KR860003252A - 아미드 유도체의 제법 - Google Patents

아미드 유도체의 제법 Download PDF

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Publication number
KR860003252A
KR860003252A KR1019850007252A KR850007252A KR860003252A KR 860003252 A KR860003252 A KR 860003252A KR 1019850007252 A KR1019850007252 A KR 1019850007252A KR 850007252 A KR850007252 A KR 850007252A KR 860003252 A KR860003252 A KR 860003252A
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KR
South Korea
Prior art keywords
formula
compound
alkyl
group
reacting
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KR1019850007252A
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English (en)
Inventor
미카엘 베어 토마스
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아이.씨.아이 아메리카스 아이엔씨.
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
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Application filed by 아이.씨.아이 아메리카스 아이엔씨. filed Critical 아이.씨.아이 아메리카스 아이엔씨.
Publication of KR860003252A publication Critical patent/KR860003252A/ko

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    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D471/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00
    • C07D471/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00 in which the condensed system contains two hetero rings
    • C07D471/04—Ortho-condensed systems
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/20—Hypnotics; Sedatives

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  • Organic Chemistry (AREA)
  • Chemical & Material Sciences (AREA)
  • Health & Medical Sciences (AREA)
  • Neurosurgery (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Neurology (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Engineering & Computer Science (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Anesthesiology (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Biomedical Technology (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Nitrogen Condensed Heterocyclic Rings (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
  • Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
  • Polysaccharides And Polysaccharide Derivatives (AREA)
  • Compounds Of Unknown Constitution (AREA)
  • Plural Heterocyclic Compounds (AREA)
  • Medicines Containing Material From Animals Or Micro-Organisms (AREA)

Abstract

내용 없음

Description

아미드 유도체의 제법
본 내용은 요부공개 건이므로 전문내용을 수록하지 않았음

Claims (2)

  1. (a) 구조식(2)의 화합물을 일반식 RcRdNH의 아민과 반응시키고;
    [식중 A는 카복실산 또는 그것의 활성화된 유도체]
    (b) Rb가 수소인 구조식(1)의 화합물을 아실화하여 Rb가 알카노일인 화합물로 하고; (c) 구조식(3)의 화합물을 알킬화, 알케닐화 또는 알키닐화하고;
    (d) 구조식(4)의 화합물을 일반식 Rb-NH2인 화합물과 반응시키고; 그 후에, 구조식(1)의
    [식중 Re는 대치가능한 래디칼]
    화합물이 유기 염기 형태로 얻어지고) 제약학적으로 허용가능한 산부가 염이 필요할 때, 염기는 제약학적으로 허용가능한 양이온을 제공하는 산과 반응하는 것으로 구성되는 구조식(1)의 화합물 및 그것의 7-N-옥사이드를 제조하는 방법.
    식중 Ra는 (1-10C)알킬,-(3-10C)알케닐, (3-10C)알키닐, (1-10C)시아노알킬, (1-10C)케토알킬, (1-10C)할로알킬 및 (3-10C)할로알케닐로 구성되는 그룹에서 선택되는데, 여기서 각 할로 그룹은 불소 및 염소로 구성되는 그룹에 선택된 최소한 하나의 할로겐을 가짐.
    Rb는 수소, (1-10)알킬 및 (1-10C)알카노일로 구성되는 그룹에서 선택.
    Rc 및 Rd는 동일하거나 상이할 수 있는데, 수소, (1-10C)알킬, (3-6C)싸이클로알킬, (3-6C)싸이클로알킬(1-6C)알킬, (3-10C)알케닐, (3-10C)알키닐, (1-6C)알콕시, (1-6C)알콕시(2-6C)알킬, (1-6C)할로알킬, (1-6C)할로알케닐, 페닐, 벤겐 및 티아졸릴로 구성되는 그룹에서 각각 독립적으로 선택될 수 있고, 부착된 질소와 함께 임의로 이중 결합을 포함하는 4-에서 7-원환을 형성.
    Ra가 (1-3C)알킬이며, Rc 및 Rd의 최소한 하나는 (3-10C)알케닐, (3-10C)알키닐
  2. (a) 구조식 (7)의 화학물을 빛의 존재하여 N-브로모숙신이미드와 반응시켜
    [식중 Rg는 수소, (1-6C)알킬]
    구조식 (8)의 화합물을 얻고
    (b) (8) 구조식(8)의 화합물을 산, 염기와 반응시키는, 단계로 구성되는 구조식 (5)의 화합물을 제조하는 방법.
    [식중 Re는 대치가능한 래디칼, Rf는 (1-6C)알킬]
    ※ 참고사항 : 최초출원 내용에 의하여 공개하는 것임.
KR1019850007252A 1984-10-04 1985-10-02 아미드 유도체의 제법 KR860003252A (ko)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
GB848425104A GB8425104D0 (en) 1984-10-04 1984-10-04 Amide derivatives
GB8425104 1984-10-04

Publications (1)

Publication Number Publication Date
KR860003252A true KR860003252A (ko) 1986-05-21

