KR880001577A - 2-아실옥시프로필아민 유도체 및 이의 제조방법과 이를 함유하는 제약학적 조성물 - Google Patents

2-아실옥시프로필아민 유도체 및 이의 제조방법과 이를 함유하는 제약학적 조성물 Download PDF

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KR880001577A
KR880001577A KR1019870008355A KR870008355A KR880001577A KR 880001577 A KR880001577 A KR 880001577A KR 1019870008355 A KR1019870008355 A KR 1019870008355A KR 870008355 A KR870008355 A KR 870008355A KR 880001577 A KR880001577 A KR 880001577A
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formula
compound
acyloxypropylamine
sulfur
oxygen
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KR1019870008355A
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트로스트만 유베
샤크텔 크리스토프
마하르트 칼
루돌프 클라우스
마르메 디에테르
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닥터. 베. 랑
궤덱 아크티엔게셀샤프트
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Publication of KR880001577A publication Critical patent/KR880001577A/ko

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    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C223/00—Compounds containing amino and —CHO groups bound to the same carbon skeleton
    • C07C223/02—Compounds containing amino and —CHO groups bound to the same carbon skeleton having amino groups bound to acyclic carbon atoms of the carbon skeleton
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D295/00—Heterocyclic compounds containing polymethylene-imine rings with at least five ring members, 3-azabicyclo [3.2.2] nonane, piperazine, morpholine or thiomorpholine rings, having only hydrogen atoms directly attached to the ring carbon atoms
    • C07D295/04—Heterocyclic compounds containing polymethylene-imine rings with at least five ring members, 3-azabicyclo [3.2.2] nonane, piperazine, morpholine or thiomorpholine rings, having only hydrogen atoms directly attached to the ring carbon atoms with substituted hydrocarbon radicals attached to ring nitrogen atoms
    • C07D295/08—Heterocyclic compounds containing polymethylene-imine rings with at least five ring members, 3-azabicyclo [3.2.2] nonane, piperazine, morpholine or thiomorpholine rings, having only hydrogen atoms directly attached to the ring carbon atoms with substituted hydrocarbon radicals attached to ring nitrogen atoms substituted by singly bound oxygen or sulfur atoms
    • C07D295/084—Heterocyclic compounds containing polymethylene-imine rings with at least five ring members, 3-azabicyclo [3.2.2] nonane, piperazine, morpholine or thiomorpholine rings, having only hydrogen atoms directly attached to the ring carbon atoms with substituted hydrocarbon radicals attached to ring nitrogen atoms substituted by singly bound oxygen or sulfur atoms with the ring nitrogen atoms and the oxygen or sulfur atoms attached to the same carbon chain, which is not interrupted by carbocyclic rings
    • C07D295/088—Heterocyclic compounds containing polymethylene-imine rings with at least five ring members, 3-azabicyclo [3.2.2] nonane, piperazine, morpholine or thiomorpholine rings, having only hydrogen atoms directly attached to the ring carbon atoms with substituted hydrocarbon radicals attached to ring nitrogen atoms substituted by singly bound oxygen or sulfur atoms with the ring nitrogen atoms and the oxygen or sulfur atoms attached to the same carbon chain, which is not interrupted by carbocyclic rings to an acyclic saturated chain
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P29/00—Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P37/00—Drugs for immunological or allergic disorders
    • A61P37/08—Antiallergic agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P7/00—Drugs for disorders of the blood or the extracellular fluid
    • A61P7/02—Antithrombotic agents; Anticoagulants; Platelet aggregation inhibitors
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • A61P9/10—Drugs for disorders of the cardiovascular system for treating ischaemic or atherosclerotic diseases, e.g. antianginal drugs, coronary vasodilators, drugs for myocardial infarction, retinopathy, cerebrovascula insufficiency, renal arteriosclerosis
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • A61P9/12—Antihypertensives
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C323/00—Thiols, sulfides, hydropolysulfides or polysulfides substituted by halogen, oxygen or nitrogen atoms, or by sulfur atoms not being part of thio groups
    • C07C323/23—Thiols, sulfides, hydropolysulfides or polysulfides substituted by halogen, oxygen or nitrogen atoms, or by sulfur atoms not being part of thio groups containing thio groups and nitrogen atoms, not being part of nitro or nitroso groups, bound to the same carbon skeleton
    • C07C323/24—Thiols, sulfides, hydropolysulfides or polysulfides substituted by halogen, oxygen or nitrogen atoms, or by sulfur atoms not being part of thio groups containing thio groups and nitrogen atoms, not being part of nitro or nitroso groups, bound to the same carbon skeleton having the sulfur atoms of the thio groups bound to acyclic carbon atoms of the carbon skeleton
    • C07C323/25—Thiols, sulfides, hydropolysulfides or polysulfides substituted by halogen, oxygen or nitrogen atoms, or by sulfur atoms not being part of thio groups containing thio groups and nitrogen atoms, not being part of nitro or nitroso groups, bound to the same carbon skeleton having the sulfur atoms of the thio groups bound to acyclic carbon atoms of the carbon skeleton the carbon skeleton being acyclic and saturated

