DE69009668D1 - Verfahren zur herstellung von aktiviertem protein c. - Google Patents

Verfahren zur herstellung von aktiviertem protein c.

Info

Publication number
DE69009668D1
DE69009668D1 DE69009668T DE69009668T DE69009668D1 DE 69009668 D1 DE69009668 D1 DE 69009668D1 DE 69009668 T DE69009668 T DE 69009668T DE 69009668 T DE69009668 T DE 69009668T DE 69009668 D1 DE69009668 D1 DE 69009668D1
Authority
DE
Germany
Prior art keywords
activated protein
pct
sec
aprotinin
producing activated
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Expired - Fee Related
Application number
DE69009668T
Other languages
English (en)
Other versions
DE69009668T2 (de
Inventor
Marion Steinbuch
Jacques Chabbat
Olivier Taby
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
FOND NAT TRANSFUSION SANGUINE
Original Assignee
FOND NAT TRANSFUSION SANGUINE
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Priority claimed from FR8904814A external-priority patent/FR2645865B1/fr
Application filed by FOND NAT TRANSFUSION SANGUINE filed Critical FOND NAT TRANSFUSION SANGUINE
Application granted granted Critical
Publication of DE69009668D1 publication Critical patent/DE69009668D1/de
Publication of DE69009668T2 publication Critical patent/DE69009668T2/de
Anticipated expiration legal-status Critical
Expired - Fee Related legal-status Critical Current

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K1/00—General methods for the preparation of peptides, i.e. processes for the organic chemical preparation of peptides or proteins of any length
    • C07K1/02—General methods for the preparation of peptides, i.e. processes for the organic chemical preparation of peptides or proteins of any length in solution
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N9/00—Enzymes; Proenzymes; Compositions thereof; Processes for preparing, activating, inhibiting, separating or purifying enzymes
    • C12N9/14—Hydrolases (3)
    • C12N9/48—Hydrolases (3) acting on peptide bonds (3.4)
    • C12N9/50—Proteinases, e.g. Endopeptidases (3.4.21-3.4.25)
    • C12N9/64—Proteinases, e.g. Endopeptidases (3.4.21-3.4.25) derived from animal tissue
    • C12N9/6421—Proteinases, e.g. Endopeptidases (3.4.21-3.4.25) derived from animal tissue from mammals
    • C12N9/6424—Serine endopeptidases (3.4.21)
    • C12N9/6464—Protein C (3.4.21.69)
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12Y—ENZYMES
    • C12Y304/00—Hydrolases acting on peptide bonds, i.e. peptidases (3.4)
    • C12Y304/21—Serine endopeptidases (3.4.21)
    • C12Y304/21069—Protein C activated (3.4.21.69)

Landscapes

  • Chemical & Material Sciences (AREA)
  • Health & Medical Sciences (AREA)
  • Organic Chemistry (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • Genetics & Genomics (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Wood Science & Technology (AREA)
  • Zoology (AREA)
  • Biochemistry (AREA)
  • General Health & Medical Sciences (AREA)
  • Biomedical Technology (AREA)
  • General Engineering & Computer Science (AREA)
  • Molecular Biology (AREA)
  • Medicinal Chemistry (AREA)
  • Microbiology (AREA)
  • Biotechnology (AREA)
  • Analytical Chemistry (AREA)
  • Biophysics (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Peptides Or Proteins (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Preparation Of Compounds By Using Micro-Organisms (AREA)
  • Medicines Containing Material From Animals Or Micro-Organisms (AREA)
  • Enzymes And Modification Thereof (AREA)
DE69009668T 1989-04-12 1990-04-10 Verfahren zur herstellung von aktiviertem protein c. Expired - Fee Related DE69009668T2 (de)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
FR8904814A FR2645865B1 (fr) 1989-04-12 1989-04-12 Procede de preparation de la proteine c activee et solution de proteine c activee ainsi obtenue
FR909002028A FR2658517B2 (fr) 1989-04-12 1990-02-20 Preparation de la proteine c activee et solution de proteine c activee ainsi obtenue.
PCT/FR1990/000258 WO1990012028A1 (fr) 1989-04-12 1990-04-10 Procede de preparation de la proteine c activee et solution de proteine c activee ainsi obtenue

Publications (2)

Publication Number Publication Date
DE69009668D1 true DE69009668D1 (de) 1994-07-14
DE69009668T2 DE69009668T2 (de) 1994-10-06

Family

ID=26227270

Family Applications (1)

Application Number Title Priority Date Filing Date
DE69009668T Expired - Fee Related DE69009668T2 (de) 1989-04-12 1990-04-10 Verfahren zur herstellung von aktiviertem protein c.

Country Status (13)

Country Link
US (1) US5198534A (de)
EP (1) EP0424498B1 (de)
JP (1) JPH03505531A (de)
KR (1) KR920700220A (de)
AT (1) ATE106893T1 (de)
CA (1) CA2030783A1 (de)
DE (1) DE69009668T2 (de)
DK (1) DK0424498T3 (de)
ES (1) ES2054355T3 (de)
FR (1) FR2658517B2 (de)
MA (1) MA21807A1 (de)
PL (1) PL284757A1 (de)
WO (1) WO1990012028A1 (de)

Families Citing this family (5)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
AT397615B (de) * 1991-05-14 1994-05-25 Immuno Ag Arzneimittel enthaltend protein c
AT402262B (de) * 1991-06-20 1997-03-25 Immuno Ag Arzneimittel enthaltend aktiviertes protein c
DE4320294A1 (de) * 1993-06-18 1994-12-22 Immuno Ag Verwendung von humanem Protein C zur Verhinderung und Behandlung von Thrombozytenablagerungen
US6867045B1 (en) * 1994-11-14 2005-03-15 The Scripps Research Institute Method for diagnosis of thrombotic disorders
JP3745805B2 (ja) * 1995-10-24 2006-02-15 日本ケミカルリサーチ株式会社 トロンボモジュリンの精製方法

Family Cites Families (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
GB8319538D0 (en) * 1983-07-20 1983-08-24 Beecham Group Plc Compounds
US4849403A (en) * 1985-05-29 1989-07-18 Pentapharm Ag Protein C activator, methods of preparation and use thereof
DE3882411T2 (de) * 1987-04-17 1993-12-16 Teijin Ltd Verfahren zur Trennung von aktiviertem menschlichem Protein C.

Also Published As

Publication number Publication date
DK0424498T3 (da) 1994-07-04
DE69009668T2 (de) 1994-10-06
WO1990012028A1 (fr) 1990-10-18
ATE106893T1 (de) 1994-06-15
EP0424498B1 (de) 1994-06-08
MA21807A1 (fr) 1990-12-31
EP0424498A1 (de) 1991-05-02
FR2658517B2 (fr) 1992-06-19
FR2658517A2 (fr) 1991-08-23
KR920700220A (ko) 1992-02-19
US5198534A (en) 1993-03-30
CA2030783A1 (fr) 1990-10-13
JPH03505531A (ja) 1991-12-05
PL284757A1 (en) 1991-01-14
ES2054355T3 (es) 1994-08-01

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Legal Events

Date Code Title Description
8364 No opposition during term of opposition
8339 Ceased/non-payment of the annual fee