KR900008277A - 진단 테스트용 수성 현탁액 - Google Patents

진단 테스트용 수성 현탁액 Download PDF

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KR900008277A
KR900008277A KR1019890016377A KR890016377A KR900008277A KR 900008277 A KR900008277 A KR 900008277A KR 1019890016377 A KR1019890016377 A KR 1019890016377A KR 890016377 A KR890016377 A KR 890016377A KR 900008277 A KR900008277 A KR 900008277A
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aqueous suspension
reagent
polymeric
test
nucleus
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KR1019890016377A
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마리아 부르베 월프리더스
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에이. 지. 제이. 베르미렌·에프. 지. 엠. 헤르만스
악조 엔. 브이
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Publication of KR900008277A publication Critical patent/KR900008277A/ko

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    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N33/00—Investigating or analysing materials by specific methods not covered by groups G01N1/00 - G01N31/00
    • G01N33/48—Biological material, e.g. blood, urine; Haemocytometers
    • G01N33/50—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing
    • G01N33/53—Immunoassay; Biospecific binding assay; Materials therefor
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N33/00—Investigating or analysing materials by specific methods not covered by groups G01N1/00 - G01N31/00
    • G01N33/48—Biological material, e.g. blood, urine; Haemocytometers
    • G01N33/50—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing
    • G01N33/58—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing involving labelled substances
    • G01N33/585—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing involving labelled substances with a particulate label, e.g. coloured latex
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N33/00—Investigating or analysing materials by specific methods not covered by groups G01N1/00 - G01N31/00
    • G01N33/48—Biological material, e.g. blood, urine; Haemocytometers
    • G01N33/50—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing
    • G01N33/53—Immunoassay; Biospecific binding assay; Materials therefor
    • G01N33/543—Immunoassay; Biospecific binding assay; Materials therefor with an insoluble carrier for immobilising immunochemicals
    • G01N33/54313—Immunoassay; Biospecific binding assay; Materials therefor with an insoluble carrier for immobilising immunochemicals the carrier being characterised by its particulate form
    • Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
    • Y10—TECHNICAL SUBJECTS COVERED BY FORMER USPC
    • Y10S—TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
    • Y10S435/00—Chemistry: molecular biology and microbiology
    • Y10S435/975—Kit
    • Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
    • Y10—TECHNICAL SUBJECTS COVERED BY FORMER USPC
    • Y10T—TECHNICAL SUBJECTS COVERED BY FORMER US CLASSIFICATION
    • Y10T428/00—Stock material or miscellaneous articles
    • Y10T428/29—Coated or structually defined flake, particle, cell, strand, strand portion, rod, filament, macroscopic fiber or mass thereof
    • Y10T428/2982—Particulate matter [e.g., sphere, flake, etc.]
    • Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
    • Y10—TECHNICAL SUBJECTS COVERED BY FORMER USPC
    • Y10T—TECHNICAL SUBJECTS COVERED BY FORMER US CLASSIFICATION
    • Y10T428/00—Stock material or miscellaneous articles
    • Y10T428/29—Coated or structually defined flake, particle, cell, strand, strand portion, rod, filament, macroscopic fiber or mass thereof
    • Y10T428/2982—Particulate matter [e.g., sphere, flake, etc.]
    • Y10T428/2984—Microcapsule with fluid core [includes liposome]
    • Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
    • Y10—TECHNICAL SUBJECTS COVERED BY FORMER USPC
    • Y10T—TECHNICAL SUBJECTS COVERED BY FORMER US CLASSIFICATION
    • Y10T428/00—Stock material or miscellaneous articles
    • Y10T428/29—Coated or structually defined flake, particle, cell, strand, strand portion, rod, filament, macroscopic fiber or mass thereof
    • Y10T428/2982—Particulate matter [e.g., sphere, flake, etc.]
    • Y10T428/2989—Microcapsule with solid core [includes liposome]
    • Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
    • Y10—TECHNICAL SUBJECTS COVERED BY FORMER USPC
    • Y10T—TECHNICAL SUBJECTS COVERED BY FORMER US CLASSIFICATION
    • Y10T428/00—Stock material or miscellaneous articles
    • Y10T428/29—Coated or structually defined flake, particle, cell, strand, strand portion, rod, filament, macroscopic fiber or mass thereof
    • Y10T428/2982—Particulate matter [e.g., sphere, flake, etc.]
    • Y10T428/2991—Coated
    • Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
    • Y10—TECHNICAL SUBJECTS COVERED BY FORMER USPC
    • Y10T—TECHNICAL SUBJECTS COVERED BY FORMER US CLASSIFICATION
    • Y10T428/00—Stock material or miscellaneous articles
    • Y10T428/29—Coated or structually defined flake, particle, cell, strand, strand portion, rod, filament, macroscopic fiber or mass thereof
    • Y10T428/2982—Particulate matter [e.g., sphere, flake, etc.]
    • Y10T428/2991—Coated
    • Y10T428/2993—Silicic or refractory material containing [e.g., tungsten oxide, glass, cement, etc.]
    • Y10T428/2996—Glass particles or spheres
    • Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
    • Y10—TECHNICAL SUBJECTS COVERED BY FORMER USPC
    • Y10T—TECHNICAL SUBJECTS COVERED BY FORMER US CLASSIFICATION
    • Y10T428/00—Stock material or miscellaneous articles
    • Y10T428/29—Coated or structually defined flake, particle, cell, strand, strand portion, rod, filament, macroscopic fiber or mass thereof
    • Y10T428/2982—Particulate matter [e.g., sphere, flake, etc.]
    • Y10T428/2991—Coated
    • Y10T428/2998—Coated including synthetic resin or polymer

