KR910007949A - 아스코르브산의 2-인산 에스테르의 제조방법 - Google Patents

아스코르브산의 2-인산 에스테르의 제조방법 Download PDF

Info

Publication number
KR910007949A
KR910007949A KR1019900017618A KR900017618A KR910007949A KR 910007949 A KR910007949 A KR 910007949A KR 1019900017618 A KR1019900017618 A KR 1019900017618A KR 900017618 A KR900017618 A KR 900017618A KR 910007949 A KR910007949 A KR 910007949A
Authority
KR
South Korea
Prior art keywords
ascorbic acid
optionally protected
carried out
reaction
phosphorylation
Prior art date
Application number
KR1019900017618A
Other languages
English (en)
Inventor
고끼찌 요시다
야스시 가와시마
Original Assignee
우메모또 요시마사
다께다야꾸힝고오교 가부시끼가이샤
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by 우메모또 요시마사, 다께다야꾸힝고오교 가부시끼가이샤 filed Critical 우메모또 요시마사
Publication of KR910007949A publication Critical patent/KR910007949A/ko

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07H—SUGARS; DERIVATIVES THEREOF; NUCLEOSIDES; NUCLEOTIDES; NUCLEIC ACIDS
    • C07H1/00—Processes for the preparation of sugar derivatives
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07F—ACYCLIC, CARBOCYCLIC OR HETEROCYCLIC COMPOUNDS CONTAINING ELEMENTS OTHER THAN CARBON, HYDROGEN, HALOGEN, OXYGEN, NITROGEN, SULFUR, SELENIUM OR TELLURIUM
    • C07F9/00—Compounds containing elements of Groups 5 or 15 of the Periodic Table
    • C07F9/02—Phosphorus compounds
    • C07F9/547—Heterocyclic compounds, e.g. containing phosphorus as a ring hetero atom
    • C07F9/655—Heterocyclic compounds, e.g. containing phosphorus as a ring hetero atom having oxygen atoms, with or without sulfur, selenium, or tellurium atoms, as the only ring hetero atoms
    • C07F9/65515—Heterocyclic compounds, e.g. containing phosphorus as a ring hetero atom having oxygen atoms, with or without sulfur, selenium, or tellurium atoms, as the only ring hetero atoms the oxygen atom being part of a five-membered ring
    • Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
    • Y02—TECHNOLOGIES OR APPLICATIONS FOR MITIGATION OR ADAPTATION AGAINST CLIMATE CHANGE
    • Y02P—CLIMATE CHANGE MITIGATION TECHNOLOGIES IN THE PRODUCTION OR PROCESSING OF GOODS
    • Y02P20/00—Technologies relating to chemical industry
    • Y02P20/50—Improvements relating to the production of bulk chemicals
    • Y02P20/55—Design of synthesis routes, e.g. reducing the use of auxiliary or protecting groups

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Biochemistry (AREA)
  • General Health & Medical Sciences (AREA)
  • Molecular Biology (AREA)
  • Engineering & Computer Science (AREA)
  • Biotechnology (AREA)
  • Genetics & Genomics (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)

Abstract

내용 없음

Description

아스코르브산의 2-인산 에스테르의 제조방법
본 내용은 요부공개 건이므로 전문내용을 수록하지 않았음

Claims (12)

