KR840004577A - 액체 크로마토그라피 시스템용 장치 - Google Patents

액체 크로마토그라피 시스템용 장치 Download PDF

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KR840004577A
KR840004577A KR1019830001744A KR830001744A KR840004577A KR 840004577 A KR840004577 A KR 840004577A KR 1019830001744 A KR1019830001744 A KR 1019830001744A KR 830001744 A KR830001744 A KR 830001744A KR 840004577 A KR840004577 A KR 840004577A
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column
columns
sealing
separation
disk
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KR1019830001744A
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KR900008957B1 (ko
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엘. 루이텐(외 3) 헨리
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이. 제이. 메비우스
듀파 인터내쇼날 리서취 비. 브이.
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    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N30/00—Investigating or analysing materials by separation into components using adsorption, absorption or similar phenomena or using ion-exchange, e.g. chromatography or field flow fractionation
    • G01N30/02—Column chromatography
    • G01N30/26—Conditioning of the fluid carrier; Flow patterns
    • G01N30/38—Flow patterns
    • G01N30/46—Flow patterns using more than one column
    • G01N30/461—Flow patterns using more than one column with serial coupling of separation columns
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01D—SEPARATION
    • B01D15/00—Separating processes involving the treatment of liquids with solid sorbents; Apparatus therefor
    • B01D15/08—Selective adsorption, e.g. chromatography
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01D—SEPARATION
    • B01D15/00—Separating processes involving the treatment of liquids with solid sorbents; Apparatus therefor
    • B01D15/08—Selective adsorption, e.g. chromatography
    • B01D15/10—Selective adsorption, e.g. chromatography characterised by constructional or operational features
    • B01D15/12—Selective adsorption, e.g. chromatography characterised by constructional or operational features relating to the preparation of the feed
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N30/00—Investigating or analysing materials by separation into components using adsorption, absorption or similar phenomena or using ion-exchange, e.g. chromatography or field flow fractionation
    • G01N30/02—Column chromatography
    • G01N30/04—Preparation or injection of sample to be analysed
    • G01N30/06—Preparation
    • G01N30/08—Preparation using an enricher
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N30/00—Investigating or analysing materials by separation into components using adsorption, absorption or similar phenomena or using ion-exchange, e.g. chromatography or field flow fractionation
    • G01N30/02—Column chromatography
    • G01N30/04—Preparation or injection of sample to be analysed
    • G01N30/06—Preparation
    • G01N30/08—Preparation using an enricher
    • G01N2030/085—Preparation using an enricher using absorbing precolumn
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N30/00—Investigating or analysing materials by separation into components using adsorption, absorption or similar phenomena or using ion-exchange, e.g. chromatography or field flow fractionation
    • G01N30/02—Column chromatography
    • G01N30/60—Construction of the column
    • G01N30/6004—Construction of the column end pieces
    • G01N30/6017—Fluid distributors
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N30/00—Investigating or analysing materials by separation into components using adsorption, absorption or similar phenomena or using ion-exchange, e.g. chromatography or field flow fractionation
    • G01N30/02—Column chromatography
    • G01N30/60—Construction of the column
    • G01N30/6052—Construction of the column body
    • G01N30/6065—Construction of the column body with varying cross section

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  • Chemical & Material Sciences (AREA)
  • Analytical Chemistry (AREA)
  • General Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Health & Medical Sciences (AREA)
  • Biochemistry (AREA)
  • Physics & Mathematics (AREA)
  • General Physics & Mathematics (AREA)
  • Immunology (AREA)
  • Pathology (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Treatment Of Liquids With Adsorbents In General (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)

Abstract

내용 없음

Description

액체 크로마토그라피 시스템용 장치
본 내용은 요부공개 건이므로 전문내용을 수록하지 않았음
제1도 및 제2도는 본 발명에 의한 예비컬럼(pre-columns)의 종단면도.
제14도는 제3도에 도시한 예비컬럼을 사용한 미량의 N-(2,6-디플루오로벤조일)-N'-(4-트리플루오로-메틸페닐)우레아 및 그의 대사 산물을 함유한 뇨의 크로마토그라피에서 측정한 분당 방사능을 나타낸 그래프.

Claims (10)

