KR880700817A - 디히드록시 에틸렌 동배체의 전이상태 삽입물을 갖는 신규한 레닌 억제 펩티드 - Google Patents

디히드록시 에틸렌 동배체의 전이상태 삽입물을 갖는 신규한 레닌 억제 펩티드

Info

Publication number
KR880700817A
KR880700817A KR1019870700991A KR870700991A KR880700817A KR 880700817 A KR880700817 A KR 880700817A KR 1019870700991 A KR1019870700991 A KR 1019870700991A KR 870700991 A KR870700991 A KR 870700991A KR 880700817 A KR880700817 A KR 880700817A
Authority
KR
South Korea
Prior art keywords
isoform
transition state
inhibitory peptide
renin inhibitory
dihydroxy ethylene
Prior art date
Application number
KR1019870700991A
Other languages
English (en)
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed filed Critical
Publication of KR880700817A publication Critical patent/KR880700817A/ko

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Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K5/00—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof
    • C07K5/02—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof containing at least one abnormal peptide link
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D233/00—Heterocyclic compounds containing 1,3-diazole or hydrogenated 1,3-diazole rings, not condensed with other rings
    • C07D233/54—Heterocyclic compounds containing 1,3-diazole or hydrogenated 1,3-diazole rings, not condensed with other rings having two double bonds between ring members or between ring members and non-ring members
    • C07D233/64—Heterocyclic compounds containing 1,3-diazole or hydrogenated 1,3-diazole rings, not condensed with other rings having two double bonds between ring members or between ring members and non-ring members with substituted hydrocarbon radicals attached to ring carbon atoms, e.g. histidine
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K5/00—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof
    • C07K5/02—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof containing at least one abnormal peptide link
    • C07K5/0227—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof containing at least one abnormal peptide link containing the (partial) peptide sequence -Phe-His-NH-(X)2-C(=0)-, e.g. Renin-inhibitors with n = 2 - 6; for n > 6 see C07K5/06 - C07K5/10

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Genetics & Genomics (AREA)
  • Biochemistry (AREA)
  • Biophysics (AREA)
  • General Health & Medical Sciences (AREA)
  • Health & Medical Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Molecular Biology (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Peptides Or Proteins (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
KR1019870700991A 1986-02-27 1987-10-26 디히드록시 에틸렌 동배체의 전이상태 삽입물을 갖는 신규한 레닌 억제 펩티드 KR880700817A (ko)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
US83399386A 1986-02-27 1986-02-27
US90414986A 1986-09-05 1986-09-05
PCT/US1987/000291 WO1987005302A2 (en) 1986-02-27 1987-02-13 Novel renin-inhibiting peptides having a dihydroxyethylene isostere transition state insert

Publications (1)

Publication Number Publication Date
KR880700817A true KR880700817A (ko) 1988-04-12

Family

ID=27125673

Family Applications (1)

Application Number Title Priority Date Filing Date
KR1019870700991A KR880700817A (ko) 1986-02-27 1987-10-26 디히드록시 에틸렌 동배체의 전이상태 삽입물을 갖는 신규한 레닌 억제 펩티드

Country Status (5)

Country Link
EP (2) EP0237202A3 (ko)
KR (1) KR880700817A (ko)
AU (1) AU593896B2 (ko)
CA (1) CA1309555C (ko)
WO (1) WO1987005302A2 (ko)

Families Citing this family (12)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US4743585A (en) * 1986-11-21 1988-05-10 Warner-Lambert Company Renin inhibitors
GB8728561D0 (en) * 1987-12-07 1988-01-13 Glaxo Group Ltd Chemical compounds
GB8728560D0 (en) * 1987-12-07 1988-01-13 Glaxo Group Ltd Chemical compounds
DE68916271T2 (de) * 1988-01-26 1995-02-23 Sankyo Co Renin inhibierende Polypeptide, ihre Herstellung und Anwendung.
IL92011A0 (en) * 1988-10-19 1990-07-12 Abbott Lab Heterocyclic peptide renin inhibitors
US5164388A (en) * 1988-10-19 1992-11-17 Abbott Laboratories Heterocyclic peptide renin inhibitors
US5360791A (en) * 1988-11-24 1994-11-01 Hoechst Aktiengesellschaft Renin-inhibiting aminodiol derivatives
NZ235234A (en) * 1989-09-12 1992-12-23 Hoechst Ag Renin-inhibiting amino acid derivatives and pharmaceutical compositions thereof
US5098924A (en) * 1989-09-15 1992-03-24 E. R. Squibb & Sons, Inc. Diol sulfonamide and sulfinyl renin inhibitors
TW198712B (ko) 1991-04-17 1993-01-21 Hoffmann La Roche
US5413999A (en) * 1991-11-08 1995-05-09 Merck & Co., Inc. HIV protease inhibitors useful for the treatment of AIDS
JP2005505517A (ja) 2001-07-10 2005-02-24 イーラン ファーマスーティカルズ、インコーポレイテッド アルツハイマー病を治療するためのアミンジオール

Family Cites Families (7)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
NO812612L (no) * 1980-08-06 1982-02-08 Ferring Pharma Ltd Enzym-inhibitorer.
CA1258748A (en) * 1981-10-08 1989-08-22 Daniel F. Veber Renin inhibitory peptides
JPS59227851A (ja) * 1983-06-09 1984-12-21 Sankyo Co Ltd レニン阻害作用を有するペプチド類
US4661473A (en) * 1984-03-27 1987-04-28 Merck & Co., Inc. Renin inhibitors containing peptide isosteres
FI88400C (fi) * 1984-08-06 1993-05-10 Upjohn Co Foerfarande foer framstaellning av renin inhiberande peptider
EP0184855A3 (en) * 1984-12-14 1989-05-03 Abbott Laboratories Resin inhibiting compounds
DK34086A (da) * 1985-01-23 1986-07-24 Abbott Lab Peptidylaminodioler

Also Published As

Publication number Publication date
CA1309555C (en) 1992-10-27
WO1987005302A3 (en) 1987-11-19
EP0237202A3 (en) 1987-11-19
EP0237202A2 (en) 1987-09-16
AU7081287A (en) 1987-09-28
AU593896B2 (en) 1990-02-22
EP0406228A1 (en) 1991-01-09
WO1987005302A2 (en) 1987-09-11

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Legal Events

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A201 Request for examination
WITB Written withdrawal of application