KR850007560A - 퍼플루오로 화합물의 수성분산액의 제조방법 - Google Patents

퍼플루오로 화합물의 수성분산액의 제조방법 Download PDF

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KR850007560A
KR850007560A KR1019850002510A KR850002510A KR850007560A KR 850007560 A KR850007560 A KR 850007560A KR 1019850002510 A KR1019850002510 A KR 1019850002510A KR 850002510 A KR850002510 A KR 850002510A KR 850007560 A KR850007560 A KR 850007560A
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perfluoro compound
dispersion
phase
surfactant
aqueous
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KR1019850002510A
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KR890000524B1 (ko
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맥코믹크 윌리암
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마아커스 다블류 하젤타인 쥬니어
애더맨테크 인코포레이팃드
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    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/21—Esters, e.g. nitroglycerine, selenocyanates
    • A61K31/215—Esters, e.g. nitroglycerine, selenocyanates of carboxylic acids
    • A61K31/25—Esters, e.g. nitroglycerine, selenocyanates of carboxylic acids with polyoxyalkylated alcohols, e.g. esters of polyethylene glycol
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/0012—Galenical forms characterised by the site of application
    • A61K9/0019—Injectable compositions; Intramuscular, intravenous, arterial, subcutaneous administration; Compositions to be administered through the skin in an invasive manner
    • A61K9/0026—Blood substitute; Oxygen transporting formulations; Plasma extender
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/10—Dispersions; Emulsions

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  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Medicinal Chemistry (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Epidemiology (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Emergency Medicine (AREA)
  • Hematology (AREA)
  • Dispersion Chemistry (AREA)
  • Dermatology (AREA)
  • Emulsifying, Dispersing, Foam-Producing Or Wetting Agents (AREA)
  • Colloid Chemistry (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
  • Medicinal Preparation (AREA)
  • Compositions Of Macromolecular Compounds (AREA)
  • Transition And Organic Metals Composition Catalysts For Addition Polymerization (AREA)
  • Agricultural Chemicals And Associated Chemicals (AREA)
  • Addition Polymer Or Copolymer, Post-Treatments, Or Chemical Modifications (AREA)
  • Processes Of Treating Macromolecular Substances (AREA)
  • Paints Or Removers (AREA)

Abstract

내용 없음

Description

퍼플루오로 화합물의 수성분산액의 제조방법
본 내용은 요부공개 건이므로 전문내용을 수록하지 않았음

Claims (10)

