KR20250078526A - 세포 산생물의 제조 방법, 세포 산생물의 정제 방법, 세포 산생물의 막 투과율의 저하를 억제하는 방법, 세포 산생물의 제조 시스템 및 세포 산생물의 정제 시스템 - Google Patents

세포 산생물의 제조 방법, 세포 산생물의 정제 방법, 세포 산생물의 막 투과율의 저하를 억제하는 방법, 세포 산생물의 제조 시스템 및 세포 산생물의 정제 시스템 Download PDF

Info

Publication number
KR20250078526A
KR20250078526A KR1020257014171A KR20257014171A KR20250078526A KR 20250078526 A KR20250078526 A KR 20250078526A KR 1020257014171 A KR1020257014171 A KR 1020257014171A KR 20257014171 A KR20257014171 A KR 20257014171A KR 20250078526 A KR20250078526 A KR 20250078526A
Authority
KR
South Korea
Prior art keywords
less
cell
contact surface
diameter
membrane
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Pending
Application number
KR1020257014171A
Other languages
English (en)
Korean (ko)
Inventor
슌 마츠다
šœ 마츠다
유야 스기야마
유타 사이토
호노카 네모토
Original Assignee
아사히 가세이 메디컬 가부시키가이샤
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by 아사히 가세이 메디컬 가부시키가이샤 filed Critical 아사히 가세이 메디컬 가부시키가이샤
Priority to KR1020257014206A priority Critical patent/KR20250078532A/ko
Priority to KR1020257014205A priority patent/KR20250078531A/ko
Publication of KR20250078526A publication Critical patent/KR20250078526A/ko
Pending legal-status Critical Current

