DE3941873A1 - Hollow fibres coated which cells with inhibit coagulation - for long-term use as implants in arteries and veins to carry sensors - Google Patents
Hollow fibres coated which cells with inhibit coagulation - for long-term use as implants in arteries and veins to carry sensorsInfo
- Publication number
- DE3941873A1 DE3941873A1 DE3941873A DE3941873A DE3941873A1 DE 3941873 A1 DE3941873 A1 DE 3941873A1 DE 3941873 A DE3941873 A DE 3941873A DE 3941873 A DE3941873 A DE 3941873A DE 3941873 A1 DE3941873 A1 DE 3941873A1
- Authority
- DE
- Germany
- Prior art keywords
- cells
- arteries
- veins
- implants
- hollow fibres
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Withdrawn
Links
Classifications
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61F—FILTERS IMPLANTABLE INTO BLOOD VESSELS; PROSTHESES; DEVICES PROVIDING PATENCY TO, OR PREVENTING COLLAPSING OF, TUBULAR STRUCTURES OF THE BODY, e.g. STENTS; ORTHOPAEDIC, NURSING OR CONTRACEPTIVE DEVICES; FOMENTATION; TREATMENT OR PROTECTION OF EYES OR EARS; BANDAGES, DRESSINGS OR ABSORBENT PADS; FIRST-AID KITS
- A61F2/00—Filters implantable into blood vessels; Prostheses, i.e. artificial substitutes or replacements for parts of the body; Appliances for connecting them with the body; Devices providing patency to, or preventing collapsing of, tubular structures of the body, e.g. stents
- A61F2/0077—Special surfaces of prostheses, e.g. for improving ingrowth
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61L—METHODS OR APPARATUS FOR STERILISING MATERIALS OR OBJECTS IN GENERAL; DISINFECTION, STERILISATION OR DEODORISATION OF AIR; CHEMICAL ASPECTS OF BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES; MATERIALS FOR BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES
- A61L31/00—Materials for other surgical articles, e.g. stents, stent-grafts, shunts, surgical drapes, guide wires, materials for adhesion prevention, occluding devices, surgical gloves, tissue fixation devices
- A61L31/005—Ingredients of undetermined constitution or reaction products thereof
Landscapes
- Health & Medical Sciences (AREA)
- Veterinary Medicine (AREA)
- Public Health (AREA)
- Animal Behavior & Ethology (AREA)
- Life Sciences & Earth Sciences (AREA)
- General Health & Medical Sciences (AREA)
- Heart & Thoracic Surgery (AREA)
- Vascular Medicine (AREA)
- Biomedical Technology (AREA)
- Transplantation (AREA)
- Oral & Maxillofacial Surgery (AREA)
- Engineering & Computer Science (AREA)
- Cardiology (AREA)
- Chemical & Material Sciences (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Surgery (AREA)
- Epidemiology (AREA)
- Materials For Medical Uses (AREA)
Abstract
Description
Die Erfindung betrifft semipermeables Material, am häufigsten in der Form einer Hohlfaser gestaltet und beschichtet mit fest angehefteten Zellen, die die Gerinnungsprozesse durch u. a. Sekretion von bestimmten Faktoren kontrollieren und aufhalten können (vor allem Endo- und Mesothelialzellen aber auch Zellen die sich in solche umwandeln können) und immunologisch wie eigene Zellen toleriert sind, was mehrjährige Implantation in Arterien und Venen ermöglicht.The invention relates to semi-permeable material, most often in the form a hollow fiber designed and coated with firmly attached cells, which the coagulation processes by u. a. Secretion of certain factors control and stop (especially endo- and mesothelial cells but also cells that can transform into such) and immunologically like own cells are tolerated, resulting in perennial implantation in arteries and Allows veins.