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  • General Chemical & Material Sciences (AREA)
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Abstract

내용 없음

Description

2-아실옥시프로필아민 유도체 및 이의 제조방법과 이를 함유하는 제약학적 조성물
본 내용은 요부공개 건이므로 전문내용을 수록하지 않았음

Claims (8)

  1. 다음 일반식 Ⅰ 의 2-아실옥시프로필아민 유도체 및 이의 약리학적으로 허용가능한 염.
    식중, R1은 C20까지 포함하는 직쇄 또는 분지된 포화 또는 불포화된 알킬라디칼:
    R2는 Ct까지 포함하는 직쇄 또는 분지된 알킬라디칼:
    R3및 R4는동일하거나 상이한 바, 수소원자, 임의로 페닐로 치환된 C14까지 포함하는 직쇄 또는 분지된 알킬라디칼, 또는 Ct까지 포함하는 알킬라디칼에 의해 임의로 치환된 R3와 R4가 합쳐진 형태의 피페리딘 또는 피페라진고리:
    X는 산소 또는 황원자:
  2. 제 1 항에 있어서, R1이 프로필, 옥타데실, 옥타데켄일, 테트라데실, 헥사데실, 에이코사노일 또는 이소부틸알킬라디칼, R2가 메틸 또는 이소프로필 라디칼, R3및 R4가 상이하거나 동일한 바, 수소원자 또는 메틸, 에틸, 프로필 또는 벤질라디칼 또는 합쳐진 형태의 피페리딘 또는 2-메틸 피페라진 고리이며, X가 산소 또는 황원자인 2-아실옥시프로필아민 유도체.
  3. (±)-3-디메틸아미노-1-옥타데실옥시-2-프로필아세테이트.
  4. 1-(2-메틸)-피페라진일-3-옥타데실옥시-2-프로필아세테이트옥살레이트.
  5. (±)-3-디메틸아미노-1-(9-시스-옥타데켄일옥시)-2-프로필아세테이트 하이드로클로라이드.
  6. 제 1항에 있어서,
    A) Y가 예컨대 토실라디칼 또는 할로겐원자와 같이 제거하기 쉬운 그룹인 다음 일반식(Ⅱ)의 화합물을
    R1및 X가 상기한 바와 같은 일반식(Ⅲ)의 화합물
    과 반응시켜
    a) 만일 X가 수성 유기 2-상 시스템내의 산소일 때 R1이 상기한 바와 같고 X가 산소인 일반식(Ⅳ)의 화합물을 만들거나
    또는
    b)만일 X가 3차 아민 형태의 알콜내의 황이면 R1및 Y가 상기한 바와 같고 X가 소듐알콜레이트와 재빨리 반응하여 X가 황인 일반식 Ⅳ의 화합물을 만드는 황인 이란식 Ⅷ의 화합물을 만들며
    B)얻어진 일반식 Ⅳ의 화합물을 R3'및 R4'가 수소가 아닌 R3및 R4와 같은 일반식(Ⅴ)의 아민과
    반응시켜 옥사이드 고리가 열린 R1, R3', R4' 가 및 X가 상기한 바와 같은 일반식(Ⅳ)의 화합물을 얻고
    C) 이를 공지된 방법으로 속히 아실화하여 원하던 일반식(Ⅰ)의 화합물을 얻고
    D)마지막으로 R3및 / 또는 R4가 벤질라디칼인 경우 촉매수소화 반응시켜 R3및 /또는 R4가 수소원자인 일반식 Ⅰ의화합물을 만드는 공지된 방법으로 2-아실옥시프로필아민 유도체를 제조하는 방법.
  7. 제 1항부터 제 3항 까지 중 어느 한 항에 있어서, 통상적인 부가제와의 혼합물 형태로 있는 최소한 하나의 2-아실옥시프로필아민을 함유하는 제약학적 조성물.
  8. 제 1항에 있어서, 단백질 카니제, C(DKC), 및 디아실글리세롤에 의해 자극된 전구응집을 억제하며, 협전증, 동맥경화증, 고혈압, 류마티스성 염증과정, 알레르기, 암 및 중추신경계의 혹종의 변성상해와 같은 순환계 질환과 심장질환을 치료하기 위해 일반식 Ⅰ의 화합물을 사용하는 방법.
    ※ 참고사항 : 최초출원 내용에 의하여 공개하는 것임.
KR1019870008355A 1986-07-30 1987-07-30 2-아실옥시프로필아민 유도체 및 이의 제조방법과 이를 함유하는 제약학적 조성물 KR880001577A (ko)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
DEP3625738.9 1986-07-30
DE19863625738 DE3625738A1 (de) 1986-07-30 1986-07-30 2-acyloxypropylamin-derivate, verfahren zu deren herstellung und deren verwendung

