KR840007408A - ±2-[(3,4-메틸렌디옥시)페네틸]-5-](3-카복스아미도-4-하이드록시)-α-하이드록시벤질] 피롤리딘의 제조방법 - Google Patents

±2-[(3,4-메틸렌디옥시)페네틸]-5-](3-카복스아미도-4-하이드록시)-α-하이드록시벤질] 피롤리딘의 제조방법 Download PDF

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Publication number
KR840007408A
KR840007408A KR1019840000278A KR840000278A KR840007408A KR 840007408 A KR840007408 A KR 840007408A KR 1019840000278 A KR1019840000278 A KR 1019840000278A KR 840000278 A KR840000278 A KR 840000278A KR 840007408 A KR840007408 A KR 840007408A
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KR
South Korea
Prior art keywords
compound
formula
carboxamido
hydroxybenzyl
hydroxy
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KR1019840000278A
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English (en)
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무쵸스키(외 5) 죠셉마틴
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원본미기재
신텍스(유. 에스. 에이) 인코포레이티드
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Application filed by 원본미기재, 신텍스(유. 에스. 에이) 인코포레이티드 filed Critical 원본미기재
Publication of KR840007408A publication Critical patent/KR840007408A/ko

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    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D295/00—Heterocyclic compounds containing polymethylene-imine rings with at least five ring members, 3-azabicyclo [3.2.2] nonane, piperazine, morpholine or thiomorpholine rings, having only hydrogen atoms directly attached to the ring carbon atoms
    • C07D295/04—Heterocyclic compounds containing polymethylene-imine rings with at least five ring members, 3-azabicyclo [3.2.2] nonane, piperazine, morpholine or thiomorpholine rings, having only hydrogen atoms directly attached to the ring carbon atoms with substituted hydrocarbon radicals attached to ring nitrogen atoms
    • C07D295/10—Heterocyclic compounds containing polymethylene-imine rings with at least five ring members, 3-azabicyclo [3.2.2] nonane, piperazine, morpholine or thiomorpholine rings, having only hydrogen atoms directly attached to the ring carbon atoms with substituted hydrocarbon radicals attached to ring nitrogen atoms substituted by doubly bound oxygen or sulphur atoms
    • C07D295/104—Heterocyclic compounds containing polymethylene-imine rings with at least five ring members, 3-azabicyclo [3.2.2] nonane, piperazine, morpholine or thiomorpholine rings, having only hydrogen atoms directly attached to the ring carbon atoms with substituted hydrocarbon radicals attached to ring nitrogen atoms substituted by doubly bound oxygen or sulphur atoms with the ring nitrogen atoms and the doubly bound oxygen or sulfur atoms attached to the same carbon chain, which is not interrupted by carbocyclic rings
    • C07D295/108—Heterocyclic compounds containing polymethylene-imine rings with at least five ring members, 3-azabicyclo [3.2.2] nonane, piperazine, morpholine or thiomorpholine rings, having only hydrogen atoms directly attached to the ring carbon atoms with substituted hydrocarbon radicals attached to ring nitrogen atoms substituted by doubly bound oxygen or sulphur atoms with the ring nitrogen atoms and the doubly bound oxygen or sulfur atoms attached to the same carbon chain, which is not interrupted by carbocyclic rings to an acyclic saturated chain
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D317/00—Heterocyclic compounds containing five-membered rings having two oxygen atoms as the only ring hetero atoms
    • C07D317/08—Heterocyclic compounds containing five-membered rings having two oxygen atoms as the only ring hetero atoms having the hetero atoms in positions 1 and 3
    • C07D317/44—Heterocyclic compounds containing five-membered rings having two oxygen atoms as the only ring hetero atoms having the hetero atoms in positions 1 and 3 ortho- or peri-condensed with carbocyclic rings or ring systems
    • C07D317/46—Heterocyclic compounds containing five-membered rings having two oxygen atoms as the only ring hetero atoms having the hetero atoms in positions 1 and 3 ortho- or peri-condensed with carbocyclic rings or ring systems condensed with one six-membered ring
    • C07D317/48—Methylenedioxybenzenes or hydrogenated methylenedioxybenzenes, unsubstituted on the hetero ring
    • C07D317/50—Methylenedioxybenzenes or hydrogenated methylenedioxybenzenes, unsubstituted on the hetero ring with only hydrogen atoms, hydrocarbon or substituted hydrocarbon radicals, directly attached to atoms of the carbocyclic ring
    • C07D317/60—Radicals substituted by carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D405/00—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom
    • C07D405/02—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom containing two hetero rings
    • C07D405/06—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom containing two hetero rings linked by a carbon chain containing only aliphatic carbon atoms

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  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Pyrrole Compounds (AREA)
  • Amplifiers (AREA)
  • Separation Using Semi-Permeable Membranes (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)

Abstract

내용 없음.

