KR880010737A - Semipermeable Neuroinduction Channel - Google Patents

Semipermeable Neuroinduction Channel Download PDF

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Publication number
KR880010737A
KR880010737A KR1019880003342A KR880003342A KR880010737A KR 880010737 A KR880010737 A KR 880010737A KR 1019880003342 A KR1019880003342 A KR 1019880003342A KR 880003342 A KR880003342 A KR 880003342A KR 880010737 A KR880010737 A KR 880010737A
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South Korea
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membrane
semipermeable
tubular
nerve
microns
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KR1019880003342A
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Korean (ko)
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KR900000845B1 (en
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에프. 발렌티니 로버트
애비셔 패트릭
엠.갤러티 피에르
Original Assignee
알렌 제이.스피겔
화이자 호스피탈 프로덕츠 그룹, 인코퍼레이티드
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Publication of KR880010737A publication Critical patent/KR880010737A/en
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Publication of KR900000845B1 publication Critical patent/KR900000845B1/en

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    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61B—DIAGNOSIS; SURGERY; IDENTIFICATION
    • A61B17/00—Surgical instruments, devices or methods, e.g. tourniquets
    • A61B17/04—Surgical instruments, devices or methods, e.g. tourniquets for suturing wounds; Holders or packages for needles or suture materials
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61B—DIAGNOSIS; SURGERY; IDENTIFICATION
    • A61B17/00—Surgical instruments, devices or methods, e.g. tourniquets
    • A61B17/11—Surgical instruments, devices or methods, e.g. tourniquets for performing anastomosis; Buttons for anastomosis
    • A61B17/1128—Surgical instruments, devices or methods, e.g. tourniquets for performing anastomosis; Buttons for anastomosis of nerves
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61B—DIAGNOSIS; SURGERY; IDENTIFICATION
    • A61B17/00—Surgical instruments, devices or methods, e.g. tourniquets
    • A61B17/11—Surgical instruments, devices or methods, e.g. tourniquets for performing anastomosis; Buttons for anastomosis
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61L—METHODS OR APPARATUS FOR STERILISING MATERIALS OR OBJECTS IN GENERAL; DISINFECTION, STERILISATION OR DEODORISATION OF AIR; CHEMICAL ASPECTS OF BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES; MATERIALS FOR BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES
    • A61L27/00—Materials for grafts or prostheses or for coating grafts or prostheses
    • A61L27/14—Macromolecular materials
    • A61L27/26—Mixtures of macromolecular compounds
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61L—METHODS OR APPARATUS FOR STERILISING MATERIALS OR OBJECTS IN GENERAL; DISINFECTION, STERILISATION OR DEODORISATION OF AIR; CHEMICAL ASPECTS OF BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES; MATERIALS FOR BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES
    • A61L31/00—Materials for other surgical articles, e.g. stents, stent-grafts, shunts, surgical drapes, guide wires, materials for adhesion prevention, occluding devices, surgical gloves, tissue fixation devices
    • A61L31/04—Macromolecular materials
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61B—DIAGNOSIS; SURGERY; IDENTIFICATION
    • A61B17/00—Surgical instruments, devices or methods, e.g. tourniquets
    • A61B17/00491—Surgical glue applicators
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61B—DIAGNOSIS; SURGERY; IDENTIFICATION
    • A61B17/00—Surgical instruments, devices or methods, e.g. tourniquets
    • A61B2017/00004—(bio)absorbable, (bio)resorbable, resorptive
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61F—FILTERS IMPLANTABLE INTO BLOOD VESSELS; PROSTHESES; DEVICES PROVIDING PATENCY TO, OR PREVENTING COLLAPSING OF, TUBULAR STRUCTURES OF THE BODY, e.g. STENTS; ORTHOPAEDIC, NURSING OR CONTRACEPTIVE DEVICES; FOMENTATION; TREATMENT OR PROTECTION OF EYES OR EARS; BANDAGES, DRESSINGS OR ABSORBENT PADS; FIRST-AID KITS
    • A61F2/00—Filters implantable into blood vessels; Prostheses, i.e. artificial substitutes or replacements for parts of the body; Appliances for connecting them with the body; Devices providing patency to, or preventing collapsing of, tubular structures of the body, e.g. stents
    • A61F2/02—Prostheses implantable into the body
    • A61F2/30—Joints
    • A61F2002/30001—Additional features of subject-matter classified in A61F2/28, A61F2/30 and subgroups thereof
    • A61F2002/30108—Shapes
    • A61F2002/30199—Three-dimensional shapes
    • A61F2002/30224—Three-dimensional shapes cylindrical
    • A61F2002/30235—Three-dimensional shapes cylindrical tubular, e.g. sleeves
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61F—FILTERS IMPLANTABLE INTO BLOOD VESSELS; PROSTHESES; DEVICES PROVIDING PATENCY TO, OR PREVENTING COLLAPSING OF, TUBULAR STRUCTURES OF THE BODY, e.g. STENTS; ORTHOPAEDIC, NURSING OR CONTRACEPTIVE DEVICES; FOMENTATION; TREATMENT OR PROTECTION OF EYES OR EARS; BANDAGES, DRESSINGS OR ABSORBENT PADS; FIRST-AID KITS
    • A61F2230/00—Geometry of prostheses classified in groups A61F2/00 - A61F2/26 or A61F2/82 or A61F9/00 or A61F11/00 or subgroups thereof
    • A61F2230/0063—Three-dimensional shapes
    • A61F2230/0069—Three-dimensional shapes cylindrical
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61L—METHODS OR APPARATUS FOR STERILISING MATERIALS OR OBJECTS IN GENERAL; DISINFECTION, STERILISATION OR DEODORISATION OF AIR; CHEMICAL ASPECTS OF BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES; MATERIALS FOR BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES
    • A61L2430/00—Materials or treatment for tissue regeneration
    • A61L2430/32—Materials or treatment for tissue regeneration for nerve reconstruction

