KR910020178A - 돼지성장 호르몬 방출인자의 전구체 형태 및 관련된 dna 화합물 - Google Patents

돼지성장 호르몬 방출인자의 전구체 형태 및 관련된 dna 화합물 Download PDF

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KR910020178A
KR910020178A KR1019910008644A KR910008644A KR910020178A KR 910020178 A KR910020178 A KR 910020178A KR 1019910008644 A KR1019910008644 A KR 1019910008644A KR 910008644 A KR910008644 A KR 910008644A KR 910020178 A KR910020178 A KR 910020178A
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징찬
루이스 하이맨 마크
맥스웰 씨웅 한센
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리로이 휘태커
일라이 릴리 앤드 캄파니
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    • C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
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    • C07K14/575—Hormones
    • C07K14/60—Growth hormone-releasing factor [GH-RF], i.e. somatoliberin
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Abstract

내용 없음

Description

돼지성장 호르몬 방출인자의 전구체 형태 및 관련된 DNA 화합물
본 내용은 요부공개 건이므로 전문내용을 수록하지 않았음

Claims (14)

  1. 하기 서열식 (Ⅰ)의 폴리펩타이드 화합물을 암호화하는 분리된 DNA 화합물.
    A―Tyr―Ala―Asp―Ala―Ile―Phe―Thr―Asn―B―Tyr―Arg―Lys―Val―Leu―Gly―Gln―Leu―Ser―Ala―Arg―Lys―Leu―Leu―Gln―Asp―Ile―Met―Ser―Arg―Gln―Gln―Gly―Gln―Arg―Asn―Gln―Glu―Gln―Gly―Ala―Arg―Val―Arg―Leu―Arg―Gln―Val―Asp―Ser―Met―Trp―Ala―Asp―Gln―Lys―Gln―Met―Ala―Leu―Glu―Ser―Ile―Leu―Ala―Thr―Leu―Leu―Gln―Glu―His―Arg―Asn―Ser―Gln―Gly―OH; (Ⅰ)
    상기식에서, A는 수소 또는 H―Met―Leu―Leu―Trp―Val―Phe―Phe―Leu―Val―Thr―Leu―Thr-Leu―Ser―Ser―Gly―Ser―Leu―Ser―Gln―Pro―Leu―Arg―Met―Pro―Arg이고, B는 Asn 또는 Ser이다.
  2. 제1항에 있어서, 하기 서열식 (Ⅰa)의 폴리펩타이드 화합물을 암호화하는 분리된 DNA 서열을 함유하는 DNA 화합물.
    H―Tyr―Ala―Asp―Ala―Ile―Phe―Thr―Asn―Ser―Tyr―Arg―Lys―Val―Leu―Gly―Gln―Leu―Ser―Ala―Arg―Lys―Leu―Leu―Gln―Asp―Ile―Met―Ser―Arg―Gln―Gln―Gly―Glu―Arg―Gln―Gln―Gly―Ala―Arg―Val―Arg―Leu―Gly―Arg―Gln―Val―Asp―Ser―Met―Trp―Ala―Asp―Gln―Lys―Gln―Met―Ala―Leu―Glu―Ser―Ile―Leu―Ala―Thr―Leu―Leu―Gln―Glu―His―Arg―Asn―Ser―Gln―Gly―OH. (Ⅰa)
  3. 제1항에 있어서, 하기 서열식(Ⅰb)의 폴리펩타이드 화합물을 암호화하는 분리된 DNA 서열을 함유하는 DNA 화합물.
    H―Tyr―Ala―Asp―Ala―Ile―Phe―Thr―Asn―Asn―Tyr―Arg―Lys―Val―Leu―Gly―Gln―Leu―Ser―Ala―Arg―Lys―Leu―Leu―Gln―Asp―Ile―Met―Ser―Arg―Gln―Gln―Gly―Glu―Arg―Asn―Gln―glu―Gln―Gly―Ala―Arg―Val―Arg―Leu―Gly―Arg―Gln―Val―Asp―Ser―Met―Trp―Ala―Asp―Gln―Lys―Gln―Met―Ala―Leu―Glu―Ser―Ile―Leu―Ala―Thr―Leu―Leu―Gln―Glu―His―Arg―Asn―Ser―Gln―Gly―OH. (Ⅰb)
