KR890010564A - 응집 반응 장치 - Google Patents

응집 반응 장치 Download PDF

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Publication number
KR890010564A
KR890010564A KR1019880017288A KR880017288A KR890010564A KR 890010564 A KR890010564 A KR 890010564A KR 1019880017288 A KR1019880017288 A KR 1019880017288A KR 880017288 A KR880017288 A KR 880017288A KR 890010564 A KR890010564 A KR 890010564A
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KR
South Korea
Prior art keywords
reaction apparatus
channels
flocculation
reagent
chamber
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KR1019880017288A
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English (en)
Inventor
파슨 로버트 지
레쎌 하우즈만 케니쓰
코왈 로버트
비.오크넬 마이클
Original Assignee
죠셉 엠. 버닉
애보트 레버러토리즈
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
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Application filed by 죠셉 엠. 버닉, 애보트 레버러토리즈 filed Critical 죠셉 엠. 버닉
Publication of KR890010564A publication Critical patent/KR890010564A/ko

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    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N33/00—Investigating or analysing materials by specific methods not covered by groups G01N1/00 - G01N31/00
    • G01N33/48—Biological material, e.g. blood, urine; Haemocytometers
    • G01N33/50—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing
    • G01N33/53—Immunoassay; Biospecific binding assay; Materials therefor
    • G01N33/558—Immunoassay; Biospecific binding assay; Materials therefor using diffusion or migration of antigen or antibody
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01L—CHEMICAL OR PHYSICAL LABORATORY APPARATUS FOR GENERAL USE
    • B01L3/00—Containers or dishes for laboratory use, e.g. laboratory glassware; Droppers
    • B01L3/50—Containers for the purpose of retaining a material to be analysed, e.g. test tubes
    • B01L3/502—Containers for the purpose of retaining a material to be analysed, e.g. test tubes with fluid transport, e.g. in multi-compartment structures
    • B01L3/5027—Containers for the purpose of retaining a material to be analysed, e.g. test tubes with fluid transport, e.g. in multi-compartment structures by integrated microfluidic structures, i.e. dimensions of channels and chambers are such that surface tension forces are important, e.g. lab-on-a-chip
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N33/00—Investigating or analysing materials by specific methods not covered by groups G01N1/00 - G01N31/00
    • G01N33/48—Biological material, e.g. blood, urine; Haemocytometers
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N33/00—Investigating or analysing materials by specific methods not covered by groups G01N1/00 - G01N31/00
    • G01N33/48—Biological material, e.g. blood, urine; Haemocytometers
    • G01N33/50—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing
    • G01N33/53—Immunoassay; Biospecific binding assay; Materials therefor
    • G01N33/5302—Apparatus specially adapted for immunological test procedures
    • G01N33/5304—Reaction vessels, e.g. agglutination plates
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01L—CHEMICAL OR PHYSICAL LABORATORY APPARATUS FOR GENERAL USE
    • B01L2300/00—Additional constructional details
    • B01L2300/08—Geometry, shape and general structure
    • B01L2300/0861—Configuration of multiple channels and/or chambers in a single devices
    • B01L2300/0864—Configuration of multiple channels and/or chambers in a single devices comprising only one inlet and multiple receiving wells, e.g. for separation, splitting
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01L—CHEMICAL OR PHYSICAL LABORATORY APPARATUS FOR GENERAL USE
    • B01L2300/00—Additional constructional details
    • B01L2300/08—Geometry, shape and general structure
    • B01L2300/0887—Laminated structure
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01L—CHEMICAL OR PHYSICAL LABORATORY APPARATUS FOR GENERAL USE
    • B01L2400/00—Moving or stopping fluids
    • B01L2400/04—Moving fluids with specific forces or mechanical means
    • B01L2400/0403—Moving fluids with specific forces or mechanical means specific forces
    • B01L2400/0406—Moving fluids with specific forces or mechanical means specific forces capillary forces
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01L—CHEMICAL OR PHYSICAL LABORATORY APPARATUS FOR GENERAL USE
    • B01L2400/00—Moving or stopping fluids
    • B01L2400/08—Regulating or influencing the flow resistance
    • B01L2400/084—Passive control of flow resistance
    • B01L2400/086—Passive control of flow resistance using baffles or other fixed flow obstructions

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  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Immunology (AREA)
  • Engineering & Computer Science (AREA)
  • Hematology (AREA)
  • Biomedical Technology (AREA)
  • Urology & Nephrology (AREA)
  • Molecular Biology (AREA)
  • Analytical Chemistry (AREA)
  • General Health & Medical Sciences (AREA)
  • General Physics & Mathematics (AREA)
  • Pathology (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Food Science & Technology (AREA)
  • Medicinal Chemistry (AREA)
  • Physics & Mathematics (AREA)
  • Biochemistry (AREA)
  • Cell Biology (AREA)
  • Microbiology (AREA)
  • Biotechnology (AREA)
  • Clinical Laboratory Science (AREA)
  • Dispersion Chemistry (AREA)
  • Investigating Or Analysing Biological Materials (AREA)
  • Physical Or Chemical Processes And Apparatus (AREA)
  • Automatic Analysis And Handling Materials Therefor (AREA)
  • Preparation Of Compounds By Using Micro-Organisms (AREA)
  • Sampling And Sample Adjustment (AREA)

