KR840000582A - 4α, 5α-에폭시-3, 20-디옥소프레그난 -2α, 16α-디카르보니트릴 및 중간체의 제조방법 - Google Patents

4α, 5α-에폭시-3, 20-디옥소프레그난 -2α, 16α-디카르보니트릴 및 중간체의 제조방법 Download PDF

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Publication number
KR840000582A
KR840000582A KR1019820002696A KR820002696A KR840000582A KR 840000582 A KR840000582 A KR 840000582A KR 1019820002696 A KR1019820002696 A KR 1019820002696A KR 820002696 A KR820002696 A KR 820002696A KR 840000582 A KR840000582 A KR 840000582A
Authority
KR
South Korea
Prior art keywords
isoxazole
pregna
carbonitrile
ino
epoxy
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Withdrawn
Application number
KR1019820002696A
Other languages
English (en)
Korean (ko)
Inventor
죠오지 크리스챤센 로버어트 (외 2)
Original Assignee
제이므즈 에이취 루우서
스터어링 드럭그 인코포레이팃드
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by 제이므즈 에이취 루우서, 스터어링 드럭그 인코포레이팃드 filed Critical 제이므즈 에이취 루우서
Publication of KR840000582A publication Critical patent/KR840000582A/ko
Withdrawn legal-status Critical Current

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07J—STEROIDS
    • C07J1/00—Normal steroids containing carbon, hydrogen, halogen or oxygen, not substituted in position 17 beta by a carbon atom, e.g. estrane, androstane
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07J—STEROIDS
    • C07J71/00—Steroids in which the cyclopenta(a)hydrophenanthrene skeleton is condensed with a heterocyclic ring
    • C07J71/0036—Nitrogen-containing hetero ring
    • C07J71/0057—Nitrogen and oxygen
    • C07J71/0063—Nitrogen and oxygen at position 2(3)
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P5/00—Drugs for disorders of the endocrine system
    • A61P5/38—Drugs for disorders of the endocrine system of the suprarenal hormones
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07J—STEROIDS
    • C07J71/00—Steroids in which the cyclopenta(a)hydrophenanthrene skeleton is condensed with a heterocyclic ring
    • C07J71/0005—Oxygen-containing hetero ring
    • C07J71/001—Oxiranes

Landscapes

  • Organic Chemistry (AREA)
  • Chemical & Material Sciences (AREA)
  • Health & Medical Sciences (AREA)
  • General Health & Medical Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Medicinal Chemistry (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Endocrinology (AREA)
  • Diabetes (AREA)
  • Animal Behavior & Ethology (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Steroid Compounds (AREA)
  • Heterocyclic Carbon Compounds Containing A Hetero Ring Having Nitrogen And Oxygen As The Only Ring Hetero Atoms (AREA)
KR1019820002696A 1981-06-19 1982-06-17 4α, 5α-에폭시-3, 20-디옥소프레그난 -2α, 16α-디카르보니트릴 및 중간체의 제조방법 Withdrawn KR840000582A (ko)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US275-294 1981-06-19
US06/275,294 US4331663A (en) 1981-06-19 1981-06-19 4α,5α-Epoxy-3,20-dioxopregnane-2α,16α-dicarbonitrile and intermediates and process for preparation, method of use and compositions thereof

Publications (1)

Publication Number Publication Date
KR840000582A true KR840000582A (ko) 1984-02-25

Family

ID=23051676

Family Applications (1)

Application Number Title Priority Date Filing Date
KR1019820002696A Withdrawn KR840000582A (ko) 1981-06-19 1982-06-17 4α, 5α-에폭시-3, 20-디옥소프레그난 -2α, 16α-디카르보니트릴 및 중간체의 제조방법

Country Status (8)

Country Link
US (1) US4331663A (GUID-C5D7CC26-194C-43D0-91A1-9AE8C70A9BFF.html)
EP (1) EP0072894A1 (GUID-C5D7CC26-194C-43D0-91A1-9AE8C70A9BFF.html)
JP (1) JPS581000A (GUID-C5D7CC26-194C-43D0-91A1-9AE8C70A9BFF.html)
KR (1) KR840000582A (GUID-C5D7CC26-194C-43D0-91A1-9AE8C70A9BFF.html)
AU (1) AU8427982A (GUID-C5D7CC26-194C-43D0-91A1-9AE8C70A9BFF.html)
DK (1) DK274882A (GUID-C5D7CC26-194C-43D0-91A1-9AE8C70A9BFF.html)
GR (1) GR75942B (GUID-C5D7CC26-194C-43D0-91A1-9AE8C70A9BFF.html)
NZ (1) NZ200779A (GUID-C5D7CC26-194C-43D0-91A1-9AE8C70A9BFF.html)

Families Citing this family (5)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JPS59221293A (ja) * 1983-05-26 1984-12-12 株式会社東京タツノ 給油装置
US4755595A (en) * 1985-11-01 1988-07-05 Sterling Drug Inc. Enhanced production of 4,5-unsaturated steroids utilizing methanol solvation
JP3226807B2 (ja) 1996-11-20 2001-11-05 静岡日本電気株式会社 無線呼出システム用の自動周波数補正装置および自動周波数補正方法
GB2375958B (en) * 2001-04-09 2005-03-02 George Margetts The use of steroids to lower the levels of cortisol
GB2400554B (en) * 2003-04-16 2007-04-18 George Margetts Treatment of angiotensin II-induced cardiovascular disease

Family Cites Families (5)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US2817671A (en) * 1956-03-20 1957-12-24 Searle & Co 16-cyano and 16-cyanoalkyl 3, 20-dioxy-genated pregnenes
US3135743A (en) * 1960-06-29 1964-06-02 Sterling Drug Inc Steroido[2. 3-d]isoxazoles and preparation thereof
GB1123770A (en) * 1966-11-15 1968-08-14 Sterling Drug Inc 2-cyano-3-oxo-steroids
US3296255A (en) * 1963-11-29 1967-01-03 Sterling Drug Inc 2-cyano steroids
DE2336438C2 (de) * 1973-07-14 1983-07-07 Schering Ag, 1000 Berlin Und 4619 Bergkamen Verfahren zur Herstellung von 17 β- Oxalylsteroiden

Also Published As

Publication number Publication date
NZ200779A (en) 1985-04-30
US4331663A (en) 1982-05-25
GR75942B (GUID-C5D7CC26-194C-43D0-91A1-9AE8C70A9BFF.html) 1984-08-02
AU8427982A (en) 1982-12-23
EP0072894A1 (en) 1983-03-02
JPS581000A (ja) 1983-01-06
DK274882A (da) 1982-12-20

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Legal Events

Date Code Title Description
PA0109 Patent application

Patent event code: PA01091R01D

Comment text: Patent Application

Patent event date: 19820617

PG1501 Laying open of application
PC1203 Withdrawal of no request for examination