KR20240135617A - 부위-특이적 유전자 편집을 위한 세린 재조합효소 시스템 - Google Patents
부위-특이적 유전자 편집을 위한 세린 재조합효소 시스템 Download PDFInfo
- Publication number
- KR20240135617A KR20240135617A KR1020247025476A KR20247025476A KR20240135617A KR 20240135617 A KR20240135617 A KR 20240135617A KR 1020247025476 A KR1020247025476 A KR 1020247025476A KR 20247025476 A KR20247025476 A KR 20247025476A KR 20240135617 A KR20240135617 A KR 20240135617A
- Authority
- KR
- South Korea
- Prior art keywords
- recombinase
- cell
- bxb1
- variant
- dna
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Pending
Links
Classifications
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N9/00—Enzymes; Proenzymes; Compositions thereof; Processes for preparing, activating, inhibiting, separating or purifying enzymes
- C12N9/14—Hydrolases (3)
- C12N9/16—Hydrolases (3) acting on ester bonds (3.1)
- C12N9/22—Ribonucleases [RNase]; Deoxyribonucleases [DNase]
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N15/00—Mutation or genetic engineering; DNA or RNA concerning genetic engineering, vectors, e.g. plasmids, or their isolation, preparation or purification; Use of hosts therefor
- C12N15/09—Recombinant DNA-technology
- C12N15/87—Introduction of foreign genetic material using processes not otherwise provided for, e.g. co-transformation
- C12N15/90—Stable introduction of foreign DNA into chromosome
- C12N15/902—Stable introduction of foreign DNA into chromosome using homologous recombination
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N15/00—Mutation or genetic engineering; DNA or RNA concerning genetic engineering, vectors, e.g. plasmids, or their isolation, preparation or purification; Use of hosts therefor
- C12N15/09—Recombinant DNA-technology
- C12N15/10—Processes for the isolation, preparation or purification of DNA or RNA
- C12N15/102—Mutagenizing nucleic acids
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N15/00—Mutation or genetic engineering; DNA or RNA concerning genetic engineering, vectors, e.g. plasmids, or their isolation, preparation or purification; Use of hosts therefor
- C12N15/09—Recombinant DNA-technology
- C12N15/11—DNA or RNA fragments; Modified forms thereof; Non-coding nucleic acids having a biological activity
- C12N15/111—General methods applicable to biologically active non-coding nucleic acids
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K2319/00—Fusion polypeptide
- C07K2319/80—Fusion polypeptide containing a DNA binding domain, e.g. Lacl or Tet-repressor
- C07K2319/81—Fusion polypeptide containing a DNA binding domain, e.g. Lacl or Tet-repressor containing a Zn-finger domain for DNA binding
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12Y—ENZYMES
- C12Y301/00—Hydrolases acting on ester bonds (3.1)
- C12Y301/22—Endodeoxyribonucleases producing 3'-phosphomonoesters (3.1.22)
Landscapes
- Health & Medical Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Genetics & Genomics (AREA)
- Engineering & Computer Science (AREA)
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Wood Science & Technology (AREA)
- Zoology (AREA)
- Biomedical Technology (AREA)
- Molecular Biology (AREA)
- General Engineering & Computer Science (AREA)
- Biotechnology (AREA)
- General Health & Medical Sciences (AREA)
- Biochemistry (AREA)
- Microbiology (AREA)
- Plant Pathology (AREA)
- Biophysics (AREA)
- Physics & Mathematics (AREA)
- Mycology (AREA)
- Medicinal Chemistry (AREA)
- Crystallography & Structural Chemistry (AREA)
- Micro-Organisms Or Cultivation Processes Thereof (AREA)