  1. 5- 및 6- 위치에서 임의로 보호된 아스코르브산을 반응 혼합물 중의 임의로 보호된 아스코르브산의 농도를 0.3M 미만으로 유지시키면서 인산화시키고 필요에 따라 보호기를 제거함을 특징으로 하는 아스코르브산의 2-인산 에스테르의 제조방법.
  2. 제1항에 있어서, 5- 및 6- 위치에서 임의로 보호된 아스코르브산 및 인산화제의 혼합물을 반응 혼합물에 간헐적으로 또는 연속적으로 적가하여 인산화 반응을 수행하는 방법.
  3. 제1항에 있어서, 인산화 반응을 유기 염기 존재하에 수행하는 방법.
  4. 제3항에 있어서, 유기 염기가 피리딘인 방법.
  5. 제1항에 있어서, 인산화 반응을 비활성 기체 대기 중에서 수행하는 방법.
  6. 제5항에 있어서, 비활성 기체가 질소 또는 아르곤인 방법.
  7. 제1항에 있어서, 임의로 보호된 아스코르부산이 아스코르브산, 5,6-0-이소프로필리덴 아스코르브산, 5,6-O-2차-부티리덴 아스코르브산, 5,6-O-1-에틸부티리덴 아스코르브산, 5,6-O-시클로펜틸리덴 아스코르브산 및 5,6-O-시클로헥실리덴 아스코르브산으로 구성된 군에서 선택된 화합물인 방법.
  8. 제1항에 있어서, 임의로 보호된 아스코르브산이 아스코르브산 또는 5,6-0-이소프로필리덴 아스코르브산인 방법.
  9. 제1항에 있어서, 반응 혼합물 중의 임의로 보호된 아스코르브산의 농도가 0.25M 이하인 방법.
  10. 제1항에 있어서, 임의로 보호된 아스코르브산의 사용량에 대해 약 1.5~약2.5배 당량의 인산화제를 사용하여 인산화반응을 수행하는 방법.
  11. 제1항에 있어서, 인산화 반응을 pH 12.5~13.5에서 수행하는 방법.
  12. 제1항에 있어서, 반응 혼합물의 pH를 1이하로 조정하여 탈보호 반응을 수행하는 방법.
    ※ 참고사항 : 최초출원 내용에 의하여 공개하는 것임.
KR1019900017618A 1989-10-31 1990-10-31 아스코르브산의 2-인산 에스테르의 제조방법 KR910007949A (ko)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
JP28580089 1989-10-31
JP1-285800 1989-10-31

Publications (1)

Publication Number Publication Date
KR910007949A true KR910007949A (ko) 1991-05-30

Family

ID=17696243

Family Applications (1)

Application Number Title Priority Date Filing Date
KR1019900017618A KR910007949A (ko) 1989-10-31 1990-10-31 아스코르브산의 2-인산 에스테르의 제조방법

Country Status (7)

Country Link
US (1) US5118817A (ko)
EP (1) EP0426020A3 (ko)
JP (1) JP2935736B2 (ko)
KR (1) KR910007949A (ko)
CN (1) CN1025858C (ko)
CA (1) CA2028911A1 (ko)
HU (1) HU207091B (ko)

Families Citing this family (8)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
ATE125814T1 (de) * 1990-03-07 1995-08-15 Hoffmann La Roche Verfahren zur herstellung von derivaten der ascorbinsäure.
DE4232997A1 (de) * 1992-10-01 1994-04-07 Basf Ag Verfahren zur Reduzierung des Phosphatgehaltes im Abwasser bei der Herstellung von Metallsalzen des Ascorbinsäure-2-monophosphats
US5516919A (en) * 1994-04-28 1996-05-14 Wako Pure Chemical Industries, Ltd. Process for producing ascorbic acid derivative
DE19831056A1 (de) * 1998-07-13 2000-01-20 Basf Ag Verfahren zur Herstellung von Salzen von Ascorbyl-2-phosphorsäureestern
US20030162760A1 (en) * 1999-01-26 2003-08-28 Eiko Masatsuji Dermal agent
WO2003084345A1 (en) * 2002-04-02 2003-10-16 Ganado Research, L.L.C. Composition and method to improve quality and yield of meat products
US20060009698A1 (en) * 2004-04-07 2006-01-12 Triage Wireless, Inc. Hand-held monitor for measuring vital signs
US20050261598A1 (en) * 2004-04-07 2005-11-24 Triage Wireless, Inc. Patch sensor system for measuring vital signs

Family Cites Families (7)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US3671549A (en) * 1970-03-05 1972-06-20 Merck & Co Inc Process for preparing ascorbyl-3-phosphate and salts thereof
US3749680A (en) * 1971-01-08 1973-07-31 Merck & Co Inc Novel derivatives of isoascorbic acid and methods of producing and using same
US3718482A (en) * 1971-05-06 1973-02-27 Merck & Co Inc A food composition with isoascorbic acid-phosphate as an antioxidant
US4179445A (en) * 1976-05-06 1979-12-18 Kansas State University Research Foundation Method of preparation of 2-phosphate esters of ascorbic acid
JPS594438B2 (ja) * 1976-05-06 1984-01-30 カンサス・ステ−ト・ユニバ−シテイ・リサ−チ・フアンデ−シヨン アスコルビン酸の燐酸エステルの製法
US4647672A (en) * 1985-06-25 1987-03-03 Kansas State University Research Foundation Ascorbate 2-polyphosphate esters and method of making same
US4939128A (en) * 1988-04-25 1990-07-03 Takeda Chemical Industries, Ltd. Ester of ascorbic acid 2-phosphate and pharmaceutical use

