KR910004812A - Method for producing cephalosporin C by microorganisms - Google Patents

Method for producing cephalosporin C by microorganisms Download PDF

Info

Publication number
KR910004812A
KR910004812A KR1019890011702A KR890011702A KR910004812A KR 910004812 A KR910004812 A KR 910004812A KR 1019890011702 A KR1019890011702 A KR 1019890011702A KR 890011702 A KR890011702 A KR 890011702A KR 910004812 A KR910004812 A KR 910004812A
Authority
KR
South Korea
Prior art keywords
cephalosporin
ratio
mixed oil
oil
kfcc
Prior art date
Application number
KR1019890011702A
Other languages
Korean (ko)
Other versions
KR910004371B1 (en
Inventor
한형환
장준환
손영선
유명규
이근철
이윤기
Original Assignee
안시환
제일제당 주식회사
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by 안시환, 제일제당 주식회사 filed Critical 안시환
Priority to KR1019890011702A priority Critical patent/KR910004371B1/en
Publication of KR910004812A publication Critical patent/KR910004812A/en
Application granted granted Critical
Publication of KR910004371B1 publication Critical patent/KR910004371B1/en

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12P—FERMENTATION OR ENZYME-USING PROCESSES TO SYNTHESISE A DESIRED CHEMICAL COMPOUND OR COMPOSITION OR TO SEPARATE OPTICAL ISOMERS FROM A RACEMIC MIXTURE
    • C12P35/00—Preparation of compounds having a 5-thia-1-azabicyclo [4.2.0] octane ring system, e.g. cephalosporin
    • C12P35/06—Cephalosporin C; Derivatives thereof
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N1/00—Microorganisms, e.g. protozoa; Compositions thereof; Processes of propagating, maintaining or preserving microorganisms or compositions thereof; Processes of preparing or isolating a composition containing a microorganism; Culture media therefor

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Engineering & Computer Science (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Health & Medical Sciences (AREA)
  • Zoology (AREA)
  • Wood Science & Technology (AREA)
  • Genetics & Genomics (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Biotechnology (AREA)
  • General Health & Medical Sciences (AREA)
  • Biochemistry (AREA)
  • General Engineering & Computer Science (AREA)
  • Microbiology (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Tropical Medicine & Parasitology (AREA)
  • Virology (AREA)
  • Biomedical Technology (AREA)
  • Micro-Organisms Or Cultivation Processes Thereof (AREA)
  • Preparation Of Compounds By Using Micro-Organisms (AREA)

Abstract

내용 없음.No content.

Description

미생물에 의한 세팔로스포린 C의 제조방법Method for producing cephalosporin C by microorganisms

본 내용은 요부공개 건이므로 전문내용을 수록하지 않았음Since this is an open matter, no full text was included.

Claims (18)

