KR20240099349A - 인터류킨-34를 표적화하는 화합물 및 방법 - Google Patents

인터류킨-34를 표적화하는 화합물 및 방법 Download PDF

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KR20240099349A
KR20240099349A KR1020247017337A KR20247017337A KR20240099349A KR 20240099349 A KR20240099349 A KR 20240099349A KR 1020247017337 A KR1020247017337 A KR 1020247017337A KR 20247017337 A KR20247017337 A KR 20247017337A KR 20240099349 A KR20240099349 A KR 20240099349A
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human subject
antibody
tau
brain
administered
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마르시오 체디드
아담 에스. 플라이셔
메건 브리타니 래넌
알버트 로
마크 민턴
빅터 에이치. 오붕구
사라 엘리자베스 레인즈
존 랜달 2세 심즈
앤드류 딕슨 스코라
로빈 엘리자베스 월쉬
엘리자베스 앤 웨스트
밍 예
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일라이 릴리 앤드 캄파니
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    • C07ORGANIC CHEMISTRY
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    • C07K16/00Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies
    • C07K16/18Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans
    • C07K16/24Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans against cytokines, lymphokines or interferons
    • C07K16/244Interleukins [IL]
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
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    • A61P25/00Drugs for disorders of the nervous system
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    • C07ORGANIC CHEMISTRY
    • C07KPEPTIDES
    • C07K16/00Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies
    • C07K16/18Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans
    • GPHYSICS
    • G01MEASURING; TESTING
    • G01NINVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N33/00Investigating or analysing materials by specific methods not covered by groups G01N1/00 - G01N31/00
    • G01N33/48Biological material, e.g. blood, urine; Haemocytometers
    • G01N33/50Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing
    • G01N33/68Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing involving proteins, peptides or amino acids
    • G01N33/6863Cytokines, i.e. immune system proteins modifying a biological response such as cell growth proliferation or differentiation, e.g. TNF, CNF, GM-CSF, lymphotoxin, MIF or their receptors
    • G01N33/6869Interleukin
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K39/00Medicinal preparations containing antigens or antibodies
    • A61K2039/505Medicinal preparations containing antigens or antibodies comprising antibodies
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K39/00Medicinal preparations containing antigens or antibodies
    • A61K2039/505Medicinal preparations containing antigens or antibodies comprising antibodies
    • A61K2039/507Comprising a combination of two or more separate antibodies
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K39/00Medicinal preparations containing antigens or antibodies
    • A61K2039/54Medicinal preparations containing antigens or antibodies characterised by the route of administration
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K39/00Medicinal preparations containing antigens or antibodies
    • A61K2039/545Medicinal preparations containing antigens or antibodies characterised by the dose, timing or administration schedule
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K39/00Medicinal preparations containing antigens or antibodies
    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07KPEPTIDES
    • C07K2317/00Immunoglobulins specific features
    • C07K2317/20Immunoglobulins specific features characterized by taxonomic origin
    • C07K2317/21Immunoglobulins specific features characterized by taxonomic origin from primates, e.g. man
    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07KPEPTIDES
    • C07K2317/00Immunoglobulins specific features
    • C07K2317/30Immunoglobulins specific features characterized by aspects of specificity or valency
    • C07K2317/33Crossreactivity, e.g. for species or epitope, or lack of said crossreactivity
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    • C07ORGANIC CHEMISTRY
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    • C07K2317/00Immunoglobulins specific features
    • C07K2317/70Immunoglobulins specific features characterized by effect upon binding to a cell or to an antigen
    • C07K2317/76Antagonist effect on antigen, e.g. neutralization or inhibition of binding
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    • C07K2317/00Immunoglobulins specific features
    • C07K2317/70Immunoglobulins specific features characterized by effect upon binding to a cell or to an antigen
    • C07K2317/77Internalization into the cell
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    • C07K2317/00Immunoglobulins specific features
    • C07K2317/90Immunoglobulins specific features characterized by (pharmaco)kinetic aspects or by stability of the immunoglobulin
    • C07K2317/92Affinity (KD), association rate (Ka), dissociation rate (Kd) or EC50 value
    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07KPEPTIDES
    • C07K2317/00Immunoglobulins specific features
    • C07K2317/90Immunoglobulins specific features characterized by (pharmaco)kinetic aspects or by stability of the immunoglobulin
    • C07K2317/94Stability, e.g. half-life, pH, temperature or enzyme-resistance
    • GPHYSICS
    • G01MEASURING; TESTING
    • G01NINVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N2333/00Assays involving biological materials from specific organisms or of a specific nature
    • G01N2333/435Assays involving biological materials from specific organisms or of a specific nature from animals; from humans
    • G01N2333/52Assays involving cytokines
    • G01N2333/54Interleukins [IL]

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  • Molecular Biology (AREA)
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  • Epidemiology (AREA)
  • Mycology (AREA)
  • Medicines Containing Antibodies Or Antigens For Use As Internal Diagnostic Agents (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
KR1020247017337A 2021-10-29 2022-10-27 인터류킨-34를 표적화하는 화합물 및 방법 Pending KR20240099349A (ko)

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US202163273216P 2021-10-29 2021-10-29
US63/273,216 2021-10-29
PCT/US2022/078776 WO2023076995A1 (en) 2021-10-29 2022-10-27 Compounds and methods targeting interleukin-34

