KR900016215A - 2,7-디아자비사이클로[3,3,0]옥탄 및 이의 제조방법 - Google Patents

2,7-디아자비사이클로[3,3,0]옥탄 및 이의 제조방법 Download PDF

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KR900016215A
KR900016215A KR1019900005297A KR900005297A KR900016215A KR 900016215 A KR900016215 A KR 900016215A KR 1019900005297 A KR1019900005297 A KR 1019900005297A KR 900005297 A KR900005297 A KR 900005297A KR 900016215 A KR900016215 A KR 900016215A
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alkoxycarbonyl
alkyl
formula
different
same
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KR1019900005297A
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KR0166963B1 (ko
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쉔케 토마스
페테르센 우베
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투디 마이어, 요아힘 그렘
바이엘 아크티엔게젤샤프트
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    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D487/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00
    • C07D487/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00 in which the condensed system contains two hetero rings
    • C07D487/04—Ortho-condensed systems
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C271/00—Derivatives of carbamic acids, i.e. compounds containing any of the groups, the nitrogen atom not being part of nitro or nitroso groups
    • C07C271/06—Esters of carbamic acids
    • C07C271/08—Esters of carbamic acids having oxygen atoms of carbamate groups bound to acyclic carbon atoms
    • C07C271/10—Esters of carbamic acids having oxygen atoms of carbamate groups bound to acyclic carbon atoms with the nitrogen atoms of the carbamate groups bound to hydrogen atoms or to acyclic carbon atoms
    • C07C271/18—Esters of carbamic acids having oxygen atoms of carbamate groups bound to acyclic carbon atoms with the nitrogen atoms of the carbamate groups bound to hydrogen atoms or to acyclic carbon atoms to carbon atoms of hydrocarbon radicals substituted by doubly-bound oxygen atoms
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D487/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00
    • C07D487/12—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00 in which the condensed system contains three hetero rings
    • C07D487/14—Ortho-condensed systems
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D513/00—Heterocyclic compounds containing in the condensed system at least one hetero ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for in groups C07D463/00, C07D477/00 or C07D499/00 - C07D507/00
    • C07D513/12—Heterocyclic compounds containing in the condensed system at least one hetero ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for in groups C07D463/00, C07D477/00 or C07D499/00 - C07D507/00 in which the condensed system contains three hetero rings
    • C07D513/14—Ortho-condensed systems

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  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Nitrogen Condensed Heterocyclic Rings (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Compositions Of Oxide Ceramics (AREA)
  • Nitrogen And Oxygen Or Sulfur-Condensed Heterocyclic Ring Systems (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)

Abstract

내용 없음.

Description

2, 7-디아자비사이클로[3,3,0]옥탄 및 이의 제조방법
본 내용은 요부공개 건이므로 전문내용을 수록하지 않았음

Claims (5)