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  • Health & Medical Sciences (AREA)
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  • Immunology (AREA)
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  • General Health & Medical Sciences (AREA)
  • General Physics & Mathematics (AREA)
  • Pathology (AREA)
  • Investigating Or Analysing Biological Materials (AREA)
  • Addition Polymer Or Copolymer, Post-Treatments, Or Chemical Modifications (AREA)
  • Measuring Or Testing Involving Enzymes Or Micro-Organisms (AREA)
  • Sampling And Sample Adjustment (AREA)
  • Investigating Materials By The Use Of Optical Means Adapted For Particular Applications (AREA)

Abstract

내용 없음.

Description

진단 테스트용 수성 현탁액
본 내용은 요부공개 건이므로 전문내용을 수록하지 않았음
제1도는 종래 기술에 따른 현탁액 입자를 도시한 것으로서 다양한 핵 입자가 입자 하나에 대하여 각각 매립되어 있는 것을 나타낸 도면이며,
제2도는 핵이 서로 친밀히 매립된 종래 기술의 현탁액 입자를 도시한 도면이며,
제3도는 핵이 공중합체에 의해 서로 분리된 종래기술의 현탁액 입자를 도시한 도면이다.

Claims (13)

  1. 작용기를 함유하는 친수성 공중합체에 의해 둘러싸인 비중합체 핵을 함유며, 비중합체 핵은 공중합체 자체의 쉘에 의해 각각 분리되어 둘러싸여져 있는 것을 특징으로 하는 진단 테스트용 수성 현탁액.
  2. 제1항에 있어서, 면역 진단 테스트용 수성 현탁액.
  3. 제1항 또는 제2항에 있어서, 핵은 금속, 금속산화물, 금속화합물, 무기 화합물, 유기염료, 유기 색소, 또는 합성 오일. 동물성 오일. 식물성유 또는 광오일의 에멀죤 소적인 것을 특징으로 하는 수성 현탁액.
  4. 제3항에 있어서, 핵이 골도졸 또는 염료졸로 구성되는 것을 특징으로 하는 수성 현탁액.
  5. 가수분해후 또는 가수분해 없이 적어도 하나의 공유결합성 작용기를 함유하는 에틸렌성 불포화 단량체와, 소수성 단량체와, 결합 단량체로 구성된 단량체 혼합물 수용액을 비-중합체 입자 존재하에 본래의 장소에서 공중합시켜 진단성 또는 면역 진단성 테스트 수성 현탁액을 제조하는 방법에 있어서, 제1항 또는 제2항의 현탁액은 출발물질로서 비-중합체 입장의 안정한 콜로이도성 분산액을 사용하고, 여기에 단량체 혼합물을 가하고, 산출 공중합체가 원래의 분산액과 동일한 사인의 전하를 갖는 단량체 혼합물을 선택하는 것을 특징으로 하는 진단성 또는 면역성 진단 데스트용 수성 현탁액의 제조방법.
