KR890014451A - Compounds in the form of novel salts, pharmaceutical compositions containing them and methods of preparing the compounds - Google Patents

Compounds in the form of novel salts, pharmaceutical compositions containing them and methods of preparing the compounds Download PDF

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KR890014451A
KR890014451A KR1019890002919A KR890002919A KR890014451A KR 890014451 A KR890014451 A KR 890014451A KR 1019890002919 A KR1019890002919 A KR 1019890002919A KR 890002919 A KR890002919 A KR 890002919A KR 890014451 A KR890014451 A KR 890014451A
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acid
lysine
salts
general formula
antiviral
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KR0140993B1 (en
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리테라티 나기 페테르
보로스 마리아
스질베레키 예노
라크츠 이스트반
수스 굔기베르
콜러 미크로스
핀터 알란
네메스 가보르
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원본미기재
비오렉스 케이 에프 티
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    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D233/00—Heterocyclic compounds containing 1,3-diazole or hydrogenated 1,3-diazole rings, not condensed with other rings
    • C07D233/54—Heterocyclic compounds containing 1,3-diazole or hydrogenated 1,3-diazole rings, not condensed with other rings having two double bonds between ring members or between ring members and non-ring members
    • C07D233/64—Heterocyclic compounds containing 1,3-diazole or hydrogenated 1,3-diazole rings, not condensed with other rings having two double bonds between ring members or between ring members and non-ring members with substituted hydrocarbon radicals attached to ring carbon atoms, e.g. histidine
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/185—Acids; Anhydrides, halides or salts thereof, e.g. sulfur acids, imidic, hydrazonic or hydroximic acids
    • A61K31/19—Carboxylic acids, e.g. valproic acid
    • A61K31/20—Carboxylic acids, e.g. valproic acid having a carboxyl group bound to a chain of seven or more carbon atoms, e.g. stearic, palmitic, arachidic acids
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A61P31/12—Antivirals
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A61P31/12—Antivirals
    • A61P31/14—Antivirals for RNA viruses
    • A61P31/18—Antivirals for RNA viruses for HIV
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P37/00—Drugs for immunological or allergic disorders
    • A61P37/02—Immunomodulators
    • A61P37/04—Immunostimulants
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    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C227/00—Preparation of compounds containing amino and carboxyl groups bound to the same carbon skeleton
    • C07C227/14—Preparation of compounds containing amino and carboxyl groups bound to the same carbon skeleton from compounds containing already amino and carboxyl groups or derivatives thereof
    • C07C227/18—Preparation of compounds containing amino and carboxyl groups bound to the same carbon skeleton from compounds containing already amino and carboxyl groups or derivatives thereof by reactions involving amino or carboxyl groups, e.g. hydrolysis of esters or amides, by formation of halides, salts or esters
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C229/00—Compounds containing amino and carboxyl groups bound to the same carbon skeleton
    • C07C229/02—Compounds containing amino and carboxyl groups bound to the same carbon skeleton having amino and carboxyl groups bound to acyclic carbon atoms of the same carbon skeleton
    • C07C229/04—Compounds containing amino and carboxyl groups bound to the same carbon skeleton having amino and carboxyl groups bound to acyclic carbon atoms of the same carbon skeleton the carbon skeleton being acyclic and saturated
    • C07C229/06—Compounds containing amino and carboxyl groups bound to the same carbon skeleton having amino and carboxyl groups bound to acyclic carbon atoms of the same carbon skeleton the carbon skeleton being acyclic and saturated having only one amino and one carboxyl group bound to the carbon skeleton
    • C07C229/08—Compounds containing amino and carboxyl groups bound to the same carbon skeleton having amino and carboxyl groups bound to acyclic carbon atoms of the same carbon skeleton the carbon skeleton being acyclic and saturated having only one amino and one carboxyl group bound to the carbon skeleton the nitrogen atom of the amino group being further bound to hydrogen atoms
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C229/00—Compounds containing amino and carboxyl groups bound to the same carbon skeleton
    • C07C229/02—Compounds containing amino and carboxyl groups bound to the same carbon skeleton having amino and carboxyl groups bound to acyclic carbon atoms of the same carbon skeleton
    • C07C229/04—Compounds containing amino and carboxyl groups bound to the same carbon skeleton having amino and carboxyl groups bound to acyclic carbon atoms of the same carbon skeleton the carbon skeleton being acyclic and saturated
    • C07C229/22—Compounds containing amino and carboxyl groups bound to the same carbon skeleton having amino and carboxyl groups bound to acyclic carbon atoms of the same carbon skeleton the carbon skeleton being acyclic and saturated the carbon skeleton being further substituted by oxygen atoms
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C229/00—Compounds containing amino and carboxyl groups bound to the same carbon skeleton