Abstract

내용 없음

Description

응집 반응 장치
본 내용은 요부공개 건이므로 전문내용을 수록하지 않았음
제1도는 하나의 시료 수용 웰(receiving well)과 네개의 반응 챔버를 보여주는, 본 발명의 응집 반응 장치의 일실시예의 상부 사시도.
제2도는 하나의 시료 수용 웰과 네개의 채널을 보여주는, 본 발명의 응집 반응장치의 하부면의 일실시예의 상부 사시도.

Claims (11)

  1. 응집 면역 검정 반응을 행하기 위한 응집 반응 장치에 있어서, 친수성 제1표면과 평행 제2표면을 구비하고 있고 ; 상기 제1표면은 제1표면과 제2표면이 서로 접촉하게 될때 모세관 작용에 의해 유체를 도입하는 응집 반응 챔버가 형성되도록 채널들을 갖고 있고 ; 상기 응집 반응 챔버는 검정을 행하기 위해 채널들을 분산된 일정량의 시약과 유체 흐름 조절 수단을 갖고 있는 것을 특징으로 하는 응집 반응 장치.
  2. 제1항에 있어서, 상기 유체 흐름 조절 수단은 채널들의 전체폭을 가로질러 그리고 적어도 채널 길이의 일부를 연장하는, 채널들에 형성된, 릿지들인 것을 특징으로 하는 응집 반응 장치.
  3. 제1항에 있어서, 상기 유체 흐름 조절 수단은 채널 부분에 건조된 수용성 물질을 구비하고 있는 것을 특징으로 하는 응집 반응 장치.
  4. 제3항에 있어서, 상기 수용성 물질은 폴리비닐피롤리돈, 폴리비닐 알코올, 젤라틴 또는 소 혈청 알부민인 것을 특징으로 하는 응집 반응 장치.
  5. 제1항에 있어서, 챔버의 길이는 약 10 내지 75mm인 것을 특징으로 하는 응집반응 장치.
  6. 제1항에 있어서, 상기 채널들은 깊이가 약 0.01 내지 5.0mm인 것을 특징으로하는 응집 반응 장치.
  7. 제1항에 있어서, 상기 채널들은 폭이 약 0.1 내지 10.0mm인 것을 특징으로 하는 응집 반응 장치.
  8. 제1항에 있어서, 상기 시약은 건조된 반점들 또는 스트립들로 존재하는 것을 특징으로하는 응집 반응 장치.
  9. 제1항에 있어서, 상기 시약은 덱스트란 및 수크로오스 용액 또는 수크로오스의 비이온 합성 용액에 미립자로 존재하는 것을 특징으로하는 응집 반응 장치.
  10. 제1항에 있어서, 상기 시약은 수용성 중합체로 현탁되는 것을 특징으로 하는 응집 반응 장치.
  11. 제1항에 있어서, 상기 제1표면과 제2표면에 의해 형성된 챔버의 입구에 인접한 시료 수용 웰을 부가적으로 구비하고 있는 것을 특징으로 하는 응집 반응 장치.
    ※ 참고사항 : 최초출원 내용에 의하여 공개하는 것임.
KR1019880017288A 1987-12-23 1988-12-23 응집 반응 장치 KR890010564A (ko)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US13825387A 1987-12-23 1987-12-23
US138,253 1987-12-23

Publications (1)

Publication Number Publication Date
KR890010564A true KR890010564A (ko) 1989-08-09

Family

ID=22481182

Family Applications (1)

Application Number Title Priority Date Filing Date
KR1019880017288A KR890010564A (ko) 1987-12-23 1988-12-23 응집 반응 장치

Country Status (7)

Country Link
EP (1) EP0321736B1 (ko)
JP (1) JPH01203038A (ko)
KR (1) KR890010564A (ko)
AT (1) ATE106567T1 (ko)
AU (1) AU623354B2 (ko)
DE (1) DE3889885T2 (ko)
ES (1) ES2056877T3 (ko)