- Enzymes And Modification Thereof (AREA)
- Medicines Containing Material From Animals Or Micro-Organisms (AREA)
Applications Claiming Priority (3)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US202263304565P | 2022-01-28 | 2022-01-28 | |
| US63/304,565 | 2022-01-28 | ||
| PCT/US2023/061500 WO2023147507A1 (en) | 2022-01-28 | 2023-01-27 | Serine recombinase systems for site-specific gene editing |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| KR20240135617A true KR20240135617A (ko) | 2024-09-11 |
Family
ID=85328719
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| KR1020247025476A Pending KR20240135617A (ko) | 2022-01-28 | 2023-01-27 | 부위-특이적 유전자 편집을 위한 세린 재조합효소 시스템 |
Country Status (9)
| Country | Link |
|---|---|
| US (1) | US20250243512A1 (https=) |
| EP (1) | EP4469569A1 (https=) |
| JP (1) | JP2025504019A (https=) |
| KR (1) | KR20240135617A (https=) |
| CN (1) | CN118591625A (https=) |
| AU (1) | AU2023214005A1 (https=) |
| CA (1) | CA3243345A1 (https=) |
| IL (1) | IL314478A (https=) |
| WO (1) | WO2023147507A1 (https=) |
Families Citing this family (3)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN121693564A (zh) | 2023-06-26 | 2026-03-17 | 夏威夷大学 | 进化的整合酶和其用于基因组编辑的方法 |
| WO2025160202A1 (en) * | 2024-01-22 | 2025-07-31 | Arc Researrch Institute | Engineered large serine recombinases |
| WO2025212976A2 (en) * | 2024-04-03 | 2025-10-09 | Sangamo Therapeutics, Inc. | Engineered modular recombinase compositions, methods, and systems for site-specific dna recombination |
Family Cites Families (1)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| GB202006462D0 (en) * | 2020-05-04 | 2020-06-17 | Mote Res Limited | Modifying genomes with integrase |
-
2023
- 2023-01-27 EP EP23706980.2A patent/EP4469569A1/en active Pending
- 2023-01-27 US US18/730,738 patent/US20250243512A1/en active Pending
- 2023-01-27 CN CN202380018612.0A patent/CN118591625A/zh active Pending
- 2023-01-27 CA CA3243345A patent/CA3243345A1/en active Pending
- 2023-01-27 KR KR1020247025476A patent/KR20240135617A/ko active Pending
- 2023-01-27 AU AU2023214005A patent/AU2023214005A1/en active Pending
- 2023-01-27 IL IL314478A patent/IL314478A/en unknown
- 2023-01-27 WO PCT/US2023/061500 patent/WO2023147507A1/en not_active Ceased
- 2023-01-27 JP JP2024544897A patent/JP2025504019A/ja active Pending
Also Published As
| Publication number | Publication date |
|---|---|
| IL314478A (en) | 2024-09-01 |
| CA3243345A1 (en) | 2023-08-03 |
| JP2025504019A (ja) | 2025-02-06 |
| EP4469569A1 (en) | 2024-12-04 |
| CN118591625A (zh) | 2024-09-03 |
| WO2023147507A1 (en) | 2023-08-03 |
| AU2023214005A1 (en) | 2024-08-15 |
| US20250243512A1 (en) | 2025-07-31 |
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Legal Events
| Date | Code | Title | Description |
|---|---|---|---|
| PA0105 | International application |
St.27 status event code: A-0-1-A10-A15-nap-PA0105 |
|
| PG1501 | Laying open of application |
St.27 status event code: A-1-1-Q10-Q12-nap-PG1501 |
|
| E13 | Pre-grant limitation requested |
Free format text: ST27 STATUS EVENT CODE: A-2-3-E10-E13-LIM-X000 (AS PROVIDED BY THE NATIONAL OFFICE) |
|
| E13-X000 | Pre-grant limitation requested |
St.27 status event code: A-2-3-E10-E13-lim-X000 |
|
| P11 | Amendment of application requested |
Free format text: ST27 STATUS EVENT CODE: A-2-2-P10-P11-NAP-X000 (AS PROVIDED BY THE NATIONAL OFFICE) |
|
| P11-X000 | Amendment of application requested |
St.27 status event code: A-2-2-P10-P11-nap-X000 |