Links

Images

Classifications

    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01D—SEPARATION
    • B01D69/00—Semi-permeable membranes for separation processes or apparatus characterised by their form, structure or properties; Manufacturing processes specially adapted therefor
    • B01D69/02—Semi-permeable membranes for separation processes or apparatus characterised by their form, structure or properties; Manufacturing processes specially adapted therefor characterised by their properties
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12M—APPARATUS FOR ENZYMOLOGY OR MICROBIOLOGY; APPARATUS FOR CULTURING MICROORGANISMS FOR PRODUCING BIOMASS, FOR GROWING CELLS OR FOR OBTAINING FERMENTATION OR METABOLIC PRODUCTS, i.e. BIOREACTORS OR FERMENTERS
    • C12M47/00—Means for after-treatment of the produced biomass or of the fermentation or metabolic products, e.g. storage of biomass
    • C12M47/04—Cell isolation or sorting
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K16/00—Immunoglobulins [IG], e.g. monoclonal or polyclonal antibodies
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01D—SEPARATION
    • B01D61/00—Processes of separation using semi-permeable membranes, e.g. dialysis, osmosis or ultrafiltration; Apparatus, accessories or auxiliary operations specially adapted therefor
    • B01D61/14—Ultrafiltration; Microfiltration
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01D—SEPARATION
    • B01D63/00—Apparatus in general for separation processes using semi-permeable membranes
    • B01D63/02—Hollow fibre modules
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K1/00—General methods for the preparation of peptides, i.e. processes for the organic chemical preparation of peptides or proteins of any length
    • C07K1/14—Extraction; Separation; Purification
    • C07K1/34—Extraction; Separation; Purification by filtration, ultrafiltration or reverse osmosis
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12M—APPARATUS FOR ENZYMOLOGY OR MICROBIOLOGY; APPARATUS FOR CULTURING MICROORGANISMS FOR PRODUCING BIOMASS, FOR GROWING CELLS OR FOR OBTAINING FERMENTATION OR METABOLIC PRODUCTS, i.e. BIOREACTORS OR FERMENTERS
    • C12M25/00—Means for supporting, enclosing or fixing the microorganisms, e.g. immunocoatings
    • C12M25/02—Membranes; Filters
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12M—APPARATUS FOR ENZYMOLOGY OR MICROBIOLOGY; APPARATUS FOR CULTURING MICROORGANISMS FOR PRODUCING BIOMASS, FOR GROWING CELLS OR FOR OBTAINING FERMENTATION OR METABOLIC PRODUCTS, i.e. BIOREACTORS OR FERMENTERS
    • C12M27/00—Means for mixing, agitating or circulating fluids in the vessel
    • C12M27/02—Stirrer or mobile mixing elements
    • C12M27/06—Stirrer or mobile mixing elements with horizontal or inclined stirrer shaft or axis
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12M—APPARATUS FOR ENZYMOLOGY OR MICROBIOLOGY; APPARATUS FOR CULTURING MICROORGANISMS FOR PRODUCING BIOMASS, FOR GROWING CELLS OR FOR OBTAINING FERMENTATION OR METABOLIC PRODUCTS, i.e. BIOREACTORS OR FERMENTERS
    • C12M29/00—Means for introduction, extraction or recirculation of materials, e.g. pumps
    • C12M29/04—Filters; Permeable or porous membranes or plates, e.g. dialysis
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12M—APPARATUS FOR ENZYMOLOGY OR MICROBIOLOGY; APPARATUS FOR CULTURING MICROORGANISMS FOR PRODUCING BIOMASS, FOR GROWING CELLS OR FOR OBTAINING FERMENTATION OR METABOLIC PRODUCTS, i.e. BIOREACTORS OR FERMENTERS
    • C12M29/00—Means for introduction, extraction or recirculation of materials, e.g. pumps
    • C12M29/10—Perfusion
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12M—APPARATUS FOR ENZYMOLOGY OR MICROBIOLOGY; APPARATUS FOR CULTURING MICROORGANISMS FOR PRODUCING BIOMASS, FOR GROWING CELLS OR FOR OBTAINING FERMENTATION OR METABOLIC PRODUCTS, i.e. BIOREACTORS OR FERMENTERS
    • C12M29/00—Means for introduction, extraction or recirculation of materials, e.g. pumps
    • C12M29/14—Pressurized fluid
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12M—APPARATUS FOR ENZYMOLOGY OR MICROBIOLOGY; APPARATUS FOR CULTURING MICROORGANISMS FOR PRODUCING BIOMASS, FOR GROWING CELLS OR FOR OBTAINING FERMENTATION OR METABOLIC PRODUCTS, i.e. BIOREACTORS OR FERMENTERS
    • C12M29/00—Means for introduction, extraction or recirculation of materials, e.g. pumps
    • C12M29/16—Hollow fibers
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12M—APPARATUS FOR ENZYMOLOGY OR MICROBIOLOGY; APPARATUS FOR CULTURING MICROORGANISMS FOR PRODUCING BIOMASS, FOR GROWING CELLS OR FOR OBTAINING FERMENTATION OR METABOLIC PRODUCTS, i.e. BIOREACTORS OR FERMENTERS
    • C12M29/00—Means for introduction, extraction or recirculation of materials, e.g. pumps
    • C12M29/18—External loop; Means for reintroduction of fermented biomass or liquid percolate
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12M—APPARATUS FOR ENZYMOLOGY OR MICROBIOLOGY; APPARATUS FOR CULTURING MICROORGANISMS FOR PRODUCING BIOMASS, FOR GROWING CELLS OR FOR OBTAINING FERMENTATION OR METABOLIC PRODUCTS, i.e. BIOREACTORS OR FERMENTERS
    • C12M33/00—Means for introduction, transport, positioning, extraction, harvesting, peeling or sampling of biological material in or from the apparatus
    • C12M33/14—Means for introduction, transport, positioning, extraction, harvesting, peeling or sampling of biological material in or from the apparatus with filters, sieves or membranes
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12M—APPARATUS FOR ENZYMOLOGY OR MICROBIOLOGY; APPARATUS FOR CULTURING MICROORGANISMS FOR PRODUCING BIOMASS, FOR GROWING CELLS OR FOR OBTAINING FERMENTATION OR METABOLIC PRODUCTS, i.e. BIOREACTORS OR FERMENTERS
    • C12M41/00—Means for regulation, monitoring, measurement or control, e.g. flow regulation
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12M—APPARATUS FOR ENZYMOLOGY OR MICROBIOLOGY; APPARATUS FOR CULTURING MICROORGANISMS FOR PRODUCING BIOMASS, FOR GROWING CELLS OR FOR OBTAINING FERMENTATION OR METABOLIC PRODUCTS, i.e. BIOREACTORS OR FERMENTERS
    • C12M41/00—Means for regulation, monitoring, measurement or control, e.g. flow regulation
    • C12M41/12—Means for regulation, monitoring, measurement or control, e.g. flow regulation of temperature
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12M—APPARATUS FOR ENZYMOLOGY OR MICROBIOLOGY; APPARATUS FOR CULTURING MICROORGANISMS FOR PRODUCING BIOMASS, FOR GROWING CELLS OR FOR OBTAINING FERMENTATION OR METABOLIC PRODUCTS, i.e. BIOREACTORS OR FERMENTERS
    • C12M41/00—Means for regulation, monitoring, measurement or control, e.g. flow regulation
    • C12M41/40—Means for regulation, monitoring, measurement or control, e.g. flow regulation of pressure
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12M—APPARATUS FOR ENZYMOLOGY OR MICROBIOLOGY; APPARATUS FOR CULTURING MICROORGANISMS FOR PRODUCING BIOMASS, FOR GROWING CELLS OR FOR OBTAINING FERMENTATION OR METABOLIC PRODUCTS, i.e. BIOREACTORS OR FERMENTERS
    • C12M41/00—Means for regulation, monitoring, measurement or control, e.g. flow regulation
    • C12M41/46—Means for regulation, monitoring, measurement or control, e.g. flow regulation of cellular or enzymatic activity or functionality, e.g. cell viability
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12M—APPARATUS FOR ENZYMOLOGY OR MICROBIOLOGY; APPARATUS FOR CULTURING MICROORGANISMS FOR PRODUCING BIOMASS, FOR GROWING CELLS OR FOR OBTAINING FERMENTATION OR METABOLIC PRODUCTS, i.e. BIOREACTORS OR FERMENTERS
    • C12M47/00—Means for after-treatment of the produced biomass or of the fermentation or metabolic products, e.g. storage of biomass
    • C12M47/10—Separation or concentration of fermentation products
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12M—APPARATUS FOR ENZYMOLOGY OR MICROBIOLOGY; APPARATUS FOR CULTURING MICROORGANISMS FOR PRODUCING BIOMASS, FOR GROWING CELLS OR FOR OBTAINING FERMENTATION OR METABOLIC PRODUCTS, i.e. BIOREACTORS OR FERMENTERS
    • C12M47/00—Means for after-treatment of the produced biomass or of the fermentation or metabolic products, e.g. storage of biomass
    • C12M47/12—Purification
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01D—SEPARATION
    • B01D2311/00—Details relating to membrane separation process operations and control
    • B01D2311/16—Flow or flux control
    • B01D2311/165—Cross-flow velocity control
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01D—SEPARATION
    • B01D2315/00—Details relating to the membrane module operation
    • B01D2315/10—Cross-flow filtration
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01D—SEPARATION
    • B01D2325/00—Details relating to properties of membranes
    • B01D2325/02—Details relating to pores or porosity of the membranes
    • B01D2325/022—Asymmetric membranes
    • B01D2325/023—Dense layer within the membrane
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01D—SEPARATION
    • B01D71/00—Semi-permeable membranes for separation processes or apparatus characterised by the material; Manufacturing processes specially adapted therefor
    • B01D71/06—Organic material
    • B01D71/30—Polyalkenyl halides
    • B01D71/32—Polyalkenyl halides containing fluorine atoms
    • B01D71/34—Polyvinylidene fluoride
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01D—SEPARATION
    • B01D71/00—Semi-permeable membranes for separation processes or apparatus characterised by the material; Manufacturing processes specially adapted therefor
    • B01D71/06—Organic material
    • B01D71/66—Polymers having sulfur in the main chain, with or without nitrogen, oxygen or carbon only
    • B01D71/68—Polysulfones; Polyethersulfones

