KR890701724A - Microorganisms having low acetate production ability and method of producing useful substances using the same - Google Patents

Microorganisms having low acetate production ability and method of producing useful substances using the same

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Publication number
KR890701724A
KR890701724A KR1019890701272A KR890701272A KR890701724A KR 890701724 A KR890701724 A KR 890701724A KR 1019890701272 A KR1019890701272 A KR 1019890701272A KR 890701272 A KR890701272 A KR 890701272A KR 890701724 A KR890701724 A KR 890701724A
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KR
South Korea
Prior art keywords
coli
biotin
producing
microorganisms
same
Prior art date
Application number
KR1019890701272A
Other languages
Korean (ko)
Other versions
KR910005626B1 (en
Inventor
신이치로 하즈
오지 이후쿠
지로 기시모토
Original Assignee
후쿠하라 요시하루
가부시기가이샤 시세이도
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
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Application filed by 후쿠하라 요시하루, 가부시기가이샤 시세이도 filed Critical 후쿠하라 요시하루
Publication of KR890701724A publication Critical patent/KR890701724A/en
Application granted granted Critical
Publication of KR910005626B1 publication Critical patent/KR910005626B1/en

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    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N1/00—Microorganisms, e.g. protozoa; Compositions thereof; Processes of propagating, maintaining or preserving microorganisms or compositions thereof; Processes of preparing or isolating a composition containing a microorganism; Culture media therefor
    • C12N1/20—Bacteria; Culture media therefor
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12P—FERMENTATION OR ENZYME-USING PROCESSES TO SYNTHESISE A DESIRED CHEMICAL COMPOUND OR COMPOSITION OR TO SEPARATE OPTICAL ISOMERS FROM A RACEMIC MIXTURE
    • C12P17/00—Preparation of heterocyclic carbon compounds with only O, N, S, Se or Te as ring hetero atoms
    • C12P17/18—Preparation of heterocyclic carbon compounds with only O, N, S, Se or Te as ring hetero atoms containing at least two hetero rings condensed among themselves or condensed with a common carbocyclic ring system, e.g. rifamycin
    • C12P17/185—Heterocyclic compounds containing sulfur atoms as ring hetero atoms in the condensed system
    • C12P17/186—Heterocyclic compounds containing sulfur atoms as ring hetero atoms in the condensed system containing a 2-oxo-thieno[3,4-d]imidazol nucleus, e.g. Biotin
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • C07K14/435—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
    • C07K14/575—Hormones
    • C07K14/585—Calcitonins
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N1/00—Microorganisms, e.g. protozoa; Compositions thereof; Processes of propagating, maintaining or preserving microorganisms or compositions thereof; Processes of preparing or isolating a composition containing a microorganism; Culture media therefor
    • C12N1/20—Bacteria; Culture media therefor
    • C12N1/205—Bacterial isolates
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N15/00—Mutation or genetic engineering; DNA or RNA concerning genetic engineering, vectors, e.g. plasmids, or their isolation, preparation or purification; Use of hosts therefor
    • C12N15/09—Recombinant DNA-technology
    • C12N15/11—DNA or RNA fragments; Modified forms thereof; Non-coding nucleic acids having a biological activity
    • C12N15/52—Genes encoding for enzymes or proenzymes
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12P—FERMENTATION OR ENZYME-USING PROCESSES TO SYNTHESISE A DESIRED CHEMICAL COMPOUND OR COMPOSITION OR TO SEPARATE OPTICAL ISOMERS FROM A RACEMIC MIXTURE
    • C12P21/00—Preparation of peptides or proteins
    • C12P21/02—Preparation of peptides or proteins having a known sequence of two or more amino acids, e.g. glutathione
    • C—CHEMISTRY; METALLURGY
    • C21—METALLURGY OF IRON
    • C21B—MANUFACTURE OF IRON OR STEEL
    • C21B13/00—Making spongy iron or liquid steel, by direct processes
    • C21B13/0006—Making spongy iron or liquid steel, by direct processes obtaining iron or steel in a molten state
    • C21B13/0013—Making spongy iron or liquid steel, by direct processes obtaining iron or steel in a molten state introduction of iron oxide into a bath of molten iron containing a carbon reductant
    • C21B13/002—Reduction of iron ores by passing through a heated column of carbon
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12R—INDEXING SCHEME ASSOCIATED WITH SUBCLASSES C12C - C12Q, RELATING TO MICROORGANISMS
    • C12R2001/00—Microorganisms ; Processes using microorganisms
    • C12R2001/01—Bacteria or Actinomycetales ; using bacteria or Actinomycetales
    • C12R2001/185—Escherichia
    • C12R2001/19—Escherichia coli
    • Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
    • Y02—TECHNOLOGIES OR APPLICATIONS FOR MITIGATION OR ADAPTATION AGAINST CLIMATE CHANGE
    • Y02P—CLIMATE CHANGE MITIGATION TECHNOLOGIES IN THE PRODUCTION OR PROCESSING OF GOODS
    • Y02P10/00—Technologies related to metal processing
    • Y02P10/10—Reduction of greenhouse gas [GHG] emissions
    • Y02P10/134—Reduction of greenhouse gas [GHG] emissions by avoiding CO2, e.g. using hydrogen

