KR920006008A - 골(骨) 형성 촉진 물질의 제조법 - Google Patents

골(骨) 형성 촉진 물질의 제조법 Download PDF

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Publication number
KR920006008A
KR920006008A KR1019910015592A KR910015592A KR920006008A KR 920006008 A KR920006008 A KR 920006008A KR 1019910015592 A KR1019910015592 A KR 1019910015592A KR 910015592 A KR910015592 A KR 910015592A KR 920006008 A KR920006008 A KR 920006008A
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dialysis
solution
dalton
extraction
preparation
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KR1019910015592A
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English (en)
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고오에이 노또야
요시다게이지
이와이 야마자끼
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모리따 가쯔라
다께다 야꾸힝 고오교 가부시끼가이샤
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Publication of KR920006008A publication Critical patent/KR920006008A/ko

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    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61L—METHODS OR APPARATUS FOR STERILISING MATERIALS OR OBJECTS IN GENERAL; DISINFECTION, STERILISATION OR DEODORISATION OF AIR; CHEMICAL ASPECTS OF BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES; MATERIALS FOR BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES
    • A61L27/00—Materials for grafts or prostheses or for coating grafts or prostheses
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61L—METHODS OR APPARATUS FOR STERILISING MATERIALS OR OBJECTS IN GENERAL; DISINFECTION, STERILISATION OR DEODORISATION OF AIR; CHEMICAL ASPECTS OF BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES; MATERIALS FOR BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES
    • A61L27/00—Materials for grafts or prostheses or for coating grafts or prostheses
    • A61L27/36—Materials for grafts or prostheses or for coating grafts or prostheses containing ingredients of undetermined constitution or reaction products thereof, e.g. transplant tissue, natural bone, extracellular matrix
    • A61L27/3604—Materials for grafts or prostheses or for coating grafts or prostheses containing ingredients of undetermined constitution or reaction products thereof, e.g. transplant tissue, natural bone, extracellular matrix characterised by the human or animal origin of the biological material, e.g. hair, fascia, fish scales, silk, shellac, pericardium, pleura, renal tissue, amniotic membrane, parenchymal tissue, fetal tissue, muscle tissue, fat tissue, enamel
    • A61L27/3608—Bone, e.g. demineralised bone matrix [DBM], bone powder
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61F—FILTERS IMPLANTABLE INTO BLOOD VESSELS; PROSTHESES; DEVICES PROVIDING PATENCY TO, OR PREVENTING COLLAPSING OF, TUBULAR STRUCTURES OF THE BODY, e.g. STENTS; ORTHOPAEDIC, NURSING OR CONTRACEPTIVE DEVICES; FOMENTATION; TREATMENT OR PROTECTION OF EYES OR EARS; BANDAGES, DRESSINGS OR ABSORBENT PADS; FIRST-AID KITS
    • A61F2/00—Filters implantable into blood vessels; Prostheses, i.e. artificial substitutes or replacements for parts of the body; Appliances for connecting them with the body; Devices providing patency to, or preventing collapsing of, tubular structures of the body, e.g. stents
    • A61F2/02—Prostheses implantable into the body
    • A61F2/28—Bones
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K35/00—Medicinal preparations containing materials or reaction products thereof with undetermined constitution
    • A61K35/12—Materials from mammals; Compositions comprising non-specified tissues or cells; Compositions comprising non-embryonic stem cells; Genetically modified cells
    • A61K35/32—Bones; Osteocytes; Osteoblasts; Tendons; Tenocytes; Teeth; Odontoblasts; Cartilage; Chondrocytes; Synovial membrane
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61L—METHODS OR APPARATUS FOR STERILISING MATERIALS OR OBJECTS IN GENERAL; DISINFECTION, STERILISATION OR DEODORISATION OF AIR; CHEMICAL ASPECTS OF BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES; MATERIALS FOR BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES
    • A61L27/00—Materials for grafts or prostheses or for coating grafts or prostheses
    • A61L27/36—Materials for grafts or prostheses or for coating grafts or prostheses containing ingredients of undetermined constitution or reaction products thereof, e.g. transplant tissue, natural bone, extracellular matrix
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61L—METHODS OR APPARATUS FOR STERILISING MATERIALS OR OBJECTS IN GENERAL; DISINFECTION, STERILISATION OR DEODORISATION OF AIR; CHEMICAL ASPECTS OF BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES; MATERIALS FOR BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES
    • A61L27/00—Materials for grafts or prostheses or for coating grafts or prostheses
    • A61L27/36—Materials for grafts or prostheses or for coating grafts or prostheses containing ingredients of undetermined constitution or reaction products thereof, e.g. transplant tissue, natural bone, extracellular matrix
    • A61L27/3683—Materials for grafts or prostheses or for coating grafts or prostheses containing ingredients of undetermined constitution or reaction products thereof, e.g. transplant tissue, natural bone, extracellular matrix subjected to a specific treatment prior to implantation, e.g. decellularising, demineralising, grinding, cellular disruption/non-collagenous protein removal, anti-calcification, crosslinking, supercritical fluid extraction, enzyme treatment
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K4/00—Peptides having up to 20 amino acids in an undefined or only partially defined sequence; Derivatives thereof
    • C07K4/12—Peptides having up to 20 amino acids in an undefined or only partially defined sequence; Derivatives thereof from animals; from humans

