KR880002803A - 플루오로벤젠 및 플루오로피리딘 화합물의 제조방법 - Google Patents

플루오로벤젠 및 플루오로피리딘 화합물의 제조방법 Download PDF

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KR880002803A
KR880002803A KR1019870008670A KR870008670A KR880002803A KR 880002803 A KR880002803 A KR 880002803A KR 1019870008670 A KR1019870008670 A KR 1019870008670A KR 870008670 A KR870008670 A KR 870008670A KR 880002803 A KR880002803 A KR 880002803A
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amino
decomposition
psig pressure
halopyridine
aromatic
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KR1019870008670A
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KR950014596B1 (ko
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스코트 호워쓰 미카엘
미카엘 톰킨슨 데이비드
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알란 브라이안 백
임페리알 케이알 인더스트리스 피엘씨
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    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C245/00—Compounds containing chains of at least two nitrogen atoms with at least one nitrogen-to-nitrogen multiple bond
    • C07C245/20—Diazonium compounds
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D213/00—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members
    • C07D213/02—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members
    • C07D213/04—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen or carbon atoms directly attached to the ring nitrogen atom
    • C07D213/60—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen or carbon atoms directly attached to the ring nitrogen atom with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
    • C07D213/61—Halogen atoms or nitro radicals
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07B—GENERAL METHODS OF ORGANIC CHEMISTRY; APPARATUS THEREFOR
    • C07B39/00—Halogenation
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C17/00—Preparation of halogenated hydrocarbons
    • C07C17/093—Preparation of halogenated hydrocarbons by replacement by halogens
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C201/00—Preparation of esters of nitric or nitrous acid or of compounds containing nitro or nitroso groups bound to a carbon skeleton
    • C07C201/06—Preparation of nitro compounds
    • C07C201/12—Preparation of nitro compounds by reactions not involving the formation of nitro groups
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C51/00—Preparation of carboxylic acids or their salts, halides or anhydrides
    • C07C51/347—Preparation of carboxylic acids or their salts, halides or anhydrides by reactions not involving formation of carboxyl groups
    • C07C51/363—Preparation of carboxylic acids or their salts, halides or anhydrides by reactions not involving formation of carboxyl groups by introduction of halogen; by substitution of halogen atoms by other halogen atoms

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  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Engineering & Computer Science (AREA)
  • Oil, Petroleum & Natural Gas (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
  • Pyridine Compounds (AREA)
  • Physical Or Chemical Processes And Apparatus (AREA)
  • Low-Molecular Organic Synthesis Reactions Using Catalysts (AREA)
  • Steroid Compounds (AREA)

Abstract

내용 없음

Description

플루오로벤젠 및 플루오로피리딘 화합물의 제조방법
본 내용은 요부공개 건이므로 전문내용을 수록하지 않았음
도면은 무수 불화 수소의 증기압에 대한 온도를 도시한 것이다.

Claims (15)

  1. 불화 수소내에서 당해 아미노-방향족 또는 아미노-복소환식 화합물을 디아조화하고, 형성된 디아조화 혼합물내에서 디아조늄 염을 분해하는 것으로 구성되는데, 높은 대기압에서 분해하는 것을 특징으로 하는, 플루오로방향족 또는 플루오로복소환식 화합물을 제조하는 방법.
  2. 제1항에 있어서, 70-200 psig 압력에서 분해를 행하는 방법.
  3. 제2항에 있어서, 80-100 psig 압력에서 분해를 행하는 방법.
  4. 제3항에 있어서, 85-95 psig 압력에서 분해를 행하는 방법.
  5. 제4항에 있어서, 90 psig 압력에서 분해를 행하는 방법.
  6. 제1항에 있어서, 200-500 psig 압력에서 분해를 행하는 방법.
  7. 제6항에 있어서, 200-300 psig 압력에서 분해를 행하는 방법.
  8. 제7항에 있어서, 220-280 psig 압력에서 분해를 행하는 방법.
  9. 제8항에 있어서, 250 psig 압력에서 분해를 행하는 방법.
  10. 전기한 항의 어느 한 항에 있어서, 당해 아미노-방향족 또는 아미노-복소환식 화합물이 구조식(I)의 아민인 방법.
    식중, A는 CH 또는 N, R은 할로겐, 바람직하게, 염소 및 불소, 니트로, 알킬, 바람직하게 C1-4알콕시, 트리끌루오로메틸, 하이드록시카보닐, 또는 알콕시-카보닐, 바람직하게 C1-4알콕시카보닐, m은 0, 1, 2 또는 3이고 m이 2 또는 3일때 R로 표시된 치환체는 같거나 다름, n은 1 또는 2.
  11. 제10항에 있어서, 당해 아미노-방향족 또는 아미노-복소환식 화합물이o-,m- 또는p-할로아닐린 2,4- 및 2,5-디메틸아닐린,m- 또는p-알콕시아닐린,m- 또는p-니트로아닐린,m- 또는p-카복시아닐린, 특히 o-카복시 아닐린, 2-메틸-5-니트로아닐린, 4,4′-디아미노-디페닐메탄,o-,m- 또는p-톨루이딘, 아닐린, 2-, 3-및 4-아미노피린딘, 2-아미노-4,5 및 6-할로피리딘, 3-아미노-5 및 6-할로피리딘, 2-아미노-4,5 및 6-할로피리딘, 3-아미노-5 및 6-할로피리딘, 2-아미노-4,5 및 6-메틸 피리딘 또는 2-아미노-4,6-디메틸 피리딘인 방법.
  12. 불화 수소내에서 당해 아미노-방향족 또는 아미노-복소환식 화학물을 디아조화하고, 형성된 디아조화 혼합물내에서 디아조늄 염을 분해하는 것으로 구성되는데, 높은 대기압에서 분해하는 것을 특징으로 하는, 2-플루오로벤조산을 제조하는 방법.
  13. 전기한 항의 어느 한 항에 있어서, 40-100℃ 온도에서 분해를 행하는 방법.
  14. 제13항에 있어서, 60-100℃온도에서 분해를 행하는 방법.
  15. 제14항에 있어서, 75-85℃ 온도에서 분해를 행하는 방법.
    ※ 참고사항 : 최초출원 내용에 의하여 공개하는 것임.
KR1019870008670A 1986-08-08 1987-08-07 플루오로벤젠 및 플루오로피리딘 화합물의 제조 방법 KR950014596B1 (ko)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
GB868619375A GB8619375D0 (en) 1986-08-08 1986-08-08 Chemical process
GB8619375 1986-08-08

