KR860001470B1 - 21-히드록시-20-케토-델타 16-스테로이드류의 신규제조방법 및 그 제조과정중 생성되는 신규 중간화합물류의 신규한 제조방법 - Google Patents

21-히드록시-20-케토-델타 16-스테로이드류의 신규제조방법 및 그 제조과정중 생성되는 신규 중간화합물류의 신규한 제조방법 Download PDF

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Publication number
KR860001470B1
KR860001470B1 KR1019840002248A KR840002248A KR860001470B1 KR 860001470 B1 KR860001470 B1 KR 860001470B1 KR 1019840002248 A KR1019840002248 A KR 1019840002248A KR 840002248 A KR840002248 A KR 840002248A KR 860001470 B1 KR860001470 B1 KR 860001470B1
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KR
South Korea
Prior art keywords
formula
group
steroids
delta
substituted
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Expired
Application number
KR1019840002248A
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English (en)
Korean (ko)
Other versions
KR840008462A (ko
Inventor
마튜스 판로이센 알베르트
마르누그 판로이센 아드리안
Original Assignee
기스트-브로카아데스 엔. 뷔,
쟝안토니 판데르 스트라아텐
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by 기스트-브로카아데스 엔. 뷔,, 쟝안토니 판데르 스트라아텐 filed Critical 기스트-브로카아데스 엔. 뷔,
Publication of KR840008462A publication Critical patent/KR840008462A/ko
Application granted granted Critical
Publication of KR860001470B1 publication Critical patent/KR860001470B1/ko
Expired legal-status Critical Current

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Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07J—STEROIDS
    • C07J5/00—Normal steroids containing carbon, hydrogen, halogen or oxygen, substituted in position 17 beta by a chain of two carbon atoms, e.g. pregnane and substituted in position 21 by only one singly bound oxygen atom, i.e. only one oxygen bound to position 21 by a single bond
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07J—STEROIDS
    • C07J53/00—Steroids in which the cyclopenta(a)hydrophenanthrene skeleton has been modified by condensation with a carbocyclic rings or by formation of an additional ring by means of a direct link between two ring carbon atoms, including carboxyclic rings fused to the cyclopenta(a)hydrophenanthrene skeleton are included in this class
    • C07J53/002—Carbocyclic rings fused
    • C07J53/004—3 membered carbocyclic rings
    • C07J53/005—3 membered carbocyclic rings in position 12
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07J—STEROIDS
    • C07J13/00—Normal steroids containing carbon, hydrogen, halogen or oxygen having a carbon-to-carbon double bond from or to position 17
    • C07J13/005—Normal steroids containing carbon, hydrogen, halogen or oxygen having a carbon-to-carbon double bond from or to position 17 with double bond in position 16 (17)
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07J—STEROIDS
    • C07J33/00—Normal steroids having a sulfur-containing hetero ring spiro-condensed or not condensed with the cyclopenta(a)hydrophenanthrene skeleton
    • C07J33/005—Normal steroids having a sulfur-containing hetero ring spiro-condensed or not condensed with the cyclopenta(a)hydrophenanthrene skeleton spiro-condensed
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07J—STEROIDS
    • C07J33/00—Normal steroids having a sulfur-containing hetero ring spiro-condensed or not condensed with the cyclopenta(a)hydrophenanthrene skeleton
    • C07J33/005—Normal steroids having a sulfur-containing hetero ring spiro-condensed or not condensed with the cyclopenta(a)hydrophenanthrene skeleton spiro-condensed
    • C07J33/007—Cyclic thioketals
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07J—STEROIDS
    • C07J43/00—Normal steroids having a nitrogen-containing hetero ring spiro-condensed or not condensed with the cyclopenta(a)hydrophenanthrene skeleton
    • C07J43/003—Normal steroids having a nitrogen-containing hetero ring spiro-condensed or not condensed with the cyclopenta(a)hydrophenanthrene skeleton not condensed

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • General Health & Medical Sciences (AREA)
  • Steroid Compounds (AREA)
  • Low-Molecular Organic Synthesis Reactions Using Catalysts (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
KR1019840002248A 1983-04-29 1984-04-27 21-히드록시-20-케토-델타 16-스테로이드류의 신규제조방법 및 그 제조과정중 생성되는 신규 중간화합물류의 신규한 제조방법 Expired KR860001470B1 (ko)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
EP83200618,3 1983-04-29
EP83,200618,3 1983-04-29
EP83200618A EP0123736A1 (en) 1983-04-29 1983-04-29 New process for the preparation of 21-hydroxy-20-keto-delta 16-steroids and new intermediate compounds formed in this process

Publications (2)

Publication Number Publication Date
KR840008462A KR840008462A (ko) 1984-12-15
KR860001470B1 true KR860001470B1 (ko) 1986-09-26

Family

ID=8190951

Family Applications (1)

Application Number Title Priority Date Filing Date
KR1019840002248A Expired KR860001470B1 (ko) 1983-04-29 1984-04-27 21-히드록시-20-케토-델타 16-스테로이드류의 신규제조방법 및 그 제조과정중 생성되는 신규 중간화합물류의 신규한 제조방법

Country Status (18)