    • C07C229/02—Compounds containing amino and carboxyl groups bound to the same carbon skeleton having amino and carboxyl groups bound to acyclic carbon atoms of the same carbon skeleton
    • C07C229/04—Compounds containing amino and carboxyl groups bound to the same carbon skeleton having amino and carboxyl groups bound to acyclic carbon atoms of the same carbon skeleton the carbon skeleton being acyclic and saturated
    • C07C229/24—Compounds containing amino and carboxyl groups bound to the same carbon skeleton having amino and carboxyl groups bound to acyclic carbon atoms of the same carbon skeleton the carbon skeleton being acyclic and saturated having more than one carboxyl group bound to the carbon skeleton, e.g. aspartic acid
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C229/00—Compounds containing amino and carboxyl groups bound to the same carbon skeleton
    • C07C229/02—Compounds containing amino and carboxyl groups bound to the same carbon skeleton having amino and carboxyl groups bound to acyclic carbon atoms of the same carbon skeleton
    • C07C229/04—Compounds containing amino and carboxyl groups bound to the same carbon skeleton having amino and carboxyl groups bound to acyclic carbon atoms of the same carbon skeleton the carbon skeleton being acyclic and saturated
    • C07C229/26—Compounds containing amino and carboxyl groups bound to the same carbon skeleton having amino and carboxyl groups bound to acyclic carbon atoms of the same carbon skeleton the carbon skeleton being acyclic and saturated having more than one amino group bound to the carbon skeleton, e.g. lysine
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C229/00—Compounds containing amino and carboxyl groups bound to the same carbon skeleton
    • C07C229/02—Compounds containing amino and carboxyl groups bound to the same carbon skeleton having amino and carboxyl groups bound to acyclic carbon atoms of the same carbon skeleton
    • C07C229/34—Compounds containing amino and carboxyl groups bound to the same carbon skeleton having amino and carboxyl groups bound to acyclic carbon atoms of the same carbon skeleton the carbon skeleton containing six-membered aromatic rings
    • C07C229/36—Compounds containing amino and carboxyl groups bound to the same carbon skeleton having amino and carboxyl groups bound to acyclic carbon atoms of the same carbon skeleton the carbon skeleton containing six-membered aromatic rings with at least one amino group and one carboxyl group bound to the same carbon atom of the carbon skeleton
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C237/00—Carboxylic acid amides, the carbon skeleton of the acid part being further substituted by amino groups
    • C07C237/02—Carboxylic acid amides, the carbon skeleton of the acid part being further substituted by amino groups having the carbon atoms of the carboxamide groups bound to acyclic carbon atoms of the carbon skeleton
    • C07C237/04—Carboxylic acid amides, the carbon skeleton of the acid part being further substituted by amino groups having the carbon atoms of the carboxamide groups bound to acyclic carbon atoms of the carbon skeleton the carbon skeleton being acyclic and saturated
    • C07C237/06—Carboxylic acid amides, the carbon skeleton of the acid part being further substituted by amino groups having the carbon atoms of the carboxamide groups bound to acyclic carbon atoms of the carbon skeleton the carbon skeleton being acyclic and saturated having the nitrogen atoms of the carboxamide groups bound to hydrogen atoms or to acyclic carbon atoms
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C279/00—Derivatives of guanidine, i.e. compounds containing the group, the singly-bound nitrogen atoms not being part of nitro or nitroso groups
    • C07C279/04—Derivatives of guanidine, i.e. compounds containing the group, the singly-bound nitrogen atoms not being part of nitro or nitroso groups having nitrogen atoms of guanidine groups bound to acyclic carbon atoms of a carbon skeleton
    • C07C279/14—Derivatives of guanidine, i.e. compounds containing the group, the singly-bound nitrogen atoms not being part of nitro or nitroso groups having nitrogen atoms of guanidine groups bound to acyclic carbon atoms of a carbon skeleton being further substituted by carboxyl groups
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C57/00—Unsaturated compounds having carboxyl groups bound to acyclic carbon atoms
    • C07C57/02—Unsaturated compounds having carboxyl groups bound to acyclic carbon atoms with only carbon-to-carbon double bonds as unsaturation
    • C07C57/03—Monocarboxylic acids
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D207/00—Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom
    • C07D207/02—Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom with only hydrogen or carbon atoms directly attached to the ring nitrogen atom
    • C07D207/04—Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having no double bonds between ring members or between ring members and non-ring members
    • C07D207/10—Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having no double bonds between ring members or between ring members and non-ring members with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
    • C07D207/16—Carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals

