KR920701314A - 디페닐포스포릴아지드에 의한 콜라겐의 교차결합 방법, 이와같이 수득된 교차결합 콜라겐 및 이러한 교차결합 콜라겐 기재 생체 물질 - Google Patents

디페닐포스포릴아지드에 의한 콜라겐의 교차결합 방법, 이와같이 수득된 교차결합 콜라겐 및 이러한 교차결합 콜라겐 기재 생체 물질

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Publication number
KR920701314A
KR920701314A KR1019910701328A KR910701328A KR920701314A KR 920701314 A KR920701314 A KR 920701314A KR 1019910701328 A KR1019910701328 A KR 1019910701328A KR 910701328 A KR910701328 A KR 910701328A KR 920701314 A KR920701314 A KR 920701314A
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South Korea
Prior art keywords
collagen
dppa
crosslinked
reaction
diphenylphosphoryl azide
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KR1019910701328A
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English (en)
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KR0160309B1 (ko
Inventor
쁘띠뜨 에르베
므나쉬 필리쁘
위끄 알랭
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삐에르 데빅또르
비오에티까
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Publication of KR920701314A publication Critical patent/KR920701314A/ko
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Publication of KR0160309B1 publication Critical patent/KR0160309B1/ko

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    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61L—METHODS OR APPARATUS FOR STERILISING MATERIALS OR OBJECTS IN GENERAL; DISINFECTION, STERILISATION OR DEODORISATION OF AIR; CHEMICAL ASPECTS OF BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES; MATERIALS FOR BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES
    • A61L27/00—Materials for grafts or prostheses or for coating grafts or prostheses
    • A61L27/36—Materials for grafts or prostheses or for coating grafts or prostheses containing ingredients of undetermined constitution or reaction products thereof, e.g. transplant tissue, natural bone, extracellular matrix
    • A61L27/3683—Materials for grafts or prostheses or for coating grafts or prostheses containing ingredients of undetermined constitution or reaction products thereof, e.g. transplant tissue, natural bone, extracellular matrix subjected to a specific treatment prior to implantation, e.g. decellularising, demineralising, grinding, cellular disruption/non-collagenous protein removal, anti-calcification, crosslinking, supercritical fluid extraction, enzyme treatment
    • A61L27/3687—Materials for grafts or prostheses or for coating grafts or prostheses containing ingredients of undetermined constitution or reaction products thereof, e.g. transplant tissue, natural bone, extracellular matrix subjected to a specific treatment prior to implantation, e.g. decellularising, demineralising, grinding, cellular disruption/non-collagenous protein removal, anti-calcification, crosslinking, supercritical fluid extraction, enzyme treatment characterised by the use of chemical agents in the treatment, e.g. specific enzymes, detergents, capping agents, crosslinkers, anticalcification agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61L—METHODS OR APPARATUS FOR STERILISING MATERIALS OR OBJECTS IN GENERAL; DISINFECTION, STERILISATION OR DEODORISATION OF AIR; CHEMICAL ASPECTS OF BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES; MATERIALS FOR BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES
    • A61L27/00—Materials for grafts or prostheses or for coating grafts or prostheses
    • A61L27/14—Macromolecular materials
    • A61L27/22—Polypeptides or derivatives thereof, e.g. degradation products
    • A61L27/24—Collagen
    • C—CHEMISTRY; METALLURGY
    • C08—ORGANIC MACROMOLECULAR COMPOUNDS; THEIR PREPARATION OR CHEMICAL WORKING-UP; COMPOSITIONS BASED THEREON
    • C08H—DERIVATIVES OF NATURAL MACROMOLECULAR COMPOUNDS
    • C08H1/00—Macromolecular products derived from proteins
    • C08H1/06—Macromolecular products derived from proteins derived from horn, hoofs, hair, skin or leather
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61F—FILTERS IMPLANTABLE INTO BLOOD VESSELS; PROSTHESES; DEVICES PROVIDING PATENCY TO, OR PREVENTING COLLAPSING OF, TUBULAR STRUCTURES OF THE BODY, e.g. STENTS; ORTHOPAEDIC, NURSING OR CONTRACEPTIVE DEVICES; FOMENTATION; TREATMENT OR PROTECTION OF EYES OR EARS; BANDAGES, DRESSINGS OR ABSORBENT PADS; FIRST-AID KITS
    • A61F2310/00—Prostheses classified in A61F2/28 or A61F2/30 - A61F2/44 being constructed from or coated with a particular material
    • A61F2310/00005—The prosthesis being constructed from a particular material
    • A61F2310/00365—Proteins; Polypeptides; Degradation products thereof
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61L—METHODS OR APPARATUS FOR STERILISING MATERIALS OR OBJECTS IN GENERAL; DISINFECTION, STERILISATION OR DEODORISATION OF AIR; CHEMICAL ASPECTS OF BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES; MATERIALS FOR BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES
    • A61L2430/00—Materials or treatment for tissue regeneration
    • A61L2430/40—Preparation and treatment of biological tissue for implantation, e.g. decellularisation, cross-linking

