KR910000599A - 세로토닌 길항제 - Google Patents
세로토닌 길항제 Download PDFInfo
- Publication number
- KR910000599A KR910000599A KR1019890007568A KR890007568A KR910000599A KR 910000599 A KR910000599 A KR 910000599A KR 1019890007568 A KR1019890007568 A KR 1019890007568A KR 890007568 A KR890007568 A KR 890007568A KR 910000599 A KR910000599 A KR 910000599A
- Authority
- KR
- South Korea
- Prior art keywords
- alkyl
- general formula
- alkylidene
- phenyl
- pharmaceutically acceptable
- Prior art date
Links
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D209/00—Heterocyclic compounds containing five-membered rings, condensed with other rings, with one nitrogen atom as the only ring hetero atom
- C07D209/02—Heterocyclic compounds containing five-membered rings, condensed with other rings, with one nitrogen atom as the only ring hetero atom condensed with one carbocyclic ring
- C07D209/04—Indoles; Hydrogenated indoles
- C07D209/08—Indoles; Hydrogenated indoles with only hydrogen atoms or radicals containing only hydrogen and carbon atoms, directly attached to carbon atoms of the hetero ring
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
- C07C215/00—Compounds containing amino and hydroxy groups bound to the same carbon skeleton
- C07C215/02—Compounds containing amino and hydroxy groups bound to the same carbon skeleton having hydroxy groups and amino groups bound to acyclic carbon atoms of the same carbon skeleton
- C07C215/04—Compounds containing amino and hydroxy groups bound to the same carbon skeleton having hydroxy groups and amino groups bound to acyclic carbon atoms of the same carbon skeleton the carbon skeleton being saturated
- C07C215/06—Compounds containing amino and hydroxy groups bound to the same carbon skeleton having hydroxy groups and amino groups bound to acyclic carbon atoms of the same carbon skeleton the carbon skeleton being saturated and acyclic
- C07C215/08—Compounds containing amino and hydroxy groups bound to the same carbon skeleton having hydroxy groups and amino groups bound to acyclic carbon atoms of the same carbon skeleton the carbon skeleton being saturated and acyclic with only one hydroxy group and one amino group bound to the carbon skeleton
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
- A61P1/04—Drugs for disorders of the alimentary tract or the digestive system for ulcers, gastritis or reflux esophagitis, e.g. antacids, inhibitors of acid secretion, mucosal protectants
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P15/00—Drugs for genital or sexual disorders; Contraceptives
- A61P15/08—Drugs for genital or sexual disorders; Contraceptives for gonadal disorders or for enhancing fertility, e.g. inducers of ovulation or of spermatogenesis
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/06—Antimigraine agents
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/18—Antipsychotics, i.e. neuroleptics; Drugs for mania or schizophrenia
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/22—Anxiolytics
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P3/00—Drugs for disorders of the metabolism
- A61P3/04—Anorexiants; Antiobesity agents
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
- C07C209/00—Preparation of compounds containing amino groups bound to a carbon skeleton
- C07C209/04—Preparation of compounds containing amino groups bound to a carbon skeleton by substitution of functional groups by amino groups
- C07C209/06—Preparation of compounds containing amino groups bound to a carbon skeleton by substitution of functional groups by amino groups by substitution of halogen atoms
- C07C209/08—Preparation of compounds containing amino groups bound to a carbon skeleton by substitution of functional groups by amino groups by substitution of halogen atoms with formation of amino groups bound to acyclic carbon atoms or to carbon atoms of rings other than six-membered aromatic rings
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
- C07C217/00—Compounds containing amino and etherified hydroxy groups bound to the same carbon skeleton
- C07C217/02—Compounds containing amino and etherified hydroxy groups bound to the same carbon skeleton having etherified hydroxy groups and amino groups bound to acyclic carbon atoms of the same carbon skeleton