  1. 2, 7´-디아자비사이클로[3. 3. 0]옥탄(옥타하이드로피롤로[3, 4-b]피롤)을 제외한 일반식(I)의 2,7-디아자비사이클로[3. 3. 0]옥탄.
    상기식에서, R1,R3, R4, R5, R7및 R8은 동일하거나 상이할 수 있고 각각 H, C1-C5-알킬(할로겐, 하이드록실 또는 C1-C3-알콕시에 의해 임의로 치환된다) C1-C3-알콕시카보닐 또는 C1-C12-아릴이며, R4는 추가로 할로겐이고, R2및 R6은 동일하거나 상이할 수 있고 H, C1-C6-알킬, 벤질, C6-C12-아릴, C1-C3-알카노일, 벤조일 또는 C1-C5-알콕시카보닐이며, 경우에 따라, R2및 R3가 함께는 구조식 (CH2)n(여기서, n은 2내지 4이다), CH2-CHOH-CH2, CH2-S-CH2또는 C(CH3)2-S-CH2의 가교이다.
  2. 제1항에 있어서, R1,R3, R4, R5, R7및 R8은 동일하거나 상이할 수 있고 H, C1-C3-알킬, C1-C3-알콕시카보닐 또는 페닐이며, R4가 추가로 불소, 염소 또는 브롬이고, R2및 R6이 동일하거나 상이할 수 있고 H, C1-C3-알킬, 벤질, C6-C12-아릴, C1-C2-알카노일, 벤조일 또는 C1-C4-알콕시카보닐이며, 경우에 따라 R2및 R3가 함께는 구조식 (CH2)n(여기서, n은 2내지 4이다), CH2-CHOH-CH2, CH2-S-CH2또는 C(CH3)2-S-CH2의 가교인, 2, 7´-디아자비사이클로[3. 3. 0]옥탄(옥타하이드로피롤로[3, 4-b]피롤)을 제외한 일반식(I)의 화합물.
  3. 제1항에 있어서, R1,R3, R4, R5, R7및 R8이 동일하거나 상이할 수 있고 H 또는 메틸이며, R4가 추가로 불소, 염소 또는 브롬이고, R2및 R6은 동일하거나 상이할 수 있고 H, 메틸, 페닐, 아세틸 또는 C2-C4-알콕시카보닐이며, 경우에 따라 R2및 R3이 함께 구조식 (CH2)n(여기서, n은 2내지 4이다), CH2-CHOH-CH2, CH2-S-CH2또는 C(CH3)2-S-CH2의 가교인, 2, 7-디아자비사이클로[3. 3. 0]옥탄(옥타하이드로피롤로[3, 4-b]피롤)을 제외한 일반식(I)의 화합물.
  4. 일반식(II)의 불포화 카보닐 화합물을 분자내 1, 3-쌍극성 고리화 첨 가반응(cycloaddition)으로 일반식(III)의 아미노산 유도체와 반응시킨 후 보호작용기를 갖는 치환체 R2또는 R6을 제거함을 특징으로 하여, 일반식(I)의 2, 7-디아자비사이클로[3. 3. 0]옥탄을 제조하는 방법.
    상기식에서, R1, R3, R4, R5, R7및 R8은 동일하거나 상이할 수 있고 각각 H, C1-C5-알킬(할로겐, 하이드록실 또는 C1-C3-알콕시에 의해 임의로 치환된다), C1-C3-알콕시카보닐 또는 C1-C12-아릴, 바람직하게는 H, C1-C3-알킬, C1-C3-알콕시카보닐 또는 페닐, 특히 바람직하게는 H 및 메틸이며, R4는 추가로 할로겐, 바람직하게는 불소, 염소 또는 브롬, 특히 바람직하게는 염소 및 브롬이고, R2및 R6은 동일하거나 상이할 수 있고 H, C1-C6-알킬, 벤질, C6-C12-아릴, C1-C3-알카노일, 벤조일 또는 C1-C5-알콕시카보닐이며, 경우에 따라 R2및 R3이 함께는 구조식 (CH2)n (여기서, n은 2내지 4이다), CH2-CHOH-CH2, CH2-S-CH2또는 C(CH3)2-S-CH2이고, R´는 H 또는 C1-C3-알킬이다.
  5. 일반식(II)의 화합물
    상기식에서, R1, R3, R4, R5, R7및 R8은 동일하거나 상이할 수 있고 각각 H, C1-C5-알킬(할로겐, 하이드록실 또는 C1-C3-알콕시에 의해 임의로 치환된다), C1-C3-알콕시 카보닐 또는 C6-C12-아릴, 바람직하게는 H, C1-C3-알킬, C1-C3-알콕시카보닐 또는 페닐 특히 바람직하게는 H 및 메틸이며, R4는 추가로 할로겐, 바람직하게는 불소, 염소 또는 브롬, 특히 바람직하게는 염소 및 브롬이고, R6은 H, C1-C6-알킬, 벤질, C6-C12-아릴, C1-C3-알카노일, 벤조일 또는 C1-C5-알콕시카보닐, 바람직하게는 H, C1-C3-알킬, 벤질, C6-C12-아릴, C1-C2-알카노일, 벤조일 또는 C1-C4-알콕시카보닐, 특히 바람직하게는 H, 메틸, 페닐, 아세틸 또는 C2-C4-알콕시카보닐이다.
    ※ 참고사항 : 최초출원 내용에 의하여 공개하는 것임.
KR1019900005297A 1989-04-17 1990-04-17 2,7-디아자비사이클로 [3,3,0] 옥탄 및 이의 제조방법 KR0166963B1 (ko)

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DE39125092 1989-04-07
DE3912509 1989-04-17
DE3912509.2 1989-04-17
DE3932903.8 1989-10-03
DE3932903 1989-10-03