Die vorgegebene beschichtete Hohlfaser soll vor allem als ein Teil oder die Hülle der in das Gefäßsystem implantablen Sensoren, Biosensoren und ion selektiven Elektroden benutzt werden. Das kann die bisher nur zeitlich sehr begrenzt (1-2 Tage) realisierbare in-vivo Überwachung der lebenswichtigen metabolischen Faktoren wie pH, pO2, pCO2, Ca++, K⁺, Na⁺, Glukose, Harnstoff, Kreatinin usw. und deren automatische Korrektur in einem open-loop oder closed-loop System möglich machen. Die vorgegebene beschichtete Hohlfaser kann auch als mehrjährig-implantierte Infusionskanüle, als eine semipermeable Kammer für die ins Gefäßsystem implantierte Zellen und Geweben und als eine Diffusionskammer für bestimmte Arzneimittel benutzt werden.The specified coated hollow fiber is to be used above all as a part or the shell of the sensors, biosensors and ion-selective electrodes which are implantable in the vascular system. This can be done in vivo monitoring of the vital metabolic factors such as pH, pO 2 , pCO 2 , Ca ++ , K⁺, Na⁺, glucose, urea, creatinine etc. make their automatic correction possible in an open-loop or closed-loop system. The specified coated hollow fiber can also be used as a multi-year implanted infusion cannula, as a semipermeable chamber for the cells and tissues implanted in the vascular system and as a diffusion chamber for certain medicinal products.
Bei bisherigen Versuchen zur Verhinderung der Aktivierung des Gerinnungs systems und der begleitenden Beschädigung der in das Gefäßsysstem implantier ten Sensoren (Armstrong und Mitarb., 1976; Goddard und Mitarb., 1974; Parce und Mitarb., 1989; Turner und Mitarb., 1987) hat man nur die Silikon- oder Teflonmembranen (Pfeiffer, 1987) und die Beschichtung von Sensoren mit hepa rinhaltigen Materialien (Hagihara und Mitarb., 1981) angewandt. In previous attempts to prevent the activation of coagulation systems and the accompanying damage to the implant in the vascular system ten sensors (Armstrong and co-workers, 1976; Goddard and co-workers, 1974; Parce and co-workers, 1989; Turner et al., 1987) you only have the silicone or Teflon membranes (Pfeiffer, 1987) and the coating of sensors with hepa materials containing (Hagihara and co-workers, 1981) applied.
Die Hauptursache des Mißerfolgs der zur in-vivo Überwachung verwendeten und in Gefäßsystem implantierten Sensoren ist die Präzipitation der Erthrozyten, Thrombozyten, Leukozyten und des Fibrins auf der Sensoroberfläche. Die Beschichtung des Sensors mit heparinhaltigen Materialien oder mit Silicon- und Teflonmembra nen verzögert nur die oben beschriebene Präzipitation aber es kann sie nicht verhindern (Pfeifer, 1987; Santiago und Mitarb., 1979; Hagihara und Mitarb., 1981). Im besten Fall muß der Sensor oder die Membran alle 24 Stunden gewechselt werden. Das macht die langzeitige Implantation von solchen Sensoren unmöglich und es ist u. a. eines der wesentlichsten Probleme bei der Konstruk tion des Systems zur automatischen Regulation des Blutzuckers bei diabetischen Patienten (Pfeiffer, 1987; Santiago und Mitarb., 1979).The main cause of failure of and used for in vivo monitoring sensors implanted in vascular system is the precipitation of erythrocytes, Platelets, leukocytes and fibrin on the sensor surface. The coating of the sensor with heparin-containing materials or with silicone and Teflon membrane NEN only delays the precipitation described above but it cannot prevent (Pfeifer, 1987; Santiago and coworkers, 1979; Hagihara and coworkers., 1981). In the best case, the sensor or membrane must be replaced every 24 hours change. This makes the long-term implantation of such sensors impossible and it is u. a. one of the most important problems in the construction tion of the system for the automatic regulation of blood sugar in diabetic Patients (Pfeiffer, 1987; Santiago and co-workers, 1979).