Landscapes

  • Chemical & Material Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • Health & Medical Sciences (AREA)
  • Organic Chemistry (AREA)
  • Wood Science & Technology (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Zoology (AREA)
  • Biotechnology (AREA)
  • General Health & Medical Sciences (AREA)
  • Biochemistry (AREA)
  • Genetics & Genomics (AREA)
  • Microbiology (AREA)
  • General Engineering & Computer Science (AREA)
  • Biomedical Technology (AREA)
  • Sustainable Development (AREA)
  • Molecular Biology (AREA)
  • Analytical Chemistry (AREA)
  • Immunology (AREA)
  • Medicinal Chemistry (AREA)
  • Biophysics (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Water Supply & Treatment (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Cell Biology (AREA)
  • Physics & Mathematics (AREA)
  • Thermal Sciences (AREA)
  • Separation Using Semi-Permeable Membranes (AREA)
  • Apparatus Associated With Microorganisms And Enzymes (AREA)
KR1020257014171A 2022-11-15 2023-11-14 세포 산생물의 제조 방법, 세포 산생물의 정제 방법, 세포 산생물의 막 투과율의 저하를 억제하는 방법, 세포 산생물의 제조 시스템 및 세포 산생물의 정제 시스템 Pending KR20250078526A (ko)

Priority Applications (2)