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US (1) US5071999A (ko)
EP (1) EP0393424B1 (ko)
JP (1) JPH02292288A (ko)
KR (1) KR0166963B1 (ko)
AT (1) ATE128466T1 (ko)
CA (1) CA2014478A1 (ko)
DE (1) DE59009705D1 (ko)
DK (1) DK0393424T3 (ko)
ES (1) ES2079391T3 (ko)
GR (1) GR3017384T3 (ko)
IE (1) IE68591B1 (ko)
PT (1) PT93702B (ko)

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US5177210A (en) * 1989-04-17 1993-01-05 Bayer Aktiengesellschaft Preparation of 2,7-diazabicyclo(3.3.0)octanes
KR960003611B1 (ko) * 1992-07-23 1996-03-20 재단법인 한국화학연구소 신규한 디아자비시클로 알켄 유도체 및 그의 제조방법
WO2001044243A2 (en) 1999-12-14 2001-06-21 Neurosearch A/S Novel heteroaryl-diazabicycloalkanes
MY145722A (en) 2000-04-27 2012-03-30 Abbott Lab Diazabicyclic central nervous system active agents
US6809105B2 (en) * 2000-04-27 2004-10-26 Abbott Laboratories Diazabicyclic central nervous system active agents
EP1368354A1 (en) * 2001-03-07 2003-12-10 Pfizer Products Inc. Modulators of chemokine receptor activity
EP1633756B1 (en) 2003-04-09 2008-12-24 Biogen Idec MA Inc. A2a adenosine receptor antagonists
US20050065178A1 (en) 2003-09-19 2005-03-24 Anwer Basha Substituted diazabicycloakane derivatives
US7728031B2 (en) 2006-02-24 2010-06-01 Abbott Laboratories Octahydro-pyrrolo[3,4-b]pyrrole derivatives
US7985745B2 (en) * 2006-10-02 2011-07-26 Abbott Laboratories Method for pain treatment
US8735411B2 (en) * 2006-10-02 2014-05-27 Abbvie Inc. Macrocyclic benzofused pyrimidine derivatives
US20080159958A1 (en) * 2006-12-27 2008-07-03 Abbott Laboratories Determination of histamine-3 bioactivity
WO2009036132A1 (en) 2007-09-11 2009-03-19 Abbott Laboratories Octahydro-pyrrolo[3,4-b]pyrrole n-oxides
US8278313B2 (en) * 2008-03-11 2012-10-02 Abbott Laboratories Macrocyclic spiro pyrimidine derivatives
ES2625547T3 (es) 2012-09-27 2017-07-19 Bayer Cropscience Ag Procedimiento de preparación de fenil y piridil pirrolidinas opcionalmente sustituidas

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HU198372B (en) * 1984-07-18 1989-10-30 Sandoz Ag Insecticide compositions containing carbaminic acid derivatives as active components and process for producing th the active components
JPH0676400B2 (ja) * 1987-08-25 1994-09-28 大日本製薬株式会社 新規ピリドンカルボン酸誘導体、そのエステルおよびその塩
DE3906365A1 (de) * 1988-07-15 1990-01-18 Bayer Ag 7-(1-pyrrolidinyl)-3-chinolon- und -naphthyridoncarbonsaeure-derivate, verfahren sowie substituierte (oxa)diazabicyclooctane und -nonane als zwischenprodukte zu ihrer herstellung, und sie enthaltende antibakterielle mittel und futterzusatzstoffe
DE3910663A1 (de) * 1989-04-03 1990-10-04 Bayer Ag 5-alkylchinoloncarbonsaeuren

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ATE128466T1 (de) 1995-10-15
CA2014478A1 (en) 1990-10-17
KR0166963B1 (ko) 1999-01-15
US5071999A (en) 1991-12-10
GR3017384T3 (en) 1995-12-31
DK0393424T3 (da) 1996-02-05
EP0393424A2 (de) 1990-10-24
ES2079391T3 (es) 1996-01-16
EP0393424A3 (de) 1991-10-16
IE901343L (en) 1990-10-17
EP0393424B1 (de) 1995-09-27
PT93702B (pt) 1996-08-30
PT93702A (pt) 1990-11-20
DE59009705D1 (de) 1995-11-02
JPH02292288A (ja) 1990-12-03
IE68591B1 (en) 1996-06-26

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