KR920019353A - 약제학적 활성 성분으로서 2-이미노티아졸리딘-4-온 유도체의 용도 - Google Patents
약제학적 활성 성분으로서 2-이미노티아졸리딘-4-온 유도체의 용도 Download PDFInfo
- Publication number
- KR920019353A KR920019353A KR1019920006034A KR920006034A KR920019353A KR 920019353 A KR920019353 A KR 920019353A KR 1019920006034 A KR1019920006034 A KR 1019920006034A KR 920006034 A KR920006034 A KR 920006034A KR 920019353 A KR920019353 A KR 920019353A
- Authority
- KR
- South Korea
- Prior art keywords
- compound
- formula
- alk
- pharmaceutically acceptable
- acceptable salt
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Ceased
Links
- HYMJHROUVPWYNQ-UHFFFAOYSA-N 2-amino-1,3-thiazol-4-one Chemical class NC1=NC(=O)CS1 HYMJHROUVPWYNQ-UHFFFAOYSA-N 0.000 title 1
- 239000004480 active ingredient Substances 0.000 title 1
- 150000001875 compounds Chemical class 0.000 claims 160
- 150000003839 salts Chemical class 0.000 claims 78
- 125000000217 alkyl group Chemical group 0.000 claims 52
- 229910052739 hydrogen Inorganic materials 0.000 claims 50
- 239000001257 hydrogen Substances 0.000 claims 50
- UFHFLCQGNIYNRP-UHFFFAOYSA-N Hydrogen Chemical compound [H][H] UFHFLCQGNIYNRP-UHFFFAOYSA-N 0.000 claims 31
- 239000008194 pharmaceutical composition Substances 0.000 claims 20
- WKCGPFOFWXAUDX-UHFFFAOYSA-N 1,1'-dithiobis Chemical compound S1C(S2)(C)CC(C)(S3)SC2(C)SC13SSC(S1)(S2)SC3(C)SC1(C)CC2(C)S3 WKCGPFOFWXAUDX-UHFFFAOYSA-N 0.000 claims 19
- 150000002431 hydrogen Chemical class 0.000 claims 19
- 150000007857 hydrazones Chemical class 0.000 claims 18
- 125000002496 methyl group Chemical group [H]C([H])([H])* 0.000 claims 16
- 125000000325 methylidene group Chemical group [H]C([H])=* 0.000 claims 16
- 125000003903 2-propenyl group Chemical group [H]C([*])([H])C([H])=C([H])[H] 0.000 claims 9
- 125000004970 halomethyl group Chemical group 0.000 claims 8
- 125000005237 alkyleneamino group Chemical group 0.000 claims 7
- 238000000034 method Methods 0.000 claims 7
- 241000534944 Thia Species 0.000 claims 5
- WFJFGMLKAISFOZ-UHFFFAOYSA-N 1-amino-3-iminourea Chemical compound NN=C(O)N=N WFJFGMLKAISFOZ-UHFFFAOYSA-N 0.000 claims 4
- -1 2-bromoisobutyl Chemical group 0.000 claims 4
- 125000004423 acyloxy group Chemical group 0.000 claims 4
- 201000010099 disease Diseases 0.000 claims 4
- 208000037265 diseases, disorders, signs and symptoms Diseases 0.000 claims 4
- 125000005394 methallyl group Chemical group 0.000 claims 4
- 125000001494 2-propynyl group Chemical group [H]C#CC([H])([H])* 0.000 claims 2
- 125000005194 alkoxycarbonyloxy group Chemical group 0.000 claims 2
- 239000000546 pharmaceutical excipient Substances 0.000 claims 2
- 239000000825 pharmaceutical preparation Substances 0.000 claims 2
- 239000003826 tablet Substances 0.000 claims 2
- 241001465754 Metazoa Species 0.000 claims 1
- 239000002775 capsule Substances 0.000 claims 1
- 239000002552 dosage form Substances 0.000 claims 1
- 239000003814 drug Substances 0.000 claims 1
- 239000003978 infusion fluid Substances 0.000 claims 1
- 239000007924 injection Substances 0.000 claims 1
- 238000002347 injection Methods 0.000 claims 1
- 238000007911 parenteral administration Methods 0.000 claims 1
- SNOOUWRIMMFWNE-UHFFFAOYSA-M sodium;6-[(3,4,5-trimethoxybenzoyl)amino]hexanoate Chemical compound [Na+].COC1=CC(C(=O)NCCCCCC([O-])=O)=CC(OC)=C1OC SNOOUWRIMMFWNE-UHFFFAOYSA-M 0.000 claims 1
- 239000000829 suppository Substances 0.000 claims 1
Classifications
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/41—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having five-membered rings with two or more ring hetero atoms, at least one of which being nitrogen, e.g. tetrazole
- A61K31/425—Thiazoles
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P29/00—Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]
Landscapes
- Health & Medical Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Veterinary Medicine (AREA)
- Chemical & Material Sciences (AREA)
- Public Health (AREA)
- Medicinal Chemistry (AREA)
- General Health & Medical Sciences (AREA)
- Animal Behavior & Ethology (AREA)
- Pharmacology & Pharmacy (AREA)
