KR890004900B1 - Process for soft capsule containing royal jelly - Google Patents

Abstract

In the method, 1kg of royal jelly (water content = 65.8%) is mixed with 5g of tocopherol and 350g of anhydrous silicic acid. The resulting mixture is dried at 45≰C for 4hr to give 699g of dried material (water content = 1.3%, yield = 99.4%). 69.9g of the resulting material is mixed with 128.1g of purified palm oil and 162g of purified soybean oil. The resulting mixture is used to prepare a soft capsule and one capsule can contain 360mg contents.

Description

Preparation of soft capsules containing royal jelly

The present invention relates to a method for producing a soft capsule containing royal jelly.

Saint Royal Jelly contains crude protein (about 12.5%), crude fat (about 3.5%), sugar (about 16%), water (about 67%), and water-soluble vitamins (about 1-200mg%). Eurasian viscous liquid containing fatty acid component 10-hydroxy-2-tesenophosphate (about 1.4% or more). In order to prepare the dosage form, it is necessary to prevent the deterioration of the ingredients and to prevent microbial contamination. Therefore, when the raw royal jelly is mainly processed by the freeze-drying method under reduced pressure, the processing time is long (about 72 hours) and energy is required. Consumption was high, and the treated freeze-dried material itself had hygroscopicity, so storage and storage were easily hygroscopically softened in the next treatment process.

In view of such a situation, the present inventors adsorb the raw royal jelly to hard silicic anhydride (adsorption ratio 1: 0.3-0.5) as a method for industrially mass-processing, and the adsorbate is weakly treated at low temperature (40-50 ° C.). After drying for 4 hours to obtain a dried product having a water content of 5% or less, the dried product was emulsified by mixing with an oily base, and then a royal jelly soft capsule filled with the blend was prepared. At this time, there was little change in the content of the indicator substance 10-hydroxy-2-decenophosphate (refer to Table 1) contained in the raw royal jelly adsorption dried product and royal jelly soft capsule, and there was no change in color, smell, and taste. . The bioburden test showed no signs of microbial contamination.

Table 1

The soft capsule prepared by this method did not deteriorate or contaminate microorganisms even after long-term storage (4 months) and did not cause a decrease in the content of the indicator substance.

Example 1

5 g of natural tocopherol is added to 1000 g of fresh royal jelly (65.8% of water content), and 350 g of hard anhydrous silicic acid is added in small amounts to make it homogeneous. Yield 99.4%).

69.9 g of this dried product (100 equivalents of fresh royal jelly) is taken, and 128.1 g of refined palm oil and 162 g of refined soy milk are added thereto, followed by mixing and emulsifying with a homo mix to prepare a soft capsule contents.

This blend was prepared in a soft capsule maker containing a soft capsule containing 360 mg (100 mg equivalent of raw royal jelly) per capsule.

Example 2

4 g of di-alpha-tocopherol acetate was added to 1000 g of fresh royal jelly (67% water content), mixed with a small amount of 400 g of light anhydrous silicic acid, and the mixture was thoroughly mixed for 4 hours and dried at 45 ° C. for 757 g of dried product. (Water content 4.8%, yield 99.0%) were obtained.

151.4 g of this dried product (200 g of raw royal jelly) is added thereto, 117 g of refined palm oil, 4 g of soy lecithin and 177.6 g of refined soybean oil are added, and the mixture is emulsified with homomixture to prepare the contents.

This blend was prepared in a soft capsule maker containing a soft capsule containing 450 mg (200 mg equivalent of fresh royal jelly) per capsule.

Example 3

4 g of di-alpha-tocopherol acetate was added to 100 g of fresh royal jelly (65% water content), mixed with a small amount of 300 g of light silicic anhydride, and the mixture was thoroughly mixed for 4 hours and dried at 45 ° C. for 4 hours to dry 670 g ( Water content 3.8% yield 99.0%).

Take 201 g of this dried product (300 g of fresh royal jelly), add 123 g of refined palm oil, Daewoo Lecithin 6, and 270 g of refined soybean oil, and mix-emulsify it with a homo mix to prepare a soft capsule.

This blend was prepared in a soft capsule maker containing 600 mg (300 mg equivalent of raw royal jelly) content per capsule.

Claims (1)

A method for producing a soft capsule containing a mixture of raw royal jelly adsorbed on hard silicic anhydride (adsorption ratio 1: 0.3-0.5) and then emulsified in low temperature (40-50 ° C.) dry oil mixed with an oily base.