KR20250007582A - 다중시스트론 키메라 단백질 발현 시스템 - Google Patents

다중시스트론 키메라 단백질 발현 시스템 Download PDF

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Publication number
KR20250007582A
KR20250007582A KR1020247038570A KR20247038570A KR20250007582A KR 20250007582 A KR20250007582 A KR 20250007582A KR 1020247038570 A KR1020247038570 A KR 1020247038570A KR 20247038570 A KR20247038570 A KR 20247038570A KR 20250007582 A KR20250007582 A KR 20250007582A
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seq
optionally
amino acid
sequence
domain
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Korean (ko)
Inventor
브라이언 스콧 게리슨
미셸 엘리자베스 헝
니콜라스 프랑켈
한 덩
고즈데 유셀
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센티 바이오사이언시스, 인코포레이티드
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Publication of KR20250007582A publication Critical patent/KR20250007582A/ko
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    • C12N15/00—Mutation or genetic engineering; DNA or RNA concerning genetic engineering, vectors, e.g. plasmids, or their isolation, preparation or purification; Use of hosts therefor
    • C12N15/09—Recombinant DNA-technology
    • C12N15/63—Introduction of foreign genetic material using vectors; Vectors; Use of hosts therefor; Regulation of expression
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    • A61K35/00—Medicinal preparations containing materials or reaction products thereof with undetermined constitution
    • A61K35/12—Materials from mammals; Compositions comprising non-specified tissues or cells; Compositions comprising non-embryonic stem cells; Genetically modified cells
    • A61K35/14—Blood; Artificial blood
    • A61K35/17—Lymphocytes; B-cells; T-cells; Natural killer cells; Interferon-activated or cytokine-activated lymphocytes
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K40/00—Cellular immunotherapy
    • A61K40/10—Cellular immunotherapy characterised by the cell type used
    • A61K40/15—Natural-killer [NK] cells; Natural-killer T [NKT] cells
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    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K40/00—Cellular immunotherapy
    • A61K40/30—Cellular immunotherapy characterised by the recombinant expression of specific molecules in the cells of the immune system
    • A61K40/31—Chimeric antigen receptors [CAR]
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
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    • A61K40/40—Cellular immunotherapy characterised by antigens that are targeted or presented by cells of the immune system
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    • A61K40/42—Cancer antigens
    • A61K40/4202—Receptors, cell surface antigens or cell surface determinants
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
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    • A61K40/40—Cellular immunotherapy characterised by antigens that are targeted or presented by cells of the immune system
    • A61K40/41—Vertebrate antigens
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    • A61K40/4202—Receptors, cell surface antigens or cell surface determinants
    • A61K40/4203—Receptors for growth factors
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    • A61K40/41—Vertebrate antigens
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    • A61K40/4202—Receptors, cell surface antigens or cell surface determinants
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    • A61K40/41—Vertebrate antigens
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    • C07K14/52—Cytokines; Lymphokines; Interferons
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    • C07K14/705—Receptors; Cell surface antigens; Cell surface determinants
    • C07K14/70503—Immunoglobulin superfamily
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    • C07K16/00—Immunoglobulins [IG], e.g. monoclonal or polyclonal antibodies
    • C07K16/18—Immunoglobulins [IG], e.g. monoclonal or polyclonal antibodies against material from animals or humans
    • C07K16/28—Immunoglobulins [IG], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants
    • C07K16/2803—Immunoglobulins [IG], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants against the immunoglobulin superfamily
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    • C07—ORGANIC CHEMISTRY
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    • C07K16/00—Immunoglobulins [IG], e.g. monoclonal or polyclonal antibodies
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    • C07K16/28—Immunoglobulins [IG], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants
    • C07K16/2863—Immunoglobulins [IG], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants against receptors for growth factors, growth regulators
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    • C07K16/28—Immunoglobulins [IG], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants
    • C07K16/30—Immunoglobulins [IG], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants from tumour cells
    • C07K16/3076—Immunoglobulins [IG], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants from tumour cells against structure-related tumour-associated moieties
    • C07K16/3092—Immunoglobulins [IG], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants from tumour cells against structure-related tumour-associated moieties against tumour-associated mucins
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    • C12N5/0602—Vertebrate cells
    • C12N5/0634—Cells from the blood or the immune system
    • C12N5/0646—Natural killers cells [NK], NKT cells
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
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    • A61K2239/11—Antigen recognition domain
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    • A61K2239/17—Hinge-spacer domain
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    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K2239/00—Indexing codes associated with cellular immunotherapy of group A61K40/00
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    • A61K2239/21—Transmembrane domain
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  • Proteomics, Peptides & Aminoacids (AREA)
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  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
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  • Peptides Or Proteins (AREA)
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  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
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KR1020247038570A 2022-04-21 2023-04-17 다중시스트론 키메라 단백질 발현 시스템 Pending KR20250007582A (ko)

Applications Claiming Priority (7)

Application Number Priority Date Filing Date Title
US202263333483P 2022-04-21 2022-04-21
US63/333,483 2022-04-21
US202263370219P 2022-08-02 2022-08-02
US63/370,219 2022-08-02
US202363440668P 2023-01-23 2023-01-23
US63/440,668 2023-01-23
PCT/US2023/065860 WO2023205614A2 (en) 2022-04-21 2023-04-17 Multicistronic chimeric protein expression systems

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Publication Number Publication Date
KR20250007582A true KR20250007582A (ko) 2025-01-14

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KR1020247038570A Pending KR20250007582A (ko) 2022-04-21 2023-04-17 다중시스트론 키메라 단백질 발현 시스템

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Country Link
US (1) US20250041345A1 (https=)
EP (1) EP4511495A2 (https=)
JP (1) JP2025513427A (https=)
KR (1) KR20250007582A (https=)
CN (1) CN119343457A (https=)
AU (1) AU2023256633A1 (https=)
CA (1) CA3247450A1 (https=)
TW (1) TW202346326A (https=)
WO (1) WO2023205614A2 (https=)

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Publication number Priority date Publication date Assignee Title
CA3247456A1 (en) * 2022-04-20 2023-10-26 Senti Biosciences, Inc. DOMAINS OF BINDING TO AN ANTIGEN AND THEIR METHODS OF USE
CN119060196A (zh) * 2023-05-31 2024-12-03 郑州大学 一种金属蛋白酶激活型car-t结构的制备及其应用
WO2025085867A1 (en) * 2023-10-20 2025-04-24 A2 Biotherapeutics, Inc. Compositions and methods for treating blood cancers

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JP7285220B2 (ja) * 2017-05-18 2023-06-01 モデルナティエックス インコーポレイテッド 連結したインターロイキン－１２（ｉｌ１２）ポリペプチドをコードするポリヌクレオチドを含む脂質ナノ粒子
TW202110873A (zh) * 2019-04-30 2021-03-16 美商聖堤生物科技股份有限公司 嵌合受體及其使用方法

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AU2023256633A1 (en) 2024-12-05
JP2025513427A (ja) 2025-04-24
WO2023205614A2 (en) 2023-10-26
WO2023205614A3 (en) 2024-01-04
CA3247450A1 (en) 2023-10-26
CN119343457A (zh) 2025-01-21
EP4511495A2 (en) 2025-02-26
US20250041345A1 (en) 2025-02-06
TW202346326A (zh) 2023-12-01

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