  4. 제3항에 있어서, 분리된 DNA 서열이 하기 서열식(1)인 DNA 화합물.
  5. 제2항에 있어서, 분리된 DNA 서열이 하기 서열식(2)인 DNA 화합물.
  6. 하기 서열식(3)의 분리된 DNA 서열을 함유하는 DNA 화합물.
  7. 하기 서열식(4)의 분리된 DNA 서열을 함유하는 DNA 화합물.
  8. 하기 서열식(Ⅰ)의 폴리펩타이드 화합물 및 이의 약제학적으로 허용되는 산 또는 카복실산 부가염.
    A―Tyr―Ala―Asp―Ala―Ile―Phe―Thr―Asn―B―Tyr―Arg―Lys―Val―Leu―Gly―Gln―Leu―Ser―Ala―Arg―Lys―Leu―Leu―Gln―Asp―Ile―Met―Ser―Arg―Gln―Gln―Gly―Arg- Asn- Gln- Glu- Gln- Gly- Ala―Arg―Val―Arg―Leu―Gly―Arg―Gln―Val―Asp―Ser―Met―Trp―Als―Asp―Gln―Lys―Gln―Met―Ala―Leu―Glu―Ser―Ile―Leu―Ala―Thr―Leu―Leu―Gln―Gln――Glu―His―Arg―Asn―Ser―Gln―Gly―OH (Ⅰ)
    상기식에서, A는 수소 또는H―Met―Leu―Leu―Trp―Val―Phe―Phe―Leu―Val―Thr―Leu―Thr- Leu- Ser―Ser―Gly―Ser―Leu―Ser―Gln―Pro―Leu―Arg―Met―Pro―Arg이고, B는 Asn 또는 Ser이다.
  9. 제8항에 있어서, 하기 서열식(Ⅰb)의 폴리펩타이드 화합물 및 이의 약제학적으로 허용되는 산 또는 카복실산 부가염.
    H―Tyr―Ala―Asp―Ala―Ile―Phe―Thr―Asn―Ser―Tyr―Arg―Lys―Val―Leu―Gly―Gln―Leu―Ser―Ala―Arg―Lys―Leu―Leu―Gln―Asp―Ile―Met―Ser―Arg―Leu―Gly―Arg―Gln―Val―Asp―Ser―Met―Trp―Als―Asp―Gln―Met―Ala―Leu―Glu―Ser―Ile―Leu―Ala―Thr―Leu―Leu―Gln―Gln―His―Arg―Asn―Ser―Gln―Gly―OH. (Ⅰa)
  10. 제8항에 있어서, 하기 서열식(Ⅰa)의 폴리펩타이드 화합물 및 이의 약제학적으로 허용되는 산 또는 카복실산 부가염.
    H―Tyr―Ala―Asp―Ala―Ile―Phe―Thr―Asn―Ser―Tyr―Arg―Lys―Val―Leu―Gly―Gln―Leu―Ser―Ala―Arg―Lys―Leu―Leu―Gln―Asp―Ile―Met―Ser―Arg―Leu―Gly―Arg―Gln―Val―Asp―Ser―Met―Trp―Als―Asp―Gln―Met―Ala―Leu―Glu―Ser―Ile―Leu―Ala―Thr―Leu―Leu―Gln―Gln―His―Arg―Asn―Ser―Gln―Gly―OH. (Ⅰa)
  11. 활성제로서 하기 서열식(Ⅱ)의 폴리펩타이드 화합물 또는 이의 약제학적으로 허용되는 산 또는 카복실산 부가염과 약제학적으로 허용되는 고체 또는 책체 담체를 함유하는 약제학적 조성물.
    H―Tyr―Ala―Asp―Ala―Ile―Phe―Thr―Asn―Ser―Tyr―Arg―Lys―Val―Leu―Gly―Gln―Leu―Ser―Ala―Arg―Lys―Leu―Leu―Gln―Asp―Ile―Met―Ser―Arg―Ley- Gly- Arg- Gln―Val―Asp―Ser―Met―Trp―Als―Asp―Gln―Met―Ala―Leu―Glu―Ser―Ile―Leu―Ala―Thr―Leu―Leu―Gln―Gln―His―Arg―Asn―Ser―Gln―Gly―OH. (Ⅱ)
    상기식에서, A는 Asn 또는 Ser 이다.
  12. 제11항에 있어서, A가 Asn 인 약제학적 조성물.
  13. 제11항에 있어서, A가 Ser 인 약제학적 조성물.
  14. 하기 서열식(Ⅲ)의 폴리펩타이드 화합물.
    H―Tyr―Ala―Asp―Ala―Ile―Phe―Thr―Asn―Ser―Tyr―Arg―Lys―Val―Leu―Gly―Gln―Leu―Ser―Ala―Arg―Lys―Leu―Leu―Gln―Asp―Ile―Met―Ser―Arg―Gln―Gln―Gly―Glu―Arg―Asn―Gln←Glu―Gln―Gly―Ala―Arg―Val―Leu―A 상기식에서 A는 OH 또는 NH2이다.
    ※ 참고사항 : 최초출원 내용에 의하여 공개되는 것임.
KR1019910008644A 1990-05-29 1991-05-27 돼지성장 호르몬 방출인자의 전구체 형태 및 관련된 dna 화합물 KR910020178A (ko)

