KR860001776A - (-)-6,6-디메틸바이싸이클로[3.3.1]엡트-2-엔-2-메탄올 유도체의 제조방법 - Google Patents
(-)-6,6-디메틸바이싸이클로[3.3.1]엡트-2-엔-2-메탄올 유도체의 제조방법 Download PDFInfo
- Publication number
- KR860001776A KR860001776A KR1019850005645A KR850005645A KR860001776A KR 860001776 A KR860001776 A KR 860001776A KR 1019850005645 A KR1019850005645 A KR 1019850005645A KR 850005645 A KR850005645 A KR 850005645A KR 860001776 A KR860001776 A KR 860001776A
- Authority
- KR
- South Korea
- Prior art keywords
- dimethylbicyclo
- ept
- ene
- preparation
- temperature
- Prior art date
Links
- YMWUJEATGCHHMB-UHFFFAOYSA-N Dichloromethane Chemical compound ClCCl YMWUJEATGCHHMB-UHFFFAOYSA-N 0.000 claims 3
- XEKOWRVHYACXOJ-UHFFFAOYSA-N Ethyl acetate Chemical compound CCOC(C)=O XEKOWRVHYACXOJ-UHFFFAOYSA-N 0.000 claims 3
- LFQSCWFLJHTTHZ-UHFFFAOYSA-N Ethanol Chemical compound CCO LFQSCWFLJHTTHZ-UHFFFAOYSA-N 0.000 claims 2
- KFSLWBXXFJQRDL-UHFFFAOYSA-N Peracetic acid Chemical compound CC(=O)OO KFSLWBXXFJQRDL-UHFFFAOYSA-N 0.000 claims 2
- FAPWRFPIFSIZLT-UHFFFAOYSA-M Sodium chloride Chemical compound [Na+].[Cl-] FAPWRFPIFSIZLT-UHFFFAOYSA-M 0.000 claims 2
- RZVAJINKPMORJF-UHFFFAOYSA-N Acetaminophen Chemical compound CC(=O)NC1=CC=C(O)C=C1 RZVAJINKPMORJF-UHFFFAOYSA-N 0.000 claims 1
- CDBYLPFSWZWCQE-UHFFFAOYSA-L Sodium Carbonate Chemical compound [Na+].[Na+].[O-]C([O-])=O CDBYLPFSWZWCQE-UHFFFAOYSA-L 0.000 claims 1
- 230000002378 acidificating effect Effects 0.000 claims 1
- 238000006735 epoxidation reaction Methods 0.000 claims 1
- 150000002118 epoxides Chemical class 0.000 claims 1
- 238000004519 manufacturing process Methods 0.000 claims 1
- OKKJLVBELUTLKV-UHFFFAOYSA-N methanol Substances OC OKKJLVBELUTLKV-UHFFFAOYSA-N 0.000 claims 1
- 229940073584 methylene chloride Drugs 0.000 claims 1
- 239000012074 organic phase Substances 0.000 claims 1
- 150000003839 salts Chemical class 0.000 claims 1
- 239000011780 sodium chloride Substances 0.000 claims 1
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
- C07C33/00—Unsaturated compounds having hydroxy or O-metal groups bound to acyclic carbon atoms
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
- C07C35/00—Compounds having at least one hydroxy or O-metal group bound to a carbon atom of a ring other than a six-membered aromatic ring
- C07C35/02—Compounds having at least one hydroxy or O-metal group bound to a carbon atom of a ring other than a six-membered aromatic ring monocyclic
- C07C35/08—Compounds having at least one hydroxy or O-metal group bound to a carbon atom of a ring other than a six-membered aromatic ring monocyclic containing a six-membered rings
- C07C35/18—Compounds having at least one hydroxy or O-metal group bound to a carbon atom of a ring other than a six-membered aromatic ring monocyclic containing a six-membered rings with unsaturation at least in the ring
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P11/00—Drugs for disorders of the respiratory system
- A61P11/10—Expectorants
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
- C07C29/00—Preparation of compounds having hydroxy or O-metal groups bound to a carbon atom not belonging to a six-membered aromatic ring
- C07C29/48—Preparation of compounds having hydroxy or O-metal groups bound to a carbon atom not belonging to a six-membered aromatic ring by oxidation reactions with formation of hydroxy groups
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07B—GENERAL METHODS OF ORGANIC CHEMISTRY; APPARATUS THEREFOR
- C07B2200/00—Indexing scheme relating to specific properties of organic compounds
- C07B2200/07—Optical isomers
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
- C07C2602/00—Systems containing two condensed rings
- C07C2602/36—Systems containing two condensed rings the rings having more than two atoms in common