무격벽으로 길게 직립하여 회백색의 집락을 형성하며 세팔로스포린C의 생산능력이 우수한 세팔로스포리움 스트레인 CBL(KFCC 10679).Cephalosporium strain CBL (KFCC 10679), which stands up to a barrier-free wall to form an off-white colony and has a high production capacity for cephalosporin C. 세팔로스포리움 스트레인 CBL(KFCC 10679)을 탄소원, 질소원 및 기타 영양물질을 함유하는 배지에 배양하여 세팔로스포린 C를 생성, 축적함을 특징으로 하는 세팔로스포린C의 제조방법.A method for producing cephalosporin C, characterized by culturing cephalosporium strain CBL (KFCC 10679) in a medium containing a carbon source, a nitrogen source, and other nutrients to produce and accumulate cephalosporin C. 제2항에 있어서, 탄소원으로서 이성화액당이나 설탕(sucrose) 혹은 원당을 1-4%의 비율로 함유함을 특징으로 하는 방법.3. The method according to claim 2, wherein the carbon source contains isomerized sugar, sucrose or raw sugar in a ratio of 1-4%. 제2항에 있어서, 유기질소원 및 영양물질로서 콘스팁리커를 1-3.5%의 비율로 함유함을 특징으로 하는 방법.The method according to claim 2, wherein the organic nitrogen source and the nutrient are contained in the ratio of 1-3.5% of corn steep liquor. 제2항에 있어서 영양물질로서 메틸올리에이트와 미강유를 동일한 비율로 혼합한 혼합오일을 함유함을 특징으로 하는 방법.The method according to claim 2, wherein the oil contains a mixed oil obtained by mixing methyl oleate and rice bran oil in the same ratio. 제2항에 있어서 혼합오일을 5-8%의 비율로 함유함을 특징으로 하는 방법.The method according to claim 2, wherein the mixed oil is contained at a ratio of 5-8%. 제2항에 있어서 혼합오일을 5-8%의 비율로 배양중간에 첨가함을 특징으로 하는 방법.The method of claim 2, wherein the mixed oil is added in the middle of the culture at a rate of 5-8%. 제2항에 있어서 황산암모늄을 0.5-1.0%의 비율로 배양중간에 첨가함을 특징으로 하는 방법.The method of claim 2, wherein ammonium sulfate is added in the middle of the culture at a rate of 0.5-1.0%. 세팔로스포린 C의 전구물질인 유기황화합물 요구성인 세팔로스포리움 스트레인 CBL을 매치오닌, 시스테인, 시스틴, 호모시스테인, 호모시스틴, 시스타치오닌을 유기황화합물로서 함유하는 영양배지에 배양하여 세팔로스포린C를 생성, 축적함을 특징으로 하는 세팔로스포린C의 제조방법.Cephalosporin C is cultured by cultivating cephalosporium strain CBL, which is a precursor of cephalosporin C, in a nutrient medium containing matchonine, cysteine, cystine, homocysteine, homocystine, and cystathionine as organic sulfur compounds. Method for producing cephalosporin C, characterized in that the production, accumulation. 무격벽으로 길게 직립하여 회백색의 집락을 형성하며 세팔로스포린C의 생산능력이 우수한 세팔로스포리움스트레인 1425(KFCC 10678).Cephalosporium strain 1425 (KFCC 10678), which stands up to a barrier-free wall, forms an off-white colony and has a high production capacity for cephalosporin C. 세팔로스포리움 스트레인 1425(KFCC 10679)을 탄소원, 질소원 및 기타 영양물질을 함유하는 배지에 배양하여 세팔로스포린 C를 생성, 축적함을 특징으로 하는 세팔로스포린C의 제조방법.A method for producing cephalosporin C, characterized by culturing cephalosporium strain 1425 (KFCC 10679) in a medium containing a carbon source, a nitrogen source, and other nutrients to produce and accumulate cephalosporin C. 제11항에 있어서, 탄소원으로서 이성화액당이나 설탕(sucrose) 혹은 원당을 1-4%의 비율로 함유함을 특징으로 하는 방법.12. The method according to claim 11, wherein the carbon source contains isomerized sugar, sucrose or raw sugar in a ratio of 1-4%. 제11항에 있어서, 유기질소원 및 영양물질로서 콘스팁리커를 1-3.5%의 비율로 함유함을 특징으로 하는 방법.12. The method according to claim 11, wherein the organic nitrogen source and the nutrient are contained in the ratio of 1-3.5% of corn steep liquor. 제11항에 있어서 영양물질로서 메틸올리에이트와 미강유를 동일한 비율로 혼합한 혼합오일을 함유함을 특징으로 하는 방법.12. The method according to claim 11, wherein the oil contains a mixed oil obtained by mixing methyl oleate and rice bran oil in equal proportions. 제11항에 있어서 혼합오일을 5-8%의 비율로 함유함을 특징으로 하는 방법.The method according to claim 11, wherein the mixed oil is contained at a ratio of 5-8%. 제11항에 있어서 혼합오일을 5-8%의 비율로 배양중간에 첨가함을 특징으로 하는 방법.12. The method according to claim 11, wherein the mixed oil is added in the middle of the culture at a rate of 5-8%. 제11항에 있어서 황산암모늄을 0.5-1.0%의 비율로 배양중간에 첨가함을 특징으로 하는 방법.12. The method of claim 11, wherein ammonium sulfate is added in the middle of the culture at a rate of 0.5-1.0%. 세팔로스포린 C의 전구물질인 유기황화합물 요구성인 세팔로스포리움 스트레인 CBL을 매치오닌, 시스테인, 시스틴, 호모시스테인, 호모시스틴, 시스타치오닌을 유기황화합물로서 함유하는 영양배지에 배양하여 세팔로스포린C를 생성, 축적함을 특징으로 하는 세팔로스포린C의 제조 방법.Cephalosporin C is cultured by cultivating cephalosporium strain CBL, which is a precursor of cephalosporin C, in a nutrient medium containing matchonine, cysteine, cystine, homocysteine, homocystine, and cystathionine as organic sulfur compounds. Method for producing cephalosporin C, characterized in that the production, accumulation. ※ 참고사항 : 최초출원 내용에 의하여 공개하는 것임.※ Note: The disclosure is based on the initial application.
KR1019890011702A 1989-08-17 1989-08-17 Method for preparation of cephalosporin -c KR910004371B1 (en)

