KR900013954A - 개량된 화학적 화합물 - Google Patents

개량된 화학적 화합물 Download PDF

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Publication number
KR900013954A
KR900013954A KR1019900003614A KR900003614A KR900013954A KR 900013954 A KR900013954 A KR 900013954A KR 1019900003614 A KR1019900003614 A KR 1019900003614A KR 900003614 A KR900003614 A KR 900003614A KR 900013954 A KR900013954 A KR 900013954A
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South Korea
Prior art keywords
formula
compound
composition
sico
oxidation state
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KR1019900003614A
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English (en)
Inventor
앤토니 머러 배리
로날드 찰스 테오발드 브라이언
데이비드 세비지 포올
Original Assignee
아이 시 위샤르트
존슨 맛쎄이 퍼블릭 리미티드 캄파니
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Publication of KR900013954A publication Critical patent/KR900013954A/ko

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    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K33/00—Medicinal preparations containing inorganic active ingredients
    • A61K33/24—Heavy metals; Compounds thereof
    • A61K33/34—Copper; Compounds thereof
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/28—Compounds containing heavy metals
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K33/00—Medicinal preparations containing inorganic active ingredients
    • A61K33/24—Heavy metals; Compounds thereof
    • A61K33/244—Lanthanides; Compounds thereof
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A61P31/12—Antivirals

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  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Veterinary Medicine (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Chemical & Material Sciences (AREA)
  • Public Health (AREA)
  • Medicinal Chemistry (AREA)
  • General Health & Medical Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • Epidemiology (AREA)
  • Inorganic Chemistry (AREA)
  • General Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Communicable Diseases (AREA)
  • Virology (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Oncology (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Inorganic Compounds Of Heavy Metals (AREA)

Abstract

내용 없음

Description

개량된 화학적 화합물
본 내용은 요부공개 건이므로 전문내용을 수록하지 않았음

Claims (10)

  1. 활성성분으로서 케긴 구조의 이온을 함유하고 다음식 I 또는 Ia로 규정된 화합물을 약학적으로 허용가능한 희석제 또는 담체와 혼합을 포함하는 의약 조성물.
    Ax[MDLW11O39]·yH2O (I)
    Ax[D(MW11O39)2]·yH2O (Ia)
    (상기 식에서 A는 양이온이고, x는 요소 M 및 요소 D 또는 D'의 산화 상태에 따라 변하는 정수이며, M은 붕소, 규소 또는 인이고, D는 금속이며, D'는 3또는 4산화상태의 란타나이드이고, L은 중성 또는 음이온 리간드이며, y는 정수이다.
    단, D가 코발트, 바나듐 또는 알루미늄인 경우, L은 물이 아니다.)
  2. 제1항에 있어서, 양이온 A는 수소, 알칼리 금속, 알칼리토금속, 암모늄 및 양성자를 얻은 염기성 질소-함유 유기 화합물로부터 선택되는 것을 특징으로 하는 조성물.
  3. 제1항 또는 2항에 있어서, 금속 D가 V, Ni, Co, Cu, Sn, Ga, Pt, Al, Rh 및 Zn으로 부터 선택되며, D'은 CeIII, CeVI, Er, Pr 및 Gd로부터 선택되는 것을 특징으로 하는 조성물.
  4. 제1항 내지 3항중의 어느하나에 있어서, 리간드 L이 물, 메틸, 암모니아 및 아민중에서 선택되는 것을 특징으로 하는 조성물.
  5. 제1항 내지 4항중의 어느 하나에 있어서, 단위 사용형으로 되어 있는 것을 특징으로 하는 조성물.
  6. 제1항에서 정의된 대로의 식 (I) 또는 (Ia)의 화합물로 되어 있는 피복물을 갖고 있는 것을 특징으로 하는 사용시 체액과 접촉하는 장치 또는 몸체.
  7. 식 (I) 또는 (Ia)의 화합물이 식 (IC)의 화합물들 중에서 선택되는 것을 특징으로 하는 상기 각항중의 어느 하나에 의한 조성물, 장치 또는 물체
    Ax[Z]·yH2(Ic)
    상기식에서 A, x 및 y는 제1항에서 정의된 대로이고, Z는 Ce(SiW11O39)2, BPt(OH2)W11O39, SiNi(OH2)W11O39, BRh(OH2)W11O39, SiCu(OH2)W11O39, PCu(OH2)W11O39, SiCo(OH2)W11O39, BCo(OH2)W11O39, BCu(OH2)W11O39, SiGa(OH2)W11O39, BGa(OH2)W11O39, SiCo(C5H5N)W11O39, SiCo(C6H11NH2)W11O39, and SiSn(CH3)W11O39중에서 선택된다.
  8. 다음식 (Ib)의 화합물.
    Aa[D'(BW11O39)2]·yH2O (Ib)
    상기식에서 A, D' 및 y는 제1항에서 정의된 대로이고, a 는 D의 산화상태에 의존하는 정수이다.
  9. 식[BW11O39]9-의 빈틈이 있는 케긴 종을 란타나이드염과, 식 Ib의 소정 화합물을 생성하기 위한 수용액중에서 반응시키는 것으로 이루어지는, 제8항의 화합물의 제조방법.
  10. HIV-감염 환자의 치료용 또는 HIV에 감염된 위험이 있는 환자의 예방학적 치료용 의약을 제조하기 위한, 제1항 또는 제8항에 규정된 바와같은 식 I, Ia 또는 Ib의 화합물의 사용.
    ※ 참고사항 : 최초출원 내용에 의하여 공개하는 것임.
KR1019900003614A 1989-03-17 1990-03-17 개량된 화학적 화합물 KR900013954A (ko)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
GB898906189A GB8906189D0 (en) 1989-03-17 1989-03-17 Improvements in chemical compounds
GB8906189.9 1989-03-17