- C07C2602/42—Systems containing two condensed rings the rings having more than two atoms in common the bicyclo ring system containing seven carbon atoms
Landscapes
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Health & Medical Sciences (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Pharmacology & Pharmacy (AREA)
- General Health & Medical Sciences (AREA)
- General Chemical & Material Sciences (AREA)
- Medicinal Chemistry (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Engineering & Computer Science (AREA)
- Life Sciences & Earth Sciences (AREA)
- Animal Behavior & Ethology (AREA)
- Pulmonology (AREA)
- Public Health (AREA)
- Veterinary Medicine (AREA)
- Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
- Low-Molecular Organic Synthesis Reactions Using Catalysts (AREA)
- Epoxy Compounds (AREA)
- Steroid Compounds (AREA)
Abstract
내용 없음
Description
본 내용은 요부공개 건이므로 전문내용을 수록하지 않았음
Claims (1)
- (-)-6,6-디메틸바이싸이클로[3.3.1] 엡트-2-엔-2-메탄올의 에폭시화가 40% 아세트 용액내의 과초산(CH3COOOH)를 적용함에 의해서 무수 탄산나트륨의 존재하에 5°에서 10℃까지의 온도에서 에탄올 유리된 무수메틸렌클로라이드 매체에서 행해지고; 염으로부터 분리하여 얻어진 순수한 에폭사이드는 약한 산수성 매체내의 1°에서 20℃까지 온도에서 수화되고 염화나트륨용액의 존재하에 에틸아세테이트로 추출되고; 유기상을 농축하여, 결정형태로 얻는 것을 특징으로 하는 다음 일반식(1)의 α,α-디메틸-5-하이드록시-3-싸이클로헥센-1,4-디메탄올의 제조방법.※ 참고사항 : 최초출원 내용에 의하여 공개하는 것임.
Applications Claiming Priority (2)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| IT22258/84A IT1196214B (it) | 1984-08-08 | 1984-08-08 | Derivato del(-)-6,6-dimetilbiciclo(3.3.1)ept-2-ene-2-metanolo ad attivita' mucosecretolitica,procedimento per la sua preparazione e sue composizioni farmaceutiche |
| IT22258A/84 | 1984-08-08 |
Publications (2)
| Publication Number | Publication Date |
|---|---|
| KR860001776A true KR860001776A (ko) | 1986-03-22 |
| KR920003100B1 KR920003100B1 (ko) | 1992-04-18 |
Family
ID=11193772
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| KR1019850005645A KR920003100B1 (ko) | 1984-08-08 | 1985-08-06 | (-)-6,6-디메틸바이싸이클로[3.3.1]엡트-2-엔-2-메탄올 유도체의 제조방법 |
Country Status (7)
| Country | Link |
|---|---|
| US (1) | US4605792A (ko) |
| EP (1) | EP0177673B1 (ko) |
| JP (1) | JPS6147431A (ko) |
| KR (1) | KR920003100B1 (ko) |
| AT (1) | ATE66667T1 (ko) |
| DE (1) | DE3583910D1 (ko) |
| IT (1) | IT1196214B (ko) |
Family Cites Families (5)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CA649603A (en) * | 1962-10-02 | J. Durbetaki Anthony | Preparation of sobrerol | |
| US2883398A (en) * | 1957-12-31 | 1959-04-21 | Union Carbide Corp | Epoxy-vinyl monomers and method of preparing the same |
| US2949489A (en) * | 1958-06-23 | 1960-08-16 | Fmc Corp | Preparation of sobrerol |
| CH568951A5 (ko) * | 1970-04-17 | 1975-11-14 | Corvi Camillo Spa | |
| CH549006A (de) * | 1971-02-11 | 1974-05-15 | Corvi Camillo Lab Biochimici F | Verfahren zur herstellung von (alpha)-pinenoxyd. |
-
1984
- 1984-08-08 IT IT22258/84A patent/IT1196214B/it active
-
1985
- 1985-06-07 US US06/742,574 patent/US4605792A/en not_active Expired - Fee Related
- 1985-06-19 DE DE8585107580T patent/DE3583910D1/de not_active Expired - Fee Related
- 1985-06-19 EP EP85107580A patent/EP0177673B1/en not_active Expired - Lifetime
- 1985-06-19 AT AT85107580T patent/ATE66667T1/de not_active IP Right Cessation
- 1985-08-05 JP JP60171262A patent/JPS6147431A/ja active Granted
- 1985-08-06 KR KR1019850005645A patent/KR920003100B1/ko active IP Right Grant
Also Published As
| Publication number | Publication date |
|---|---|
| EP0177673A3 (en) | 1986-07-16 |
| EP0177673B1 (en) | 1991-08-28 |
| JPS6147431A (ja) | 1986-03-07 |
| EP0177673A2 (en) | 1986-04-16 |
| ATE66667T1 (de) | 1991-09-15 |
| IT8422258A0 (it) | 1984-08-08 |
| JPS647056B2 (ko) | 1989-02-07 |
| KR920003100B1 (ko) | 1992-04-18 |
| US4605792A (en) | 1986-08-12 |
| IT1196214B (it) | 1988-11-16 |
| DE3583910D1 (de) | 1991-10-02 |
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