- Epidemiology (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Organic Chemistry (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- General Chemical & Material Sciences (AREA)
- Rheumatology (AREA)
- Pain & Pain Management (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Plural Heterocyclic Compounds (AREA)
- Thiazole And Isothizaole Compounds (AREA)
Applications Claiming Priority (2)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CH108791 | 1991-04-12 | ||
| CH1087/91-2 | 1991-04-12 |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| KR920019353A true KR920019353A (ko) | 1992-11-19 |
Family
ID=4202162
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| KR1019920006034A Ceased KR920019353A (ko) | 1991-04-12 | 1992-04-11 | 약제학적 활성 성분으로서 2-이미노티아졸리딘-4-온 유도체의 용도 |
Country Status (15)
| Country | Link |
|---|---|
| US (1) | US5229405A (OSRAM) |
| EP (1) | EP0508955B1 (OSRAM) |
| JP (1) | JPH0597827A (OSRAM) |
| KR (1) | KR920019353A (OSRAM) |
| AT (1) | ATE139441T1 (OSRAM) |
| AU (1) | AU658175B2 (OSRAM) |
| CA (1) | CA2065798A1 (OSRAM) |
| DE (1) | DE59206593D1 (OSRAM) |
| DK (1) | DK0508955T3 (OSRAM) |
| ES (1) | ES2088567T3 (OSRAM) |
| GR (1) | GR3020292T3 (OSRAM) |
| IE (1) | IE75692B1 (OSRAM) |
| IL (1) | IL101506A (OSRAM) |
| TW (1) | TW225989B (OSRAM) |
| ZA (1) | ZA922625B (OSRAM) |
Families Citing this family (7)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| AU664084B2 (en) * | 1992-06-03 | 1995-11-02 | Ciba-Geigy Ag | Novel thiosemicarbazonic acid esters |
| AU665073B2 (en) * | 1992-06-03 | 1995-12-14 | Ciba-Geigy Ag | Novel thiosemicarbazone derivatives |
| JPH07501834A (ja) * | 1992-10-06 | 1995-02-23 | チバーガイギー アクチェンゲゼルシャフト | 新規チオセミカルバゾンチオン |
| AU8143494A (en) * | 1993-11-25 | 1995-06-13 | Ciba-Geigy Ag | Novel substituted thiosemicarbazonic acid esters |
| FI953518A0 (fi) * | 1993-11-25 | 1995-07-21 | Ciba Geigy Ag | Uudet substituoidut tiosemikarbatsonijohdannaiset |
| AU8143394A (en) * | 1993-11-25 | 1995-06-13 | Ciba-Geigy Ag | Novel substitued thiosemicarbazonethiones |
| EP0753147A1 (en) | 1994-03-30 | 1997-01-15 | Novartis AG | Screening method using the rzr receptor family |
Family Cites Families (11)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US3699116A (en) * | 1965-10-29 | 1972-10-17 | Ciba Geigy Corp | 2,2'-azines of 2,4-thiazolidinediones |
| CH511877A (de) * | 1969-07-17 | 1971-08-31 | Ciba Geigy Ag | Verfahren zur Herstellung eines neuen Thiosemicarbazons |
| GB1257971A (OSRAM) * | 1969-07-18 | 1971-12-22 | ||
| AR204619A1 (es) * | 1973-02-13 | 1976-02-20 | Ciba Geigy Ag | Procedimiento para la elaboracion de un nuevo derivado de 2,2-azina-2,4-tiazolidindiona |
| CH579063A5 (OSRAM) * | 1973-02-13 | 1976-08-31 | Ciba Geigy Ag | |
| DE2632746A1 (de) * | 1975-08-06 | 1977-02-24 | Ciba Geigy Ag | Methylen- oder substituierte methyl-thiazaheterocyclyl-azine |
| DE2632747A1 (de) * | 1975-08-06 | 1977-02-24 | Ciba Geigy Ag | Azine von sechs- und siebengliedrigen thiazaheterocyclen |
| DE2632745A1 (de) * | 1975-08-06 | 1977-02-24 | Ciba Geigy Ag | 1,1'-dithiobis-(formamid-hydrazone) |
| DE3064485D1 (en) * | 1979-07-04 | 1983-09-08 | Erba Farmitalia | Anthracycline glycosides, process for their preparation and therapeutical composition containing them |
| EP0085275B1 (de) * | 1982-01-22 | 1986-02-19 | Ciba-Geigy Ag | Substituierte Thiazolidinylester von Mineralsäuren |
| US4582841A (en) * | 1983-07-19 | 1986-04-15 | Ciba-Geigy Corporation | Substituted thiazolidinyl esters of mineral acids |
-
1992
- 1992-03-30 AU AU13906/92A patent/AU658175B2/en not_active Ceased
- 1992-04-03 DK DK92810257.3T patent/DK0508955T3/da not_active Application Discontinuation
- 1992-04-03 ES ES92810257T patent/ES2088567T3/es not_active Expired - Lifetime
- 1992-04-03 AT AT92810257T patent/ATE139441T1/de not_active IP Right Cessation
- 1992-04-03 DE DE59206593T patent/DE59206593D1/de not_active Expired - Fee Related
- 1992-04-03 EP EP92810257A patent/EP0508955B1/de not_active Expired - Lifetime
- 1992-04-06 IL IL10150692A patent/IL101506A/en not_active IP Right Cessation
- 1992-04-09 JP JP4087445A patent/JPH0597827A/ja active Pending
- 1992-04-09 TW TW081102728A patent/TW225989B/zh active
