
- 102000009123 Fibrin Human genes 0.000 abstract 1
- 108010073385 Fibrin Proteins 0.000 abstract 1
- BWGVNKXGVNDBDI-UHFFFAOYSA-N Fibrin monomer Chemical compound CNC(=O)CNC(=O)CN BWGVNKXGVNDBDI-UHFFFAOYSA-N 0.000 abstract 1
- 239000008280 blood Substances 0.000 abstract 1
- 210000004369 blood Anatomy 0.000 abstract 1
- 229950003499 fibrin Drugs 0.000 abstract 1
- 239000003527 fibrinolytic agent Substances 0.000 abstract 1
- 230000003480 fibrinolytic effect Effects 0.000 abstract 1
- 101100309714 Arabidopsis thaliana SD16 gene Proteins 0.000 description 1
- 238000010276 construction Methods 0.000 description 1
- 230000035772 mutation Effects 0.000 description 1
Classifications
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N15/00—Mutation or genetic engineering; DNA or RNA concerning genetic engineering, vectors, e.g. plasmids, or their isolation, preparation or purification; Use of hosts therefor
- C12N15/09—Recombinant DNA-technology
- C12N15/11—DNA or RNA fragments; Modified forms thereof; Non-coding nucleic acids having a biological activity
- C12N15/52—Genes encoding for enzymes or proenzymes
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N9/00—Enzymes; Proenzymes; Compositions thereof; Processes for preparing, activating, inhibiting, separating or purifying enzymes
- C12N9/14—Hydrolases (3)
- C12N9/48—Hydrolases (3) acting on peptide bonds (3.4)
- C12N9/50—Proteinases, e.g. Endopeptidases (3.4.21-3.4.25)
- C12N9/64—Proteinases, e.g. Endopeptidases (3.4.21-3.4.25) derived from animal tissue
- C12N9/6421—Proteinases, e.g. Endopeptidases (3.4.21-3.4.25) derived from animal tissue from mammals
- C12N9/6424—Serine endopeptidases (3.4.21)
- C12N9/6456—Plasminogen activators
- C12N9/6462—Plasminogen activators u-Plasminogen activator (3.4.21.73), i.e. urokinase
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12Y—ENZYMES
- C12Y304/00—Hydrolases acting on peptide bonds, i.e. peptidases (3.4)
- C12Y304/21—Serine endopeptidases (3.4.21)
- C12Y304/21073—Serine endopeptidases (3.4.21) u-Plasminogen activator (3.4.21.73), i.e. urokinase
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K38/00—Medicinal preparations containing peptides
Landscapes
- Health & Medical Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Engineering & Computer Science (AREA)
- Life Sciences & Earth Sciences (AREA)
- Genetics & Genomics (AREA)
- Organic Chemistry (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Wood Science & Technology (AREA)
- Zoology (AREA)
- Biomedical Technology (AREA)
- General Engineering & Computer Science (AREA)
- General Health & Medical Sciences (AREA)
- Biochemistry (AREA)
- Molecular Biology (AREA)
- Biotechnology (AREA)
- Microbiology (AREA)
- Medicinal Chemistry (AREA)
- Physics & Mathematics (AREA)
- Biophysics (AREA)
- Plant Pathology (AREA)
- Micro-Organisms Or Cultivation Processes Thereof (AREA)
- Preparation Of Compounds By Using Micro-Organisms (AREA)
- Enzymes And Modification Thereof (AREA)
Applications Claiming Priority (2)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| JP91-289257 | 1991-10-07 | ||
| JP3289257A JPH0595786A (ja) | 1991-10-07 | 1991-10-07 | 変異ヒトプロウロキナーゼ |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| KR930008148A true KR930008148A (ko) | 1993-05-21 |
Family
ID=17740820
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| KR1019920018372A Withdrawn KR930008148A (ko) | 1991-10-07 | 1992-10-07 | 변이 인간 프로우로키나아제 |