Die Konstruktion der Hülle für implantable Sensoren und andere Materialien, die einerseits den Kontakt des Sensors mit dem Blutultrafiltrat, dessen bio chemische Zusammensetzung in bestimmten, sehr kleinen Zeitabständen die Zusam mensetzung des Blutes (ohne morphotische Elemente und bestimmte Proteine, die größer als die Permeablitätsgrenze sind) wiederspiegelt, andererseits die mehrjährige Implantation in Arterien und Venen ermöglicht.The design of the case for implantable sensors and other materials, on the one hand the contact of the sensor with the blood ultrafiltrate, the bio chemical composition in certain, very small time intervals blood composition (without morphotic elements and certain proteins, which are greater than the permeability limit), on the other hand allows for several years of implantation in arteries and veins.
Diese Aufgabe wird erfindungsmäßig dadurch gelöst, daß semipermeables Material mit entsprechend poröser und aktivierter Oberfläche mit fest angehefteten Zellen, die die Gerinnugsprozesse kontrollieren und aufhalten können und immunologisch wie eigene Zellen toleriert sind, beschichtet worden ist.This object is achieved according to the invention in that semipermeable material with a correspondingly porous and activated surface with firmly attached Cells that can control and stop the coagulation processes and immunologically how own cells are tolerated, has been coated.
Der Gegenstand der Erfindung ist gewerblich anwendbar durch die Herstellung von semipermeablen Materialien in Gestalt von z. B. Hohlfasern, die vor allem mit autogenen oder gewebetypisierten und gewebekulturproduzierten allogenen Endo- und Mesothelialzellen beschichtet sind. Diese Hohlfasern können einfach transportiert und in das Gefäßsystem implantiert werden. Die zellbeschichteten Hohlfasern können z. B. auch zusammen mit eingebauten Sensoren hergestellt und in implantationsfertiger Form transportiert werden. The object of the invention is industrially applicable through the production of semipermeable materials in the form of e.g. B. hollow fibers, especially with autogenous or tissue-typed and tissue culture-produced allogeneic Endo- and mesothelial cells are coated. These hollow fibers can be simple transported and implanted in the vascular system. The cell-coated Hollow fibers can e.g. B. also produced together with built-in sensors and transported in a form ready for implantation.
Abb. 1 und 2 zeigen das semipermeable Material in Gestalt einer Hohlfaser, mit eine Permeabilitätsgrenze von 50 kD, beschichtet in vitro mit autogenen Endothelialzellen, die aus der Jugularvene isoliert und durch Gewebekultur technik vermehrt worden sind. Die Hohlfaser war danach in die untere Hohlvene der Ratte auf die Dauer von einem Jahr implantiert worden (Abb. 1, 2). Es wurde in einer Reihe von ähnlichen Versuchen festgestellt, daß die vorgegebe nen beschichteten Hohlfasern keine Aktivierung des Gerinnungssystem induzier ten und auch nie immunologisch oder biologisch als Fremdkörper erkannt wurden. Die biochemische Zusammensetzung des Blutultrafiltrats in inneren Teil der Hohlfaser spiegelt genau die biochemische Zusammensetzung des Blutes wieder (ohne Moleküle die großer als 50 kD sind). Eine pH und pO2-Mikroelektrode, die im inneren Teil der Hohlfaser installiert und mit einem Meßsystem verbun den war, konnte sehr genau und langzeitig die pH oder pO2-Werte messen. Fig. 1 and 2 show the semipermeable material in the form of a hollow fiber, with a permeability limit of 50 kD, coated in vitro with autogenous endothelial cells that have been isolated from the jugular vein and have been multiplied by tissue culture technology. The hollow fiber was then implanted in the rat's inferior vena cava for a period of one year ( Fig. 1, 2). It was found in a series of similar experiments that the predetermined coated hollow fibers did not induce activation of the coagulation system and were never recognized as foreign matter immunologically or biologically. The biochemical composition of the blood ultrafiltrate in the inner part of the hollow fiber exactly reflects the biochemical composition of the blood (without molecules larger than 50 kD). A pH and pO 2 microelectrode, which was installed in the inner part of the hollow fiber and connected to a measuring system, was able to measure the pH or pO 2 values very precisely and over the long term.
1. Armstrong R.F., Hutchinson J.M., Lincoln C., lngram D., Soutter L.: Conti
nous mesurement of arterial oxygen tension during one-lung anaesthesia. Bri
tish Journal of Anaesthesiology, 48, 1005-1010, 1976.