Priority Applications (1)

Application Number Priority Date Filing Date Title
KR1019890011702A KR910004371B1 (en) 1989-08-17 1989-08-17 Method for preparation of cephalosporin -c

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
KR1019890011702A KR910004371B1 (en) 1989-08-17 1989-08-17 Method for preparation of cephalosporin -c

Publications (2)

Publication Number Publication Date
KR910004812A true KR910004812A (en) 1991-03-29
KR910004371B1 KR910004371B1 (en) 1991-06-26

Family

ID=19288998

Family Applications (1)

Application Number Title Priority Date Filing Date
KR1019890011702A KR910004371B1 (en) 1989-08-17 1989-08-17 Method for preparation of cephalosporin -c

Country Status (1)

Country Link
KR (1) KR910004371B1 (en)

Families Citing this family (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CN102808011B (en) * 2012-08-28 2013-10-16 伊犁川宁生物技术有限公司 Fermentation method for cephalosporin C
CN102808013B (en) * 2012-08-28 2013-10-16 伊犁川宁生物技术有限公司 Method for preparing cephalosporin C through fermentation

Also Published As

Publication number Publication date
KR910004371B1 (en) 1991-06-26

Similar Documents

Publication Publication Date Title
Huang et al. Circadian rhythm of the prokaryote Synechococcus sp. RF-1
KR950703653A (en) Microorganisms for Tryptophan Production
FR2469453B1 (en)
BR8601804A (en) PROCESS TO PREPARE AN AGRICOLATELY USEFUL INOCULATOR OF BORING BACTERIA, INOCULANT FOR VEGETABLE SEEDS AND AGRICALLY USEFUL COMPOSITION
KR890014024A (en) Method for producing algae with improved biological effect
KR910004812A (en) Method for producing cephalosporin C by microorganisms
US3219543A (en) Production of amino acids
KR840004442A (en) Improved manufacturing method of lancassidine
JPS6167493A (en) Production of isopropyl alcohol
KR930013127A (en) Production of L-Leucine by Microbial Fermentation
KR830007831A (en) Preparation of Antibiotic A-4696 Factor G
KR830006432A (en) Preparation of Heteropolysaccharide S-119
JPS5537136A (en) Preparation of cephalosporin antibiotic
KR920000939A (en) Method for producing L-glutamine by microorganisms
KR960023039A (en) Microorganisms That Produce Sepharosporin C and Methods of Preparing Sepharosporin C Using the Same
JPS55118396A (en) Preparation of mitomycin derivative
KR950023709A (en) Microorganisms Producing Cephalosporin C and Methods of Making Cephalosporin C Using the Same
KR910009933A (en) Method for producing L-glutamine by microorganisms
KR890008324A (en) Method for preparing L-glutamic acid by fermentation
SU663713A1 (en) Method of continuous two-stage cultivation of yeast
KR860008272A (en) Cultivation Method of Streptococcus Microorganism for Simultaneous Production of Hyaluronic Acid and Streptokinase
KR950011611A (en) Microorganisms Producing Docosahexaenoic Acid and Manufacturing Method of Docosahexaenoic Acid Using the Same
KR940014774A (en) Microorganisms That Produce Cephalosporin C and Methods of Making Cephalosporin C Using the Same
KR920000938A (en) Method for producing L-glutamine by microorganisms
KR870000027A (en) Method for preparing 5'-inosinic acid by fermentation method

Legal Events

Date Code Title Description
A201 Request for examination
G160 Decision to publish patent application
E701 Decision to grant or registration of patent right
GRNT Written decision to grant
FPAY Annual fee payment

Payment date: 20060502

Year of fee payment: 16

LAPS Lapse due to unpaid annual fee