KR880002434B1 - 8-(3-(6-fluoro-1,2-benzisoxazol-3-yl)propy)-1-phenyl-1,3,8-triazaspiro-(4,5)decan-4-ones, and a process for the preparation thereof - Google Patents

8-(3-(6-fluoro-1,2-benzisoxazol-3-yl)propy)-1-phenyl-1,3,8-triazaspiro-(4,5)decan-4-ones, and a process for the preparation thereof

Info

Publication number
KR880002434B1
KR880002434B1 KR8204816A KR820004816A KR880002434B1 KR 880002434 B1 KR880002434 B1 KR 880002434B1 KR 8204816 A KR8204816 A KR 8204816A KR 820004816 A KR820004816 A KR 820004816A KR 880002434 B1 KR880002434 B1 KR 880002434B1
Authority
KR
South Korea
Prior art keywords
triazaspiro
decan
fluoro
phenyl
benzisoxazol
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Expired
Application number
KR8204816A
Other languages
English (en)
Korean (ko)
Other versions
KR840002000A (ko
Inventor
Larry Davis
Joseph Thomas Klein
Original Assignee
Hoechst Roussel Pharma
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Hoechst Roussel Pharma filed Critical Hoechst Roussel Pharma
Publication of KR840002000A publication Critical patent/KR840002000A/ko
Application granted granted Critical
Publication of KR880002434B1 publication Critical patent/KR880002434B1/ko
Expired legal-status Critical Current

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Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D471/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00
    • C07D471/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00 in which the condensed system contains two hetero rings
    • C07D471/10—Spiro-condensed systems
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/04—Centrally acting analgesics, e.g. opioids
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/18—Antipsychotics, i.e. neuroleptics; Drugs for mania or schizophrenia

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Veterinary Medicine (AREA)
  • Neurology (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Biomedical Technology (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Neurosurgery (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Pain & Pain Management (AREA)
  • Psychiatry (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Heterocyclic Carbon Compounds Containing A Hetero Ring Having Nitrogen And Oxygen As The Only Ring Hetero Atoms (AREA)
  • Plural Heterocyclic Compounds (AREA)
  • Agricultural Chemicals And Associated Chemicals (AREA)
  • Developing Agents For Electrophotography (AREA)
  • Photoreceptors In Electrophotography (AREA)
  • Low-Molecular Organic Synthesis Reactions Using Catalysts (AREA)
  • Nitrogen Condensed Heterocyclic Rings (AREA)
  • Other In-Based Heterocyclic Compounds (AREA)
  • Hydrogenated Pyridines (AREA)
KR8204816A 1982-04-09 1982-10-26 8-(3-(6-fluoro-1,2-benzisoxazol-3-yl)propy)-1-phenyl-1,3,8-triazaspiro-(4,5)decan-4-ones, and a process for the preparation thereof Expired KR880002434B1 (en)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US366246 1982-04-09
US06/366,246 US4374245A (en) 1982-04-09 1982-04-09 8-[3-(6-Fluoro-1,2-benzisoxazol-3-yl)propyl]-1-phenyl-1,3,8-triazaspiro[4.5]decan-4-one

Publications (2)

Publication Number Publication Date
KR840002000A KR840002000A (ko) 1984-06-11
KR880002434B1 true KR880002434B1 (en) 1988-11-12

Family

ID=23442248

Family Applications (1)

Application Number Title Priority Date Filing Date
KR8204816A Expired KR880002434B1 (en) 1982-04-09 1982-10-26 8-(3-(6-fluoro-1,2-benzisoxazol-3-yl)propy)-1-phenyl-1,3,8-triazaspiro-(4,5)decan-4-ones, and a process for the preparation thereof

Country Status (19)

Country Link
US (1) US4374245A (https=)
EP (1) EP0091510B1 (https=)
JP (1) JPS58177990A (https=)
KR (1) KR880002434B1 (https=)
AT (1) ATE32898T1 (https=)
AU (1) AU560413B2 (https=)
CA (1) CA1200552A (https=)
DE (1) DE3278202D1 (https=)
DK (1) DK474482A (https=)
ES (1) ES516829A0 (https=)
FI (1) FI823435A7 (https=)
GR (1) GR77704B (https=)
HU (1) HU188331B (https=)
IL (1) IL66867A (https=)
NO (1) NO160658C (https=)
NZ (1) NZ202046A (https=)
PH (1) PH19051A (https=)
PT (1) PT75727A (https=)
ZA (1) ZA827813B (https=)