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EP (1) EP0459747A1 (ko)
JP (1) JPH0568559A (ko)
KR (1) KR910020178A (ko)
AU (1) AU639107B2 (ko)
CA (1) CA2043049A1 (ko)
CS (1) CS158391A3 (ko)
HU (1) HUT58799A (ko)
IE (1) IE911816A1 (ko)
IL (1) IL98210A0 (ko)
NZ (1) NZ238233A (ko)
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ZA922695B (en) * 1991-04-19 1993-10-13 Lilly Co Eli Precursor form of bovine growth hormone releasing factor and related DNA compounds
EP0988388A2 (en) * 1997-07-24 2000-03-29 Valentis Inc. Ghrh expression system and methods of use
KR100358937B1 (ko) * 1998-04-23 2003-03-17 주식회사 엘지생명과학 성장호르몬 분비자극 활성을 가지는 수용성지모 추출물 및 그로부터 분리한 성장호르몬 분비촉진 인자
US7468273B2 (en) 2003-05-01 2008-12-23 Meial Limited Canine GHRH gene, polypeptides and methods of use
JP2008500010A (ja) 2003-05-01 2008-01-10 メリアル リミテッド イヌ科動物のｇｈｒｈ遺伝子、ポリペプチド及び使用方法
CN100404679C (zh) * 2005-09-23 2008-07-23 张永亮 GRF（1-32）与SS-HBsAg融合基因组合及其构建成的表达系统和药物制剂

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DE3381567D1 (de) * 1982-11-04 1990-06-21 Hoffmann La Roche Hestellung von rekombinanten wachstumsausloesenden faktoren.
US4728609A (en) * 1983-01-10 1988-03-01 Hoffmann-La-Roche Inc. Recombinant growth hormone releasing factor
US4610976A (en) * 1983-08-29 1986-09-09 The Salk Institute For Biological Studies Porcine GRF
ZA866026B (en) * 1985-08-12 1988-04-27 Syntex Inc Bovine growth hormone releasing factor derivative

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EP0459747A1 (en) 1991-12-04
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HU911783D0 (en) 1991-12-30
NZ238233A (en) 1992-12-23
ZA913876B (en) 1993-01-27
IL98210A0 (en) 1992-06-21
AU639107B2 (en) 1993-07-15
HUT58799A (en) 1992-03-30
IE911816A1 (en) 1991-12-04
AU7800391A (en) 1991-12-05
CS158391A3 (en) 1992-01-15

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