Publications (2)

Publication Number Publication Date
KR880002803A true KR880002803A (ko) 1988-05-11
KR950014596B1 KR950014596B1 (ko) 1995-12-11

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KR1019870008670A KR950014596B1 (ko) 1986-08-08 1987-08-07 플루오로벤젠 및 플루오로피리딘 화합물의 제조 방법

Country Status (11)

Country Link
US (1) US4812572A (ko)
EP (1) EP0258985B2 (ko)
JP (1) JP2706454B2 (ko)
KR (1) KR950014596B1 (ko)
AT (1) ATE62658T1 (ko)
DE (1) DE3769402D1 (ko)
ES (1) ES2021715T5 (ko)
GB (2) GB8619375D0 (ko)
GR (1) GR3001792T3 (ko)
HU (1) HU202808B (ko)
IL (1) IL83321A (ko)

Families Citing this family (5)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US4876387A (en) * 1989-02-27 1989-10-24 Occidental Chemical Corporation Process for preparing 2,4,5-trifluorobenzoic acid
GB8926430D0 (en) * 1989-11-22 1990-01-10 Ici Plc Process for the preparation of fluoroaromatic compounds
US5107046A (en) * 1990-05-23 1992-04-21 Mallinckrodt Specialty Chemicals Co., Inc. Process for preparing aromatic fluorides
FR2866023B1 (fr) * 2004-02-05 2007-10-12 Rhodia Chimie Sa Procede de preparation d'un compose fluoaromatique a partir d'un compose aminoaromatique
IN2015DN00714A (ko) * 2012-07-18 2015-07-10 Basf Se

Family Cites Families (7)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US3798228A (en) * 1970-04-13 1974-03-19 Olin Corp Method for the preparation of difluoropyridines
GB1360327A (en) * 1972-11-13 1974-07-17 Daikin Ind Ltd Process for the nuclear fluorination of a compound having a benzene ring
JPS5314057B2 (ko) * 1972-12-15 1978-05-15
US4075252A (en) * 1975-10-31 1978-02-21 Olin Corporation Diazotization-fluorination in a medium of hydrogen fluoride-containing ammonium ions
US4096196A (en) * 1975-10-31 1978-06-20 Olin Corporation Diazotization-fluorination in a medium of hydrogen fluoride containing tertiary amine compounds
GB1534841A (en) * 1976-07-23 1978-12-06 Olin Corp Preparation of fluorobenzenes and fluoropyridines
DE2652810C3 (de) * 1976-11-20 1979-05-10 Bayer Ag, 5090 Leverkusen Verfahren zur Herstellung von aromatischen Fluorverbindungen

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Publication number Publication date
IL83321A (en) 1992-06-21
ES2021715B3 (es) 1991-11-16
EP0258985A1 (en) 1988-03-09
GB8716947D0 (en) 1987-08-26
GR3001792T3 (en) 1992-11-23
US4812572A (en) 1989-03-14
KR950014596B1 (ko) 1995-12-11
JP2706454B2 (ja) 1998-01-28
JPS6366132A (ja) 1988-03-24
ES2021715T5 (es) 1995-08-16
EP0258985B2 (en) 1994-01-12
HU202808B (en) 1991-04-29
DE3769402D1 (de) 1991-05-23
EP0258985B1 (en) 1991-04-17
GB8619375D0 (en) 1986-09-17
ATE62658T1 (de) 1991-05-15
HUT47891A (en) 1989-04-28

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