Also Published As

Publication number Publication date
EP0426020A2 (en) 1991-05-08
CA2028911A1 (en) 1991-05-01
CN1051361A (zh) 1991-05-15
JP2935736B2 (ja) 1999-08-16
CN1025858C (zh) 1994-09-07
HU207091B (en) 1993-03-01
US5118817A (en) 1992-06-02
JPH03204891A (ja) 1991-09-06
EP0426020A3 (en) 1991-07-03
HUT55400A (en) 1991-05-28

Similar Documents

Publication Publication Date Title
AU3408989A (en) Macrocyclic amine complexes for ligand extraction and generation
ES2059408T3 (es) Un proceso para la preparacion de un compuesto.
FI893750A0 (fi) Menetelmä valmistaa terapeuttisesti aktiivista makrosyklistä johdannaista
MX167702B (es) Composicion farmaceutica anti-retroviral de 3'azid-2',3'-dideoxiuridina y metodo para elaborarla
YU114487A (en) Process for obtaining pharmaceuticaly active 1-substituted oxindole-3-carboxamide
UA41341C2 (uk) СПОСІБ ОДЕРЖАННЯ ФІНАСТЕРИДУ, 17<font face="Symbol">b</font>-[N-ТРЕТ-БУТИЛКАРБАМОЇЛ]-4-АЗА-5<font face="Symbol">a</font>-АНДРОСТ-1-ЕН-3-ОН У ПОЛІМОРФНІЙ ФОРМІ I ТА ІI, СПОСОБИ ЇХ ОДЕРЖАННЯ (ВАРІАНТИ)
AU8737698A (en) Method of manufacturing phosphine compound
KR910007949A (ko) 아스코르브산의 2-인산 에스테르의 제조방법
ATE531375T1 (de) Formulierung enthaltend phosphatderivate von elektronentransfermitteln
EE03114B1 (et) Meetod tsüklosporiin A tootmiseks
DE59602236D1 (de) Verfahren zur Herstellung von Ascorbinsäure
KR890014480A (ko) 2-피리딜아세트산 유도체, 이의 제조방법 및 이를 함유하는 약제학적 조성물
KR910007923A (ko) 3-(l-피로글루타밀)-l-티아졸리딘-4-카르복실산과 그 유도체의 제조방법
ATE191915T1 (de) Herstellung von borester
AU3161899A (en) Preparation of phosphine ligands
FR2616663B1 (fr) Nouveaux tripeptides a structure polycyclique azotee, leur procede de preparation et les compositions pharmaceutiques qui les contiennent
ATE286431T1 (de) Verfahren zur immobilisierung von liganden oder verbindungen, an die liganden gebunden sind
HK1032916A1 (en) N,n'-bis(sulfonyl)hydrazines useful as antineoplastic agents
MX9304397A (es) Metodo de preparacion de derivados de carbamato de disoestigmina a partir de fisoestigmina.
DE69204388T2 (de) Tritiane und phosphorsäure und/oder thiophosphorsäurederivate.
DE3775711D1 (de) Verfahren zur herstellung von alkoxysilanen.
GR3036868T3 (en) Amino alcohol derivatives, methods of producing said derivatives and medicaments containing them
Brestkin et al. Inhibition of cholinesterases by O, O-dibutyl S-(β-N, N-arylmethylaminoethyl) thiophosphates and their methiodides
MY122773A (en) Solvent-free method for preparing sterically hindered phosphoramidates.
JPS5239699A (en) Improved methods of producing adenosine derivatives

Legal Events

Date Code Title Description
A201 Request for examination
E902 Notification of reason for refusal
E601 Decision to refuse application