KR930003925A - 코 및 눈에 국부적으로 사용하기 위한 브래디키닌 길항제 함유 약제학적 조성물 - Google Patents

코 및 눈에 국부적으로 사용하기 위한 브래디키닌 길항제 함유 약제학적 조성물 Download PDF

Info

Publication number
KR930003925A
KR930003925A KR1019920015022A KR920015022A KR930003925A KR 930003925 A KR930003925 A KR 930003925A KR 1019920015022 A KR1019920015022 A KR 1019920015022A KR 920015022 A KR920015022 A KR 920015022A KR 930003925 A KR930003925 A KR 930003925A
Authority
KR
South Korea
Prior art keywords
arg
pro
tic
gly
ser
Prior art date
Application number
KR1019920015022A
Other languages
English (en)
Inventor
자이델 하인쯔-뤼디거
비르트 클라우스
기쓸러 노르베르트
Original Assignee
짜우너, 라피체
훽스트 아크티엔게젤샤프트
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by 짜우너, 라피체, 훽스트 아크티엔게젤샤프트 filed Critical 짜우너, 라피체
Publication of KR930003925A publication Critical patent/KR930003925A/ko

Links

Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K38/00—Medicinal preparations containing peptides
    • A61K38/04—Peptides having up to 20 amino acids in a fully defined sequence; Derivatives thereof
    • A61K38/10—Peptides having 12 to 20 amino acids
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/0012—Galenical forms characterised by the site of application
    • A61K9/0048—Eye, e.g. artificial tears
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/0012—Galenical forms characterised by the site of application
    • A61K9/0043—Nose
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/06—Ointments; Bases therefor; Other semi-solid forms, e.g. creams, sticks, gels
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P11/00—Drugs for disorders of the respiratory system
    • A61P11/08—Bronchodilators
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/04—Centrally acting analgesics, e.g. opioids
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P29/00—Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • A61P9/02—Non-specific cardiovascular stimulants, e.g. drugs for syncope, antihypotensives
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K7/00—Peptides having 5 to 20 amino acids in a fully defined sequence; Derivatives thereof
    • C07K7/04—Linear peptides containing only normal peptide links
    • C07K7/18—Kallidins; Bradykinins; Related peptides
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K38/00—Medicinal preparations containing peptides

Landscapes

  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • General Health & Medical Sciences (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Animal Behavior & Ethology (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Organic Chemistry (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Engineering & Computer Science (AREA)
  • General Chemical & Material Sciences (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Epidemiology (AREA)
  • Pain & Pain Management (AREA)
  • Heart & Thoracic Surgery (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Cardiology (AREA)
  • Biophysics (AREA)
  • Biomedical Technology (AREA)
  • Biochemistry (AREA)
  • Ophthalmology & Optometry (AREA)
  • Genetics & Genomics (AREA)
  • Molecular Biology (AREA)
  • Otolaryngology (AREA)
  • Rheumatology (AREA)
  • Neurology (AREA)
  • Neurosurgery (AREA)
  • Pulmonology (AREA)
  • Gastroenterology & Hepatology (AREA)
  • Immunology (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Medicinal Preparation (AREA)

Abstract

내용 없음.

Description

코 및 눈에 국부적으로 사용하기 위한 브래디키닌 길항제 함유 약제학적 조성물
본 내용은 요부공개 건이므로 전문내용을 수록하지 않았음

Claims (5)

