KR830005145A - 2-아미노-4-메틸피리딘의 아미드 제조방법 - Google Patents
2-아미노-4-메틸피리딘의 아미드 제조방법 Download PDFInfo
- Publication number
- KR830005145A KR830005145A KR1019810000597A KR810000597A KR830005145A KR 830005145 A KR830005145 A KR 830005145A KR 1019810000597 A KR1019810000597 A KR 1019810000597A KR 810000597 A KR810000597 A KR 810000597A KR 830005145 A KR830005145 A KR 830005145A
- Authority
- KR
- South Korea
- Prior art keywords
- methylpyridine
- amino
- formula
- preparing amide
- reacted
- Prior art date
Links
- ORLGLBZRQYOWNA-UHFFFAOYSA-N 4-methylpyridin-2-amine Chemical compound CC1=CC=NC(N)=C1 ORLGLBZRQYOWNA-UHFFFAOYSA-N 0.000 title claims 3
- 229950011175 aminopicoline Drugs 0.000 title claims 3
- 150000001408 amides Chemical class 0.000 title claims 2
- 238000000034 method Methods 0.000 title claims 2
- YMWUJEATGCHHMB-UHFFFAOYSA-N Dichloromethane Chemical compound ClCCl YMWUJEATGCHHMB-UHFFFAOYSA-N 0.000 claims 3
- HEDRZPFGACZZDS-UHFFFAOYSA-N Chloroform Chemical compound ClC(Cl)Cl HEDRZPFGACZZDS-UHFFFAOYSA-N 0.000 claims 2
- JUJWROOIHBZHMG-UHFFFAOYSA-N Pyridine Chemical compound C1=CC=NC=C1 JUJWROOIHBZHMG-UHFFFAOYSA-N 0.000 claims 2
- 239000002904 solvent Substances 0.000 claims 2
- VEXZGXHMUGYJMC-UHFFFAOYSA-M Chloride anion Chemical compound [Cl-] VEXZGXHMUGYJMC-UHFFFAOYSA-M 0.000 claims 1
- 238000009835 boiling Methods 0.000 claims 1
- 239000013078 crystal Substances 0.000 claims 1
- 238000004821 distillation Methods 0.000 claims 1
- 238000002955 isolation Methods 0.000 claims 1
- DKYWVDODHFEZIM-UHFFFAOYSA-N ketoprofen Chemical compound OC(=O)C(C)C1=CC=CC(C(=O)C=2C=CC=CC=2)=C1 DKYWVDODHFEZIM-UHFFFAOYSA-N 0.000 claims 1
- FAIAAWCVCHQXDN-UHFFFAOYSA-N phosphorus trichloride Chemical compound ClP(Cl)Cl FAIAAWCVCHQXDN-UHFFFAOYSA-N 0.000 claims 1
- UMJSCPRVCHMLSP-UHFFFAOYSA-N pyridine Natural products COC1=CC=CN=C1 UMJSCPRVCHMLSP-UHFFFAOYSA-N 0.000 claims 1
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D213/00—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members
- C07D213/02—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members
- C07D213/04—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen or carbon atoms directly attached to the ring nitrogen atom
- C07D213/60—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen or carbon atoms directly attached to the ring nitrogen atom with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
- C07D213/78—Carbon atoms having three bonds to hetero atoms, with at the most one bond to halogen, e.g. ester or nitrile radicals
- C07D213/81—Amides; Imides
Landscapes
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Pyridine Compounds (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
Abstract
내용 없음
Description
본 내용은 요부공개 건이므로 전문내용을 수록하지 않았음
Claims (1)
- 2-아미노-4-메틸피리딘을 실온하의 피리딘 중에서 삼염화인과 반응시켜 포스파조 유도체(하기식 Ⅴ)를 얻어, 단리시키지 않고 2-(m-벤조일페닐)프로피온산(하기식 Ⅵ)과 반응시킴에 있어서 상기 본 반응을 비등점에서 실시하고, 반응이 종결되면 용매는 증류로서 제거하고, 생성물을 염화메틸렌 또는 클로로포름과 같은 용매로 추출시키고, 염화물로 변형시킨 후 결정으로 단리시킴을 특징으로 하는 하기 구조식(Ⅰ)의 2-아미노-4-메틸피리딘(하기식 Ⅰ)의 아미드 제조방법.※ 참고사항 : 최초출원 내용에 의하여 공개하는 것임.
Applications Claiming Priority (3)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| ES488,909 | 1980-02-25 | ||
| ES488909 | 1980-02-25 | ||
| ES488909A ES488909A0 (es) | 1980-02-25 | 1980-02-25 | Procedimiento para la preparacion de una amida de la 2-ami- no-4-metilpiridina |
Publications (2)
| Publication Number | Publication Date |
|---|---|
| KR830005145A true KR830005145A (ko) | 1983-08-03 |
| KR850001036B1 KR850001036B1 (ko) | 1985-07-19 |
Family
ID=8479879
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| KR1019810000597A KR850001036B1 (ko) | 1980-02-25 | 1981-02-24 | 2-아미노-4-메틸피리딘의 아미드의 제조방법 |
Country Status (4)
| Country | Link |
|---|---|
| KR (1) | KR850001036B1 (ko) |
| BE (1) | BE882711A (ko) |
| ES (1) | ES488909A0 (ko) |
| IT (1) | IT1130573B (ko) |
-
1980
- 1980-02-25 ES ES488909A patent/ES488909A0/es active Granted
- 1980-03-27 IT IT20949/80A patent/IT1130573B/it active
- 1980-04-09 BE BE0/200169A patent/BE882711A/fr not_active IP Right Cessation
-
1981
- 1981-02-24 KR KR1019810000597A patent/KR850001036B1/ko active
Also Published As
| Publication number | Publication date |
|---|---|
| ES8102556A1 (es) | 1981-02-16 |
| IT1130573B (it) | 1986-06-18 |
| BE882711A (fr) | 1980-07-31 |
| KR850001036B1 (ko) | 1985-07-19 |
| ES488909A0 (es) | 1981-02-16 |
| IT8020949A0 (it) | 1980-03-27 |
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