  1. (a)(i) 퍼플루오르 화합물과 복합체로 존재하는 기본 계면활성제를 함유하는 퍼플루오로 화합물상과 (ⅱ) 유리상태의 기본 계면활성제를 함유하는 수상으로 구성된 최초분산액을 얻은 다음; (b) 퍼플루오로 화합물상을 농축시키고; (c) 수상의 일부 또는 전부를 농축된 퍼플루오로 화합물상으로 부터 분리하고; (d) 농축된 퍼플루오로 화합물상을 재분산시키기에 효과적인 양의 수성매체에 재분산시켜 최종 분산액을 얻는 것으로 구성된 퍼플루오로 화합물의 수성분산액을 제조하는 방법.
  2. 제1항에 있어서, 단계(c)에서 실질적으로 모든 수상을 퍼플루오로 화합물상으로 부터 분리시키는 방법.
  3. 제1항 또는 제2항에 있어서, 단계(d)에서 농축된 퍼풀루오로 화합물상의 재분산을 촉진시키는데 효과적인 양의 보조계면활성제를 첨가해주는 방법.
  4. 제1항 내지 제3항중 어느 하나에 있어서, 단계(b)의 농축을 원심분리로 수행하는 방법.
  5. 제1항 재지 제4항중 어느 하나에 있어서, 최종분산액중의 기본 계면활성제의 양이 최초분산액중의 양보다 적은 방법.
  6. 제1항 내지 제5항중 어느 하나에 있어서, 퍼플루오로 화합물과 기본 계면활성제의 혼합물을 수성매체내에서 진탕해 줌으로써 최초생성물을 제조하는 방법.
  7. 제1항 내지 제6항중 어느 하나에 있어서, 최초분산액으로 부터 단계(c)에서 분리된 퍼플루오로 화합물상이 어떤 범위의 입자크기를 특징으로하며, 여기서 입자들은 바람직한 입자크기 범위의 물질과 바람직하지 못한 입자크기 범위의 물질로 분류되며, 바람직한 입자크기 범위의 물질이 단계(d)에서 재분산되는 방법.
  8. 제7항에 있어서, 최초분산액을 퍼플루오로 화합물과 기본 계면활성제의 혼합물을 수성매체중에서 진탕하여 줌으로써 제조하며 바람직하지 못한 입자크기 범위의 물질을 상기 초기분산액 제조용 혼합물에 재순환시켜주는 방법.
  9. 제1항 내지 제8항중 어느 하나에 있어서, 퍼플루오로 화합물이 적어도 하나의 탄소원자를 함유하는 다리를 통해 결합된 적어도 2개의 다리목 탄소원자를 함유하는 비-방향족화될 수 있는 퍼플루오로화된 C9-C18다환식 탄화수소이며, 계면활성제가 비이온성인 방법.
  10. 제1항 내지 제8항중 어느 하나에 있어서, 퍼플루오로 화합물이Ｆ-디메틸아다만탄과Ｆ-트리메틸비사이클로 [3.3.1] 노난의 혼합물로 구성된 방법.
    ※ 참고사항 : 최초출원내용에 의하여 공개하는 것임.
KR1019850002510A 1984-04-16 1985-04-15 퍼플루오로 화합물의 수성분산액의 재조방법 KR890000524B1 (ko)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
US60065384A 1984-04-16 1984-04-16
US600653 1984-04-16
US600,653 1984-04-16

Publications (2)

Publication Number Publication Date
KR850007560A true KR850007560A (ko) 1985-12-07
KR890000524B1 KR890000524B1 (ko) 1989-03-20

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ID=24404519

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KR1019850002510A KR890000524B1 (ko) 1984-04-16 1985-04-15 퍼플루오로 화합물의 수성분산액의 재조방법

Country Status (17)

Country Link
EP (1) EP0158996B1 (ko)
JP (1) JPS61181533A (ko)
KR (1) KR890000524B1 (ko)
AT (1) ATE69950T1 (ko)
AU (1) AU581652B2 (ko)
CA (1) CA1257828A (ko)
DE (1) DE3584785D1 (ko)
DK (1) DK166258B (ko)
ES (1) ES8602571A1 (ko)
FI (1) FI84882C (ko)
GR (1) GR850926B (ko)
IL (1) IL74913A (ko)
MX (1) MX167527B (ko)
NO (1) NO171397C (ko)
PH (1) PH21360A (ko)
PT (1) PT80283B (ko)
ZA (1) ZA852544B (ko)

