KR890014129A - 인간 psti를 인지하는 단클론성 항체, 항체를 생산하는 하이브리도마 및 인산 psti의 결정 - Google Patents

인간 psti를 인지하는 단클론성 항체, 항체를 생산하는 하이브리도마 및 인산 psti의 결정 Download PDF

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KR890014129A
KR890014129A KR1019890002855A KR890002855A KR890014129A KR 890014129 A KR890014129 A KR 890014129A KR 1019890002855 A KR1019890002855 A KR 1019890002855A KR 890002855 A KR890002855 A KR 890002855A KR 890014129 A KR890014129 A KR 890014129A
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pstis
monoclonal antibody
hybridoma
human
monoclonal antibodies
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KR1019890002855A
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KR970008426B1 (ko
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교오조 하야시
마사유끼 구로베
기요시 나가따
노부오 요시다
마사오 고노
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요시또시 가즈오
시오노기세이야꾸 가부시끼가이샤
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    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K39/00—Medicinal preparations containing antigens or antibodies
    • A61K39/395—Antibodies; Immunoglobulins; Immune serum, e.g. antilymphocytic serum
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K16/00—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies
    • C07K16/40—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against enzymes
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K16/00—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies
    • C07K16/38—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against protease inhibitors of peptide structure
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N5/00—Undifferentiated human, animal or plant cells, e.g. cell lines; Tissues; Cultivation or maintenance thereof; Culture media therefor
    • C12N5/10—Cells modified by introduction of foreign genetic material
    • C12N5/12—Fused cells, e.g. hybridomas
    • C12N5/16—Animal cells
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12P—FERMENTATION OR ENZYME-USING PROCESSES TO SYNTHESISE A DESIRED CHEMICAL COMPOUND OR COMPOSITION OR TO SEPARATE OPTICAL ISOMERS FROM A RACEMIC MIXTURE
    • C12P21/00—Preparation of peptides or proteins
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N33/00—Investigating or analysing materials by specific methods not covered by groups G01N1/00 - G01N31/00
    • G01N33/48—Biological material, e.g. blood, urine; Haemocytometers
    • G01N33/50—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing
    • G01N33/53—Immunoassay; Biospecific binding assay; Materials therefor
    • G01N33/577—Immunoassay; Biospecific binding assay; Materials therefor involving monoclonal antibodies binding reaction mechanisms characterised by the use of monoclonal antibodies; monoclonal antibodies per se are classified with their corresponding antigens

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  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
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  • Urology & Nephrology (AREA)
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  • Chemical Kinetics & Catalysis (AREA)
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  • Proteomics, Peptides & Aminoacids (AREA)
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  • Preparation Of Compounds By Using Micro-Organisms (AREA)
  • Micro-Organisms Or Cultivation Processes Thereof (AREA)
  • Peptides Or Proteins (AREA)
  • Medicines Containing Material From Animals Or Micro-Organisms (AREA)

Abstract

내용 없음.

Description

인간 PSTI를 인지하는 단클론성 항체, 항체를 생산하는 하이브리도마 및 인간 PSTI의 결정
본 내용은 요부공개 건이므로 전문내용을 수록하지 않았음
제1도는 본 발명의 단클론성 항체를 사용하는 면역 방사선 측정 분석용 표준 곡선을 나타낸다.
제2도는 본 발명의 단클론성 항체의 희석 곡선을 나타낸다.
제3도는 본 발명의 단클론성 항체의 교차 반응성을 나타낸다.
제3A,3B 및 3C도는 각각 단클론성 항체 167,150 및 360의 교차 반응성을 나타낸다.

Claims (10)

  1. 인간 PSTI를 인지하는 단클론성 항체.
  2. 제1항에 있어서, 하이브리도마 hPSTI-150에 의해 생산되고 항-인간 PSTI 단클론성 항체 150으로 명명된 단클론성 항체.
  3. 제1항에 있어서, 하이브리도마 hPSTI-167에 의해 생산되고 항-인간 PSTI 단클론성 항체 167으로 명명된 단클론성 항체.
  4. 제1항에 있어서, 하이브리도마 hPSTI-360에 의해 생산되고 항-인간 PSTI 단클론성 항체 360으로 명명된 단클론성 항체.
  5. 인간 PSTI를 인지하는 단클론성 항체를 생산하는 하이브리도마.
  6. 제5항에 있어서, 단클론성 항체150을 생산할 수 있는 하이브리도마 hPSTI-150으로 명명된 하이브리도마.
  7. 제5항에 있어서, 단클론성 항체167을 생산할 수 있는 하이브리도마 hPSTI-167으로 명명된 하이브리도마.
  8. 제5항에 있어서, 단클론성 항체 360을 생산할 수 있는 하이브리도마 hPSTI-360으로 명명된 하이브리도마.
  9. 인간 PSTI를 인지하는 단클론성 항체 또는 항체를 사용하는 방사선 면역 분석 또는 효소 면역 분석에 의해 인간 PSTI를 측정함을 특징으로 하는 인간 PSTI의 결정 방법.
  10. 제9항에 있어서, 적어도 하나의 단클론성 항체를 항-인간 PSTI 단클론성 항체 150,167 및 360에서 선택하는 방법.
    ※ 참고사항:최초출원 내용에 의하여 공개하는 것임.
KR1019890002855A 1988-03-08 1989-03-08 인간 psti를 인지하는 단클론성 항체, 이러한 항체를 생산하는 하이브리도마 및 인간 psti의 결정 방법 KR970008426B1 (ko)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
JP63-55431 1988-03-08
JP63055431A JPH0677518B2 (ja) 1988-03-08 1988-03-08 ヒトｐｓｔｉを認識するモノクローナル抗体、該抗体産生ハイブリドーマおよびヒトｐｓｔｉの測定方法

Publications (2)

Publication Number Publication Date
KR890014129A true KR890014129A (ko) 1989-10-21
KR970008426B1 KR970008426B1 (ko) 1997-05-24

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Application Number Title Priority Date Filing Date
KR1019890002855A KR970008426B1 (ko) 1988-03-08 1989-03-08 인간 psti를 인지하는 단클론성 항체, 이러한 항체를 생산하는 하이브리도마 및 인간 psti의 결정 방법

Country Status (7)

Country Link
EP (1) EP0332421B1 (ko)
JP (1) JPH0677518B2 (ko)
KR (1) KR970008426B1 (ko)
AT (1) ATE94881T1 (ko)
CA (1) CA1334077C (ko)
DE (1) DE68909276T2 (ko)
ES (1) ES2059726T3 (ko)

Family Cites Families (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
DE3827145A1 (de) * 1987-12-03 1989-06-15 Biotechnolog Forschung Gmbh Monoklonale antikoerper, hybridoma-zellinien zur gewinnung der antikoerper, verfahren zur gewinnung der antikoerper und der zellinien, sowie verwendung der antikoerper

Also Published As

Publication number Publication date
JPH0677518B2 (ja) 1994-10-05
ES2059726T3 (es) 1994-11-16
DE68909276T2 (de) 1994-04-07
EP0332421B1 (en) 1993-09-22
CA1334077C (en) 1995-01-24
EP0332421A2 (en) 1989-09-13
KR970008426B1 (ko) 1997-05-24
ATE94881T1 (de) 1993-10-15
EP0332421A3 (en) 1990-01-31
JPH01228494A (ja) 1989-09-12
DE68909276D1 (de) 1993-10-28

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