KR880005136A - 퀴놀린계 화합물, 그의 제조방법 및 그 화합물을 약효성분으로 함유하는 항암제 - Google Patents
퀴놀린계 화합물, 그의 제조방법 및 그 화합물을 약효성분으로 함유하는 항암제 Download PDFInfo
- Publication number
- KR880005136A KR880005136A KR870011530A KR870011530A KR880005136A KR 880005136 A KR880005136 A KR 880005136A KR 870011530 A KR870011530 A KR 870011530A KR 870011530 A KR870011530 A KR 870011530A KR 880005136 A KR880005136 A KR 880005136A
- Authority
- KR
- South Korea
- Prior art keywords
- compound
- anticancer agent
- general formula
- preparation
- active ingredient
- Prior art date
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Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D498/00—Heterocyclic compounds containing in the condensed system at least one hetero ring having nitrogen and oxygen atoms as the only ring hetero atoms
- C07D498/02—Heterocyclic compounds containing in the condensed system at least one hetero ring having nitrogen and oxygen atoms as the only ring hetero atoms in which the condensed system contains two hetero rings
- C07D498/04—Ortho-condensed systems
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D491/00—Heterocyclic compounds containing in the condensed ring system both one or more rings having oxygen atoms as the only ring hetero atoms and one or more rings having nitrogen atoms as the only ring hetero atoms, not provided for by groups C07D451/00 - C07D459/00, C07D463/00, C07D477/00 or C07D489/00
- C07D491/02—Heterocyclic compounds containing in the condensed ring system both one or more rings having oxygen atoms as the only ring hetero atoms and one or more rings having nitrogen atoms as the only ring hetero atoms, not provided for by groups C07D451/00 - C07D459/00, C07D463/00, C07D477/00 or C07D489/00 in which the condensed system contains two hetero rings
- C07D491/04—Ortho-condensed systems
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P35/00—Antineoplastic agents
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D221/00—Heterocyclic compounds containing six-membered rings having one nitrogen atom as the only ring hetero atom, not provided for by groups C07D211/00 - C07D219/00
- C07D221/02—Heterocyclic compounds containing six-membered rings having one nitrogen atom as the only ring hetero atom, not provided for by groups C07D211/00 - C07D219/00 condensed with carbocyclic rings or ring systems
- C07D221/04—Ortho- or peri-condensed ring systems
- C07D221/18—Ring systems of four or more rings
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D495/00—Heterocyclic compounds containing in the condensed system at least one hetero ring having sulfur atoms as the only ring hetero atoms
- C07D495/02—Heterocyclic compounds containing in the condensed system at least one hetero ring having sulfur atoms as the only ring hetero atoms in which the condensed system contains two hetero rings
- C07D495/04—Ortho-condensed systems
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- Organic Chemistry (AREA)
- Chemical & Material Sciences (AREA)
- Health & Medical Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Medicinal Chemistry (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- General Chemical & Material Sciences (AREA)
- Pharmacology & Pharmacy (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Animal Behavior & Ethology (AREA)
- General Health & Medical Sciences (AREA)
- Public Health (AREA)
- Veterinary Medicine (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Other In-Based Heterocyclic Compounds (AREA)
- Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
Abstract
내용 없음
Description
본 내용은 요부공개 건이므로 전문내용을 수록하지 않았음
Claims (4)
- 다음 일반식(1)로 표시되는 퀴놀린계 화합물.여기서 X는 CH2, O 또는 S이다.
- 다음 일반식(2)로 표시되는 화합물과 N-(4-아미노-3-메톡시페닐)메탄술폰아미드를 반응시키는 단계로 이루어진 것을 특징으로 하는 다음 일반식(1)로 표시되는 퀴놀린계 화합물의 제조방법.상기 식들에서 X는 CH2, O 또는 S이며, Ha1은 할로겐원소를 나타낸다.
- 제 2 항에 있어서, 상기 일반식(2) 중의 Ha1은 염소인 것을 특징으로 하는 제조방법.
- 다음 일반식(1)로 표시되는 약효성분을 포함하는 것을 특징으로 하는 항암제.여기서 X는 CH2, O 또는 S이다.※ 참고사항 : 최초출원 내용에 의하여 공개하는 것임.