- C07C217/04—Compounds containing amino and etherified hydroxy groups bound to the same carbon skeleton having etherified hydroxy groups and amino groups bound to acyclic carbon atoms of the same carbon skeleton the carbon skeleton being acyclic and saturated
- C07C217/28—Compounds containing amino and etherified hydroxy groups bound to the same carbon skeleton having etherified hydroxy groups and amino groups bound to acyclic carbon atoms of the same carbon skeleton the carbon skeleton being acyclic and saturated having one amino group and at least two singly-bound oxygen atoms, with at least one being part of an etherified hydroxy group, bound to the carbon skeleton, e.g. ethers of polyhydroxy amines
- C07C217/30—Compounds containing amino and etherified hydroxy groups bound to the same carbon skeleton having etherified hydroxy groups and amino groups bound to acyclic carbon atoms of the same carbon skeleton the carbon skeleton being acyclic and saturated having one amino group and at least two singly-bound oxygen atoms, with at least one being part of an etherified hydroxy group, bound to the carbon skeleton, e.g. ethers of polyhydroxy amines having the oxygen atom of at least one of the etherified hydroxy groups further bound to a carbon atom of a six-membered aromatic ring
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
- C07C2601/00—Systems containing only non-condensed rings
- C07C2601/06—Systems containing only non-condensed rings with a five-membered ring
- C07C2601/08—Systems containing only non-condensed rings with a five-membered ring the ring being saturated
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
- C07C2601/00—Systems containing only non-condensed rings
- C07C2601/12—Systems containing only non-condensed rings with a six-membered ring
- C07C2601/14—The ring being saturated
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
- C07C2601/00—Systems containing only non-condensed rings
- C07C2601/18—Systems containing only non-condensed rings with a ring being at least seven-membered
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
- C07C2602/00—Systems containing two condensed rings
- C07C2602/02—Systems containing two condensed rings the rings having only two atoms in common
- C07C2602/14—All rings being cycloaliphatic
- C07C2602/20—All rings being cycloaliphatic the ring system containing seven carbon atoms
Landscapes
- Health & Medical Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Veterinary Medicine (AREA)
- Engineering & Computer Science (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Public Health (AREA)
- General Health & Medical Sciences (AREA)
- Animal Behavior & Ethology (AREA)
- Life Sciences & Earth Sciences (AREA)
- Medicinal Chemistry (AREA)
- Pharmacology & Pharmacy (AREA)
- General Chemical & Material Sciences (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Biomedical Technology (AREA)
- Neurosurgery (AREA)
- Neurology (AREA)
- Reproductive Health (AREA)
- Psychiatry (AREA)
- Obesity (AREA)
- Pain & Pain Management (AREA)
- Cardiology (AREA)
- Child & Adolescent Psychology (AREA)
- Diabetes (AREA)
- Hematology (AREA)
- Gynecology & Obstetrics (AREA)
- Pregnancy & Childbirth (AREA)
- Heart & Thoracic Surgery (AREA)
- Endocrinology (AREA)
- Epidemiology (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
- Indole Compounds (AREA)
- Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
- Quinoline Compounds (AREA)
- Thiazole And Isothizaole Compounds (AREA)
- Heterocyclic Carbon Compounds Containing A Hetero Ring Having Nitrogen And Oxygen As The Only Ring Hetero Atoms (AREA)
Abstract
내용 없음
Description
본 내용은 요부공개 건이므로 전문내용을 수록하지 않았음
Claims (6)
- 일반식(Ia)의 화합물 및 약제학적으로 허용되는 이의 염.상기식에서, Za는 (C6-C8사이클로알킬)-C-, C6-C10알킬, 페닐-치환된 C2-C10알킬, -(C1-C4알킬리덴)-T-(C1-C4알킬) 또는 일반식의 그룹이며,Ar은또는의그룹이고, 단 Ar이 1-나프틸일 경우에 Za는 사이클로헥실, C6-C10알킬, 페닐-치환된 C2-C10알킬 또는 -(C1-C4알킬리덴)-T-(C1-C4알킬) 일 수 없으며, 3Ar이 일반식의그룹일 경우에 Za는 페닐 페닐-치환된 C2-C10알킬, -(C1-C4알킬리덴)-T-(C1-C4알킬) 또는 일반식의그룹일 수 없고, X1는 -H 또는 -CN이며, G는 각각 하나의 결합이거나, C1-C4알킬리덴이고, T는 -O-, -S-, -SO- 또는 -SO2-이며, a 및 c는 각각 1 내지 5이고, (a+c)는 2보다 크며, b는 0 내지 5이고, m은 0,1,2 또는 3이다.