2. Goddard P., Keith J., Marcovitch H., Roberton N.R.C., Rolfe P., Scopes
J.W.: Use of a continously recording intravascular oxygen electrode in the
newborn. Archives of Disease in Childhood, 49, 853-860, 1974.
3. Hagihara B., Ishibashi F., Sato N., Minami T., Okada Y., Sugimoto T.:
Intravascular oxygen monitoring with a polarographic oxygen cathode. Journal
of Biomedical Engineering, 3/1, 9-16, 1981.
4. Parce W.J., Owicki J.C., Kerco K.M., Sigal G.B., Wada H.G., Muir V.C.,
Bousse L.J., Ross K.L., Sikic B.J., MCConnel H.M.: Detection of cell-affecting
agents with a silicon biosensor. Scince, 246, 243-247, 1989.
5. Pfeiffer E.F.: On the way to the automated (blood) glucose regulation
in diabetes: the dark past, the grey present and the rose future. Diabetolo
gia, 30, 51-65, 1987.
6. Santiago J.V., Clemens A.H., Clarke W.L., Kipnis D.M.: Closed-loop and
open-loop devices for blood glucose control in normal and diabetic subjects.
Diabetes, 28/1, 71-84, 1979.
7. Turner A.P.F., Karube J., Wilson G.S. (eds.): Biosensors. Fundamentals
and applications. Oxford Univ. Press, 1987, ISBN 0-19-854724-2.1. Armstrong RF, Hutchinson JM, Lincoln C., Ingram D., Soutter L .: Conti nous mesurement of arterial oxygen tension during one-lung anesthesia. British Journal of Anaesthesiology, 48, 1005-1010, 1976.
2. Goddard P., Keith J., Marcovitch H., Roberton NRC, Rolfe P., Scopes JW: Use of a continously recording intravascular oxygen electrode in the newborn. Archives of Disease in Childhood, 49, 853-860, 1974.
3. Hagihara B., Ishibashi F., Sato N., Minami T., Okada Y., Sugimoto T .: Intravascular oxygen monitoring with a polarographic oxygen cathode. Journal of Biomedical Engineering, 3/1, 9-16, 1981.
4. Parce WJ, Owicki JC, Kerco KM, Sigal GB, Wada HG, Muir VC, Bousse LJ, Ross KL, Sikic BJ, MCConnel HM: Detection of cell-affecting agents with a silicon biosensor. Scince, 246, 243-247, 1989.
5. Pfeiffer EF: On the way to the automated (blood) glucose regulation in diabetes: the dark past, the gray present and the rose future. Diabetolo gia, 30, 51-65, 1987.
6. Santiago JV, Clemens AH, Clarke WL, Kipnis DM: Closed-loop and open-loop devices for blood glucose control in normal and diabetic subjects. Diabetes, 28/1, 71-84, 1979.
7. Turner APF, Karube J., Wilson GS (eds.): Biosensors. Fundamentals and applications. Oxford Univ. Press, 1987, ISBN 0-19-854724-2.