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  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Surgery (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Heart & Thoracic Surgery (AREA)
  • Medical Informatics (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Engineering & Computer Science (AREA)
  • Biomedical Technology (AREA)
  • Molecular Biology (AREA)
  • Epidemiology (AREA)
  • Chemical & Material Sciences (AREA)
  • Dermatology (AREA)
  • Medicinal Chemistry (AREA)
  • Oral & Maxillofacial Surgery (AREA)
  • Transplantation (AREA)
  • Vascular Medicine (AREA)
  • Neurology (AREA)
  • Materials For Medical Uses (AREA)
  • Prostheses (AREA)
  • External Artificial Organs (AREA)
  • Steroid Compounds (AREA)
  • Electrotherapy Devices (AREA)
  • Surgical Instruments (AREA)
  • Photovoltaic Devices (AREA)
  • Control Of Motors That Do Not Use Commutators (AREA)
  • Devices For Executing Special Programs (AREA)
  • Superconductors And Manufacturing Methods Therefor (AREA)
  • Transition And Organic Metals Composition Catalysts For Addition Polymerization (AREA)
  • Measuring Pulse, Heart Rate, Blood Pressure Or Blood Flow (AREA)
  • Bipolar Transistors (AREA)
  • Measurement And Recording Of Electrical Phenomena And Electrical Characteristics Of The Living Body (AREA)
  • Control And Other Processes For Unpacking Of Materials (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)

Abstract

Medical devices and methods employing semipermeable materials, such as acrylic copolymers, polyurethane isocyanate, and other biocompatible semipermeable polymers, are disclosed for use as guidance channels in regenerating nerves. The devices can be formed by tubular semipermeable conduits adapted to receive the ends of a severed or damaged nerve. The tubular conduits define lumens through which axons can regenerate to restore motor and/or sensory functions. The guidance materials are chosen such that they are capable of allowing the diffusion of nutrients and other metabolites to the regenerating nerve site while excluding fibroblasts and other scar-forming cells. In particular, tubular channels which have a smooth inner surface and longitudinally oriented trabeculae result in significantly larger regenerated nerve cables and higher numbers of regenerated myelinated axons.

Description

반투성 신경유도 채널Semipermeable Neuroinduction Channel

본 내용은 요부공개 건이므로 전문내용을 수록하지 않았음As this is a public information case, the full text was not included.

제 1 도는 반투성, 전투성 및 불투성 신경 유도물질의 재생능력(신경섬유화된 축색돌기의 수로 판정)을 비교한 그래프이다.1 is a graph comparing the regenerative ability (determined by the number of neurofibrillated axons) of semi-permeable, combatable and impermeable nerve inducers.

제 2 도는 반투성 및 불투성 신경 유도물질의 재생 능력(상이한 신경 케이블 성분의 상대적 횡단면적을 백분율로 표시)을 비교한 챠트이다.2 is a chart comparing the regenerative capacity (expressed as a percentage of the relative cross-sectional areas of different neural cable components) of semi-permeable and opaque neuro-inducers.

Claims (10)

