KR20250012058A - 신규 이미다졸 유도체 - Google Patents

신규 이미다졸 유도체 Download PDF

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Publication number
KR20250012058A
KR20250012058A KR1020247037659A KR20247037659A KR20250012058A KR 20250012058 A KR20250012058 A KR 20250012058A KR 1020247037659 A KR1020247037659 A KR 1020247037659A KR 20247037659 A KR20247037659 A KR 20247037659A KR 20250012058 A KR20250012058 A KR 20250012058A
Authority
KR
South Korea
Prior art keywords
compound
methyl
compound according
formula
mmol
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Pending
Application number
KR1020247037659A
Other languages
English (en)
Korean (ko)
Inventor
게오르크 얘슈케
브루노 마르토글리오
이본느 앨리스 나겔
크리스타 울리케 옵스트-샌더
안토니오 리치
산드라 스타이너
Original Assignee
에프. 호프만-라 로슈 아게
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by 에프. 호프만-라 로슈 아게 filed Critical 에프. 호프만-라 로슈 아게
Publication of KR20250012058A publication Critical patent/KR20250012058A/ko
Pending legal-status Critical Current

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D487/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00
    • C07D487/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00 in which the condensed system contains two hetero rings
    • C07D487/04—Ortho-condensed systems
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/535—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with at least one nitrogen and one oxygen as the ring hetero atoms, e.g. 1,2-oxazines
    • A61K31/5375—1,4-Oxazines, e.g. morpholine
    • A61K31/5377—1,4-Oxazines, e.g. morpholine not condensed and containing further heterocyclic rings, e.g. timolol
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/08—Solutions

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Pharmacology & Pharmacy (AREA)
  • General Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Medicinal Chemistry (AREA)
  • Epidemiology (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
KR1020247037659A 2022-05-13 2023-05-11 신규 이미다졸 유도체 Pending KR20250012058A (ko)

Applications Claiming Priority (5)

Application Number Priority Date Filing Date Title
EP22173211 2022-05-13
EP22173211.8 2022-05-13
EP22175324.7 2022-05-25
EP22175324 2022-05-25
PCT/EP2023/062529 WO2023217923A1 (en) 2022-05-13 2023-05-11 New indazole derivatives

Publications (1)

Publication Number Publication Date
KR20250012058A true KR20250012058A (ko) 2025-01-23

Family

ID=86604076

Family Applications (1)

Application Number Title Priority Date Filing Date
KR1020247037659A Pending KR20250012058A (ko) 2022-05-13 2023-05-11 신규 이미다졸 유도체

Country Status (10)

Country Link
US (1) US20250313565A1 (cg-RX-API-DMAC7.html)
EP (1) EP4522617A1 (cg-RX-API-DMAC7.html)
JP (1) JP2025515833A (cg-RX-API-DMAC7.html)
KR (1) KR20250012058A (cg-RX-API-DMAC7.html)
CN (1) CN119173518A (cg-RX-API-DMAC7.html)
AR (1) AR129307A1 (cg-RX-API-DMAC7.html)
AU (1) AU2023269227A1 (cg-RX-API-DMAC7.html)
CA (1) CA3256325A1 (cg-RX-API-DMAC7.html)
TW (1) TW202402276A (cg-RX-API-DMAC7.html)
WO (1) WO2023217923A1 (cg-RX-API-DMAC7.html)

Families Citing this family (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
ES2961187T3 (es) 2019-06-21 2024-03-08 Hoffmann La Roche Inhibidor de EGFR para el tratamiento del cáncer
CN116507328A (zh) 2020-12-01 2023-07-28 豪夫迈·罗氏有限公司 新的吲唑衍生物
IL303064A (en) 2020-12-01 2023-07-01 Hoffmann La Roche NEW INDAZOLE ACETYLENE DERIVATIVES

Family Cites Families (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
ES2961187T3 (es) * 2019-06-21 2024-03-08 Hoffmann La Roche Inhibidor de EGFR para el tratamiento del cáncer

Also Published As

Publication number Publication date
AU2023269227A1 (en) 2024-10-03
CN119173518A (zh) 2024-12-20
EP4522617A1 (en) 2025-03-19
TW202402276A (zh) 2024-01-16
JP2025515833A (ja) 2025-05-20
US20250313565A1 (en) 2025-10-09
CA3256325A1 (en) 2023-11-16
AR129307A1 (es) 2024-08-07
WO2023217923A1 (en) 2023-11-16

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Legal Events

Date Code Title Description
PA0105 International application

St.27 status event code: A-0-1-A10-A15-nap-PA0105

PG1501 Laying open of application

St.27 status event code: A-1-1-Q10-Q12-nap-PG1501

P11 Amendment of application requested

Free format text: ST27 STATUS EVENT CODE: A-2-2-P10-P11-NAP-X000 (AS PROVIDED BY THE NATIONAL OFFICE)

P11-X000 Amendment of application requested

St.27 status event code: A-2-2-P10-P11-nap-X000