Claims (1)
Priority Applications (1)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
DE3941873A DE3941873A1 (en) | 1989-12-19 | 1989-12-19 | Hollow fibres coated which cells with inhibit coagulation - for long-term use as implants in arteries and veins to carry sensors |
Applications Claiming Priority (1)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
DE3941873A DE3941873A1 (en) | 1989-12-19 | 1989-12-19 | Hollow fibres coated which cells with inhibit coagulation - for long-term use as implants in arteries and veins to carry sensors |
Publications (1)
Publication Number | Publication Date |
---|---|
DE3941873A1 true DE3941873A1 (en) | 1991-06-20 |
Family
ID=6395778
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
DE3941873A Withdrawn DE3941873A1 (en) | 1989-12-19 | 1989-12-19 | Hollow fibres coated which cells with inhibit coagulation - for long-term use as implants in arteries and veins to carry sensors |
Country Status (1)
Country | Link |
---|---|
DE (1) | DE3941873A1 (en) |
Cited By (6)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
DE4123629A1 (en) * | 1990-08-06 | 1992-02-20 | Jakob Dr Bodziony | Implantable semi-permeable bio-artificial organ - allowing biological signal and metabolic substance flow by pressure gradient |
US5704910A (en) * | 1995-06-05 | 1998-01-06 | Nephros Therapeutics, Inc. | Implantable device and use therefor |
WO2002056796A1 (en) * | 2000-12-01 | 2002-07-25 | Nephros Therapeutics, Inc. | Intravascular blood conditioning device and use thereof |
FR2955179A1 (en) * | 2010-01-13 | 2011-07-15 | Univ Bordeaux 1 | SENSOR FOR MEASURING INSULIN NEEDS OF A PATIENT AND METHOD FOR MANUFACTURING THE SAME |
US8048419B2 (en) | 2006-02-02 | 2011-11-01 | Innovative Biotherapies, Inc. | Extracorporeal cell-based therapeutic device and delivery system |
US9029144B2 (en) | 2008-06-18 | 2015-05-12 | Innovative Bio Therapies, Inc. | Methods for enhanced propagation of cells |
Citations (13)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
WO1980002378A1 (en) * | 1979-05-03 | 1980-11-13 | Commw Scient Ind Res Org | Device for promoting endothelial cell motility and/or vascularisation |
DE3410631A1 (en) * | 1983-03-23 | 1984-09-27 | Ramot University Authority For Applied Research And Industrial Development Ltd., Tel Aviv | IMPLANTATION MATERIAL FOR RESTORING DEFECTIVE CARTILAGE AND BONE |
DE3432143A1 (en) * | 1983-09-01 | 1985-03-21 | Damon Biotech, Inc., Needham Heights, Mass. | METHOD FOR ENCLOSURE A MATERIAL TO BE ENCLOSED |
DE3422639C2 (en) * | 1984-06-19 | 1986-07-10 | Gebrüder Sulzer AG, Winterthur | Glandular prosthesis |
GB2185408A (en) * | 1986-01-16 | 1987-07-22 | Rhode Island Hospital | Neovascularization |
EP0259536A2 (en) * | 1986-09-11 | 1988-03-16 | BAXTER INTERNATIONAL INC. (a Delaware corporation) | Biological implant with textured surface |
DE3637260A1 (en) * | 1986-11-03 | 1988-05-11 | Max Planck Gesellschaft | METHOD FOR POPULATING SURFACES WITH ENDOTHEL CELLS |
EP0286284A1 (en) * | 1987-03-30 | 1988-10-12 | Brown University Research Foundation | Semipermeable nerve guidance channels |
EP0290642A1 (en) * | 1987-05-12 | 1988-11-17 | Mittermayer, Christian, Dr. med. | Method for seeding polymeric surfaces with human endothelial cells |
EP0296475A1 (en) * | 1987-06-23 | 1988-12-28 | Istituto Nazionale Per La Ricerca Sul Cancro | Method for preserving transplantable sheets of epithelium cultured in vitro |
EP0301777A1 (en) * | 1987-07-28 | 1989-02-01 | Queen's University At Kingston | Multiple membrane microencapsulation |
WO1989005345A1 (en) * | 1987-12-11 | 1989-06-15 | Whitehead Institute For Biomedical Research | Genetic modification of endothelial cells |
WO1989007425A2 (en) * | 1988-02-17 | 1989-08-24 | Genethics Limited | Clinical developments using amniotic cells |