모세혈관이 안쪽으로 성장하도록 하는 다공성 외막 표면 및 막을 통해 손상된 신경의 재생이 가능하도록 하는 매끄로운 내막 표면을 지님을 특징으로 하는, 손상된 신경의 말단을 수용하기에 적합한 개방부를 지닌 관상 반투성 막을 함유하는, 손상된 신경을 재생시키는데 사용하는 의료장치.Containing a tubular semipermeable membrane with an opening suitable for receiving the ends of the damaged nerve, characterized by a porous outer membrane surface that allows the capillaries to grow inwards and a smooth inner membrane surface that allows regeneration of the damaged nerve through the membrane. , Medical devices used to regenerate damaged nerves. 제 1 항에 있어서, 막의 두께가 약 0.05 내지 약 1.0mm 범위내임을 특징으로 하는 장치.The device of claim 1, wherein the thickness of the membrane is in the range of about 0.05 to about 1.0 mm. 제 1 항에 있어서, 장치의 관강(lumen)의 직경이 약 0.5mm 내지 약 2cm 범위내임에 특징으로 하는 장치.The device of claim 1, wherein the diameter of the lumen of the device is in the range of about 0.5 mm to about 2 cm. 제 1 항에 있어서, 막이 약 100,000달톤 이하의 분자량을 갖는 용질에 대해 투과성임을 특지응로 하는 장치.The apparatus of claim 1, wherein the membrane is permeable to solutes having a molecular weight of about 100,000 Daltons or less. 제 1 항에 있어서, 막이 섬유아세포 및 그밖의 반흔-형성 결합 조직세포에 대해 불투성임을 특징으로 하는 장치.The device of claim 1, wherein the membrane is impermeable to fibroblasts and other scar-forming connective tissue cells. 제 1 항에 있어서, 외막표면이 크기가 약 1 내지 약 20마이크론 범위내인 포어(pore)를 지님을 특징으로 하는 장치.The device of claim 1, wherein the envelope surface has pores ranging in size from about 1 to about 20 microns. 제 1 항에 있어서, 내막표면이 크기가 약 20 내지 2000Å 범위내인 포어를 지님을 특징으로 하는 장치.The device of claim 1, wherein the endocardium surface has pores ranging in size from about 20 to 2000 microns. 제 1 항에 있어서, 막이 외막 및 내막표면 사이에 위치하는 상호소통을 위한 방사상 공극의 망상구조를 포함함을 특징으로 하는 장치.The device of claim 1, wherein the membrane comprises a network of radial voids for intercommunication located between the outer membrane and the inner membrane surface. 제 1 항에 있어서, 막이 외막 및 내막 표면 사이에 위치하는 세로 방향으로 배향된 트라베쿨라(trabeculae)의 명상구조를 포함함을 특징으로 하는 장치.The device of claim 1, wherein the membrane comprises a meditation structure of trabeculae oriented longitudinally located between the outer membrane and the inner membrane surface. 제 1 항에 있어서, 막이 아크릴 공중합체, 폴리비닐리덴 플루오라이드 및 폴리우레탄 이소시아네이트로 구성된 그룹 중에서 선택된 중합체 물질을 함유함을 특징으로 하는 장치.2. An apparatus according to claim 1 wherein the membrane contains a polymeric material selected from the group consisting of acrylic copolymers, polyvinylidene fluorides and polyurethane isocyanates. ※ 참고사항 : 최초출원 내용에 의하여 공개하는 것임.※ Note: The disclosure is based on the initial application.
KR1019880003342A 1987-03-30 1988-03-28 Semipermeable nerve guidance channels KR900000845B1 (en)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
US07/032,489 US4877029A (en) 1987-03-30 1987-03-30 Semipermeable nerve guidance channels
US32489 1987-03-30
US032489 1987-03-30

Publications (2)

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KR880010737A true KR880010737A (en) 1988-10-24
KR900000845B1 KR900000845B1 (en) 1990-02-17

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US (1) US4877029A (en)
EP (1) EP0286284B1 (en)
KR (1) KR900000845B1 (en)
AT (1) ATE69710T1 (en)
AU (1) AU597811B2 (en)
BR (1) BR8801435A (en)
CA (1) CA1293596C (en)
DE (2) DE3866399D1 (en)
DK (1) DK172888A (en)
FI (1) FI881473A (en)
IL (1) IL85839A0 (en)
NO (1) NO166832C (en)
NZ (1) NZ224064A (en)
PT (1) PT87106B (en)
ZA (1) ZA882234B (en)

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Also Published As

Publication number Publication date
EP0286284A1 (en) 1988-10-12
NO166832B (en) 1991-06-03
NO881382D0 (en) 1988-03-29
DK172888A (en) 1988-09-30
NO166832C (en) 1991-09-11
DK172888D0 (en) 1988-03-29
AU597811B2 (en) 1990-06-07
IL85839A0 (en) 1988-09-30
DE3866399D1 (en) 1992-01-09
PT87106A (en) 1989-03-30
EP0286284B1 (en) 1991-11-27
JPS642637A (en) 1989-01-06
ZA882234B (en) 1990-02-28
US4877029A (en) 1989-10-31
AU1382988A (en) 1988-09-29
FI881473A0 (en) 1988-03-29
NZ224064A (en) 1990-10-26
KR900000845B1 (en) 1990-02-17
PT87106B (en) 1995-03-01
NO881382L (en) 1988-10-03
ATE69710T1 (en) 1991-12-15
CA1293596C (en) 1991-12-31
FI881473A (en) 1988-10-01
BR8801435A (en) 1988-11-01
DE8804334U1 (en) 1988-08-04
JPH0478301B2 (en) 1992-12-10

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