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  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • General Health & Medical Sciences (AREA)
  • Biomedical Technology (AREA)
  • Public Health (AREA)
  • Animal Behavior & Ethology (AREA)
  • Engineering & Computer Science (AREA)
  • Veterinary Medicine (AREA)
  • Medicinal Chemistry (AREA)
  • Transplantation (AREA)
  • Epidemiology (AREA)
  • Oral & Maxillofacial Surgery (AREA)
  • Dermatology (AREA)
  • Botany (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Molecular Biology (AREA)
  • Orthopedic Medicine & Surgery (AREA)
  • Zoology (AREA)
  • Organic Chemistry (AREA)
  • Cell Biology (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Vascular Medicine (AREA)
  • Rheumatology (AREA)
  • Biotechnology (AREA)
  • Cardiology (AREA)
  • Developmental Biology & Embryology (AREA)
  • Immunology (AREA)
  • Virology (AREA)
  • Heart & Thoracic Surgery (AREA)
  • Toxicology (AREA)
  • Biochemistry (AREA)
  • Biophysics (AREA)
  • Genetics & Genomics (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Urology & Nephrology (AREA)
  • Medicines Containing Material From Animals Or Micro-Organisms (AREA)
  • Peptides Or Proteins (AREA)

Abstract

내용 없음

Description

골(骨)형성 촉진물질의 제조법
본 내용은 요부공개 건이므로 전문내용을 수록하지 않았음

Claims (8)

  1. 골(骨)형성 촉진 물질의 제조법에서 탈무기(demineralized)골 분말을 카오트로픽시약(chaotropic reagent)으로 추출하고, 추출 용액을 한외 여과시켜 1,000∼100,000 달톤 분자량 범위의 물질을 함유하는 분획을 수집하고 수집된 분획을 투석하여 투석 액체에서 수-비용해성 분획을 수집하는 것으로 구성되는 것을 특징으로 하는 골형성 촉진 물질의 제조법.
  2. 제1항에 있어서, 탈무기 골 분말이 소 또는 신생 송아지 골(骨)에서 수득된 것임을 특징으로 하는 제조법.
  3. 제1항에 있어서, 카오트로픽 시약 용액이 구아니딘 히드로클로라이드 수용액 임을 특징으로 하는 제조법.
  4. 제2항에 있어서, 추출시에 탈무기 골분말의 1kg 당 10∼50ℓ양으로 1 내지 5M 구아니딘 히드로클로라이드 수용액을 사용하는 것을 특징으로 하는 제조법.
  5. 제1항에 있어서, 추출을 프로테아제 억제제 존재하에 수행하는 것을 특징으로 하는 제조법.
  6. 제1항에 있어서, 한외여과 과정을 1,000 달톤 임계 한외 여과기 및 100,000 달톤 임계 한외 여과기를 사용하여 수행하는 것을 특징으로 하는 제조법.
  7. 제1항에 있어서, 투석과정을 반투성막으로 구성되며 약 1,000∼8,000 달톤의 분획 분자량 및 탈이온수의 외부 용액을 가지는 투석 튜브를 사용하여 수행하는 것을 특징으로 하는 제조법.
  8. 제1항에 있어서, 수-비용해성 분획은 원심분리하여 수집하고 또한 친액성화하여 분말을 수득하는 것을 특징으로 하는 제조법.
    ※ 참고사항 : 최초출원 내용에 의하여 공개하는 것임.
KR1019910015592A 1990-09-06 1991-09-06 골(骨) 형성 촉진 물질의 제조법 KR920006008A (ko)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
JP90-238424 1990-09-06
JP23842490 1990-09-06

Publications (1)

Publication Number Publication Date
KR920006008A true KR920006008A (ko) 1992-04-27

Family

ID=17030007

Family Applications (1)

Application Number Title Priority Date Filing Date
KR1019910015592A KR920006008A (ko) 1990-09-06 1991-09-06 골(骨) 형성 촉진 물질의 제조법

Country Status (4)

Country Link
EP (1) EP0474174A3 (ko)
KR (1) KR920006008A (ko)
AU (1) AU8361991A (ko)
CA (1) CA2050744A1 (ko)

Families Citing this family (4)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CN1678631A (zh) 2002-06-20 2005-10-05 尼古拉斯·杜内斯 骨诱导性生物材料
GB2404854A (en) * 2003-07-03 2005-02-16 Phyto Res Ltd Extracts and extraction method
WO2005023325A1 (ja) * 2003-08-27 2005-03-17 Pentax Corporation 微細骨粉を含浸させた生体適合性材料からなる構造体及びその製造方法
WO2012172220A1 (fr) * 2011-04-22 2012-12-20 L'oreal Signature moléculaire des taches pigmentaires cutanées, associée à la matrice extracellulaire

Family Cites Families (5)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US4455256A (en) * 1981-05-05 1984-06-19 The Regents Of The University Of California Bone morphogenetic protein
US4434094A (en) * 1983-04-12 1984-02-28 Collagen Corporation Partially purified osteogenic factor and process for preparing same from demineralized bone
US4563350A (en) * 1984-10-24 1986-01-07 Collagen Corporation Inductive collagen based bone repair preparations
US4743259A (en) * 1986-10-29 1988-05-10 The University Of Virginia Alumni Patents Foundation Use of demineralized bone matrix in the repair of segmental defects
DE68918043T2 (de) * 1988-10-25 1995-03-02 Takao Yamamuro Knochenersatzmaterial und Knochenzement.

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Publication number Publication date
EP0474174A2 (en) 1992-03-11
CA2050744A1 (en) 1992-03-07
AU8361991A (en) 1992-03-12
EP0474174A3 (en) 1993-01-27

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