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  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Medicinal Chemistry (AREA)
  • Engineering & Computer Science (AREA)
  • Epidemiology (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • General Health & Medical Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • Dermatology (AREA)
  • Oral & Maxillofacial Surgery (AREA)
  • Transplantation (AREA)
  • Polymers & Plastics (AREA)
  • Biochemistry (AREA)
  • Organic Chemistry (AREA)
  • Materials Engineering (AREA)
  • Molecular Biology (AREA)
  • General Chemical & Material Sciences (AREA)
  • Biophysics (AREA)
  • Biomedical Technology (AREA)
  • Botany (AREA)
  • Materials For Medical Uses (AREA)
  • Peptides Or Proteins (AREA)
  • Polysaccharides And Polysaccharide Derivatives (AREA)
  • Saccharide Compounds (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Processes Of Treating Macromolecular Substances (AREA)

Abstract

내용 없음

Description

디페닐포스포릴아지드에 의한 콜라겐의 교차결합 방법, 이와 같이 수득된 교차결합 콜라겐 및 이러한 교차결합 콜라겐 기재 생체 물질
본 내용은 요부공개 건이므로 전문내용을 수록하지 않았음
제1도는 디페닐포스포릴아지드와 콜라겐의 카르복실기와의 반응으로 이루어진 콜라겐 교차 결합 반응의 반응 메카니즘 가정을 나타낸 것이다. 제2도는 DPPA 농도식으로서 송아지 심낭에서 콜라겐 변성 피이크 온도 (TP) 로 부터 측정한 콜라겐 교차 결합 백분율(RTP)의 평가를 나타낸다: 및 제3도는 DPPA 농도식으로서 콜라겐 필름에서 교차 결합 RTP 백분율의 평가를 나타낸다.

Claims (12)