Country Link
US (1) US4548749A (https=)
EP (2) EP0123736A1 (https=)
JP (2) JPS59206400A (https=)
KR (1) KR860001470B1 (https=)
AT (1) ATE71108T1 (https=)
AU (1) AU567934B2 (https=)
CA (1) CA1302401C (https=)
DE (1) DE3485399D1 (https=)
DK (2) DK166544B1 (https=)
ES (2) ES8608536A1 (https=)
FI (1) FI82059C (https=)
GR (1) GR81987B (https=)
HU (2) HU194906B (https=)
IE (1) IE57392B1 (https=)
IL (1) IL71659A (https=)
NO (1) NO167512C (https=)
NZ (1) NZ207986A (https=)
PT (1) PT78504B (https=)

Families Citing this family (6)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
EP0123735A1 (en) * 1983-04-29 1984-11-07 Gist-Brocades N.V. New process for the preparation of 20-keto-delta-16-steroids and new intermediate compounds formed in this process
FR2677028B1 (fr) * 1991-05-23 1994-01-21 Roussel Uclaf Nouveaux derives sterouides du pregna-4,9(11),17(20)-trien-3-one.
FR2677029B1 (fr) * 1991-05-23 1994-01-21 Roussel Uclaf Nouveaux derives sterouides de l'andostra-4,9(11),16-trien-3-one.
FR2676740B1 (fr) * 1991-05-23 1993-11-05 Roussel Uclaf Nouveaux derives sterouides du pregna-4,9(11),17(20)-trie-3-one, leur preparation, leur application a la preparation de composes sterouides de type pregna-4,9(11),16-triene-3,20-dione et nouveaux intermediaires.
WO2001005364A1 (en) * 1999-07-15 2001-01-25 The Procter & Gamble Company Nitrogen-containing steroid compounds and their use to regulate hair growth
US8569275B2 (en) * 2002-08-28 2013-10-29 Harbor Therapeutics, Inc. Steroids having 7-oxgen and 17-heteroaryl substitution

Family Cites Families (10)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
DE927029C (de) * 1952-02-12 1955-04-28 Hoechst Ag Verfahren zur Herstellung von 16, 17-Oxydo-20, 21-ketolen der Pregnanreihe
US2963496A (en) * 1957-06-05 1960-12-06 Olin Mathieson 9 alpha-halo-16-dehydro steroids of the pregnane series
US3056730A (en) * 1961-06-14 1962-10-02 Olin Mathieson 21-hydroxylation of steroids
US3281415A (en) * 1963-08-30 1966-10-25 Upjohn Co Steroidal delta16-20 (alpha and beta)-hydroperoxides
NL6801762A (https=) * 1967-02-20 1968-08-21
US3493563A (en) * 1968-02-23 1970-02-03 Squibb & Sons Inc Process for the production of intermediates for triamcinolone and related compounds
FR2462445A1 (fr) * 1979-07-31 1981-02-13 Roussel Uclaf Nouveaux derives 17-/(hydroxymethyl) (formamido) methylene/steroides, leur procede de preparation et leur application a l'introduction de la chaine laterale hydroxyacetyle
FR2493324B1 (https=) * 1980-11-05 1983-01-21 Roussel Uclaf
FR2498607A1 (fr) * 1981-01-29 1982-07-30 Roussel Uclaf Nouveau procede de preparation de 17a-hydroxy 17b-hydroxyacetyle steroides, produits intermediaires correspondants et produits finals obtenus
US4460509A (en) * 1981-08-19 1984-07-17 Beth Israel Medical Center Chemical synthesis

Also Published As

Publication number Publication date
ES8608536A1 (es) 1986-07-16
GR81987B (https=) 1984-12-12
JPS59206400A (ja) 1984-11-22
IE57392B1 (en) 1992-08-26
DK166544B1 (da) 1993-06-07
AU2713584A (en) 1984-11-01
HUT34217A (en) 1985-02-28
US4548749A (en) 1985-10-22
PT78504B (en) 1986-05-20
DK167443B1 (da) 1993-11-01
FI841680A0 (fi) 1984-04-27
ES532031A0 (es) 1986-07-16
HU194906B (en) 1988-03-28
DE3485399D1 (de) 1992-02-13
DK22292A (da) 1992-02-21
EP0127216A1 (en) 1984-12-05
EP0127216B1 (en) 1992-01-02
NO841701L (no) 1984-10-30
NO167512B (no) 1991-08-05
JPH06287200A (ja) 1994-10-11
IL71659A (en) 1988-11-15
PT78504A (en) 1984-05-01
FI841680L (fi) 1984-10-30
ES553608A0 (es) 1987-11-01
KR840008462A (ko) 1984-12-15
FI82059C (fi) 1991-01-10
JPH0699470B2 (ja) 1994-12-07
DK22292D0 (da) 1992-02-21
ES8800262A1 (es) 1987-11-01
IL71659A0 (en) 1984-07-31
CA1302401C (en) 1992-06-02
IE841039L (en) 1984-10-29
NZ207986A (en) 1986-11-12
DK212384A (da) 1984-10-30
JPH053479B2 (https=) 1993-01-14
AU567934B2 (en) 1987-12-10
FI82059B (fi) 1990-09-28
HU203767B (en) 1991-09-30
DK212384D0 (da) 1984-04-27
EP0123736A1 (en) 1984-11-07
ATE71108T1 (de) 1992-01-15
NO167512C (no) 1991-11-13

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