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  • Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
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Abstract

내용 없음.No content.

Description

신규 염류 형태의 화합물, 이들을 함유하는 약학적 조성물 및 이 화합물을 제조하는 방법Compounds in the form of novel salts, pharmaceutical compositions containing them and methods of preparing the compounds

내용없음No content

Claims (11)

일반구조식(I)의 신규 항바이러스성 및 면역 자극성 염류New Antiviral and Immune Stimulating Salts of General Formula (I) R-COO-AH+(I)R-COO - AH + (I) 식중, R은 적어도 2개의 2중 결합을 가지는 C18-24알킬기이며, A는 생체에서 생기는 아미노산 및/또는 C1-4알킬기나 또는 아미노기로 치환된 카복실가를 가지는 그 유도체 또는 알카리금속 양이온으로 치환된 카복실기를 가지는 아미노산 유도체이다.Wherein R is a C 18-24 alkyl group having at least two double bonds, and A is substituted with an amino acid and / or a C 1-4 alkyl group or a derivative thereof having an carboxyl value substituted with an amino group or an alkali metal cation Amino acid derivative having a carboxyl group. 제1항에서 산 성분으로 에이코사펜타에노익 산(EPA)과 염기성분으로 L-라이신을 함유하는 염류.A salt containing eicosapentaenoic acid (EPA) as an acid component and L-lysine as a base component according to claim 1. 제1항에서 산 성분으로 도코사헥사에노익 산(DHA)과 염기성분으로 L-라이신을 함유하는 염류.A salt containing docosahexaenoic acid (DHA) as an acid component and L-lysine as a base component according to claim 1. 제1항에서 산 성분으로 도코사헥사에노익과 에이코산펜타에노익산의 혼합물과 염기성분으로 L-라이신을 함유하는 염류.2. A salt containing L-lysine as a base component as a mixture of docosahexaenoic acid and pentaenoic acid eicosan as an acid component. 일반구조식(I)의 염류(여기에서 치환체는 제1항에서 정의한 바와같다)를 약학 공업에서 통상으로 사용되는 담체 및/또는 첨가제와 임의로 항산화제를 혼합하여 이루어진 항바이러스성 및 면역자극성 약학적 조성물.Antiviral and immunostimulatory pharmaceutical compositions formed by mixing the salts of general formula (I), wherein the substituents are as defined in claim 1, with carriers and / or additives commonly used in the pharmaceutical industry and optionally antioxidants. . 염기성분(여기에서 치환체는 청구범위 제1항에서와 같다)을 일반구조식(II)의 산The base component (wherein the substituents are as defined in claim 1) is an acid of general formula (II) R-COOH (II)R-COOH (II) 식중 R은 청구범위 제1항에서와 같다. 과 극성용매중에서 반응시켜서 일반구조식 (I)의 신규 염류를 제조하는 방법.Wherein R is as defined in claim 1. A method for preparing novel salts of general formula (I) by reacting with a polar solvent. R-COO-AH+(I)R-COO - AH + (I) 식중 R과 A는 청구범위 1항에서와 같다.Wherein R and A are as defined in claim 1. 제6항에서 에이코펜타에노익산과 L-라이신을 반응시키는 방법.The method of claim 6 reacting eicopentaenoic acid and L-lysine. 