Country Status (5)
| Country | Link |
|---|---|
| US (1) | US5389538A (https=) |
| EP (1) | EP0541952A1 (https=) |
| JP (1) | JPH0595786A (https=) |
| KR (1) | KR930008148A (https=) |
| TW (1) | TW215928B (https=) |
Families Citing this family (7)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| JPH08508172A (ja) | 1993-06-01 | 1996-09-03 | カイロン コーポレイション | ウロキナーゼプラスミノーゲン活性化因子インヒビターの発現 |
| US6248715B1 (en) * | 1993-06-01 | 2001-06-19 | Chiron Corporation | Method of treating a urokinase-type plasminogen activator-mediated disorder |
| ES2066733B1 (es) * | 1993-06-30 | 1995-11-01 | Antibioticos Farma S A | Complejo consistente en un activador del plasminogeno y albumina de suero y procedimiento para prepararlo. |
| US6271364B1 (en) | 1999-02-23 | 2001-08-07 | Amgen Inc. | Analogs of NT-3 |
| IL127872A0 (en) | 1996-07-19 | 1999-10-28 | Amgen Inc | Analogs of cationic proteins |
| US7801830B1 (en) | 1999-12-30 | 2010-09-21 | At&T Intellectual Property I, L.P. | System and method for marketing, managing, and maintaining intellectual property |
| US7346518B1 (en) | 1999-12-30 | 2008-03-18 | At&T Bls Intellectual Property, Inc. | System and method for determining the marketability of intellectual property assets |
Family Cites Families (9)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| JPH0761266B2 (ja) * | 1986-07-03 | 1995-07-05 | 株式会社ミドリ十字 | 変異ヒトプロウロキナ−ゼ |
| US5098840A (en) * | 1986-07-03 | 1992-03-24 | The Green Cross Corporation | Human prourokinase mutants |
| EP0266032A1 (en) * | 1986-08-29 | 1988-05-04 | Beecham Group Plc | Modified fibrinolytic enzyme |
| JPS63105675A (ja) * | 1986-10-23 | 1988-05-10 | Green Cross Corp:The | ヒトウロキナ−ゼの製造方法 |
| NO179874C (no) * | 1987-06-04 | 1997-01-02 | Zymogenetics Inc | Fremgangsmåte for fremstilling av en t-PA-analog, DNA-sekvens som koder for t-PA-analogen, samt ekspresjonsvektor omfattende DNA-sekvensen og vertcelle omfattende denne |
| KR960015610B1 (ko) * | 1987-06-22 | 1996-11-18 | 제네틱스 인스티튜트, 인코포레이티드 | 신규의 혈전붕괴 단백질의 제조방법 |
| GB8721023D0 (en) * | 1987-09-07 | 1987-10-14 | Lepetit Spa | Modified plasminogen activators |
| GB8815135D0 (en) * | 1988-06-24 | 1988-08-03 | British Bio Technology | Proteins & nucleic acids |
| AU5515790A (en) * | 1989-05-18 | 1990-11-22 | Green Cross Corporation, The | Human prourokinase variants, methods of producing same, dna sequences, plasmids and hosts therefor |
-
1991
- 1991-10-07 JP JP3289257A patent/JPH0595786A/ja active Pending
-
1992
- 1992-10-06 EP EP92117000A patent/EP0541952A1/en not_active Withdrawn
- 1992-10-06 TW TW081107912A patent/TW215928B/zh active
- 1992-10-06 US US07/957,039 patent/US5389538A/en not_active Expired - Fee Related
- 1992-10-07 KR KR1019920018372A patent/KR930008148A/ko not_active Withdrawn
Also Published As
| Publication number | Publication date |
|---|---|
| JPH0595786A (ja) | 1993-04-20 |
| EP0541952A1 (en) | 1993-05-19 |
| US5389538A (en) | 1995-02-14 |
| TW215928B (https=) | 1993-11-11 |
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Legal Events
| Date | Code | Title | Description |
|---|---|---|---|
| PA0109 | Patent application |
Patent event code: PA01091R01D Comment text: Patent Application Patent event date: 19921007 |
|
| PG1501 | Laying open of application | ||
| PC1203 | Withdrawal of no request for examination | ||
| WITN | Application deemed withdrawn, e.g. because no request for examination was filed or no examination fee was paid |