Families Citing this family (7)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US4409230A (en) * 1982-04-09 1983-10-11 Hoechst-Roussel Pharmaceuticals Inc. Pharmaceutical compositions and methods employing 8-[3-(6-fluoro-1,2-benzisoxazol-3-yl)propyl]-1-phenyl-1,3,8-triazaspiro-[4.]decan-4-one and derivatives thereof
US4469868A (en) * 1982-05-24 1984-09-04 Warner-Lambert Company Alkylimidazo[1,2-c]pyrazolo[3,4-e]pyrimidines
US4707484A (en) * 1986-11-25 1987-11-17 Hoffmann-La Roche Inc. Substituted piperidinomethylindolone and cyclopent(b)indolone derivatives
US4980365A (en) * 1987-07-13 1990-12-25 Hoechst-Roussel Pharmaceuticals Inc. N-substituted-5,6-dimethoxy-1,2-benzisoxazole-3-propanamine and related compounds as analgesic and hypotensive agents
CA2226058C (en) * 1997-01-30 2008-01-29 F. Hoffmann-La Roche Ag 8-substituted-1,3,8-triaza-spiro[4.5]decan-4-one derivatives
US6686370B2 (en) * 1999-12-06 2004-02-03 Euro-Celtique S.A. Triazospiro compounds having nociceptin receptor affinity
US6995168B2 (en) 2002-05-31 2006-02-07 Euro-Celtique S.A. Triazaspiro compounds useful for treating or preventing pain

Family Cites Families (7)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US3826835A (en) * 1971-01-08 1974-07-30 Ciba Geigy Corp 8-benzofurylmethyl-1,3,8-triazaspiro(4,5)decanes as neuroleptics
JPS4970963A (https=) * 1972-11-09 1974-07-09
GB1488003A (en) * 1973-10-23 1977-10-05 Lilly Industries Ltd 1,2-benzisoxazole derivatives processes for their preparation and their use as pharmaceuticals
FI60390C (fi) * 1975-03-05 1982-01-11 Sumitomo Chemical Co Foerfarande foer framstaellning av neuroleptiska butyrofenoner
JPS51136666A (en) * 1975-05-19 1976-11-26 Dainippon Pharmaceut Co Ltd Process for preparing 3-aminoalkyl-1,2-benzisoxazole derivatives.
US4051248A (en) * 1975-07-14 1977-09-27 E. R. Squibb & Sons, Inc. 1,3,8-triazaspiro(4.5)decan-4-one derivatives
JPS6043064B2 (ja) * 1979-11-28 1985-09-26 ウェルファイド株式会社 新規イソオキサゾ−ル誘導体

Also Published As

Publication number Publication date
ZA827813B (en) 1983-08-31
HU188331B (en) 1986-04-28
NO160658B (no) 1989-02-06
KR840002000A (ko) 1984-06-11
ES8401485A1 (es) 1983-12-01
PT75727A (en) 1982-11-01
NO160658C (no) 1989-05-16
FI823435L (fi) 1983-10-10
AU8977682A (en) 1983-10-13
AU560413B2 (en) 1987-04-09
EP0091510A2 (en) 1983-10-19
ES516829A0 (es) 1983-12-01
IL66867A (en) 1986-02-28
EP0091510A3 (en) 1984-12-19
PH19051A (en) 1985-12-11
GR77704B (https=) 1984-09-25
NZ202046A (en) 1986-01-24
FI823435A0 (fi) 1982-10-08
ATE32898T1 (de) 1988-03-15
US4374245A (en) 1983-02-15
CA1200552A (en) 1986-02-11
DE3278202D1 (en) 1988-04-14
EP0091510B1 (en) 1988-03-09
DK474482A (da) 1983-10-10
IL66867A0 (en) 1982-12-31
JPS58177990A (ja) 1983-10-18
NO823558L (no) 1983-10-10
FI823435A7 (fi) 1983-10-10

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