KR890008313A - 안티 pci모노클론 항체 - Google Patents

안티 pci모노클론 항체 Download PDF

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Publication number
KR890008313A
KR890008313A KR870012827A KR870012827A KR890008313A KR 890008313 A KR890008313 A KR 890008313A KR 870012827 A KR870012827 A KR 870012827A KR 870012827 A KR870012827 A KR 870012827A KR 890008313 A KR890008313 A KR 890008313A
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KR
South Korea
Prior art keywords
human placenta
derived
monoclonal antibody
coagulation
monoclonal antibodies
Prior art date
Application number
KR870012827A
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English (en)
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KR960013460B1 (ko
Inventor
히로시 나까오
다까오 나고야
유시 사이노
Original Assignee
미와 다까 야수
코와 가부시끼 가이샤
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
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Application filed by 미와 다까 야수, 코와 가부시끼 가이샤 filed Critical 미와 다까 야수
Publication of KR890008313A publication Critical patent/KR890008313A/ko
Application granted granted Critical
Publication of KR960013460B1 publication Critical patent/KR960013460B1/ko

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    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K16/00—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies
    • C07K16/18—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans
    • C07K16/36—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans against blood coagulation factors
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N5/00—Undifferentiated human, animal or plant cells, e.g. cell lines; Tissues; Cultivation or maintenance thereof; Culture media therefor
    • C12N5/10—Cells modified by introduction of foreign genetic material
    • C12N5/12—Fused cells, e.g. hybridomas
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12P—FERMENTATION OR ENZYME-USING PROCESSES TO SYNTHESISE A DESIRED CHEMICAL COMPOUND OR COMPOSITION OR TO SEPARATE OPTICAL ISOMERS FROM A RACEMIC MIXTURE
    • C12P21/00—Preparation of peptides or proteins
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N33/00—Investigating or analysing materials by specific methods not covered by groups G01N1/00 - G01N31/00
    • G01N33/48—Biological material, e.g. blood, urine; Haemocytometers
    • G01N33/50—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing
    • G01N33/53—Immunoassay; Biospecific binding assay; Materials therefor
    • G01N33/577—Immunoassay; Biospecific binding assay; Materials therefor involving monoclonal antibodies binding reaction mechanisms characterised by the use of monoclonal antibodies; monoclonal antibodies per se are classified with their corresponding antigens
    • Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
    • Y10—TECHNICAL SUBJECTS COVERED BY FORMER USPC
    • Y10S—TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
    • Y10S436/00—Chemistry: analytical and immunological testing
    • Y10S436/807—Apparatus included in process claim, e.g. physical support structures
    • Y10S436/808—Automated or kit
    • Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
    • Y10—TECHNICAL SUBJECTS COVERED BY FORMER USPC
    • Y10S—TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
    • Y10S530/00—Chemistry: natural resins or derivatives; peptides or proteins; lignins or reaction products thereof
    • Y10S530/827—Proteins from mammals or birds
    • Y10S530/85—Reproductive organs or embryos
    • Y10S530/851—Placenta; amniotic fluid

Abstract

내용 없음

Description

안티 PCI모노클론 항체
본 내용은 요부공개 건이므로 전문내용을 수록하지 않았음
제1도 및 제2도는 실시에 4에서 PCI의 검정중 PCI농도의 기능으로서 흡광도(492mm에서)를 나타낸다.
제1도:PCI-A46및 176은 각각 코팅모노클론 항체로서 사용된 반면 PCI-A180은 통상 접합되는 모노클론 항체 사용되었으며,
제2도:PCI-146은 통상 코팅모노클론 항체로서 사용된 반면 PCI-A39,169 및 176은 접합되는 모노클론 항체로서 분리하여 적용되었음.

Claims (4)

  1. 사람의 태반에서 유래된 응고억제 인자인 특이한 모노클론 항체.
  2. 사람의 태반에서 유래된 응고억제제에 특이한 모노클론 항체를 분비하는 하이브리도마.
  3. 사람의 태반에서 유래된 응고억제제에 특이한 모노클론 항체를 면역흡착제로 사용함을 특징으로 하는 인간의 태반에서 유래된 응고억제제의 정제과정.
  4. 사람의 태반에서 유래된 응고억제제에 특이한 모노클론 항체를 사용함을 특징으로 하는 인간의 태반에서 유래된 응고억제의 면역검정.
    ※ 참고사항 : 최초출원 내용에 의하여 공개하는 것임.
KR1019870012827A 1986-11-14 1987-11-13 안티-pci 모노클로날 항체 KR960013460B1 (ko)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
JP?61-269588 1986-11-14
JP61269588A JPH08840B2 (ja) 1986-11-14 1986-11-14 抗ｐｃｉモノクローナル抗体、これを用いた抗ｐｃｉの精製法及び免疫学的測定法

