KR850004498A - 밀베마이신 유도체의 제조방법 - Google Patents
밀베마이신 유도체의 제조방법 Download PDFInfo
- Publication number
- KR850004498A KR850004498A KR1019840008551A KR840008551A KR850004498A KR 850004498 A KR850004498 A KR 850004498A KR 1019840008551 A KR1019840008551 A KR 1019840008551A KR 840008551 A KR840008551 A KR 840008551A KR 850004498 A KR850004498 A KR 850004498A
- Authority
- KR
- South Korea
- Prior art keywords
- derivative
- general formula
- following general
- milbamycin
- preparing
- Prior art date
Links
- 125000002252 acyl group Chemical group 0.000 claims 1
- 239000003153 chemical reaction reagent Substances 0.000 claims 1
- 125000001495 ethyl group Chemical group [H]C([H])([H])C([H])([H])* 0.000 claims 1
- 229910052739 hydrogen Inorganic materials 0.000 claims 1
- 239000001257 hydrogen Substances 0.000 claims 1
- 125000004435 hydrogen atom Chemical class [H]* 0.000 claims 1
- 125000001449 isopropyl group Chemical group [H]C([H])([H])C([H])(*)C([H])([H])[H] 0.000 claims 1
- 125000002496 methyl group Chemical group [H]C([H])([H])* 0.000 claims 1
- 125000001181 organosilyl group Chemical group [SiH3]* 0.000 claims 1
- 239000002904 solvent Substances 0.000 claims 1
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07H—SUGARS; DERIVATIVES THEREOF; NUCLEOSIDES; NUCLEOTIDES; NUCLEIC ACIDS
- C07H15/00—Compounds containing hydrocarbon or substituted hydrocarbon radicals directly attached to hetero atoms of saccharide radicals
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07H—SUGARS; DERIVATIVES THEREOF; NUCLEOSIDES; NUCLEOTIDES; NUCLEIC ACIDS
- C07H19/00—Compounds containing a hetero ring sharing one ring hetero atom with a saccharide radical; Nucleosides; Mononucleotides; Anhydro-derivatives thereof
- C07H19/01—Compounds containing a hetero ring sharing one ring hetero atom with a saccharide radical; Nucleosides; Mononucleotides; Anhydro-derivatives thereof sharing oxygen
-
- A—HUMAN NECESSITIES
- A01—AGRICULTURE; FORESTRY; ANIMAL HUSBANDRY; HUNTING; TRAPPING; FISHING
- A01N—PRESERVATION OF BODIES OF HUMANS OR ANIMALS OR PLANTS OR PARTS THEREOF; BIOCIDES, e.g. AS DISINFECTANTS, AS PESTICIDES OR AS HERBICIDES; PEST REPELLANTS OR ATTRACTANTS; PLANT GROWTH REGULATORS
- A01N43/00—Biocides, pest repellants or attractants, or plant growth regulators containing heterocyclic compounds
- A01N43/90—Biocides, pest repellants or attractants, or plant growth regulators containing heterocyclic compounds having two or more relevant hetero rings, condensed among themselves or with a common carbocyclic ring system
-
- A—HUMAN NECESSITIES
- A01—AGRICULTURE; FORESTRY; ANIMAL HUSBANDRY; HUNTING; TRAPPING; FISHING
- A01N—PRESERVATION OF BODIES OF HUMANS OR ANIMALS OR PLANTS OR PARTS THEREOF; BIOCIDES, e.g. AS DISINFECTANTS, AS PESTICIDES OR AS HERBICIDES; PEST REPELLANTS OR ATTRACTANTS; PLANT GROWTH REGULATORS
- A01N55/00—Biocides, pest repellants or attractants, or plant growth regulators, containing organic compounds containing elements other than carbon, hydrogen, halogen, oxygen, nitrogen and sulfur
Landscapes
- Life Sciences & Earth Sciences (AREA)
- Chemical & Material Sciences (AREA)
- General Health & Medical Sciences (AREA)
- Organic Chemistry (AREA)
- Health & Medical Sciences (AREA)
- Engineering & Computer Science (AREA)
- Wood Science & Technology (AREA)
- Dentistry (AREA)
- Plant Pathology (AREA)
- Zoology (AREA)
- Environmental Sciences (AREA)
- Pest Control & Pesticides (AREA)
- Biochemistry (AREA)
- Biotechnology (AREA)
- Genetics & Genomics (AREA)
- Molecular Biology (AREA)
- Agronomy & Crop Science (AREA)
- Heterocyclic Carbon Compounds Containing A Hetero Ring Having Oxygen Or Sulfur (AREA)
Abstract
내용 없음
Description
본 내용은 요부공개 건이므로 전문내용을 수록하지 않았음
Claims (1)
- 하기 일반식(Ⅲ)의 14.15―에폭시―밀베마이신 유도체를, 불활성 무수 용매상중의 ―30°내지 +10℃의 온도에서, 복합시약 [HN3]m/[AlC3]n과 반응시킴을 특징으로 하여, 하기 일반식(Ⅰ)의 14―아지도―15―히드록시―밀베마이신 유도체 및 하기 일반식(Ⅱ)의 15―히드록시―△13.14―밀베마이신 유도체를 제조하는 방법.상기식에서, R1은 수소, 실릴기 또는 아실기이고, R2는 메틸, 에틸, 이소프로필 또는 2급―부틸이고, m 및 n은 각각 독립적으로, 1 또는 2이거나 1내지 2의 값이다.※ 참고사항 : 최초출원 내용에 의하여 공개하는 것임.