- 1-(2-사이클로펜틸페녹시)-3-(사이클로옥틸아미노)-2-프로판올 또는 약제학적으로 허용되는 이의 염.
- 1-(2-사이클로펜틸페녹시)-3-(사이클로옥틸아미노)-2-프로판올 또는 약제학적으로 허용되는 이의 염.
- 제1항, 2항 또는 3항중 어느 한 항에 청구된 화합물을 하나 이상의 약제학적으로 허용되는 부형제, 희석제 또는 담체와 함께 함유함을 특징으로 하는 약제학적 조성물.
- 일반식(IV)의 에폭사이드 화합물을 일반식(V)의 아민과 반응시키고, 임의로는 생성물을 화학적으로 허용되는 염으로 전환시킴을 특징으로 하여, 제1항, 2항 또는 3항중 어느 한 항에 청구된 화합물을 제조하는 방법.H2NZa (Ⅴ)상기식에서, Ar 및 Za는 제1항에서 정의한 바와 같다.
- 제5항의 방법에 따라 제조된 제1항에서 정의한 일반식(Ia)의 화합물.※ 참고사항 : 최초출원 내용에 의하여 공개하는 것임.
Applications Claiming Priority (3)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
US20276788A | 1988-06-03 | 1988-06-03 | |
US07//202,767 | 1988-06-03 | ||
US7/202.767 | 1988-06-03 |
Publications (2)
Publication Number | Publication Date |
---|---|
KR910000599A true KR910000599A (ko) | 1991-01-29 |
KR0132779B1 KR0132779B1 (ko) | 1998-04-13 |
Family
ID=22751177
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
KR1019890007568A KR0132779B1 (ko) | 1988-06-03 | 1989-06-02 | 세로토닌 길항제 |
Country Status (17)
Country | Link |
---|---|
EP (1) | EP0345056B1 (ko) |
JP (2) | JP2806555B2 (ko) |
KR (1) | KR0132779B1 (ko) |
CN (1) | CN1023402C (ko) |
AT (1) | ATE117980T1 (ko) |
CA (1) | CA1336911C (ko) |
DE (1) | DE68920913T2 (ko) |
DK (1) | DK271889A (ko) |
ES (1) | ES2067541T3 (ko) |
GR (1) | GR3015297T3 (ko) |
HU (1) | HUT56056A (ko) |
IE (1) | IE66225B1 (ko) |
IL (1) | IL90498A (ko) |
NZ (1) | NZ229376A (ko) |
PT (1) | PT90716B (ko) |
RU (1) | RU1795965C (ko) |
ZA (1) | ZA894145B (ko) |
Families Citing this family (11)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
US5340838A (en) * | 1990-05-04 | 1994-08-23 | Eli Lilly And Company | Method of inhibiting gastric acid secretion with 2-phenylcyclopropylamines |
US5258379A (en) * | 1990-05-04 | 1993-11-02 | Eli Lilly And Company | Method of inhibiting gastric acid secretion with n-arylpiperazines |
US5096908A (en) * | 1990-05-04 | 1992-03-17 | Eli Lilly And Company | Method of inhibiting gastric acid secretion |
IL110857A0 (en) * | 1993-09-09 | 1994-11-28 | Lilly Co Eli | Cessation of tobacco use |
US5576321A (en) * | 1995-01-17 | 1996-11-19 | Eli Lilly And Company | Compounds having effects on serotonin-related systems |
US6075040A (en) | 1996-09-05 | 2000-06-13 | Eli Lilly And Company | Selective β3 adrenergic agonists |
ZA967892B (en) * | 1995-09-21 | 1998-03-18 | Lilly Co Eli | Selective β3 adrenergic agonists. |
EP0827746B1 (en) | 1996-09-05 | 2002-04-03 | Eli Lilly And Company | Carbazole analogues as selective beta3 adrenergic agonists |
CO5011072A1 (es) | 1997-12-05 | 2001-02-28 | Lilly Co Eli | Etanolaminas pirazinil substituidas como agfonistas de los receptores |
FR2817257B1 (fr) | 2000-11-30 | 2009-03-20 | Sanofi Synthelabo | Cyclohexyl(alkyl)-propanolamines, leur preparation et compositions pharmaceutiques en contenant |
FR2840301B1 (fr) * | 2002-05-29 | 2007-03-23 | Sanofi Synthelabo | Derives de phenyl-cyclohexyl-propanolamine, leur preparation et leur applicaton en therapeutique |