Publications (2)

Publication Number Publication Date
KR890008313A true KR890008313A (ko) 1989-07-10
KR960013460B1 KR960013460B1 (ko) 1996-10-05

Family

ID=17474448

Family Applications (1)

Application Number Title Priority Date Filing Date
KR1019870012827A KR960013460B1 (ko) 1986-11-14 1987-11-13 안티-pci 모노클로날 항체

Country Status (7)

Country Link
US (2) US5192694A (ko)
EP (1) EP0267601B1 (ko)
JP (1) JPH08840B2 (ko)
KR (1) KR960013460B1 (ko)
CA (1) CA1335354C (ko)
DE (1) DE3780256T2 (ko)
ES (1) ES2044893T3 (ko)

Families Citing this family (9)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
DE4012341A1 (de) * 1990-04-18 1991-10-24 Behringwerke Ag Monoklonale antikoerper gegen pp4, verfahren zu ihrer herstellung und ihre verwendung
US5607841A (en) * 1994-06-20 1997-03-04 Lipinski; Boguslaw Preparation and proteolytic degradation of a macromolecular protein complex from fibrinogen
US5767247A (en) * 1994-11-11 1998-06-16 Noboru Kaneko Anti-annexin-V monoclonal antibodies, and preparation and use thereof
US7635680B2 (en) * 2001-02-21 2009-12-22 Alavita Pharmaceuticals, Inc. Attenuation of reperfusion injury
US7635676B2 (en) * 2001-02-21 2009-12-22 Alavita Pharmaccuticals, Inc. Modified annexin proteins and methods for their use in organ transplantation
ATE359807T1 (de) * 2001-02-21 2007-05-15 Surromed Inc Modifizierte annexin-proteine und verhinderung und behandlung von thrombose
US7645739B2 (en) * 2001-02-21 2010-01-12 Alavita Pharmaceuticals, Inc. Modified annexin compositions and methods of using same
US20090291086A1 (en) * 2001-02-21 2009-11-26 Alavita Pharmaceuticals, Inc. Compositions and Methods for Treating Cerebral Thrombosis and Global Cerebral Ischemia
US6982154B2 (en) * 2002-02-21 2006-01-03 Surromed, Inc. Modified annexin proteins and methods for treating vaso-occlusive sickle-cell disease

Family Cites Families (10)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
DE2842467A1 (de) * 1978-09-29 1980-04-10 Behringwerke Ag Neues ubiquitaeres gewebsprotein pp tief 8
US4486530A (en) * 1980-08-04 1984-12-04 Hybritech Incorporated Immunometric assays using monoclonal antibodies
JPS59196824A (ja) * 1983-04-21 1984-11-08 Kowa Co 吸着防止剤
DE3315000A1 (de) * 1983-04-26 1984-10-31 Behringwerke Ag, 3550 Marburg Gewebeprotein pp(pfeil abwaerts)4(pfeil abwaerts), verfahren zu seiner gewinnung sowie seine verwendung
EP0156169B1 (en) * 1984-02-29 1991-12-18 Asahi Kasei Kogyo Kabushiki Kaisha An aqueous solution of a tissue plasminogen activator dissolved therein at an increased concentration and a method
FI83882C (fi) * 1984-09-21 1991-09-10 Boehringer Ingelheim Int Foerfarande foer framstaellning av blodlevring haemmande proteiner.
CA1265446A (en) * 1985-09-30 1990-02-06 Masahiro Maki Anticoagulating substance, process for preparing same and anticoagulant comprising same as an effective component
US4751084A (en) * 1986-02-26 1988-06-14 Monsanto Company Tissue plasminogen activator from normal human colon cells
US4937324A (en) * 1987-02-06 1990-06-26 Zymogenetics, Inc. Chromatographic purification of human proteins having anticoagulant and anti-inflammatory activity
WO1988005659A1 (en) * 1987-02-06 1988-08-11 Zymogenetics, Inc. Human proteins having anticoagulant and anti-inflammatory activity

Also Published As

Publication number Publication date
EP0267601A3 (en) 1988-10-12
DE3780256D1 (de) 1992-08-13
KR960013460B1 (ko) 1996-10-05
EP0267601A2 (en) 1988-05-18
ES2044893T3 (es) 1994-01-16
US5192694A (en) 1993-03-09
US5290915A (en) 1994-03-01
DE3780256T2 (de) 1993-01-28
EP0267601B1 (en) 1992-07-08
CA1335354C (en) 1995-04-25
JPH08840B2 (ja) 1996-01-10
JPS63123395A (ja) 1988-05-27

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