  1. 콜라겐이 디페닐포스포릴아지드(DPPA)와 반응하는 것을 특징으로 하는, 아실아지드기를 사용하여 아미드 결합을 형성하는 것으로 이루어진 형태인 콜라겐의 교차 결합 방법.
  2. 제1항에 있어서, DPPA와의 반응이 비수성 용매 매체에서 일어나는 것을 특징으로 하는 방법.
  3. 제2항에 있어서, 비수성 용매가 디메틸포름아미드인 것을 특징으로 하는 방법.
  4. 제1항 내지 제3항중의 어느 한 항에 있어서, DPPA 농도가 부피/부피로 0.0125%~1%, 바람직하게는 0.25~0.70%으로 이루어진 것을 특징으로 하는 방법.
  5. 제1항 내지 제4항중의 어느 한항에 있어서, 반응은 온도가 약 0℃~약10℃, 바람직하게는 약 4℃에서 배양하여 수득되고, 배양기간은 수시간~수일, 바람직하게는 하루정도인 것을 특징으로 하는 방법.
  6. 제1항 내지 제5항중 어느 한 항에 있어서, DPPA 와 반응후에 적어도 한번 세척하여 DPPA를 제거하고 그후 아실아지드기를 함유하는 콜라겐을 붕산염 완충액에 가하는 것을 특징으로 하는 방법.
  7. 제6항에 있어서, 붕산염 완충 용매중에서 약 0℃~약 10℃, 바람직하게는 약 4℃로 이루어진 온도에서 배양이 행해지는 것을 특징으로 하는 방법.
  8. 제7항에 있어서, 붕산염 완충액의 pH가 약 8.9인 것을 특징으로 하는 방법.
  9. 제1항 내지 제8항중의 어느 한 항에 있어서, 출발 물질로 사용된 콜라겐이 겔, 필름, 예를 들어 심낭, 혈관 이식과 같은 천연 조직 형태인 것을 특징으로 하는 방법.
  10. 디페닐포스포릴아지드에 의해 교차 결합되는 것을 특징으로 하는 교차 결합 콜라겐.
  11. 제1항 내지 제9항의 어느 한 항에서 기재한 방법에 의해 수득되는 것을 특징으로 하는 교차 결합 콜라겐.
  12. 디페닐포스포릴아지드에 의해 교차 결합되었다는 것을 특징으로 하는 콜라겐 기재 생체 물질.
    ※ 참고사항 : 최초출원 내용에 의하여 공개하는 것임.
KR1019910701328A 1989-04-12 1990-04-10 디페닐포스포릴아지드에 의한 콜라겐의 교차결합 방법, 이와같이 수득된 교차결합 콜라겐 및 이러한 교차결합 콜라겐 기재 생체 물질 KR0160309B1 (ko)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
FR89-04846 1989-04-12
FR8904846A FR2645870B1 (fr) 1989-04-12 1989-04-12 Procede de reticulation du collagene par le diphenylphosphorylazide, collagene reticule ainsi obtenu et biomateriaux a base de collagene ainsi reticules

Publications (2)

Publication Number Publication Date
KR920701314A true KR920701314A (ko) 1992-08-11
KR0160309B1 KR0160309B1 (ko) 1999-01-15

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Family Applications (1)

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Country Status (17)

Country Link
US (1) US5264551A (ko)
EP (1) EP0466829B1 (ko)
JP (1) JPH07103239B2 (ko)
KR (1) KR0160309B1 (ko)
AT (1) ATE140709T1 (ko)
AU (1) AU5531690A (ko)
BR (1) BR9007287A (ko)
CA (1) CA2051426C (ko)
DE (1) DE69027925T2 (ko)
ES (1) ES2092507T3 (ko)
FI (1) FI914798A0 (ko)
FR (1) FR2645870B1 (ko)
HU (1) HU208840B (ko)
MC (1) MC2187A1 (ko)
NO (1) NO177502C (ko)
RU (1) RU2061000C1 (ko)
WO (1) WO1990012055A2 (ko)

