KR900017980A - 불소화 아라키돈산 유도체 - Google Patents

불소화 아라키돈산 유도체 Download PDF

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KR900017980A
KR900017980A KR1019900006304A KR900006304A KR900017980A KR 900017980 A KR900017980 A KR 900017980A KR 1019900006304 A KR1019900006304 A KR 1019900006304A KR 900006304 A KR900006304 A KR 900006304A KR 900017980 A KR900017980 A KR 900017980A
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hydrogen
arachidonic acid
group
acid derivative
fluorinated arachidonic
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KR1019900006304A
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KR0168643B1 (ko
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베르나르 뒤세 쟝
나브 쟝-프랑스와
야코비 데틀레프
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게리 디.스트리트
메렐 다우 파마슈티칼스 인크.
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    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C57/00—Unsaturated compounds having carboxyl groups bound to acyclic carbon atoms
    • C07C57/30—Unsaturated compounds having carboxyl groups bound to acyclic carbon atoms containing six-membered aromatic rings
    • C07C57/34—Unsaturated compounds having carboxyl groups bound to acyclic carbon atoms containing six-membered aromatic rings containing more than one carboxyl group
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C57/00—Unsaturated compounds having carboxyl groups bound to acyclic carbon atoms
    • C07C57/52—Unsaturated compounds having carboxyl groups bound to acyclic carbon atoms containing halogen
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P11/00—Drugs for disorders of the respiratory system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P17/00—Drugs for dermatological disorders
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P29/00—Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A61P31/04—Antibacterial agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P37/00—Drugs for immunological or allergic disorders
    • A61P37/08—Antiallergic agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
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    • C07—ORGANIC CHEMISTRY
    • C07F—ACYCLIC, CARBOCYCLIC OR HETEROCYCLIC COMPOUNDS CONTAINING ELEMENTS OTHER THAN CARBON, HYDROGEN, HALOGEN, OXYGEN, NITROGEN, SULFUR, SELENIUM OR TELLURIUM
    • C07F7/00—Compounds containing elements of Groups 4 or 14 of the Periodic Table
    • C07F7/02—Silicon compounds
    • C07F7/08—Compounds having one or more C—Si linkages
    • C07F7/18—Compounds having one or more C—Si linkages as well as one or more C—O—Si linkages
    • C07F7/1804—Compounds having Si-O-C linkages
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07F—ACYCLIC, CARBOCYCLIC OR HETEROCYCLIC COMPOUNDS CONTAINING ELEMENTS OTHER THAN CARBON, HYDROGEN, HALOGEN, OXYGEN, NITROGEN, SULFUR, SELENIUM OR TELLURIUM
    • C07F9/00—Compounds containing elements of Groups 5 or 15 of the Periodic Table
    • C07F9/02—Phosphorus compounds
    • C07F9/28—Phosphorus compounds with one or more P—C bonds
    • C07F9/54—Quaternary phosphonium compounds
    • C07F9/5428—Acyclic unsaturated phosphonium compounds

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  • Health & Medical Sciences (AREA)
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  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
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Abstract

내용 없음

Description

불소화 아라키돈산 유도체
본 내용은 요부공개 건이므로 전문내용을 수록하지 않았음

Claims (11)