Application Number Priority Date Filing Date Title
KR1020257014206A KR20250078532A (ko) 2022-11-15 2023-11-14 세포 산생물의 제조 방법, 세포 산생물의 정제 방법, 세포 산생물의 막 투과율의 저하를 억제하는 방법, 세포 산생물의 제조 시스템 및 세포 산생물의 정제 시스템
KR1020257014205A KR20250078531A (ko) 2022-11-15 2023-11-14 세포 산생물의 제조 방법, 세포 산생물의 정제 방법, 세포 산생물의 막 투과율의 저하를 억제하는 방법, 세포 산생물의 제조 시스템 및 세포 산생물의 정제 시스템

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
JP2022182784 2022-11-15
JPJP-P-2022-182784 2022-11-15
PCT/JP2023/040994 WO2024106441A1 (ja) 2022-11-15 2023-11-14 細胞産生物の製造方法、細胞産生物の精製方法、細胞産生物の膜透過率の低下を抑制する方法、細胞産生物の製造システム、及び細胞産生物の精製システム

Related Child Applications (2)

Application Number Title Priority Date Filing Date
KR1020257014206A Division KR20250078532A (ko) 2022-11-15 2023-11-14 세포 산생물의 제조 방법, 세포 산생물의 정제 방법, 세포 산생물의 막 투과율의 저하를 억제하는 방법, 세포 산생물의 제조 시스템 및 세포 산생물의 정제 시스템
KR1020257014205A Division KR20250078531A (ko) 2022-11-15 2023-11-14 세포 산생물의 제조 방법, 세포 산생물의 정제 방법, 세포 산생물의 막 투과율의 저하를 억제하는 방법, 세포 산생물의 제조 시스템 및 세포 산생물의 정제 시스템

Publications (1)

Publication Number Publication Date
KR20250078526A true KR20250078526A (ko) 2025-06-02

Family

ID=91084491

Family Applications (3)

Application Number Title Priority Date Filing Date
KR1020257014171A Pending KR20250078526A (ko) 2022-11-15 2023-11-14 세포 산생물의 제조 방법, 세포 산생물의 정제 방법, 세포 산생물의 막 투과율의 저하를 억제하는 방법, 세포 산생물의 제조 시스템 및 세포 산생물의 정제 시스템
KR1020257014206A Pending KR20250078532A (ko) 2022-11-15 2023-11-14 세포 산생물의 제조 방법, 세포 산생물의 정제 방법, 세포 산생물의 막 투과율의 저하를 억제하는 방법, 세포 산생물의 제조 시스템 및 세포 산생물의 정제 시스템
KR1020257014205A Pending KR20250078531A (ko) 2022-11-15 2023-11-14 세포 산생물의 제조 방법, 세포 산생물의 정제 방법, 세포 산생물의 막 투과율의 저하를 억제하는 방법, 세포 산생물의 제조 시스템 및 세포 산생물의 정제 시스템

Family Applications After (2)

Application Number Title Priority Date Filing Date
KR1020257014206A Pending KR20250078532A (ko) 2022-11-15 2023-11-14 세포 산생물의 제조 방법, 세포 산생물의 정제 방법, 세포 산생물의 막 투과율의 저하를 억제하는 방법, 세포 산생물의 제조 시스템 및 세포 산생물의 정제 시스템
KR1020257014205A Pending KR20250078531A (ko) 2022-11-15 2023-11-14 세포 산생물의 제조 방법, 세포 산생물의 정제 방법, 세포 산생물의 막 투과율의 저하를 억제하는 방법, 세포 산생물의 제조 시스템 및 세포 산생물의 정제 시스템

Country Status (6)

Country Link
US (3) US20260062664A1 (https=)
EP (3) EP4644526A3 (https=)
JP (1) JPWO2024106441A1 (https=)
KR (3) KR20250078526A (https=)
CN (1) CN120153085A (https=)
WO (1) WO2024106441A1 (https=)

Citations (5)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JP2009045019A (ja) 2007-08-21 2009-03-05 Toray Ind Inc タンパク質の製造方法
JP5696479B2 (ja) 2009-11-10 2015-04-08 東レ株式会社 化学品製造用中空糸膜モジュールおよび化学品の製造方法
JP2018076291A (ja) 2016-10-28 2018-05-17 旭化成メディカル株式会社 連続培養における有用物質の回収方法
JP2021048776A (ja) 2019-09-20 2021-04-01 株式会社日立製作所 培養方法および培養装置
JP2022516516A (ja) 2018-12-31 2022-02-28 レプリゲン・コーポレーション 疎水性中空繊維による哺乳類細胞培養物の灌流および浄化用フィルター

