KR860002455A - 디페닐아조메틴 유도체의 제조방법 - Google Patents

디페닐아조메틴 유도체의 제조방법 Download PDF

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Publication number
KR860002455A
KR860002455A KR1019850007090A KR850007090A KR860002455A KR 860002455 A KR860002455 A KR 860002455A KR 1019850007090 A KR1019850007090 A KR 1019850007090A KR 850007090 A KR850007090 A KR 850007090A KR 860002455 A KR860002455 A KR 860002455A
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South Korea
Prior art keywords
general formula
preparing
process according
isomers
compound
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KR1019850007090A
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English (en)
Inventor
위크 알렉산더 (외 1)
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에뚜레-레메뜨르
신떼라보
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Application filed by 에뚜레-레메뜨르, 신떼라보 filed Critical 에뚜레-레메뜨르
Publication of KR860002455A publication Critical patent/KR860002455A/ko

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    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C245/00—Compounds containing chains of at least two nitrogen atoms with at least one nitrogen-to-nitrogen multiple bond
    • C07C245/02—Azo compounds, i.e. compounds having the free valencies of —N=N— groups attached to different atoms, e.g. diazohydroxides
    • C07C245/04—Azo compounds, i.e. compounds having the free valencies of —N=N— groups attached to different atoms, e.g. diazohydroxides with nitrogen atoms of azo groups bound to acyclic carbon atoms or to carbon atoms of rings other than six-membered aromatic rings
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/185—Acids; Anhydrides, halides or salts thereof, e.g. sulfur acids, imidic, hydrazonic or hydroximic acids
    • A61K31/19—Carboxylic acids, e.g. valproic acid
    • A61K31/195—Carboxylic acids, e.g. valproic acid having an amino group
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/04—Centrally acting analgesics, e.g. opioids
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/08—Antiepileptics; Anticonvulsants
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/20—Hypnotics; Sedatives
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/24—Antidepressants
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/26—Psychostimulants, e.g. nicotine, cocaine
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P29/00—Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]

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  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • General Health & Medical Sciences (AREA)
  • Veterinary Medicine (AREA)
  • Public Health (AREA)
  • Medicinal Chemistry (AREA)
  • Animal Behavior & Ethology (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Pharmacology & Pharmacy (AREA)
  • General Chemical & Material Sciences (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Biomedical Technology (AREA)
  • Neurosurgery (AREA)
  • Neurology (AREA)
  • Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Pain & Pain Management (AREA)
  • Psychiatry (AREA)
  • Epidemiology (AREA)
  • Rheumatology (AREA)
  • Anesthesiology (AREA)
  • Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Thiazole And Isothizaole Compounds (AREA)

Abstract

내용 없음

Description

디페닐아조메틴 유도체의 제조방법
본 내용은 요부공개 건이므로 전문내용을 수록하지 않았음

Claims (4)

  1. 다음 일반식(Ⅱ)의 벤조페논을 다음 일반식(Ⅲ)의 화합물과 반응시킨 다음, 필요에 따라서는 공지된 방법으로 R2가 -OH인 일반식(Ⅰ)의 화합물을 R2가 -OM, NH2또는 -O(C1-4알킬)인 일반식(Ⅰ)의 화합물로 전환시키는 것을 특징으로 하여, 씨스나 트랜스 이성체 또는 이들 이성체의 혼합물 형태로 다음 일반식(Ⅰ)의 디페닐아조메틴 유도체를 제조하는 방법.
    상기 식에서 R1은 수소 또는 메틸, R2는 -OH, -OM(이때 M은 알칼리금속 또는 알칼리토금속이다, -NH2또는 -O(C1-4알킬)기이다.
  2. 제2항에 있어서, 반응을 메탄올내에서 20℃ 내지 메탄올의 비점까지의 온도에서 수행하는 것을 특징으로 하는 제조방법.
  3. 제1항에 있어서, 씨스 및 트랜스 이성체의 혼합물을 반복 결정화에 의하여 성분이성체로 분리하는 것을 특징으로 하는 제조방법.
  4. 제1항에 있어서, R2가 -OH, -OCH3, -OC2H5, -NH2또는 -ONa인 것을 특징으로 하는 제조방법.
    ※ 참고사항 : 최초출원 내용에 의하여 공개하는 것임.
KR1019850007090A 1984-09-27 1985-09-26 디페닐아조메틴 유도체의 제조방법 KR860002455A (ko)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
FR8414841A FR2570696B1 (fr) 1984-09-27 1984-09-27 Derives de diphenylazomethines a chaine insaturee, leur preparation et leur application en therapeutique
FR84/1484/ 1984-09-27

Publications (1)

Publication Number Publication Date
KR860002455A true KR860002455A (ko) 1986-04-26

Family

ID=9308135

Family Applications (1)

Application Number Title Priority Date Filing Date
KR1019850007090A KR860002455A (ko) 1984-09-27 1985-09-26 디페닐아조메틴 유도체의 제조방법

Country Status (15)

Country Link
US (1) US4663350A (ko)
EP (1) EP0177390A1 (ko)
JP (1) JPS61106549A (ko)
KR (1) KR860002455A (ko)
AU (1) AU4795185A (ko)
DK (1) DK435385A (ko)
ES (1) ES8605474A1 (ko)
FI (1) FI853718L (ko)
FR (1) FR2570696B1 (ko)
GR (1) GR852355B (ko)
HU (1) HUT38608A (ko)
IL (1) IL76504A0 (ko)
NO (1) NO853781L (ko)
PT (1) PT81205B (ko)
ZA (1) ZA857455B (ko)

Family Cites Families (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
FR2319338A1 (fr) * 1975-08-01 1977-02-25 Synthelabo Nouveaux derives de a- phenyl benzylideniques des acides amines, leur preparation et les medicaments qui en contiennent
FR2516509B1 (fr) * 1981-11-18 1985-07-26 Synthelabo Derives benzylideniques, leur preparation et leur application en therapeutique

Also Published As

Publication number Publication date
DK435385D0 (da) 1985-09-26
HUT38608A (en) 1986-06-30
PT81205A (fr) 1985-10-01
FI853718L (fi) 1986-03-28
FR2570696B1 (fr) 1986-11-21
ZA857455B (en) 1986-05-28
FI853718A0 (fi) 1985-09-26
FR2570696A1 (fr) 1986-03-28
NO853781L (no) 1986-04-01
ES8605474A1 (es) 1986-03-16
IL76504A0 (en) 1986-01-31
PT81205B (fr) 1987-07-08
GR852355B (ko) 1986-01-28
JPS61106549A (ja) 1986-05-24
AU4795185A (en) 1986-04-10
DK435385A (da) 1986-03-28
ES547316A0 (es) 1986-03-16
EP0177390A1 (fr) 1986-04-09
US4663350A (en) 1987-05-05

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