  1. 양쪽 단부로 내부가 좁고, 상류에는 전 농축시킬 액체의 입구관과, 하류에는 분리컬럼과 실링(seaing)연결한 장치를 가진 용기 형태의 몸체로 구성됨을 특징으로하는, 승압에서 크로마토 그리피할 물질의 전농축용 압력-저항 물질의 예비컬럼.
  2. 제1항에 있어서, 용기형태의 몸체의 내벽이 양쪽단부를 향하여 원추형으로 좁아지거나 한점으로 집중함을 특징으로 하는 컬럼.
  3. 제1항 또는 제2항에 있어서, 연결장치가 용기형태 몸체의 양쪽 단부에서 서로 상반되게 존재함을 특징으로하는 특징으로 하는 컬럼.
  4. 제1항 내지 제3항중 어느 하나에 있어서, 용기형태 몸체의 내부벽이 하류단부 방향에서 보다 상류단부 방향에서 더 심하게 좁아짐을 특징으로하는 컬럼.
  5. 상기 제1항 내지 제4항중 어느 하나에 있어서, 용기형태 몸체의 하류구멍 직경이, 예비 컬럼에 연결되는 분리컬럼의 직경과 거의 일치함을 특징으로하는 컬럼.
  6. 상기 제1항 내지 제5항중 어느 하나에 있어서, 용기 형태의 몸체가 압력-저항방법으로 함께 연결된 2개 또는 그 이상의 부분으로 구성됨을 특징으로 하는 컬럼.
  7. 하나 또는 그 이상의 예비컬럼, 예비컬럼 또는 컬럼들 및 액체 입구관을, 또는 하나 또는 그 이상의 분리컬럼 및 용출액의 출구관을 커플링하는 부재(member), 및 임의로 하나 또는 그 이상의 분리컬럼으로 구성된 장치에 있어서, 상기 항에서 기술한 하나 또는 그 이상의 예비 컬럼을 포함함을 특징으로 하는 액체 크로마토그라피 시스템용 장치.
  8. 제7항에 있어서, 디스크중 하나는 예비컬럼 또는 컬럼들 및 액체의 입구관을 실링 연결시킬 수 있는 구멍을 가지며, 나머지 디스크는 분리컬럼 또는 컬럼들 및 용출액의 출구관을 실링 연결시킬 수 있는 구멍을 가졌으며, 이 두 디스크상의 구멍은 임의로 각각 서로 상대편에 대하여 한 디스크를 회전하여 서로 연통하도록 만들어진, 상호 실링 연결에서 서로 각각에 대하여 회전하는 2개의 동심 디스크로 구성된 커플링 부재를 특징으로 하는 장치.
  9. 하나 또는 그 이상의 예비컬럼, 예비컬럼 또는 컬럼들 및 액체를 입구관을, 또는 하나 또는 그 이상의 분리 컬럼 및 용출액의 출구관을 커플링시키기 위한 부재 및 임의로 하나 또는 그 이상의 분리컬럼을 포함한 장치에 있어서, 제8항의 커플링 부재를 포함함을 특징으로하는 액체 크로마토그라피 시스템용 장치.
  10. 상호 실링 연결되어 각각에 대하여 회전할 수 있고, 예비컬럼 또는 컬럼들 및 액체의 입구관을 한 디스크에 실링 연결할 수 있는 구멍 및 분리 컬럼 또는 컬럼 및 용출액의 출구관을 나머지 디스크에 실링 연결할 수 있는 구멍을 가지며 이 두 디스크상의 구멍은 임의로 서로 상대편의 디스크에 대하여 한 디스크를 회전시켜 서로 연통하도록 만들어진 2개의 동심 디스크를 함유함을 특징으로한, 제8항 또는 제9항의 장치에 사용되는 커플링 부재.
    ※ 참고사항 : 최초출원 내용에 의하여 공개하는 것임.
KR1019830001744A 1982-04-28 1983-04-25 액체 크로마토그라피 시스템용 장치 KR900008957B1 (ko)

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NL8201757 1982-04-28
NL8201757 1982-04-28

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KR900008957B1 KR900008957B1 (ko) 1990-12-15

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US (1) US4554071A (ko)
EP (1) EP0092860B1 (ko)
JP (1) JPS58196455A (ko)
KR (1) KR900008957B1 (ko)
AT (1) ATE20829T1 (ko)
AU (1) AU558353B2 (ko)
CA (2) CA1203224A (ko)
DE (1) DE3364639D1 (ko)
DK (1) DK163801C (ko)
ES (2) ES279037Y (ko)
IL (1) IL68480A0 (ko)
ZA (1) ZA832902B (ko)

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Publication number Publication date
DK163801C (da) 1992-09-07
KR900008957B1 (ko) 1990-12-15
CA1205751A (en) 1986-06-10
DK163801B (da) 1992-04-06
EP0092860A1 (en) 1983-11-02
EP0092860B1 (en) 1986-07-23
ES8402165A1 (es) 1984-01-16
AU558353B2 (en) 1987-01-29
US4554071A (en) 1985-11-19
AU1388983A (en) 1983-11-03
ZA832902B (en) 1984-01-25
DE3364639D1 (en) 1986-08-28
ATE20829T1 (de) 1986-08-15
ES521816A0 (es) 1984-01-16
DK182383D0 (da) 1983-04-25
DK182383A (da) 1983-10-29
CA1203224A (en) 1986-04-15
JPH0546499B2 (ko) 1993-07-14
ES279037U (es) 1984-12-01
ES279037Y (es) 1985-06-01
IL68480A0 (en) 1983-07-31
JPS58196455A (ja) 1983-11-15

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