-
1989
- 1989-12-19 DE DE3941873A patent/DE3941873A1/en not_active Withdrawn
Patent Citations (15)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
WO1980002378A1 (en) * | 1979-05-03 | 1980-11-13 | Commw Scient Ind Res Org | Device for promoting endothelial cell motility and/or vascularisation |
DE3410631A1 (en) * | 1983-03-23 | 1984-09-27 | Ramot University Authority For Applied Research And Industrial Development Ltd., Tel Aviv | IMPLANTATION MATERIAL FOR RESTORING DEFECTIVE CARTILAGE AND BONE |
DE3432143A1 (en) * | 1983-09-01 | 1985-03-21 | Damon Biotech, Inc., Needham Heights, Mass. | METHOD FOR ENCLOSURE A MATERIAL TO BE ENCLOSED |
DE3422639C2 (en) * | 1984-06-19 | 1986-07-10 | Gebrüder Sulzer AG, Winterthur | Glandular prosthesis |
DE3701148C2 (en) * | 1986-01-16 | 1989-08-31 | Rhode Island Hospital, Providence, R.I., Us | |
GB2185408A (en) * | 1986-01-16 | 1987-07-22 | Rhode Island Hospital | Neovascularization |
EP0259536A2 (en) * | 1986-09-11 | 1988-03-16 | BAXTER INTERNATIONAL INC. (a Delaware corporation) | Biological implant with textured surface |
DE3637260A1 (en) * | 1986-11-03 | 1988-05-11 | Max Planck Gesellschaft | METHOD FOR POPULATING SURFACES WITH ENDOTHEL CELLS |
EP0286284A1 (en) * | 1987-03-30 | 1988-10-12 | Brown University Research Foundation | Semipermeable nerve guidance channels |
EP0290642A1 (en) * | 1987-05-12 | 1988-11-17 | Mittermayer, Christian, Dr. med. | Method for seeding polymeric surfaces with human endothelial cells |
EP0296475A1 (en) * | 1987-06-23 | 1988-12-28 | Istituto Nazionale Per La Ricerca Sul Cancro | Method for preserving transplantable sheets of epithelium cultured in vitro |
EP0301777A1 (en) * | 1987-07-28 | 1989-02-01 | Queen's University At Kingston | Multiple membrane microencapsulation |
WO1989005345A1 (en) * | 1987-12-11 | 1989-06-15 | Whitehead Institute For Biomedical Research | Genetic modification of endothelial cells |
WO1989007425A2 (en) * | 1988-02-17 | 1989-08-24 | Genethics Limited | Clinical developments using amniotic cells |
EP0333328A2 (en) * | 1988-02-17 | 1989-09-20 | Genethics Limited | Clinical developments using amniotic cells |
Cited By (13)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
DE4123629A1 (en) * | 1990-08-06 | 1992-02-20 | Jakob Dr Bodziony | Implantable semi-permeable bio-artificial organ - allowing biological signal and metabolic substance flow by pressure gradient |
US5704910A (en) * | 1995-06-05 | 1998-01-06 | Nephros Therapeutics, Inc. | Implantable device and use therefor |
US5911704A (en) * | 1995-06-05 | 1999-06-15 | Nephros Therapeutics, Inc. | Implantable device and uses therefor |
US6572605B1 (en) | 1995-06-05 | 2003-06-03 | Nephros Therapeutics, Inc. | Implantable device and use therefor |
US6716208B2 (en) | 1995-06-05 | 2004-04-06 | Nephros Therapeutics, Inc. | Implantable device and use therefor |
WO2002056796A1 (en) * | 2000-12-01 | 2002-07-25 | Nephros Therapeutics, Inc. | Intravascular blood conditioning device and use thereof |
US8048419B2 (en) | 2006-02-02 | 2011-11-01 | Innovative Biotherapies, Inc. | Extracorporeal cell-based therapeutic device and delivery system |
US9029144B2 (en) | 2008-06-18 | 2015-05-12 | Innovative Bio Therapies, Inc. | Methods for enhanced propagation of cells |
WO2011086105A1 (en) * | 2010-01-13 | 2011-07-21 | Universite De Bordeaux 1 | Sensor for measuring the activity of beta-pancreatic cells or of islets of langerhans, manufacture and use of such a sensor |
FR2955179A1 (en) * | 2010-01-13 | 2011-07-15 | Univ Bordeaux 1 | SENSOR FOR MEASURING INSULIN NEEDS OF A PATIENT AND METHOD FOR MANUFACTURING THE SAME |
AU2011206641B2 (en) * | 2010-01-13 | 2016-06-09 | Centre National De La Recherche Scientifique | Sensor for measuring the activity of beta-pancreatic cells or of islets of Langerhans, manufacture and use of such a sensor |