Abstract

내용 없음No content

Description

아세테이트 저생성 능력을 갖는 미생물 및 그것을 사용한 유용물질의 생성방법Microorganisms having low acetate production ability and method of producing useful substances using the same

본 내용은 요부공개 건이므로 전문내용을 수록하지 않았음Since this is an open matter, no full text was included.

제1도는 실시예 3에 설명된 플라즈미드 pXBA 312의 제조공정을 기술하고 있다.FIG. 1 describes the preparation of plasmid pXBA 312 described in Example 3. FIG.

Claims (9)

아세테이트의 생성 능력이 야생주, 이.콜리에 배해 1/5 이하인 것을 특징으로 하는 이.콜리(E.coli).E. coli, characterized in that the production capacity of acetate is 1/5 or less in wild wine, E. coli. 제1항에 있어서, 유용물질의 생성에 관한 유전정보를 갖는 재조합 플라즈미드를 더 포함하는 이.콜리.The E. coli of claim 1, further comprising a recombinant plasmid having genetic information about the generation of a useful substance. 제1항에 있어서, 비오틴에 의한 티이드 백 억제가 제거된 이.콜리.The E. coli of claim 1, wherein the inhibition of tide bag inhibition by biotin is eliminated. 제1항에 있어서, 비오틴 생성 이.콜리로부터 수득된 비오틴 오페론을 갖는 재조합 플라즈미드를 포함하는 이.콜리.The E. coli of claim 1 comprising a recombinant plasmid with a biotin operon obtained from a biotin producing E. coli. 제3항에 있어서, 비오틴 생성 이.콜리로부터 수득된 비오틴을 갖는 재조합 플라즈미드를 포함하는 이.콜리.4. The E. coli of claim 3 comprising a recombinant plasmid with biotin obtained from a biotin producing E. coli. 야생주 이.콜리에 비해 아세테이트 생성능역이 1/5이하이며 유동 물질의 생성에 관한 유전 정보를 갖는 제조합 플라즈미드를 함유하는 이.콜리를 고밀도로 배양하며；생성된 유용 물질을 회수하는 것을 특징으로 하는 유용물질의 제조방법.Cultivating E. coli containing the synthesized plasmid with less than 1/5 of the acetate production capacity compared to the wild strain E. coli and having genetic information on the formation of flowable substances; recovering the produced useful substance Method for producing a useful material to 제6항에 있어서, 유용 물질이 비오틴 또는 디티오비오틴인 방법.The method of claim 6, wherein the useful substance is biotin or dithiobiotin. 제7항에 있어서, 이.콜리의 비오틴에 의한 피이드 백 억제를 제거한 방법.8. The method of claim 7, wherein the suppression of feedback inhibition by biotin of E. coli is eliminated. 제8항에 있어서, 이.콜리를 1 내지 10g/1의 알라닌을 함유한 배지중에서 배양한 방법.The method of claim 8, wherein the E. coli is cultured in a medium containing 1 to 10 g / 1 of alanine. ※ 참고사항：최초출원 내용에 의하여 공개하는 것임.※ Note: The disclosure is based on the initial application.
KR1019890701272A 1987-11-07 1988-11-07 Microorganism having low acetate forming capability and its application KR910005626B1 (en)

Applications Claiming Priority (4)

Application Number Priority Date Filing Date Title
JP28182687 1987-11-07
JP62/281826 1987-11-07
JP62-281826 1987-11-07
PCT/JP1988/001124 WO1989004365A1 (en) 1987-11-07 1988-11-07 Microorganism having low acetate forming capability and its application

Publications (2)

Publication Number Publication Date
KR890701724A true KR890701724A (en) 1989-12-21
KR910005626B1 KR910005626B1 (en) 1991-08-01