  1. a) 활성 화합물로서 브래디키닌 길항제, b) 활성 화합물을 위한 생리학적으로 허용되는 용매, c) 임의로, 생리학적으로 허용되는 완충제, d) 임의로, 등장성 첨가제, e) 임의로, 방부제, f) 임의로, 증검제 및 g) 임의로, 연고제기제를 함유하는 코 또는 눈에 국부적으로 사용하기 위한 약제학적 조성물.
  2. 제1항에 있어서, 브래디키닌 길항제로서
    H-D-Arg-Arg-Hyp-Pro-Gly-Thi-Ser-D-Tic-Aoc-Arg-OH
    H-D-Arg-Arg-Pro-Hyp-Gly-Thi-Ser-D-Tic-Aoc-Arg-OH
    H-D-Arg-Arg-Pro-Hyp-Gly-Thi-Ser-D-Tic-Tic-Arg-OH
    H-D-Arg-Arg-Pro-Hyp-Gly-Thi-Ser-D-Tic-Oic-Arg-OH
    H-D-Arg-Arg-Pro-Pro-Gly-Thi-Ser-D-Tic-Oic-Arg-OH
    H-D-Arg-Arg-Pro-Hyp-Gly-Phe-Ser-D-Tic-Oic-Arg-OH
    H-D-Arg-Arg-(NO2)-Pro-Hyp-Gly-Phe-Ser-D-Tic-Aoc-Arg-OH
    H-Arg(Tos)-Pro-Hyp-Gly-Thi-Ser-D-Tic-Oic-Arg-OH
    H-D-Arg-Arg-Pro-Hyp-Gly-Leu-Ser-D-Tic-Oic-Arg-OH 또는
    H-D-Arg-Arg-Pro-Hrp-Gly-Thi-Ser-D-Phe-Oic-Arg-OH를 함유하는 약제학적 조성물.
  3. 제1항에 있어서, 브래디키닌 길항제로서 H-D-Arg-Arg-Pro-Hyp-Gly-Thi-Ser-D-Tic-Oic-Arg-OH(HOE 140)을 함유하는 약제학적 조성물.
  4. 제1항에 있어서, 브래디키닌 길항제가 HOE 140이고, 용매는 물이며, 생리학적으로 허용되는 완충제가 아세트산나트륨인 약제학적 조성물.
  5. 브래디키닌 길항제를 생리학적으로 허용되는 용매에 용해시키고, 임의로 이 용액을 생리학적으로 허용되는 완충제, 등장성 첨가제, 방부제, 증점제 및/또는 연고제 기제와 배합함을 특징으로 하는 제1항에서 청구된 조성물의 제조방법.
    ※ 참고사항 : 최초출원 내용에 의하여 공개되는 것임.
KR1019920015022A 1991-08-22 1992-08-21 코 및 눈에 국부적으로 사용하기 위한 브래디키닌 길항제 함유 약제학적 조성물 KR930003925A (ko)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
DEP4127738.4 1991-08-22
DE4127738 1991-08-22

Publications (1)

Publication Number Publication Date
KR930003925A true KR930003925A (ko) 1993-03-22

Family

ID=6438805

Family Applications (1)

Application Number Title Priority Date Filing Date
KR1019920015022A KR930003925A (ko) 1991-08-22 1992-08-21 코 및 눈에 국부적으로 사용하기 위한 브래디키닌 길항제 함유 약제학적 조성물

Country Status (10)

Country Link
EP (1) EP0529499A1 (ko)
JP (1) JPH05221873A (ko)
KR (1) KR930003925A (ko)
AU (1) AU2124592A (ko)
CA (1) CA2076558A1 (ko)
CZ (1) CZ256592A3 (ko)
HU (1) HUT63060A (ko)
IL (1) IL102885A0 (ko)
NO (1) NO923293L (ko)
ZA (1) ZA926313B (ko)

Families Citing this family (6)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
AU696429B2 (en) * 1994-03-09 1998-09-10 Cortech, Inc. Bradykinin antagonist peptides incorporating n-substituted glycines
US5585355A (en) * 1994-04-22 1996-12-17 Alkermes, Inc. Method for increasing blood-ocular barrier permeability with permeabilizer peptides
US6531480B1 (en) 1998-04-03 2003-03-11 Alcon Manufacturing, Ltd. Non-peptide bradykinin receptor antagonists for use in treating ophthalmic diseases and disorders
US6500831B1 (en) 1998-04-03 2002-12-31 Alcon Manufacturing, Ltd. Non-peptide bradykinin receptor antagonists for use in controlling intraocular pressure and treating glaucoma
DE20009841U1 (de) * 2000-05-31 2001-10-25 Phyt-Immun GmbH, 66424 Homburg Nasensalbe auf Basis von Vaselin
CN104043101B (zh) * 2014-05-23 2016-04-20 杭州阿德莱诺泰制药技术有限公司 一种艾替班特注射用组合物及其制备方法和制剂

