KR830009114A - 알파-(파라-클로로페녹시)-이소부티릴-알파-아미노벤질 페니실란익에시드 및 그 염의 제조방법 - Google Patents
알파-(파라-클로로페녹시)-이소부티릴-알파-아미노벤질 페니실란익에시드 및 그 염의 제조방법 Download PDFInfo
- Publication number
- KR830009114A KR830009114A KR1019820001165A KR820001165A KR830009114A KR 830009114 A KR830009114 A KR 830009114A KR 1019820001165 A KR1019820001165 A KR 1019820001165A KR 820001165 A KR820001165 A KR 820001165A KR 830009114 A KR830009114 A KR 830009114A
- Authority
- KR
- South Korea
- Prior art keywords
- alpha
- para
- aminobenzyl
- chlorophenoxy
- isobutyryl
- Prior art date
Links
- 238000002360 preparation method Methods 0.000 title claims 3
- -1 Alpha- (para-chlorophenoxy) -isobutyryl-alpha-aminobenzyl Chemical group 0.000 title 1
- 239000002253 acid Substances 0.000 title 1
- 150000003839 salts Chemical class 0.000 title 1
- 150000008065 acid anhydrides Chemical class 0.000 claims 2
- 238000006243 chemical reaction Methods 0.000 claims 2
- 125000001495 ethyl group Chemical group [H]C([H])([H])C([H])([H])* 0.000 claims 2
- 125000002496 methyl group Chemical group [H]C([H])([H])* 0.000 claims 2
- 229930182555 Penicillin Natural products 0.000 claims 1
- JGSARLDLIJGVTE-MBNYWOFBSA-N Penicillin G Chemical compound N([C@H]1[C@H]2SC([C@@H](N2C1=O)C(O)=O)(C)C)C(=O)CC1=CC=CC=C1 JGSARLDLIJGVTE-MBNYWOFBSA-N 0.000 claims 1
- 150000001447 alkali salts Chemical class 0.000 claims 1
- 230000002860 competitive effect Effects 0.000 claims 1
- 150000001875 compounds Chemical class 0.000 claims 1
- 230000002401 inhibitory effect Effects 0.000 claims 1
- 229940049954 penicillin Drugs 0.000 claims 1
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D499/00—Heterocyclic compounds containing 4-thia-1-azabicyclo [3.2.0] heptane ring systems, i.e. compounds containing a ring system of the formula:, e.g. penicillins, penems; Such ring systems being further condensed, e.g. 2,3-condensed with an oxygen-, nitrogen- or sulfur-containing hetero ring
- C07D499/21—Heterocyclic compounds containing 4-thia-1-azabicyclo [3.2.0] heptane ring systems, i.e. compounds containing a ring system of the formula:, e.g. penicillins, penems; Such ring systems being further condensed, e.g. 2,3-condensed with an oxygen-, nitrogen- or sulfur-containing hetero ring with a nitrogen atom directly attached in position 6 and a carbon atom having three bonds to hetero atoms with at the most one bond to halogen, e.g. an ester or nitrile radical, directly attached in position 2
- C07D499/44—Compounds with an amino radical acylated by carboxylic acids, attached in position 6
- C07D499/48—Compounds with an amino radical acylated by carboxylic acids, attached in position 6 with a carbon chain, substituted by hetero atoms or by carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, attached to the carboxamido radical
- C07D499/50—Compounds with an amino radical acylated by carboxylic acids, attached in position 6 with a carbon chain, substituted by hetero atoms or by carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, attached to the carboxamido radical substituted in beta-position to the carboxamido radical
- C07D499/54—Compounds with an amino radical acylated by carboxylic acids, attached in position 6 with a carbon chain, substituted by hetero atoms or by carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, attached to the carboxamido radical substituted in beta-position to the carboxamido radical by nitrogen atoms
Landscapes
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
Abstract
내용 없음
Description
본 내용은 요부공개 건이므로 전문내용을 수록하지 않았음
Claims (1)
- 구조식(V)의 화합물을 제조함에 있어 구조식(I)과 같은 파라-클로로 페녹시 이소부티락산 무수물을 사용하여 일반적으로 페니실린 제제의 제조에 사용되는 혼합산 무수물 구조식(II),(III)과 달리 동일산 무수물을 사용하여 반응식(I) 또는 (II)에서와 같은 경쟁적 저해 반응에 의한 여러가지 단점을 보완하여 보다 쉽고 간단한 반응 조건하에서 목적물을 거의 정량적으로 얻는데 있다.(여기서 R은 메칠 혹은 에칠기)(여기서 R은 메칠 혹은 에칠기이고, R1은 t-3 이다)(여기서 R2은 H 혹은 알카리염 Na, K 이다)※ 참고사항 : 최초출원 내용에 의하여 공개하는 것임.
Priority Applications (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| KR1019820001165A KR830002685B1 (ko) | 1982-03-18 | 1982-03-18 | 알파-(파라-콜로로페녹시)-이소부티릴-알파아미노벤질 페니실란산 및 그 염의 제조방법 |
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| KR1019820001165A KR830002685B1 (ko) | 1982-03-18 | 1982-03-18 | 알파-(파라-콜로로페녹시)-이소부티릴-알파아미노벤질 페니실란산 및 그 염의 제조방법 |
Publications (2)
| Publication Number | Publication Date |
|---|---|
| KR830002685B1 KR830002685B1 (ko) | 1983-12-07 |
| KR830009114A true KR830009114A (ko) | 1983-12-17 |
Family
ID=19224203
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| KR1019820001165A KR830002685B1 (ko) | 1982-03-18 | 1982-03-18 | 알파-(파라-콜로로페녹시)-이소부티릴-알파아미노벤질 페니실란산 및 그 염의 제조방법 |
Country Status (1)
| Country | Link |
|---|---|
| KR (1) | KR830002685B1 (ko) |
-
1982
- 1982-03-18 KR KR1019820001165A patent/KR830002685B1/ko active IP Right Grant
Also Published As
| Publication number | Publication date |
|---|---|
| KR830002685B1 (ko) | 1983-12-07 |
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