Family

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KR1019890701272A KR910005626B1 (en) 1987-11-07 1988-11-07 Microorganism having low acetate forming capability and its application

Country Status (11)

Country Link
US (1) US5919662A (en)
EP (1) EP0316229B1 (en)
JP (1) JP2763119B2 (en)
KR (1) KR910005626B1 (en)
CN (1) CN1024809C (en)
AU (1) AU602274B2 (en)
CA (1) CA1322735C (en)
DE (1) DE3888789T2 (en)
ES (1) ES2061711T3 (en)
NZ (1) NZ226875A (en)
WO (1) WO1989004365A1 (en)

Families Citing this family (18)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CN1053217C (en) * 1990-03-27 2000-06-07 资生堂株式会社 Microorganisms and process for producing biotin vitamers using same
JP3006847B2 (en) * 1990-03-27 2000-02-07 株式会社資生堂 Novel microorganism and method for producing biotin using the same
KR100250692B1 (en) * 1991-09-13 2000-04-01 후쿠하라 요시하루 Biotin operon
EP0623135A4 (en) * 1992-01-17 1995-02-22 Universal Foods Corp Method for recovering biotin.
JP3428078B2 (en) * 1992-09-10 2003-07-22 住友化学工業株式会社 Biotin production method and microorganism used
SK279669B6 (en) * 1992-10-02 1999-02-11 Lonza A.G. (Dir.:Basel) Dna fragments, plasmids and microorganisms containing dna fragments and biotechnological method of biotin production
US6277609B1 (en) 1993-01-06 2001-08-21 Basf Aktiengesellschaft Method to produce biotin
JP3629290B2 (en) * 1993-10-01 2005-03-16 協和醗酵工業株式会社 Manufacturing method of substance
KR0151534B1 (en) * 1995-10-30 1998-08-17 이종호 Escherichiacoli for suppressing the production of organic acid
US20050118580A1 (en) * 2001-03-16 2005-06-02 Helmut Merk Nucleic acid which is stabilized against decomposition
WO2004085613A2 (en) * 2003-03-19 2004-10-07 Stratagene Electrocompetent host cells
JP4700357B2 (en) * 2005-01-26 2011-06-15 中部電力株式会社 Fixing structure of terminal cover support member in bushing for switch
JP5149619B2 (en) * 2005-05-25 2013-02-20 サントリーホールディングス株式会社 Processing method of green coffee beans by pH control
EP2119789A1 (en) 2008-05-16 2009-11-18 Université Libre de Bruxelles Hyperproliferative recombinant cell
JP5599171B2 (en) * 2009-08-07 2014-10-01 花王株式会社 Dodecahydro-3a, 6,6,9a-tetramethylnaphtho [2,1-b] furan synthetic intermediate high productivity mutant microorganism
JP2013528048A (en) 2010-05-20 2013-07-08 ユニベルシテ リブル ドゥ ブリュッセル Hyperproliferative recombinant cells
WO2015178465A1 (en) 2014-05-21 2015-11-26 味の素株式会社 Method for producing fibroin-like protein
EP3382031B1 (en) * 2015-11-25 2023-11-29 Ajinomoto Co., Inc. Method for producing fibroin-like protein

Family Cites Families (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JPH0740922B2 (en) * 1985-03-05 1995-05-10 株式会社資生堂 Biotin-producing microorganism
JPH07110232B2 (en) * 1985-10-14 1995-11-29 株式会社日立製作所 Method and apparatus for collecting gene product of transgenic E. coli
JPS62155081A (en) * 1985-12-27 1987-07-10 Shiseido Co Ltd Novel microorganism and production of biotin by fermentation with said microorganism

Also Published As

Publication number Publication date
JPH02502065A (en) 1990-07-12
EP0316229A1 (en) 1989-05-17
CN1033646A (en) 1989-07-05
JP2763119B2 (en) 1998-06-11
DE3888789T2 (en) 1994-08-18
AU602274B2 (en) 1990-10-04
AU2614688A (en) 1989-06-01
EP0316229B1 (en) 1994-03-30
CN1024809C (en) 1994-06-01
ES2061711T3 (en) 1994-12-16
DE3888789D1 (en) 1994-05-05
US5919662A (en) 1999-07-06
CA1322735C (en) 1993-10-05
KR910005626B1 (en) 1991-08-01
NZ226875A (en) 1990-09-26
WO1989004365A1 (en) 1989-05-18

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