Family Cites Families (3)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
US3471515A (en) * | 1965-02-01 | 1969-10-07 | Sandoz Ag | (2-hydroxy-3-substituted aminopropoxy)indoles |
DE1668055B2 (de) * | 1967-03-10 | 1973-09-06 | Farbwerke Hoechst AG, vormals Mei ster Lucius & Bruning, 6000 Frankfurt | Basisch substituierte cyclopentylphenolaether, deren salze mit physiologisch vertraeglichen saeuren und verfahren zu deren herstellung |
US5229412A (en) * | 1988-03-25 | 1993-07-20 | The Board Of Trustees Of The Leland Stanford Junior University | Method for relieving anxiety using 5-hydroxytryptamine-1a-receptor-binding compounds |
-
1989
- 1989-06-01 CA CA000601438A patent/CA1336911C/en not_active Expired - Fee Related
- 1989-06-01 NZ NZ229376A patent/NZ229376A/en unknown
- 1989-06-01 ZA ZA894145A patent/ZA894145B/xx unknown
- 1989-06-01 DE DE68920913T patent/DE68920913T2/de not_active Expired - Fee Related
- 1989-06-01 JP JP1140240A patent/JP2806555B2/ja not_active Expired - Fee Related
- 1989-06-01 ES ES89305516T patent/ES2067541T3/es not_active Expired - Lifetime
- 1989-06-01 IL IL9049889A patent/IL90498A/en not_active IP Right Cessation
- 1989-06-01 PT PT90716A patent/PT90716B/pt not_active IP Right Cessation
- 1989-06-01 CN CN89103839A patent/CN1023402C/zh not_active Expired - Fee Related
- 1989-06-01 AT AT89305516T patent/ATE117980T1/de active
- 1989-06-01 RU SU894614121A patent/RU1795965C/ru active
- 1989-06-01 EP EP89305516A patent/EP0345056B1/en not_active Expired - Lifetime
- 1989-06-02 KR KR1019890007568A patent/KR0132779B1/ko not_active IP Right Cessation
- 1989-06-02 DK DK271889A patent/DK271889A/da not_active Application Discontinuation
- 1989-06-02 HU HU892827A patent/HUT56056A/hu unknown
- 1989-06-12 IE IE181189A patent/IE66225B1/en unknown
-
1995
- 1995-03-03 GR GR950400475T patent/GR3015297T3/el unknown
-
1998
- 1998-03-16 JP JP10065275A patent/JP3050844B2/ja not_active Expired - Fee Related
Also Published As
Publication number | Publication date |
---|---|
AU3601989A (en) | 1989-12-07 |
DE68920913T2 (de) | 1995-06-22 |
DK271889D0 (da) | 1989-06-02 |
EP0345056B1 (en) | 1995-02-01 |
EP0345056A3 (en) | 1992-07-01 |
IE891811L (en) | 1989-12-03 |
JPH0225416A (ja) | 1990-01-26 |
PT90716A (pt) | 1989-12-29 |
DK271889A (da) | 1989-12-05 |
JP3050844B2 (ja) | 2000-06-12 |
KR0132779B1 (ko) | 1998-04-13 |
NZ229376A (en) | 1991-07-26 |
AU609997B2 (en) | 1991-05-09 |
PT90716B (pt) | 1995-03-01 |
EP0345056A2 (en) | 1989-12-06 |
JPH10273437A (ja) | 1998-10-13 |
DE68920913D1 (de) | 1995-03-16 |
IL90498A (en) | 1995-12-08 |
GR3015297T3 (en) | 1995-06-30 |
RU1795965C (ru) | 1993-02-15 |
HUT56056A (en) | 1991-07-29 |
ATE117980T1 (de) | 1995-02-15 |
CA1336911C (en) | 1995-09-05 |
ZA894145B (en) | 1991-02-27 |
IE66225B1 (en) | 1995-12-13 |
JP2806555B2 (ja) | 1998-09-30 |
CN1023402C (zh) | 1994-01-05 |
ES2067541T3 (es) | 1995-04-01 |
CN1045774A (zh) | 1990-10-03 |
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