KR20240141309A - 치아의 재생 치료를 위한 usag-1을 표적 분자로 한 중화 항체 - Google Patents

치아의 재생 치료를 위한 usag-1을 표적 분자로 한 중화 항체 Download PDF

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Publication number
KR20240141309A
KR20240141309A KR1020247029062A KR20247029062A KR20240141309A KR 20240141309 A KR20240141309 A KR 20240141309A KR 1020247029062 A KR1020247029062 A KR 1020247029062A KR 20247029062 A KR20247029062 A KR 20247029062A KR 20240141309 A KR20240141309 A KR 20240141309A
Authority
KR
South Korea
Prior art keywords
antibody
usag
seq
antigen
amino acid
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Pending
Application number
KR1020247029062A
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English (en)
Korean (ko)
Inventor
가츠 다카하시
마나부 스가이
요시히토 도키타
준이치 다카기
에미코 미하라
Original Assignee
고쿠리츠 다이가쿠 호진 교토 다이가쿠
고쿠리츠다이가쿠호징 후쿠이다이가쿠
아이치 프레펙츄러
고꾸리쯔 다이가꾸 호우징 오사까 다이가꾸
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by 고쿠리츠 다이가쿠 호진 교토 다이가쿠, 고쿠리츠다이가쿠호징 후쿠이다이가쿠, 아이치 프레펙츄러, 고꾸리쯔 다이가꾸 호우징 오사까 다이가꾸 filed Critical 고쿠리츠 다이가쿠 호진 교토 다이가쿠
Publication of KR20240141309A publication Critical patent/KR20240141309A/ko
Pending legal-status Critical Current

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Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K16/00—Immunoglobulins [IG], e.g. monoclonal or polyclonal antibodies
    • C07K16/18—Immunoglobulins [IG], e.g. monoclonal or polyclonal antibodies against material from animals or humans
    • C07K16/22—Immunoglobulins [IG], e.g. monoclonal or polyclonal antibodies against material from animals or humans against growth factors ; against growth regulators
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
    • A61P1/02—Stomatological preparations, e.g. drugs for caries, aphtae, periodontitis
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K16/00—Immunoglobulins [IG], e.g. monoclonal or polyclonal antibodies
    • C07K16/18—Immunoglobulins [IG], e.g. monoclonal or polyclonal antibodies against material from animals or humans
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K39/00—Medicinal preparations containing antigens or antibodies
    • A61K2039/505—Medicinal preparations containing antigens or antibodies comprising antibodies
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2317/00—Immunoglobulins specific features
    • C07K2317/20—Immunoglobulins specific features characterized by taxonomic origin
    • C07K2317/24—Immunoglobulins specific features characterized by taxonomic origin containing regions, domains or residues from different species, e.g. chimeric, humanized or veneered
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2317/00—Immunoglobulins specific features
    • C07K2317/70—Immunoglobulins specific features characterized by effect upon binding to a cell or to an antigen
    • C07K2317/76—Antagonist effect on antigen, e.g. neutralization or inhibition of binding
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2317/00—Immunoglobulins specific features
    • C07K2317/90—Immunoglobulins specific features characterized by (pharmaco)kinetic aspects or by stability of the immunoglobulin
    • C07K2317/92—Affinity (KD), association rate (Ka), dissociation rate (Kd) or EC50 value

Landscapes

  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Medicinal Chemistry (AREA)
  • General Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • General Chemical & Material Sciences (AREA)
  • Immunology (AREA)
  • Engineering & Computer Science (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Animal Behavior & Ethology (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Biochemistry (AREA)
  • Biophysics (AREA)
  • Genetics & Genomics (AREA)
  • Molecular Biology (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Medicines Containing Antibodies Or Antigens For Use As Internal Diagnostic Agents (AREA)
  • Peptides Or Proteins (AREA)
KR1020247029062A 2022-02-03 2022-02-03 치아의 재생 치료를 위한 usag-1을 표적 분자로 한 중화 항체 Pending KR20240141309A (ko)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
PCT/JP2022/004300 WO2023148894A1 (ja) 2022-02-03 2022-02-03 歯の再生治療のためのｕｓａｇ－１を標的分子とした中和抗体

Publications (1)

Publication Number Publication Date
KR20240141309A true KR20240141309A (ko) 2024-09-26

Family

ID=87553416

Family Applications (1)

Application Number Title Priority Date Filing Date
KR1020247029062A Pending KR20240141309A (ko) 2022-02-03 2022-02-03 치아의 재생 치료를 위한 usag-1을 표적 분자로 한 중화 항체

Country Status (6)

Country Link
US (1) US20250136674A1 (https=)
EP (1) EP4474394A4 (https=)
JP (1) JPWO2023148894A1 (https=)
KR (1) KR20240141309A (https=)
CN (1) CN118742563A (https=)
WO (1) WO2023148894A1 (https=)

Family Cites Families (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CN114364694B (zh) * 2019-07-12 2024-05-10 国立大学法人京都大学 靶向usag-1分子的用于牙齿再生治疗的中和抗体
US20240043841A1 (en) * 2020-02-21 2024-02-08 Kyoto University Medicine Containing USAG-1-Targeting RNA Molecule for Tooth Regeneration Therapy

Non-Patent Citations (2)

* Cited by examiner, † Cited by third party
Title
Nakao, Nat Methods, 2007
Ohazama, J Denr Res, 2004

Also Published As

Publication number Publication date
WO2023148894A1 (ja) 2023-08-10
JPWO2023148894A1 (https=) 2023-08-10
US20250136674A1 (en) 2025-05-01
EP4474394A4 (en) 2026-04-15
CN118742563A (zh) 2024-10-01
EP4474394A1 (en) 2024-12-11

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Patent event date: 20240829

Patent event code: PA01051R01D

Comment text: International Patent Application

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PA0201 Request for examination

Patent event code: PA02012R01D

Patent event date: 20250131

Comment text: Request for Examination of Application