  1. 다음 식의 불소화 아라키돈산 유도체 및 X가 C(O)OR′이고 R′가 수소인 경우에 그의 제약학상 허용되는 염.
    상기식에서, R5및 R6중 하나는 플루오르기이고 다른 하나는 수소이거나, 또는 R5및 R6는 모두 수소이고, R5및 R6중 하나는 플루오르기이고 다른 하나는 수소이며, X는 C(O)OR′기로서, 여기서 R′는 수소 또는 직쇄(C1-C6)알킬기이거나, 또는 X는 식 -C(O)OCH2CH(OR)CH2(OR″′)의 기로서, 여기서 R는 장쇄형 지방산 잔기이고, R″′는 수소 또는 장쇄형 지방산 잔기이거나, 또는 X는 -C(O)NH2또는 -C(O)NH(OH)기이거나, 또는 X는 1H-테트라졸-5-일기이고, R은 다음 구조식
    기들 중 어느 하나로서, 여기서 R3은 수소 또는 직쇄(C1-C4)알킬기이고, R4는 수소 또는 직쇄(C1-C6)알킬기이며, 점선은 임의의 이중 결합이나 삼중 결합을 나타낸다.
  2. 제1항에 있어서, X가 CO2H기인 불소화 아라키돈산 유도체.
  3. 제1항 또는 제2항에 있어서, X가 식 -C(O)OCH2CH(OR)CH2(OR″′)의 기로서, 여기서 R″는 장쇄형 지방산 잔기이고, R″′는 수소 또는 장쇄형 지방산 잔기인 불소화 아라키돈산 유도체.
  4. 제1항 또는 제2항에 있어서, R이 다음 구조식;
    의 기이고, R3이 수소 또는 직쇄(C1-C4)알킬이고, 점선이 임의의 이중결합 또는 삼중 결합을 나타내는 불소화 아라키돈산 유도체.
  5. 제4항에 있어서, R3이 에틸기인 불소화 아라키돈산 유도체.
  6. 제1항 또는 제2항에 있어서, R이 다음 구조식;
    의 기이고, R3이 수소 또는 직쇄(C1-C4)알킬인 불소화 아라키돈산 유도체.
  7. 제6항에 있어서, R3이 에틸기인 불소화 알라키돈산 유도체.
  8. 제1항 내지 제7항 중 어느 하나의 항에 의한 불소화 아라키돈산 유도체를 유효 성분으로 하는 의약품.
  9. 제1항 내지 제7항 중 어느 하나의 항에 의한 불소화 아라키돈산 유도체를 유효 성분으로 하는 5-리폭시게나제 억제제.
  10. 제1항 내지 제7항 중 어느 하나의 항에 의한 불소화 아라키돈산 유도체를 유효 성분으로 하는 항천식제.
  11. 제1항 내지 제7항 중 어느 하나의 항에 의한 불소화 아라키돈산 유도체와 제약항상 허용되는 담체로 되는 제약 조성물.
    ※ 참고사항 : 최초출원 내용에 의하여 공개하는 것임.
KR1019900006304A 1989-05-02 1990-05-01 불소화 아라키돈산 유도체 KR0168643B1 (ko)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
EP89401244A EP0396841B1 (en) 1989-05-02 1989-05-02 Fluorinated arachidonic acid derivatives
EP89401244.2 1989-05-02

Publications (2)

Publication Number Publication Date
KR900017980A true KR900017980A (ko) 1990-12-20
KR0168643B1 KR0168643B1 (ko) 1999-03-20

Family

ID=8202950

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KR1019900006304A KR0168643B1 (ko) 1989-05-02 1990-05-01 불소화 아라키돈산 유도체

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Country Link
EP (1) EP0396841B1 (ko)
JP (1) JP2867165B2 (ko)
KR (1) KR0168643B1 (ko)
CN (1) CN1046892A (ko)
AT (1) ATE101114T1 (ko)
AU (1) AU626413B2 (ko)
CA (1) CA2015470C (ko)
DE (1) DE68912933T2 (ko)
DK (1) DK108090A (ko)
ES (1) ES2063152T3 (ko)
HU (1) HU208517B (ko)
IL (1) IL94255A0 (ko)
NO (1) NO173495C (ko)
NZ (1) NZ233467A (ko)
PT (1) PT93932A (ko)
ZA (1) ZA903195B (ko)

Family Cites Families (4)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US3057893A (en) * 1961-01-10 1962-10-09 Jr Cecil R Smith Method of preparing 14-hydroxy-cis-11-eicosenoic acid and ester derivatives thereof
US4497827A (en) * 1982-08-30 1985-02-05 Syntex (U.S.A.) Inc. Arachidonic acid analogues as anti-inflammatory and anti-allergic agents
JPS61271246A (ja) * 1985-05-25 1986-12-01 Asahi Glass Co Ltd ５−フレオロアラキドン酸誘導体およびその製造法
ZA888155B (en) * 1987-11-04 1989-07-26 Merrell Dow Pharma Fluorinated arachidonic acid derivatives

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Publication number Publication date
CN1046892A (zh) 1990-11-14
AU5386190A (en) 1990-11-29
HUT53583A (en) 1990-11-28
NO173495B (no) 1993-09-13
IL94255A0 (en) 1991-03-10
NO901941L (no) 1990-11-05
CA2015470A1 (en) 1990-11-02
NO901941D0 (no) 1990-04-30
DE68912933T2 (de) 1994-08-11
DK108090A (da) 1990-11-03
NO173495C (no) 1993-12-22
HU208517B (en) 1993-11-29
HU902619D0 (en) 1990-09-28
DE68912933D1 (de) 1994-03-17
JP2867165B2 (ja) 1999-03-08
CA2015470C (en) 2001-10-16
EP0396841B1 (en) 1994-02-02
EP0396841A1 (en) 1990-11-14
AU626413B2 (en) 1992-07-30
ES2063152T3 (es) 1995-01-01
KR0168643B1 (ko) 1999-03-20
ATE101114T1 (de) 1994-02-15
NZ233467A (en) 1993-04-28
JPH02306932A (ja) 1990-12-20
PT93932A (pt) 1991-01-08
ZA903195B (en) 1991-11-27
DK108090D0 (da) 1990-05-01

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