- 1992-04-10 ZA ZA922625A patent/ZA922625B/xx unknown
- 1992-04-10 IE IE921165A patent/IE75692B1/en not_active IP Right Cessation
- 1992-04-10 US US07/866,926 patent/US5229405A/en not_active Expired - Fee Related
- 1992-04-10 CA CA002065798A patent/CA2065798A1/en not_active Abandoned
- 1992-04-11 KR KR1019920006034A patent/KR920019353A/ko not_active Ceased
-
1996
- 1996-06-20 GR GR960401463T patent/GR3020292T3/el unknown
Also Published As
| Publication number | Publication date |
|---|---|
| IL101506A (en) | 1996-08-04 |
| TW225989B (OSRAM) | 1994-07-01 |
| IE921165A1 (en) | 1992-10-21 |
| IL101506A0 (en) | 1992-12-30 |
| JPH0597827A (ja) | 1993-04-20 |
| ES2088567T3 (es) | 1996-08-16 |
| AU658175B2 (en) | 1995-04-06 |
| AU1390692A (en) | 1992-10-15 |
| IE75692B1 (en) | 1997-09-10 |
| GR3020292T3 (en) | 1996-09-30 |
| EP0508955B1 (de) | 1996-06-19 |
| ATE139441T1 (de) | 1996-07-15 |
| US5229405A (en) | 1993-07-20 |
| ZA922625B (en) | 1992-11-25 |
| CA2065798A1 (en) | 1992-10-13 |
| DK0508955T3 (da) | 1996-07-15 |
| EP0508955A1 (de) | 1992-10-14 |
| DE59206593D1 (de) | 1996-07-25 |
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Legal Events
| Date | Code | Title | Description |
|---|---|---|---|
| PA0109 | Patent application |
Patent event code: PA01091R01D Comment text: Patent Application Patent event date: 19920411 |
|
| PG1501 | Laying open of application | ||
| A201 | Request for examination | ||
| AMND | Amendment | ||
| PA0201 | Request for examination |
Patent event code: PA02012R01D Patent event date: 19970410 Comment text: Request for Examination of Application Patent event code: PA02011R01I Patent event date: 19920411 Comment text: Patent Application |
|
| N231 | Notification of change of applicant | ||
| PN2301 | Change of applicant |
Patent event date: 19970731 Comment text: Notification of Change of Applicant Patent event code: PN23011R01D |
|
| E902 | Notification of reason for refusal | ||
| PE0902 | Notice of grounds for rejection |
Comment text: Notification of reason for refusal Patent event date: 19990316 Patent event code: PE09021S01D |
|
| AMND | Amendment | ||
| E601 | Decision to refuse application | ||
| PE0601 | Decision on rejection of patent |
Patent event date: 19991108 Comment text: Decision to Refuse Application Patent event code: PE06012S01D Patent event date: 19990316 Comment text: Notification of reason for refusal Patent event code: PE06011S01I |
|
| J201 | Request for trial against refusal decision | ||
| PJ0201 | Trial against decision of rejection |
Patent event date: 20000208 Comment text: Request for Trial against Decision on Refusal Patent event code: PJ02012R01D Patent event date: 19991108 Comment text: Decision to Refuse Application Patent event code: PJ02011S01I Appeal kind category: Appeal against decision to decline refusal Decision date: 20020329 Appeal identifier: 2000101000289 Request date: 20000208 |
|
| PB0901 | Examination by re-examination before a trial |
Comment text: Request for Trial against Decision on Refusal Patent event date: 20000208 Patent event code: PB09011R01I Comment text: Amendment to Specification, etc. Patent event date: 19990816 Patent event code: PB09011R02I Comment text: Amendment to Specification, etc. Patent event date: 19970410 Patent event code: PB09011R02I |
|
| B601 | Maintenance of original decision after re-examination before a trial | ||
| PB0601 | Maintenance of original decision after re-examination before a trial | ||
| J301 | Trial decision |
Free format text: TRIAL DECISION FOR APPEAL AGAINST DECISION TO DECLINE REFUSAL REQUESTED 20000208 Effective date: 20020329 Free format text: TRIAL NUMBER: 2000101000289; TRIAL DECISION FOR APPEAL AGAINST DECISION TO DECLINE REFUSAL REQUESTED 20000208 Effective date: 20020329 |
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| PJ1301 | Trial decision |
Patent event code: PJ13011S01D Patent event date: 20020329 Comment text: Trial Decision on Objection to Decision on Refusal Appeal kind category: Appeal against decision to decline refusal Request date: 20000208 Decision date: 20020329 Appeal identifier: 2000101000289 |