Publications (1)

Publication Number Publication Date
KR900013954A true KR900013954A (ko) 1990-10-22

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ID=10653539

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Application Number Title Priority Date Filing Date
KR1019900003614A KR900013954A (ko) 1989-03-17 1990-03-17 개량된 화학적 화합물

Country Status (14)

Country Link
US (1) US5093134A (ko)
EP (1) EP0390365A1 (ko)
JP (1) JPH0347130A (ko)
KR (1) KR900013954A (ko)
AU (1) AU622779B2 (ko)
CA (1) CA2012153A1 (ko)
FI (1) FI901319A0 (ko)
GB (1) GB8906189D0 (ko)
HU (1) HU207333B (ko)
IL (1) IL93727A0 (ko)
NO (1) NO901232L (ko)
NZ (1) NZ232929A (ko)
PT (1) PT93478A (ko)
ZA (1) ZA901993B (ko)

Families Citing this family (16)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
GB9003430D0 (en) * 1990-02-15 1990-04-11 Johnson Matthey Plc Improvements in chemical compounds
CZ396292A3 (en) * 1990-06-29 1994-01-19 Commw Scient Ind Res Org Pharmaceutical preparation for treating and prophylaxis of infection
GB9025847D0 (en) * 1990-11-28 1991-01-09 Johnson Matthey Plc Improvements in chemical compounds
WO1993021934A1 (en) * 1992-05-01 1993-11-11 Commonwealth Scientific And Industrial Research Organisation Heteropolytungstates in the treatment of flavivirus infections
US5364568A (en) * 1992-07-08 1994-11-15 Georgetown University Compounds and methods for separation and molecular encapsulation of metal ions
DE4336642C2 (de) * 1993-10-22 1995-08-10 Deutsches Rheuma Forschungszen Verwendung von Vanadiumverbindungen mit antiviraler Wirkung
WO1995011033A1 (en) * 1993-10-22 1995-04-27 Commonwealth Scientific And Industrial Research Organisation Polyoxometallates in the treatment of flavivirus infections
US5824706A (en) * 1994-09-26 1998-10-20 Schinazi; Raymond F. Method, compositions, and apparatus for treating and preventing respiratory viral infections
AUPO820197A0 (en) * 1997-07-24 1997-08-14 Biomolecular Research Institute Limited Inorganic angiogenesis inhibitors
AT405017B (de) * 1997-10-06 1999-04-26 Jakoby Marie Luise Mittel zur stimulation der körpereigenen abwehr
AUPO995297A0 (en) * 1997-10-24 1997-11-13 Starpharma Limited Inorganic antiviral compounds
US6713076B1 (en) * 1998-04-13 2004-03-30 Emory University Methods for removing a contaminant by a polyoxometalate-modified fabric or a polyoxometalate-modified cellulosic fiber and fabrics thereof
US6113934A (en) * 1998-06-11 2000-09-05 Virginia Commonwealth University Platinum complexes with anti-viral activity and method of using same
WO2000007194A1 (en) * 1998-07-27 2000-02-10 Georgetown University Preparation of tungsten bronzes for nuclear waste storage forms and electronic materials
US6723349B1 (en) * 1999-10-12 2004-04-20 Emory University Polyoxometalate materials, metal-containing materials, and methods of use thereof
WO2005021435A2 (en) * 2003-02-25 2005-03-10 Emory University Compositions materials incorporating the compositions, and methods of using the compositions and materials

Family Cites Families (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
FR2117803B1 (ko) * 1970-12-18 1974-03-22 Anvar
FR2587214B1 (fr) * 1985-09-13 1987-12-24 Pasteur Institut Anticoagulants constitues d'heteropolyanions tungstiques et utilisation de ces heteropolyanions a la preparation de medicaments anticoagulants
IL91750A0 (en) * 1988-09-22 1990-06-10 Schinazi Raymond F Polyoxometallate compounds as antiviral agents

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Publication number Publication date
HU207333B (en) 1993-03-29
EP0390365A1 (en) 1990-10-03
IL93727A0 (en) 1990-12-23
CA2012153A1 (en) 1990-09-17
US5093134A (en) 1992-03-03
NO901232D0 (no) 1990-03-16
NZ232929A (en) 1991-07-26
AU622779B2 (en) 1992-04-16
JPH0347130A (ja) 1991-02-28
HU901593D0 (en) 1990-06-28
NO901232L (no) 1990-09-18
AU5141090A (en) 1990-09-20
GB8906189D0 (en) 1989-05-04
PT93478A (pt) 1990-11-20
HUT53655A (en) 1990-11-28
ZA901993B (en) 1991-01-30
FI901319A0 (fi) 1990-03-16

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