  6. 제5항에 있어서, 사용된 소수성 단량체는 친수성기에 가수분해성인 기를 함유하는 단량체이고 중합후에, 이들 가수분해성기가 가수 분해되는 것을 특징으로 하는 방법.
  7. 제6항에 있어서, 단량체 혼합물은 2-98중량%의 글리시딜 메타아크릴레이트, 0-96중량%의 비닐 황산염 나트륨 및 2-40 중량%의 N, N-메틸렌비스 아크릴아미드로 구성되는 것을 특징으로 하는 방법.
  8. 반응물로서 제공된 제1항의 친수성 공중합체에 의해 둘러싸인 비-중합체 핵을 함유하는 시약.
  9. 면역화학적 활성성분으로 제공된, 제2항의 친수성 공중합체에 의해 둘러싸인 비-중합체 핵을 함유하는 시약.
  10. 시약중에 존재하는 반응물에 대하여 결합 친화도를 지닌 특이적 결합 성분을 테스트 유세중에서 제8항에 따른 적어도 하나의 시약을 사용하여 검출하는 방법.
  11. 면역 화학적 시약중에 존재하는 면역 화학적 활성 성분에 대하여 결합 친화도를 지닌 면역 화학적 활성성분을 테스트유체중에서 제9항에 따른 적어도 하나의 시약을 사용하여 검출하는 방법.
  12. 제8항에 따른 적어도 하나의 시약을 함유하는 진단 테스트용 테스트 키트.
  13. 제9항에 따른 적어도 하나의 면역화학적 시약을 함유하는 면역분석용 테스트 키트.
    ※ 참고사항 : 최초출원 내용에 의하여 공개하는 것임.
KR1019890016377A 1988-11-14 1989-11-13 진단 테스트용 수성 현탁액 KR900008277A (ko)

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US (2) US5583056A (ko)
EP (1) EP0369515B1 (ko)
JP (1) JPH02183165A (ko)
KR (1) KR900008277A (ko)
AT (1) ATE129075T1 (ko)
AU (1) AU637333B2 (ko)
CA (1) CA2002672A1 (ko)
DE (1) DE68924517T2 (ko)
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EP0369515A1 (en) 1990-05-23
US5583056A (en) 1996-12-10
AU4462289A (en) 1990-05-17
FI98863B (fi) 1997-05-15
JPH02183165A (ja) 1990-07-17
FI98863C (fi) 1997-08-25
IE893553L (en) 1990-05-14
IE71197B1 (en) 1997-02-12
ATE129075T1 (de) 1995-10-15
DE68924517T2 (de) 1996-05-15
US5635405A (en) 1997-06-03
ZA898482B (en) 1990-07-25
CA2002672A1 (en) 1990-05-14
EP0369515B1 (en) 1995-10-11
DK567389A (da) 1990-05-15
ES2080740T3 (es) 1996-02-16
FI895366A0 (fi) 1989-11-10
DK567389D0 (da) 1989-11-13
DE68924517D1 (de) 1995-11-16
AU637333B2 (en) 1993-05-27

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