Applications Claiming Priority (4)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CH698783 | 1983-12-30 | ||
| CH411884 | 1984-08-28 | ||
| CH4118/84-0 | 1984-08-28 | ||
| CH6987/839 | 1985-12-30 |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| KR850004498A true KR850004498A (ko) | 1985-07-15 |
Family
ID=25694713
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| KR1019840008551A KR850004498A (ko) | 1983-12-30 | 1984-12-29 | 밀베마이신 유도체의 제조방법 |
Country Status (5)
| Country | Link |
|---|---|
| EP (1) | EP0147852A3 (ko) |
| KR (1) | KR850004498A (ko) |
| AU (1) | AU579599B2 (ko) |
| DK (1) | DK614084A (ko) |
| IL (1) | IL73965A (ko) |
Families Citing this family (12)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US4582852A (en) * | 1983-11-02 | 1986-04-15 | Ciba-Geigy Corporation | 14- and 15-hydroxy milbemycin derivatives for controlling plant and animal parasites |
| US4584314A (en) * | 1983-11-25 | 1986-04-22 | Ciba-Geigy Corporation | Lactone derivative, process for the preparation thereof, and use thereof in pest control |
| FI860233A (fi) * | 1985-01-22 | 1986-07-23 | Ciba Geigy Ag | 13 -alkyl-milbemycinderivat foer bekaempning av parasiter hos djur och vaexter. |
| JPH0678342B2 (ja) * | 1986-01-07 | 1994-10-05 | 三共株式会社 | 新規マクロライド化合物 |
| EP0237482A1 (de) * | 1986-03-06 | 1987-09-16 | Ciba-Geigy Ag | C(29)-Carbonyloxi-milbemycin-Derivate zur Bekämpfung von tier- und pflanzenparasitären Schädlingen |
| NZ219467A (en) * | 1986-03-07 | 1990-03-27 | Ciba Geigy Ag | 5-acyloxy 13b-alkyl milbemycins and parasiticidal compositions |
| US4897416A (en) * | 1987-02-18 | 1990-01-30 | Ciba-Geigy Corporation | Insecticides and parasiticides |
| US4855317A (en) * | 1987-03-06 | 1989-08-08 | Ciba-Geigy Corporation | Insecticides and parasiticides |
| US4851428A (en) * | 1987-03-06 | 1989-07-25 | American Cyanamid Company | Mono- and diepoxide derivatives of Δ22-LL-F28249 compounds |
| US4886830A (en) * | 1987-03-06 | 1989-12-12 | American Cyanamid Company | Mono- and diepoxide derivatives of 23-deoxyl-LL-F28249 compounds |
| US4806527A (en) * | 1987-03-16 | 1989-02-21 | Merck & Co., Inc. | Avermectin derivatives |
| CN111217828B (zh) * | 2018-11-26 | 2022-11-25 | 浙江海正药业股份有限公司 | 一种乐平霉素的制备方法及其中间体 |
Family Cites Families (4)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| JPS57139080A (en) * | 1981-02-23 | 1982-08-27 | Sankyo Co Ltd | 14,15-epoxy derivative of antibiotic substance b-41 and its preparation |
| US4530921A (en) * | 1983-10-03 | 1985-07-23 | Merck & Co., Inc. | Avermectin epoxide derivatives and method of use |
| US4582852A (en) * | 1983-11-02 | 1986-04-15 | Ciba-Geigy Corporation | 14- and 15-hydroxy milbemycin derivatives for controlling plant and animal parasites |
| US4584314A (en) * | 1983-11-25 | 1986-04-22 | Ciba-Geigy Corporation | Lactone derivative, process for the preparation thereof, and use thereof in pest control |
-
1984
- 1984-12-20 DK DK614084A patent/DK614084A/da not_active Application Discontinuation
- 1984-12-27 EP EP84116374A patent/EP0147852A3/de not_active Withdrawn
- 1984-12-28 AU AU37194/84A patent/AU579599B2/en not_active Expired - Fee Related
- 1984-12-28 IL IL73965A patent/IL73965A/xx unknown
- 1984-12-29 KR KR1019840008551A patent/KR850004498A/ko not_active Application Discontinuation
Also Published As
| Publication number | Publication date |
|---|---|
| AU579599B2 (en) | 1988-12-01 |
| EP0147852A3 (de) | 1986-06-11 |
| DK614084D0 (da) | 1984-12-20 |
| IL73965A (en) | 1988-03-31 |
| DK614084A (da) | 1985-07-01 |
| AU3719484A (en) | 1985-07-04 |
| EP0147852A2 (de) | 1985-07-10 |
| IL73965A0 (en) | 1985-03-31 |
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Legal Events
| Date | Code | Title | Description |
|---|---|---|---|
| WITN | Application deemed withdrawn, e.g. because no request for examination was filed or no examination fee was paid |