Applications Claiming Priority (3)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
JP61246776A JPS63101369A (ja) | 1986-10-17 | 1986-10-17 | インデノキノリン系化合物、その製造法及びその化合物を有効成分とする抗癌剤 |
JP246776 | 1986-10-17 | ||
JP61-246776 | 1986-10-17 |
Publications (2)
Publication Number | Publication Date |
---|---|
KR880005136A true KR880005136A (ko) | 1988-06-28 |
KR900003499B1 KR900003499B1 (ko) | 1990-05-21 |
Family
ID=17153489
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
KR1019870011530A KR900003499B1 (ko) | 1986-10-17 | 1987-10-17 | 퀴놀린계 화합물, 그의 제조방법 및 그 화합물을 약효성분으로 함유하는 항암제 |
Country Status (12)
Country | Link |
---|---|
US (1) | US4826850A (ko) |
EP (1) | EP0264124B1 (ko) |
JP (1) | JPS63101369A (ko) |
KR (1) | KR900003499B1 (ko) |
CN (1) | CN1009826B (ko) |
AT (1) | ATE73447T1 (ko) |
AU (1) | AU598878B2 (ko) |
DE (1) | DE3777319D1 (ko) |
DK (1) | DK543987A (ko) |
ES (1) | ES2033279T3 (ko) |
GR (1) | GR3004353T3 (ko) |
NZ (1) | NZ222185A (ko) |
Families Citing this family (13)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
JPH01228965A (ja) * | 1988-03-10 | 1989-09-12 | Mect Corp | 縮合キノリン系化合物及び縮合アクリジン系化合物、それらの製造法ならびにそれらの化合物を有効成分とする抗癌剤 |
JPH0692410B2 (ja) * | 1988-08-30 | 1994-11-16 | キッセイ薬品工業株式会社 | 新規なベンゾフロキノリン誘導体 |
US5217961A (en) * | 1988-12-27 | 1993-06-08 | Mect Corporation | Condensed quinoline system N-glycosides |
JPH02256667A (ja) * | 1988-12-27 | 1990-10-17 | Masatoshi Yamato | 縮合キノリン系化合物およびその製造方法 |
AU640135B2 (en) * | 1990-03-20 | 1993-08-19 | Wellcome Foundation Limited, The | Hetero polycyclic biocidal compounds and their use in medicine |
US5223506A (en) * | 1991-06-04 | 1993-06-29 | Glaxo Inc. | Cyclic antitumor compounds |
US5681958A (en) * | 1995-06-07 | 1997-10-28 | Shaman Pharmaceuticals, Inc. | Cryptolepine analogs with hypoglycemic activity |
US5917052A (en) * | 1994-09-28 | 1999-06-29 | Shaman Pharmaceuticals, Inc. | Hypoglycemic agent from cryptolepis |
JP3141148B2 (ja) * | 1995-08-08 | 2001-03-05 | 大鵬薬品工業株式会社 | 縮合インダン誘導体及びその塩 |
US5741926A (en) * | 1997-02-12 | 1998-04-21 | Shaman Pharmaceuticals, Inc. | Aniline derivatives having antihyperglycemic activity |
CN105622508B (zh) * | 2015-12-22 | 2018-08-21 | 广西师范大学 | 一种新的[1,2,b]茚并喹啉类衍生物及其制备方法和在抗肿瘤药物中的应用 |
CN107325110B (zh) * | 2017-07-21 | 2019-06-11 | 太原理工大学 | 一种四元杂环苯并噻吩并喹啉化合物及其合成方法 |
CN110256451B (zh) * | 2019-07-15 | 2021-09-03 | 河南省科学院化学研究所有限公司 | 一种苯并呋喃并[2,3-b]喹啉衍生物的合成方法 |
Family Cites Families (1)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
NZ200715A (en) * | 1982-05-24 | 1986-06-11 | New Zealand Dev Finance | Acridine derivatives and pharmaceutical compositions containing such |
-
1986
- 1986-10-17 JP JP61246776A patent/JPS63101369A/ja active Pending
-
1987
- 1987-10-14 DE DE8787115032T patent/DE3777319D1/de not_active Expired - Fee Related
- 1987-10-14 AT AT87115032T patent/ATE73447T1/de not_active IP Right Cessation
- 1987-10-14 EP EP87115032A patent/EP0264124B1/en not_active Expired - Lifetime
- 1987-10-14 ES ES198787115032T patent/ES2033279T3/es not_active Expired - Lifetime
- 1987-10-15 NZ NZ222185A patent/NZ222185A/xx unknown
- 1987-10-16 DK DK543987A patent/DK543987A/da not_active Application Discontinuation
- 1987-10-16 AU AU79875/87A patent/AU598878B2/en not_active Ceased
- 1987-10-17 KR KR1019870011530A patent/KR900003499B1/ko not_active IP Right Cessation
- 1987-10-17 CN CN87106996A patent/CN1009826B/zh not_active Expired
- 1987-10-19 US US07/110,222 patent/US4826850A/en not_active Expired - Fee Related
-
1992
- 1992-04-15 GR GR920400714T patent/GR3004353T3/el unknown
Also Published As
Publication number | Publication date |
---|---|
NZ222185A (en) | 1990-07-26 |
CN1009826B (zh) | 1990-10-03 |
EP0264124A1 (en) | 1988-04-20 |
EP0264124B1 (en) | 1992-03-11 |
KR900003499B1 (ko) | 1990-05-21 |
DK543987A (da) | 1988-04-18 |
AU598878B2 (en) | 1990-07-05 |
US4826850A (en) | 1989-05-02 |
DE3777319D1 (de) | 1992-04-16 |
CN87106996A (zh) | 1988-06-15 |
GR3004353T3 (ko) | 1993-03-31 |
JPS63101369A (ja) | 1988-05-06 |
AU7987587A (en) | 1988-04-21 |
ATE73447T1 (de) | 1992-03-15 |
ES2033279T3 (es) | 1993-03-16 |
DK543987D0 (da) | 1987-10-16 |
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