제6항에서 도코사헥사에노익산을 L-라이신과 반응시키는 방법.The method of claim 6, wherein the docosahexaenoic acid is reacted with L-lysine. 제6항에서 도코사헥사에노익산과 에이코사펜타에노익산의 혼합물은 L-라이신과 반응시키는 방법.The method of claim 6, wherein the mixture of docosahexaenoic acid and eicosapentaenoic acid is reacted with L-lysine. 청구범위 제6항에서 제조된 일반식(I)의 염류를 제약공업에서 통상으로 사용되는 담체 및/또는 보조제와 임의로 항산화제와 혼합한 후 이렇게 얻어진 혼합물을 정제, 환제, 캡슐제, 좌제 등으로 제제화하여 항바이러스성 및 면역자극 효과를 가지는 약학적 조성물을 제조방법.The salts of formula (I) prepared in claim 6 are mixed with a carrier and / or adjuvant commonly used in the pharmaceutical industry, optionally with an antioxidant, and then the resulting mixture is converted into tablets, pills, capsules, suppositories, etc. Formulated to prepare a pharmaceutical composition having an antiviral and immunostimulatory effect. 일반구조식(I)의 염류를 항바이러스성 및 면역자극 작용을 가지는 약학적 조성물의 제조에 사용하는 용도.Use of salts of general formula (I) in the preparation of pharmaceutical compositions having antiviral and immunostimulatory action. ※ 참고사항 : 최초출원 내용에 의하여 공개하는 것임.※ Note: The disclosure is based on the initial application.
KR1019890002919A 1988-03-09 1989-03-09 Aminoacid salts of long chain unsaturated carboxylic acids KR0140993B1 (en)

Applications Claiming Priority (3)

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HU6059 1988-03-09
HU1131/88 1988-03-09
HU881131A HU199775B (en) 1988-03-09 1988-03-09 Process for production of formed by fatty acids salts of amin acids and medical compositions containing them

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KR0140993B1 KR0140993B1 (en) 1998-07-01

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AT (1) AT398073B (en)
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FI891144A0 (en) 1989-03-09
SE8900827L (en) 1989-09-10
IT8919705A0 (en) 1989-03-09
GB8905384D0 (en) 1989-04-19
JP2751068B2 (en) 1998-05-18
IT1229563B (en) 1991-09-04
SE8900827D0 (en) 1989-03-09
CH678851A5 (en) 1991-11-15
HUT49564A (en) 1989-10-30
AT398073B (en) 1994-09-26
LU87470A1 (en) 1990-10-02
FI891144A (en) 1989-09-10
GB2216522A (en) 1989-10-11
KR0140993B1 (en) 1998-07-01
GB2216522B (en) 1992-01-02
FR2628419B1 (en) 1992-02-14
DE3907688C2 (en) 1996-09-05
JPH024746A (en) 1990-01-09
FR2628419A1 (en) 1989-09-15
ATA50989A (en) 1994-01-15
NL8900573A (en) 1989-10-02
DE3907688A1 (en) 1989-09-21
SE508603C2 (en) 1998-10-19
ES2010439A6 (en) 1989-11-01
FI93949C (en) 1995-06-26
CA1339147C (en) 1997-07-29
BE1003663A3 (en) 1992-05-19
HU199775B (en) 1990-03-28
FI93949B (en) 1995-03-15

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