Families Citing this family (27)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US5209904A (en) * 1987-12-23 1993-05-11 Abbott Laboratories Agglutination reaction device utilizing selectively impregnated porous material
GB8903046D0 (en) * 1989-02-10 1989-03-30 Vale David R Testing of liquids
US5066465A (en) * 1989-12-27 1991-11-19 Olympus Optical Co., Ltd. Reaction apparatus
US5188968A (en) * 1989-12-28 1993-02-23 Olympus Optical Co., Ltd. Method and reaction kit for agglutination detection
EP0435245B1 (en) * 1989-12-28 1995-05-10 Olympus Optical Co., Ltd. Reaction kit
WO1992008973A1 (en) * 1990-11-16 1992-05-29 Abbott Laboratories Improved agglutination reaction device utilizing porous absorbent material
CA2100365A1 (en) * 1990-11-16 1992-05-17 Robert G. Parsons Agglutination reaction device having geometrically modified chambers
US5518887A (en) * 1992-03-30 1996-05-21 Abbott Laboratories Immunoassays empolying generic anti-hapten antibodies and materials for use therein
US7524456B1 (en) 1992-05-21 2009-04-28 Biosite Incorporated Diagnostic devices for the controlled movement of reagents without membranes
US6767510B1 (en) 1992-05-21 2004-07-27 Biosite, Inc. Diagnostic devices and apparatus for the controlled movement of reagents without membranes
US6905882B2 (en) 1992-05-21 2005-06-14 Biosite, Inc. Diagnostic devices and apparatus for the controlled movement of reagents without membranes
US6696286B1 (en) 1997-04-09 2004-02-24 3M Innovative Properties Company Method and devices for detecting and enumerating microorganisms
US6391578B2 (en) 1997-04-09 2002-05-21 3M Innovative Properties Company Method and devices for partitioning biological sample liquids into microvolumes
GB9800263D0 (en) * 1998-01-08 1998-03-04 Bio Diagnostics Ltd A device for testing liquids
US6174699B1 (en) 1999-03-09 2001-01-16 3M Innovative Properties Company Disc assay device with inoculation pad and methods of use
US6375818B1 (en) * 1999-06-08 2002-04-23 Beckman Coulter, Inc. Surfaces with reduced electroosmotic flow
JP2001159618A (ja) * 1999-12-03 2001-06-12 Matsushita Electric Ind Co Ltd バイオセンサ
US6797139B2 (en) 2001-03-19 2004-09-28 Applera Corporation Detection cell for guiding excitation light therein and method for using same
US7108775B2 (en) 2002-11-08 2006-09-19 Applera Corporation Apparatus and method for confining eluted samples in electrophoresis systems
GB0306098D0 (en) * 2003-03-18 2003-04-23 Platform Diagnostics Group Ltd Sample testing device
US8124177B2 (en) * 2004-03-23 2012-02-28 Velocys Tailored and uniform coatings in microchannel apparatus
GB0423885D0 (en) * 2004-10-28 2004-12-01 Platform Diagnostics Ltd Blood analysis
WO2006047831A1 (en) * 2004-11-03 2006-05-11 Agen Biomedical Limited Detection device and method
JP2008082897A (ja) * 2006-09-27 2008-04-10 Fujifilm Corp 血漿回収方法及び器具並びに血液簡易検査方法及び器具
JP5309312B2 (ja) 2007-11-01 2013-10-09 Ｊｆｅテクノス株式会社 マイクロチップ、マイクロチップデバイス及びマイクロチップを用いた蒸発操作方法
GB201005191D0 (en) 2010-03-26 2010-05-12 Cambridge Entpr Ltd Immunoassays,methods for carrying out immunoassays,immunoassay kits and method for manufacturing immunoassay kits
US11602751B2 (en) 2017-03-31 2023-03-14 Forward Biotech, Inc. Liquid evaluation

Family Cites Families (8)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JPS5533651A (en) * 1978-08-31 1980-03-08 Fuji Photo Film Co Ltd Laminated plate of multi-layered chemical analysis material and using method thereof
CA1129498A (en) * 1978-10-25 1982-08-10 Richard L. Columbus Structural configuration and method for transport of a liquid drop through an ingress aperture
JPS561352A (en) * 1979-06-20 1981-01-09 Olympus Optical Co Ltd Container for corpuscular cohesion judgement
JPS57154322A (en) * 1981-03-20 1982-09-24 Nippon Steel Corp Hot steel band winder
JPS6086468A (ja) * 1983-10-18 1985-05-16 Olympus Optical Co Ltd 抗原抗体反応の判定方法
US4756884A (en) * 1985-08-05 1988-07-12 Biotrack, Inc. Capillary flow device
CA1292176C (en) * 1985-09-18 1991-11-19 Joel M. Blatt Volume metering capillary gap device for applying a liquid sample onto a reactive surface
US4918025A (en) * 1987-03-03 1990-04-17 Pb Diagnostic Systems, Inc. Self contained immunoassay element

Also Published As

Publication number Publication date
DE3889885T2 (de) 1994-12-15
JPH01203038A (ja) 1989-08-15
AU623354B2 (en) 1992-05-14
DE3889885D1 (de) 1994-07-07
ATE106567T1 (de) 1994-06-15
EP0321736B1 (en) 1994-06-01
ES2056877T3 (es) 1994-10-16
EP0321736A2 (en) 1989-06-28
AU2661988A (en) 1989-06-29
EP0321736A3 (en) 1990-03-14

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