Description

±2-〔(3,4-메틸렌디옥시)페네틸〕-5-〔(3-카복스아마이도-4-하이드록시)-α-하이드록시벤질〕피롤리딘의 제조방법
본 내용은 요부공개 건이므로 전문내용을 수록하지 않았음

Claims (8)

  1. 하기 일반식(A)의 화합물을 탈보호시키거나, 또는 하기 구조식(1)의 유리 염기를 염으로 전환시키거나, 또는 구조식(1)의 하나의 염을 구조식(1)의 다른 염으로 전환시키거나, 또는 구조식(1)의 염을 구조식(1)의 염을 구조식(1)의 유리염기로 전환시켜서 이루어지는 구조식(1)의 화합물, 즉 ±2-〔(3,4-메틸렌디옥시)페네틸〕-5-〔(3-카복스아마이도-4-하이드록시)-α-하이드록시벤질〕피롤리딘 및 그의 약학적으로 허용되는 산부가염의 제조방법.
    상기식에서, Q는 보호 그룹이다.
  2. 제1항에 있어서, 화합물의 시스 이성체의 제조방법.
  3. 제2항에 있어서, 하기 구조식의 화합물, 그의 에난티오머, 및 그들의 라세미 혼합물, 즉, (±), (+) 및 (-)시스 에리트로 2-〔(3,4-메틸렌디옥시)페네틸〕-5-〔(3-카복스아마이도-4-하이드록시)-α-하이드록시벤질〕피롤리딘 및 그의 약학적으로 허용되는 산부가염의 제조방법.
  4. 제3항에 있어서, 그의 약학적으로 허용되는 염으로써 ± 시스 에리트로 2-〔(3,4-메틸렌디옥시)-페네틸〕-5-〔(3-카복스아마이도-4-하이드록시)-α-하이드록시벤질〕피롤리딘의 제조방법.
  5. 제12항에 있어서, 하기 구조식의 화합물, 그의 에난티오머, 및 그들의 라세미 혼합물, 즉, (±), (+), 및 (-) 시스 트레오 2-〔(3,4-메틸렌디옥시)페네틸〕-5-〔(3-카복스아마이도-4-하이드록시)-α-하이드록시벤질〕피롤리딘 및 그들의 약학적으로 허용되는 산부가염의 제조방법.
  6. 제1항에 있어서, 화합물의 트랜스 이성체의 제조방법.
  7. 제6항에 있어서, 하기 구조식의 화합물, 그의 에난티오머, 및 그들의 라세미 혼합물, 즉 (±), (+), 및 (-)트랜스 에리트로 2-〔(3,4-메틸렌디옥시)페네틸〕-5-〔(3-카복스아마이도-4-하이드록시)-α-하이드록시벤질〕 및 그들의 약학적으로 허용되는 산부가염의 제조방법.
  8. 제6항에 있어서, 하기 구조식의 화합물, 그의 에난티오머, 및 그들의 라세미 혼합물, 즉, (±), (+), 및 (-) 트랜스트레오 2-〔(3,4-메틸렌디옥시)페네틸〕-5-〔(3-카복스아마이도-4-하이드록시)-α-하이드록시벤질〕 및 그들의 약학적으로 허용되는 산부가염의 제조방법.
    ※ 참고사항 : 최초출원 내용에 의하여 공개하는 것임.
KR1019840000278A 1983-01-24 1984-01-23 ±2-[(3,4-메틸렌디옥시)페네틸]-5-](3-카복스아미도-4-하이드록시)-α-하이드록시벤질] 피롤리딘의 제조방법 KR840007408A (ko)

Applications Claiming Priority (4)

Application Number Priority Date Filing Date Title
US46020483A 1983-01-24 1983-01-24
US460204 1983-01-24
US527716 1983-08-29
US06/527,716 US4548949A (en) 1983-01-24 1983-08-29 +2-[(3,4-Methylenedioxy)phenethyl]-5-[(3-carboxamido-4-hydroxy)-α-hydroxybenzyl]pyrrolidines

Publications (1)

Publication Number Publication Date
KR840007408A true KR840007408A (ko) 1984-12-07

Family

ID=27039598

Family Applications (1)

Application Number Title Priority Date Filing Date
KR1019840000278A KR840007408A (ko) 1983-01-24 1984-01-23 ±2-[(3,4-메틸렌디옥시)페네틸]-5-](3-카복스아미도-4-하이드록시)-α-하이드록시벤질] 피롤리딘의 제조방법

Country Status (5)

Country Link
US (1) US4548949A (ko)
KR (1) KR840007408A (ko)
AT (1) ATE23528T1 (ko)
DE (1) DE3461281D1 (ko)
DK (1) DK30284A (ko)

Families Citing this family (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
ATE215079T1 (de) * 1992-07-24 2002-04-15 Univ California Arzneimittel, die den durch ampa rezeptoren vermittelten synaptischen respons erhöhen
US5852008A (en) * 1995-01-24 1998-12-22 The Regents Of The University Of California Heteroatom substituted benzoyl derivatives that enhance synaptic response mediated by receptors

Family Cites Families (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US4342692A (en) * 1980-10-20 1982-08-03 Usv Pharmaceutical Corporation Pyrrolidines

Also Published As

Publication number Publication date
US4548949A (en) 1985-10-22
DE3461281D1 (en) 1987-01-02
DK30284D0 (da) 1984-01-23
ATE23528T1 (de) 1986-11-15
DK30284A (da) 1984-07-25

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