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KR20240099349A true KR20240099349A (ko) 2024-06-28

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EP (1) EP4423127A1 (enExample)
JP (3) JP7622019B2 (enExample)
KR (1) KR20240099349A (enExample)
CN (1) CN118475610A (enExample)
AR (1) AR127484A1 (enExample)
AU (1) AU2022376940A1 (enExample)
CA (1) CA3236555A1 (enExample)
CL (1) CL2024001303A1 (enExample)
CO (1) CO2024005417A2 (enExample)
CR (1) CR20240170A (enExample)
DO (1) DOP2024000076A (enExample)
EC (1) ECSP24032906A (enExample)
IL (1) IL312380A (enExample)
MX (1) MX2024005153A (enExample)
PE (1) PE20241471A1 (enExample)
TW (1) TW202336034A (enExample)
WO (1) WO2023076995A1 (enExample)

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KR20240145486A (ko) * 2022-02-03 2024-10-07 일라이 릴리 앤드 캄파니 알츠하이머병을 진단 및 치료하기 위한 국소 타우 영상화

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EA028427B1 (ru) 2008-07-21 2017-11-30 Пробиодруг Аг АНТИТЕЛО, СВЯЗЫВАЮЩЕЕСЯ С Aβ-ПЕПТИДАМИ ИЛИ ИХ ВАРИАНТАМИ, КОМПОЗИЦИЯ, СОДЕРЖАЩАЯ ЭТО АНТИТЕЛО, И ЕГО ПРИМЕНЕНИЕ
US8795664B2 (en) 2010-06-04 2014-08-05 Georg-August-Universität Göttingen Stiftung Öffentlichen Rechts, Universitätsmedizin Monoclonal antibodies targeting amyloid beta oligomers
WO2012019061A2 (en) * 2010-08-05 2012-02-09 Stem Centrx, Inc. Novel effectors and methods of use
PT3042917T (pt) 2010-08-12 2018-05-02 Lilly Co Eli Anticorpos do péptido beta amilóide anti-n3pglu e seus usos
US9499610B2 (en) 2011-04-08 2016-11-22 H. Lundbeck A/S Antibodies specific to pyroglutamated Aβ
US9161968B2 (en) 2011-04-08 2015-10-20 The Board Of Trustees Of The Leland Stanford Junior University Methods of neuroprotection involving macrophage colony stimulating factor receptor agonists
CN104093740B (zh) 2012-02-06 2018-01-09 弗·哈夫曼-拉罗切有限公司 使用csf1r抑制剂的组合物和方法
EP3174895A1 (en) 2014-07-28 2017-06-07 Nogra Pharma Limited Methods and compositions for diagnosing and treating inflammatory bowel disorders
WO2016097420A1 (en) 2014-12-19 2016-06-23 Universite De Nantes Anti il-34 antibodies
AU2016248946C1 (en) * 2015-04-13 2024-10-17 Pfizer Inc. Therapeutic antibodies and their uses
JP2018516933A (ja) * 2015-06-02 2018-06-28 ジェネンテック, インコーポレイテッド 抗il−34抗体を使用して神経学的疾患を治療するための組成物及び方法
JOP20170004B1 (ar) 2016-01-15 2022-09-15 Lilly Co Eli الأجسام المضادة لببتيد بيتا النشوي مضاد N3pGlu واستخداماته
TWI735600B (zh) * 2016-07-01 2021-08-11 美商美國禮來大藥廠 抗-N3pGlu類澱粉β肽抗體及其用途
CN109562167A (zh) * 2016-08-09 2019-04-02 伊莱利利公司 联合治疗
JOP20190247A1 (ar) 2017-04-20 2019-10-20 Lilly Co Eli أجسام بيتا ببتيد النشوانية المضادة لـ N3pGlu واستخداماتها
CA3091810A1 (en) 2018-03-02 2019-09-06 The United States Of America, As Represented By The Secretary, Department Of Health And Human Services Use of il-34 to treat retinal inflammation and neurodegeneration
BR112021021062A2 (pt) 2019-05-31 2021-12-14 Lilly Co Eli Compostos e métodos que alvejam tau humano
TWI799840B (zh) * 2020-04-30 2023-04-21 美商美國禮來大藥廠 靶向介白素-34之化合物及方法

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CN118475610A (zh) 2024-08-09
US20240309082A1 (en) 2024-09-19
JP2023067832A (ja) 2023-05-16
CL2024001303A1 (es) 2024-08-30
JP2025063187A (ja) 2025-04-15
IL312380A (en) 2024-06-01
TW202336034A (zh) 2023-09-16
WO2023076995A1 (en) 2023-05-04
US11976114B2 (en) 2024-05-07
CO2024005417A2 (es) 2024-05-30
JP2024091777A (ja) 2024-07-05
PE20241471A1 (es) 2024-07-17
AR127484A1 (es) 2024-01-31
US20230279094A1 (en) 2023-09-07
CA3236555A1 (en) 2023-05-04
AU2022376940A1 (en) 2024-05-02
DOP2024000076A (es) 2024-06-16
EP4423127A1 (en) 2024-09-04
ECSP24032906A (es) 2024-05-31
MX2024005153A (es) 2024-05-13
CR20240170A (es) 2024-05-24
JP7622019B2 (ja) 2025-01-27

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