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US5660692A (en) * 1988-02-24 1997-08-26 Cedars-Sinai Medical Center Method of crosslinking amino acid-containing polymers using photoactivatable chemical crosslinkers
FR2675048B1 (fr) * 1991-04-12 1995-06-23 Coletica Utilisation de collagene reticule par un agent de reticulation pour la fabrication de fils de collagene destines a constituer un implant pour le comblement de tissus mous et implant ainsi obtenu.
US5314874A (en) * 1991-04-19 1994-05-24 Koken Co., Ltd. Intracorporeally injectable composition for implanting highly concentrated cross-linked atelocollagen
FR2679778B1 (fr) * 1991-08-02 1995-07-07 Coletica Utilisation de collagene reticule par un agent de reticulation pour la fabrication d'une membrane suturable, biocompatible, a resorption lente, ainsi qu'une telle membrane.
GB9215002D0 (en) * 1992-07-15 1992-08-26 Univ Singapore Method of fixing biological tissue
US5741319A (en) * 1995-01-27 1998-04-21 Medtronic, Inc. Biocompatible medical lead
US20020015724A1 (en) * 1998-08-10 2002-02-07 Chunlin Yang Collagen type i and type iii hemostatic compositions for use as a vascular sealant and wound dressing
US6375672B1 (en) 1999-03-22 2002-04-23 Board Of Trustees Of Michigan State University Method for controlling the chemical and heat induced responses of collagenous materials
FR2801313A1 (fr) 1999-05-19 2001-05-25 Coletica Produit collagenique contenant du collagene d'origine marine a faible odeur et de preference a proprietes mecaniques ameliorees, ainsi que son utilisation sous forme de compositions ou de produits cosmetiques ou pharmaceutiques
US6385491B1 (en) * 1999-10-04 2002-05-07 Medtronic, Inc. Temporary medical electrical lead having biodegradable electrode mounting pad loaded with therapeutic drug
WO2001092322A1 (fr) * 2000-05-26 2001-12-06 Coletica Utilisation de collagene d'origine aquatique pour la realisation de supports destines a l'ingenierie tissulaire, et supports et biomateriaux obtenus
US6790454B1 (en) 2000-05-26 2004-09-14 Coletica Processes for the preparation of novel collagen-based supports for tissue engineering, and biomaterials obtained
FR2809412A1 (fr) 2000-05-26 2001-11-30 Coletica Utilisation de collagene d'origine aquatique pour la realisation de supports destines a l'ingenierie tissulaire, et supports et biomateriaux obtenus
FR2809314B1 (fr) * 2000-05-26 2005-11-18 Coletica Utilisation de collagene d'origine aquatique pour la realisation de supports destines a l'ingenierie tissulaire, et supports et biomateriaux obtenus
US6974679B2 (en) * 2000-05-26 2005-12-13 Coletica Support with collagen base for tissue engineering and manufacture of biomaterials
ATE430593T1 (de) * 2003-10-28 2009-05-15 Medtronic Inc Verfahren zur herstellung von vernetzten materialien und bioprothetischen vorrichtungen
US20070092494A1 (en) * 2005-10-26 2007-04-26 Biomet Manufacturing Corp. Composition for wound healing using lyophilized skin or skin-derived collagen

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JPS4881838A (ko) * 1972-02-15 1973-11-01
US4374060A (en) * 1981-07-15 1983-02-15 Merck & Co., Inc. Process for the preparation of cyclic hexapeptide
US4755593A (en) * 1985-07-24 1988-07-05 Lauren Mark D Novel biomaterial of cross-linked peritoneal tissue
FR2617855B1 (fr) * 1987-07-08 1992-02-21 Bioetica Sa Procede de reticulation du collagene par introduction de groupes azides ainsi que les tissus et biomateriaux obtenus par mise en oeuvre du procede

Also Published As

Publication number Publication date
DE69027925D1 (de) 1996-08-29
EP0466829A1 (fr) 1992-01-22
NO177502B (no) 1995-06-19
CA2051426A1 (en) 1990-10-13
FI914798A0 (fi) 1991-10-11
WO1990012055A2 (fr) 1990-10-18
HU208840B (en) 1994-01-28
US5264551A (en) 1993-11-23
FR2645870A1 (fr) 1990-10-19
DE69027925T2 (de) 1996-12-19
NO914012L (no) 1991-12-10
ATE140709T1 (de) 1996-08-15
AU5531690A (en) 1990-11-05
HUT60753A (en) 1992-10-28
JPH07103239B2 (ja) 1995-11-08
FR2645870B1 (fr) 1993-01-22
EP0466829B1 (fr) 1996-07-24
RU2061000C1 (ru) 1996-05-27
KR0160309B1 (ko) 1999-01-15
BR9007287A (pt) 1992-03-03
MC2187A1 (fr) 1992-09-16
ES2092507T3 (es) 1996-12-01
HU903751D0 (en) 1991-12-30
NO914012D0 (no) 1991-10-11
JPH04504586A (ja) 1992-08-13
CA2051426C (en) 2000-07-25
WO1990012055A3 (fr) 1990-11-15
NO177502C (no) 1995-09-27

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