Families Citing this family (14)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
EP0231091B1 (en) * 1986-01-24 1993-03-31 Children's Hospital Medical Center Stable emulsions of highly fluorinated organic compound
US5684050A (en) * 1986-01-24 1997-11-04 Hemagen/Pfc Stable emulsions of highly fluorinated organic compounds
US5514720A (en) * 1986-07-09 1996-05-07 Hemagen/Pfc Stable emulsions of highly fluorinated organic compounds
DE3867924D1 (de) * 1987-06-23 1992-03-05 Eniricerche Spa Ein-phasen-praeparat, das ein perfluoriertes oel und ein oder mehrere oberflaechenaktive stoffe enthaelt, verwendbar als hilfsstoff fuer kosmetische und dermatologische mittel sowie fuer biomedizinische anwendungen.
US5171755A (en) * 1988-04-29 1992-12-15 Hemagen/Pfc Emulsions of highly fluorinated organic compounds
US5114703A (en) * 1989-05-30 1992-05-19 Alliance Pharmaceutical Corp. Percutaneous lymphography using particulate fluorocarbon emulsions
US5403575A (en) * 1991-12-12 1995-04-04 Hemagen/Pfc Highly fluorinated, chloro-substituted organic compound-containing emulsions and methods of using them
FR2688006A1 (fr) * 1992-02-27 1993-09-03 Oreal Dispersion d'un hydrocarbure fluore dans une solution aqueuse d'un polymere filmogene et son utilisation pour la formation de films composites notamment en cosmetique.
FR2696931B1 (fr) * 1992-10-21 1994-12-30 Oreal Emulsions eau dans l'huile à phase continue fluorohydrocarbonée et utilisation de certains tensioactifs siliconés pour leur préparation.
FR2710840B1 (fr) * 1993-10-04 1995-12-01 Applic Transferts Technolo Compositions viscoélastiques hautement concentrées en composés fluorés, leur préparation et leurs utilisations dans le domaine médical et en cosmétique.
US5502094A (en) * 1994-05-20 1996-03-26 Minnesota Mining And Manufacturing Company Physiologically acceptable emulsions containing perfluorocarbon ether hydrides and methods for use
US5658962A (en) * 1994-05-20 1997-08-19 Minnesota Mining And Manufacturing Company Omega-hydrofluoroalkyl ethers, precursor carboxylic acids and derivatives thereof, and their preparation and application
US5614170A (en) * 1994-11-30 1997-03-25 Hemagen/Pfc Paramagnetic complexes of N-alkyl-N-hydroxylamides of organic acids and emulsions containing same for magnetic resonance imaging (MRI)
GB0625071D0 (en) * 2006-12-15 2007-01-24 3M Innovative Properties Co Process for removing fluorinated emulsifier from fluoropolmer dispersions using an ion-exchange resin and dispersions obtained therefrom

Family Cites Families (5)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US3958014A (en) * 1970-09-05 1976-05-18 The Green Cross Corporation Process for preparing injection-purpose fluorocarbon emulsion capable of carrying oxygen
US3760090A (en) * 1971-08-19 1973-09-18 Globe Union Inc Electronic circuit package and method for making same
US4105798A (en) * 1976-07-19 1978-08-08 Sun Ventures, Inc. Perfluoro polycyclic compounds for use as synthetic blood and perfusion media
JPS5841814A (ja) * 1981-08-10 1983-03-11 ザ・ウエルカム・フアウンデ−シヨン・リミテツド 抗レ−シユマニア症薬剤組成物およびその製造法
AU559559B2 (en) * 1982-08-17 1987-03-12 Suntech, Inc. Perfluorocarbon emulsions and their preparation and use in therapy

Also Published As

Publication number Publication date
NO851503L (no) 1985-10-17
DE3584785D1 (de) 1992-01-16
AU581652B2 (en) 1989-03-02
PH21360A (en) 1987-10-15
IL74913A (en) 1988-07-31
EP0158996A2 (en) 1985-10-23
NO171397C (no) 1993-03-10
EP0158996B1 (en) 1991-12-04
CA1257828A (en) 1989-07-25
PT80283A (en) 1985-05-01
EP0158996A3 (en) 1987-04-29
DK140985D0 (da) 1985-03-28
GR850926B (ko) 1985-11-25
FI851502A0 (fi) 1985-04-15
JPS61181533A (ja) 1986-08-14
MX167527B (es) 1993-03-29
ES542140A0 (es) 1985-12-16
ES8602571A1 (es) 1985-12-16
ATE69950T1 (de) 1991-12-15
DK140985A (da) 1985-10-17
AU4129085A (en) 1985-10-24
ZA852544B (en) 1985-12-24
NO171397B (no) 1992-11-30
FI851502L (fi) 1985-10-17
FI84882B (fi) 1991-10-31
PT80283B (pt) 1987-06-17
IL74913A0 (en) 1985-08-30
FI84882C (fi) 1992-02-10
DK166258B (da) 1993-03-29
KR890000524B1 (ko) 1989-03-20

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