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KR880001577A true KR880001577A (ko) 1988-04-25

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US (1) US4855489A (ko)
EP (1) EP0255126B1 (ko)
JP (1) JPS6348250A (ko)
KR (1) KR880001577A (ko)
AT (1) ATE81499T1 (ko)
AU (1) AU597090B2 (ko)
CA (1) CA1318670C (ko)
DD (1) DD266349A5 (ko)
DE (2) DE3625738A1 (ko)
DK (1) DK374887A (ko)
ES (1) ES2052525T3 (ko)
FI (1) FI89042C (ko)
GR (1) GR3006081T3 (ko)
HU (1) HU197720B (ko)
IL (1) IL83368A (ko)
SU (1) SU1470177A3 (ko)
ZA (1) ZA875640B (ko)

Families Citing this family (9)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
DE3705384A1 (de) * 1987-02-20 1988-09-01 Goedecke Ag 2-propylamin-derivate, verfahren zu deren herstellung sowie deren verwendung
DE3868712D1 (de) * 1987-06-25 1992-04-09 Hoechst Ag Ein neues antibiotikum, fumifungin, ein mikrobielles verfahren zu seiner herstellung und seine verwendung als arzneimittel.
DE3836987A1 (de) * 1988-10-31 1990-05-23 Goedecke Ag 2-aminocarbonsaeuren und deren derivate, verfahren zu deren herstellung und deren verwendung als arzneimittel
DE4243321A1 (de) * 1992-12-21 1994-06-23 Goedecke Ag Aminosäurederivate von Heterocyclen als PKC-Inhibitoren
GB2321455A (en) * 1997-01-24 1998-07-29 Norsk Hydro As Lipophilic derivatives of biologically active compounds
CA2393720C (en) * 2002-07-12 2010-09-14 Eli Lilly And Company Crystalline 2,5-dione-3-(1-methyl-1h-indol-3-yl)-4-[1-(pyridin-2-ylmethyl)piperidin-4-yl]-1h-indol-3-yl]-1h-pyrrole mono-hydrochloride
US7476656B2 (en) * 2004-11-09 2009-01-13 University Of Florida Research Foundation, Inc. Fluorescent affinity tag to enhance phosphoprotein detection and characterization
US8930331B2 (en) 2007-02-21 2015-01-06 Palantir Technologies Providing unique views of data based on changes or rules
US9092482B2 (en) 2013-03-14 2015-07-28 Palantir Technologies, Inc. Fair scheduling for mixed-query loads

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* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
LU66207A1 (ko) * 1972-09-29 1974-04-02
CH618958A5 (en) * 1975-07-01 1980-08-29 Ciba Geigy Ag Process for the preparation of novel secondary acyloxyamines
DE2820892A1 (de) * 1978-05-12 1979-11-22 Nattermann A & Cie Neue strukturanaloga von glyveriden und verfahren zu deren herstellung
GB2172284B (en) * 1985-03-12 1988-07-27 Ciba Geigy Ag Nitrogen-containing additives for non-aqueous functional fluids

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EP0255126A3 (en) 1989-01-11
EP0255126A2 (de) 1988-02-03
FI873313A0 (fi) 1987-07-29
FI89042B (fi) 1993-04-30
ES2052525T3 (es) 1994-07-16
US4855489A (en) 1989-08-08
GR3006081T3 (ko) 1993-06-21
DK374887D0 (da) 1987-07-17
AU7624887A (en) 1988-02-04
CA1318670C (en) 1993-06-01
FI89042C (fi) 1993-08-10
ATE81499T1 (de) 1992-10-15
EP0255126B1 (de) 1992-10-14
HU197720B (en) 1989-05-29
DE3625738A1 (de) 1988-02-11
IL83368A0 (en) 1987-12-31
SU1470177A3 (ru) 1989-03-30
ZA875640B (en) 1988-11-30
AU597090B2 (en) 1990-05-24
DE3782207D1 (de) 1992-11-19
IL83368A (en) 1991-05-12
FI873313A (fi) 1988-01-31
DK374887A (da) 1988-01-31
JPS6348250A (ja) 1988-02-29
HUT44228A (en) 1988-02-29
DD266349A5 (de) 1989-03-29

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