KR830005229A - Method for preparing tetrahydrothiopyrano [3, 2-b] indole derivative - Google Patents

Method for preparing tetrahydrothiopyrano [3, 2-b] indole derivative Download PDF

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Publication number
KR830005229A
KR830005229A KR1019810000158A KR810000158A KR830005229A KR 830005229 A KR830005229 A KR 830005229A KR 1019810000158 A KR1019810000158 A KR 1019810000158A KR 810000158 A KR810000158 A KR 810000158A KR 830005229 A KR830005229 A KR 830005229A
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South Korea
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hydrogen
alkyl
compound
general formula
formula
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KR1019810000158A
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Korean (ko)
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KR840002159B1 (en
Inventor
야스오 마끼스미
다까시 사사다니
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요시도시 가즈오
시오노기 세이야꾸 가부시끼 가이샤
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Priority to KR1019810000158A priority Critical patent/KR840002159B1/en
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    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D495/00—Heterocyclic compounds containing in the condensed system at least one hetero ring having sulfur atoms as the only ring hetero atoms
    • C07D495/02—Heterocyclic compounds containing in the condensed system at least one hetero ring having sulfur atoms as the only ring hetero atoms in which the condensed system contains two hetero rings
    • C07D495/04—Ortho-condensed systems

Abstract

내용 없음No content

Description

테트라히드로티오피라노[3, 2-b] 인돌 유도체의 제조방법Method for preparing tetrahydrothiopyrano [3, 2-b] indole derivative

본 내용은 요부공개 건이므로 전문내용을 수록하지 않았음As this is a public information case, the full text was not included.

Claims (1)

하기 일반식(Ⅱ)로 표시되는 화합물을 암모니아 또는 제1 또는 제2아민과 환원성 조건하에 반응시키거나, 또는 필요에 따라서 하기 일반식(Ⅱ)로 표시되는 화합물을 암모니아 또는 제1 또는 제2아민과 반응시킨 다음, 필요에 따라서 환원시키고(a), 하기 일반식(Ⅰ)에 있어서 R1이 수소인 화합물을 제5위에 치환기의 도입반응을 수행하여(b), 하기 일반식(Ⅰ)에 있어서 n이 0인 화합물을 과산에 의해 산화반응을 수행함으로서 상당하는 산화물 또는 이 산화물을 얻은 다음(c), 하기 일반식(Ⅰ)의 화합물을 그의 치환체로 수식반응을 수행함을 특징으로 하는 하기 일반식(Ⅰ)로 표시되는 화합물의 제조방법.The compound represented by the following general formula (II) is reacted with ammonia or the first or second amine under reducing conditions, or if necessary, the compound represented by the following general formula (II) is ammonia or the first or second amine. After reacting with (a) and reducing the compound as necessary (a), a compound in which R 1 is hydrogen in general formula (I) is subjected to introduction reaction of a substituent in the fifth position (b) to general formula (I) In which the compound of n is 0 is subjected to oxidation reaction with peracid to obtain the corresponding oxide or the oxide (c), followed by modification of the compound of formula (I) with its substituents. The manufacturing method of a compound represented by Formula (I). 식 중,In the formula, R1는 수소, C1-3알킬, C2-6알케닐, C2-6알키닐, C7-12아르알킬, C2-11아실 또는(단, Y는 C1-4알킬렌 또는 C1-4옥소알킬렌, R5및 R6는 각각 수소 또는 C1-6알킬,R 1 is hydrogen, C 1-3 alkyl, C 2-6 alkenyl, C 2-6 alkynyl, C 7-12 aralkyl, C 2-11 acyl or Wherein Y is C 1-4 alkylene or C 1-4 oxoalkylene, R 5 and R 6 are each hydrogen or C 1-6 alkyl, R2는 수소 또는 C1-6알킬,R 2 is hydrogen or C 1-6 alkyl, R3는 수소, C1-6알킬 또는(단, Y,R5및 R6는 각각 상기에서 정의한 바와 같다),는 피롤리디노, 피페리디닐, 피페라지닐, 4-C1-6알킬피페라지닐 또는 모르폴리노,R 3 is hydrogen, C 1-6 alkyl or (Wherein Y, R 5 and R 6 are each as defined above), Pyrrolidino, piperidinyl, piperazinyl, 4-C 1-6 alkylpiperazinyl or morpholino, R4는 수소 또는 C1-6알킬.R 4 is hydrogen or C 1-6 alkyl. n는 0, 1 또는 2의 정수.n is an integer of 0, 1 or 2. ※ 참고사항 : 최초출원 내용에 의하여 공개하는 것임.※ Note: The disclosure is based on the initial application.
KR1019810000158A 1981-01-20 1981-01-20 Process for preparing tetrahydrothiopyrano(3,2-b)indole derivatives KR840002159B1 (en)

Priority Applications (1)

Application Number Priority Date Filing Date Title
KR1019810000158A KR840002159B1 (en) 1981-01-20 1981-01-20 Process for preparing tetrahydrothiopyrano(3,2-b)indole derivatives

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
KR1019810000158A KR840002159B1 (en) 1981-01-20 1981-01-20 Process for preparing tetrahydrothiopyrano(3,2-b)indole derivatives

Publications (2)

Publication Number Publication Date
KR830005229A true KR830005229A (en) 1983-08-03
KR840002159B1 KR840002159B1 (en) 1984-11-24

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KR840002159B1 (en) 1984-11-24

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