Family Cites Families (4)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US4923963A (en) * 1987-09-02 1990-05-08 Nova Technology Limited Partnership Bradykinin antagonist peptides
EP0334244A3 (en) * 1988-03-25 1991-05-29 The Procter & Gamble Company Bradykinin antagonist peptides
IE63490B1 (en) * 1988-11-24 1995-05-03 Hoechst Ag Peptides having bradykinin antagonist action
MX9100717A (es) * 1990-08-24 1992-04-01 Syntex Inc Antagonistas de la bradiquinina

Also Published As

Publication number Publication date
HUT63060A (en) 1993-07-28
CA2076558A1 (en) 1993-02-23
IL102885A0 (en) 1993-01-31
EP0529499A1 (de) 1993-03-03
AU2124592A (en) 1993-02-25
NO923293L (no) 1993-02-23
CZ256592A3 (en) 1993-03-17
JPH05221873A (ja) 1993-08-31
ZA926313B (en) 1993-04-28
NO923293D0 (no) 1992-08-21

Similar Documents

Publication Publication Date Title
CY1120513T1 (el) Υψηλης συμπυκνωσης συνθεση μινοξιδιλης
EA199800563A1 (ru) Антагонисты гормона, высвобождающего гонадотропин
KR910015298A (ko) 오메프라졸 직장투여조성물
MD1434C2 (ro) Analogi nucleozidici ai 1,3-oxatiolanului, compoziţie farmaceutică conţinând analogi nucleozidici ai 1,3-oxatiolanului şi metodă de tratament al infecţiilor virale
HUP0001247A2 (hu) Eljárás vizes kompozíciók viszkozitási stabilitásának fokozására
MX9202328A (es) Composicion farmaceutica local que contiene un compuesto alilamina como el agente activo.
FR2408345A1 (fr) Nouvelle composition a action anti-conceptionnelle
CO4440476A1 (es) Composicion sinergistica que comprende una combinacion plaguicida de ingredientes activos .
ES2108129T3 (es) Nuevos derivados de pirazina, su preparacion y empleo.
KR840000236A (ko) 포유류의 국부용 제형의 수분 손실량을 극소화시키는 방법
KR890700125A (ko) 신규 벤즈이미다졸 유도체, 그 제조방법 및 이 화합물을 함유하는 제약 조성물
RU95103922A (ru) Состав красителя и способ его получения
KR930003925A (ko) 코 및 눈에 국부적으로 사용하기 위한 브래디키닌 길항제 함유 약제학적 조성물
EA200401298A1 (ru) Жидкие фармацевтические композиции, содержащие низкую дозу энтекавира, и их применение
AR246160A1 (es) Preservativo para composiciones acuosas.
KR970061246A (ko) 테스토스테론을 증가시키기 위한 약학 조성물
KR880013444A (ko) 수성 유동성 살충제 농축 조성물
TR200000153T2 (tr) İl-5 inhibite eden 6-azaurasil türevleri.
KR890009385A (ko) 피막 형성성 항진균제 조성물
CO4890881A1 (es) Composiciones de grasa de urea y mecanismos que contienen tales composiciones
SE8303136L (sv) Optiskt aktiva derivat av n-arylerat oxazolidinon-2, specifika och reversibla inhibitorer av monoaminoxydas av typ b, och deras framstellningssett
AR245497A1 (es) Una composicion de jabon
ATE205386T1 (de) Einphasige,transparente wässrige zusammensetzung
PE13395A1 (es) Composicion farmaceutica de imidazolil carbazolona
ES367981A1 (es) Procedimiento para preparar agentes de lavado, agentes au- xiliares del lavado y agentes de limpieza

Legal Events

Date Code Title Description
WITN Application deemed withdrawn, e.g. because no request for examination was filed or no examination fee was paid