AU2011206641A8 (en) * | 2010-01-13 | 2016-07-07 | Centre National De La Recherche Scientifique | Sensor for measuring the activity of beta-pancreatic cells or of islets of Langerhans, manufacture and use of such a sensor |
US9962113B2 (en) | 2010-01-13 | 2018-05-08 | Universite De Bordeaux 1 | Sensor for measuring the activity of beta-pancreatic cells or of islets of langerhans, manufacture and use of such a sensor |
Similar Documents
Publication | Publication Date | Title |
---|---|---|
US5322063A (en) | Hydrophilic polyurethane membranes for electrochemical glucose sensors | |
DE69322968T2 (en) | Method and device for continuously monitoring an anolyte level | |
DE3850972T2 (en) | PROCESS AND SYSTEM AND MEASURING CELL ARRANGEMENT FOR THE DETERMINATION OF GLUCOSE. | |
US10449270B2 (en) | Collagen scaffolds, medical implants with same and methods of use | |
Sakakida et al. | Ferrocene-mediated needle-type glucose sensor covered with newly designed biocompatible membrane | |
Fischer et al. | Assessment of subcutaneous glucose concentration: validation of the wick technique as a reference for implanted electrochemical sensors in normal and diabetic dogs | |
DE2817363C2 (en) | Method for determining the concentration of sugar and a suitable electrocatalytic sugar sensor | |
Wisniewski et al. | Characterization of implantable biosensor membrane biofouling | |
DE69723689T2 (en) | ELECTROCHEMICAL BIOSENSORS | |
DE69622700T2 (en) | HOMOGENEOUS POLYMER COMPOSITIONS CONTAINING SILICONE FOR BIOSENSOR MEMBRANES | |
Wisniewski et al. | Decreased analyte transport through implanted membranes: differentiation of biofouling from tissue effects | |
DE69837709T2 (en) | DEVICE AND METHOD FOR DETERMINING THE ANALYTICAL LEVEL | |
Wisniewski et al. | Methods for reducing biosensor membrane biofouling | |
DE60037592T2 (en) | Method for measuring an analyte with the aid of an electrochemical biosensor, which can be switched off by applying a potential | |
EP0455072B1 (en) | Silver chloride reference electrode | |
DE10020352A1 (en) | Implantable blood glucose meter | |
DE3941873A1 (en) | Hollow fibres coated which cells with inhibit coagulation - for long-term use as implants in arteries and veins to carry sensors | |
DE3422639C2 (en) | Glandular prosthesis | |
DE4426694C2 (en) | Device for long-term determination of the content of at least one substance in body fluids | |
DE69904293T2 (en) | COMPOSITIONS AND METHODS FOR BIO-COMPATIBLE IMPLANTS | |
EP2452624A1 (en) | Implantable theranostic article | |
DE19507107C1 (en) | Implantable sensor system for determining substance concentrations in living organisms | |
Reach et al. | BIOMED concerted action chemical sensors for in vivo monitoring. The biocompatibility issue | |
DE4011100A1 (en) | Extracorporeal or implantable artificial organs - esp. to replace kidney or liver function, with semipermeable membrane controlled by biological and metabolic substances | |
DE4123629A1 (en) | Implantable semi-permeable bio-artificial organ - allowing biological signal and metabolic substance flow by pressure gradient |
Legal Events
Date | Code | Title | Description |
---|---|---|---|
OM8 | Search report available as to paragraph 43 lit. 1 sentence 1 patent law | ||
8127 | New person/name/address of the applicant |
Owner name: BODZIONY, JAKOB, DR., 6650 HOMBURG, DE |
|
8127 | New person/name/address of the applicant |
Owner name: BODZIONY, JAKOB, DR., 66117 SAARBRUECKEN, DE |
|
8141 | Disposal/no request for examination | ||
8110 | Request for examination paragraph 44 | ||
8170 | Reinstatement of the former position | ||
8139 | Disposal/non-payment of the annual fee | ||
8170 | Reinstatement of the former position | ||
8139 | Disposal/non-payment of the annual fee |