Family Cites Families (7)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JP3781679B2 (ja) 2000-01-18 2006-05-31 旭化成ケミカルズ株式会社 懸濁水の膜濾過浄化方法
US8758625B2 (en) 2008-09-26 2014-06-24 Asahi Kasei Chemicals Corporation Use of porous hollow-fiber membrane for producing clarified biomedical culture medium
WO2017180814A1 (en) * 2016-04-15 2017-10-19 Boehringer Ingelheim International Gmbh Cell retention device and method
WO2020076776A1 (en) * 2018-10-10 2020-04-16 Boehringer Ingelheim International Gmbh Method for membrane gas transfer in high density bioreactor culture
CN113692420B (zh) * 2019-04-08 2023-09-12 旭化成医疗株式会社 用于纯化含蛋白质的溶液的聚酰胺介质及其制造方法
CN113265330B (zh) * 2021-06-04 2022-04-01 河南大学 一种适用于疫苗及抗体高效生产的动物细胞高密度培养系统
CN113846017B (zh) * 2021-10-13 2024-04-26 无锡药明生物技术股份有限公司 选择截留装置和降低截留率的方法

Patent Citations (5)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JP2009045019A (ja) 2007-08-21 2009-03-05 Toray Ind Inc タンパク質の製造方法
JP5696479B2 (ja) 2009-11-10 2015-04-08 東レ株式会社 化学品製造用中空糸膜モジュールおよび化学品の製造方法
JP2018076291A (ja) 2016-10-28 2018-05-17 旭化成メディカル株式会社 連続培養における有用物質の回収方法
JP2022516516A (ja) 2018-12-31 2022-02-28 レプリゲン・コーポレーション 疎水性中空繊維による哺乳類細胞培養物の灌流および浄化用フィルター
JP2021048776A (ja) 2019-09-20 2021-04-01 株式会社日立製作所 培養方法および培養装置

Also Published As

Publication number Publication date
US20250361290A1 (en) 2025-11-27
US20260062664A1 (en) 2026-03-05
EP4644526A2 (en) 2025-11-05
WO2024106441A1 (ja) 2024-05-23
US20250361289A1 (en) 2025-11-27
EP4644526A3 (en) 2026-01-07
EP4621062A1 (en) 2025-09-24
JPWO2024106441A1 (https=) 2024-05-23
CN120153085A (zh) 2025-06-13
EP4647486A3 (en) 2026-01-14
KR20250078532A (ko) 2025-06-02
EP4647486A2 (en) 2025-11-12
KR20250078531A (ko) 2025-06-02

Similar Documents

Publication Publication Date Title
US10188099B2 (en) High density cell banking methods
KR102476633B1 (ko) 세포 배양 방법, 생산물의 제조 방법, 및 세포 배양 장치
CN109072154A (zh) 细胞保留装置和方法
US10988725B2 (en) Perfusion filtration systems
AU766583B2 (en) Filter membranes for physiologically active substances
JP2019505240A (ja) 灌流バイオリアクタおよび連続細胞培養を実施するためのその使用方法
US11685888B2 (en) Method for producing product
US20160068565A1 (en) Method for harvesting culture product
JP2009045019A (ja) タンパク質の製造方法
KR20250078526A (ko) 세포 산생물의 제조 방법, 세포 산생물의 정제 방법, 세포 산생물의 막 투과율의 저하를 억제하는 방법, 세포 산생물의 제조 시스템 및 세포 산생물의 정제 시스템
EP4621063A1 (en) Evaluation method of filtration condition and production method of cell product
Veje et al. Investigation of fouling in perfusion cell culture processes using alternating tangential flow filtration
EP2527423A1 (en) Dialysis fermenter - biorector with dialysis device
Büntemeyer et al. Evaluation of membranes for use in on-line cell separation during mammalian cell perfusion processes
Fallahianbijan Evaluating the Performance Characteristics of Virus Filtration Membranes
CA2906600C (en) High-density cell banking methods
HK1213284B (en) High-density cell banking methods

Legal Events

Date Code Title Description
A107 Divisional application of patent
A201 Request for examination
PA0104 Divisional application for international application

Comment text: Divisional Application for International Patent

Patent event code: PA01041R01D

Patent event date: 20250429

PA0105 International application

Patent event date: 20250429

Patent event code: PA01051R01D

Comment text: International Patent Application

PA0201 Request for examination

Patent event code: PA02012R01D

Patent event date: 20250429

Comment text: Request for Examination of Application

PG1501 Laying open of application