Family

ID=10567707

Family Applications (1)

Application Number Title Priority Date Filing Date
KR1019850007252A KR860003252A (ko) 1984-10-04 1985-10-02 아미드 유도체의 제법

Country Status (19)

Country Link
US (1) US4745121A (ko)
EP (1) EP0180318B1 (ko)
JP (1) JPS6191188A (ko)
KR (1) KR860003252A (ko)
CN (1) CN85107874A (ko)
AT (1) ATE69228T1 (ko)
AU (1) AU573899B2 (ko)
DE (1) DE3584608D1 (ko)
DK (1) DK454685A (ko)
ES (1) ES8703464A1 (ko)
FI (1) FI853859L (ko)
GB (2) GB8425104D0 (ko)
GR (1) GR852395B (ko)
HU (1) HUT38344A (ko)
NO (1) NO853923L (ko)
NZ (1) NZ213697A (ko)
PT (1) PT81246B (ko)
ZA (1) ZA857173B (ko)
ZM (1) ZM7585A1 (ko)

Families Citing this family (12)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
GB8610981D0 (en) * 1986-05-06 1986-06-11 Ici America Inc Quinoline amides
FR2719587B1 (fr) * 1994-05-03 1996-07-12 Roussel Uclaf Nouveaux dérivés de l'érythromycine, leur procédé de préparation et leur application comme médicaments.
AU2794099A (en) * 1998-02-26 1999-09-15 Neurogen Corporation Substituted cycloalkyl-4-oxonicotinic carboxamides; gaba brain receptor ligands
US6326379B1 (en) 1998-09-16 2001-12-04 Bristol-Myers Squibb Co. Fused pyridine inhibitors of cGMP phosphodiesterase
US20030220646A1 (en) * 2002-05-23 2003-11-27 Thelen Sarah L. Method and apparatus for reducing femoral fractures
GB0230045D0 (en) 2002-12-23 2003-01-29 Glaxo Group Ltd Compounds
CA2559629A1 (en) * 2004-03-16 2005-09-29 Glaxo Group Limited Pyrazolo[3,4-b]pyridine compound, and its use as a pde4 inhibitor
US7465795B2 (en) * 2005-12-20 2008-12-16 Astrazeneca Ab Compounds and uses thereof
AU2006327300A1 (en) * 2005-12-20 2007-06-28 Astrazeneca Ab Substituted Cinnoline derivatives as GABAa-receptor modulators and method for their synthesis
EP2124944B1 (en) * 2007-03-14 2012-02-15 Ranbaxy Laboratories Limited Pyrazolo[3,4-b]pyridine derivatives as phosphodiesterase inhibitors
TW200911760A (en) * 2007-06-19 2009-03-16 Astrazeneca Ab Compounds and uses thereof
CN107501525B (zh) * 2017-08-30 2020-06-09 本源精化环保科技有限公司 N,n’烷基化二氨基二环己基甲烷类固化剂及制备方法

Family Cites Families (5)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
BE787249A (fr) * 1971-08-05 1973-02-05 Squibb & Sons Inc Derives amino d'acides pyrazolopyridine carboxyliques, leurs esters et les sels de ces composes, ainsi que leurs procedes de preparation
US3979399A (en) * 1972-11-15 1976-09-07 E. R. Squibb & Sons, Inc. Amino derivatives of pyrazolopyridine carboxamides
US3840546A (en) * 1972-11-15 1974-10-08 Squibb & Sons Inc Amino derivatives of pyrazolopyridine carboxamides
US4511568A (en) * 1982-05-12 1985-04-16 Ici Americas Inc. CNS-Depressant pyrazolopyridines
US4552883A (en) * 1982-06-15 1985-11-12 Ici Americas Inc. Pyrazolo[3,4-b]pyridine carboxylic acid esters and their pharmaceutical use

Also Published As

Publication number Publication date
GB8425104D0 (en) 1984-11-07
HUT38344A (en) 1986-05-28
AU573899B2 (en) 1988-06-23
PT81246B (pt) 1987-11-30
JPS6191188A (ja) 1986-05-09
ZA857173B (en) 1986-07-30
DK454685D0 (da) 1985-10-04
EP0180318B1 (en) 1991-11-06
NZ213697A (en) 1989-03-29
GB8522642D0 (en) 1985-10-16
DK454685A (da) 1986-04-05
FI853859A0 (fi) 1985-10-04
ZM7585A1 (en) 1986-04-28
PT81246A (en) 1985-11-01
AU4759785A (en) 1986-04-10
GR852395B (ko) 1985-12-03
US4745121A (en) 1988-05-17
NO853923L (no) 1986-04-07
ATE69228T1 (de) 1991-11-15
CN85107874A (zh) 1986-07-30
DE3584608D1 (de) 1991-12-12
EP0180318A1 (en) 1986-05-07
FI853859L (fi) 1986-04-05
ES8703464A1 (es) 1987-02-16
ES547620A0 (es) 1987-02-16

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