KR20240094023A - S1p1 수용체 작용제의 부가 염 및 이의 결정 형태 및 약제학적 조성물 - Google Patents

S1p1 수용체 작용제의 부가 염 및 이의 결정 형태 및 약제학적 조성물 Download PDF

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Publication number
KR20240094023A
KR20240094023A KR1020247018420A KR20247018420A KR20240094023A KR 20240094023 A KR20240094023 A KR 20240094023A KR 1020247018420 A KR1020247018420 A KR 1020247018420A KR 20247018420 A KR20247018420 A KR 20247018420A KR 20240094023 A KR20240094023 A KR 20240094023A
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South Korea
Prior art keywords
formula
compound represented
salt
crystalline form
present application
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Pending
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KR1020247018420A
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English (en)
Korean (ko)
Inventor
웨이 젱
우빈 판
지아왕 구오
Original Assignee
쑤저우 커넥트 바이오파마슈티컬즈, 엘티디.
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Publication of KR20240094023A publication Critical patent/KR20240094023A/ko
Pending legal-status Critical Current

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    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D413/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms
    • C07D413/02—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms containing two hetero rings
    • C07D413/10—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms containing two hetero rings linked by a carbon chain containing aromatic rings
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/41—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having five-membered rings with two or more ring hetero atoms, at least one of which being nitrogen, e.g. tetrazole
    • A61K31/4245—Oxadiazoles
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P17/00—Drugs for dermatological disorders
    • A61P17/06—Antipsoriatics
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P19/00—Drugs for skeletal disorders
    • A61P19/02—Drugs for skeletal disorders for joint disorders, e.g. arthritis, arthrosis
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/28—Drugs for disorders of the nervous system for treating neurodegenerative disorders of the central nervous system, e.g. nootropic agents, cognition enhancers, drugs for treating Alzheimer's disease or other forms of dementia
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P29/00—Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P37/00—Drugs for immunological or allergic disorders
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P37/00—Drugs for immunological or allergic disorders
    • A61P37/02—Immunomodulators
    • A61P37/06—Immunosuppressants, e.g. drugs for graft rejection
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07B—GENERAL METHODS OF ORGANIC CHEMISTRY; APPARATUS THEREFOR
    • C07B2200/00—Indexing scheme relating to specific properties of organic compounds
    • C07B2200/13—Crystalline forms, e.g. polymorphs

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  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • General Health & Medical Sciences (AREA)
  • Veterinary Medicine (AREA)
  • Public Health (AREA)
  • Animal Behavior & Ethology (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Medicinal Chemistry (AREA)
  • Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • General Chemical & Material Sciences (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Immunology (AREA)
  • Biomedical Technology (AREA)
  • Neurology (AREA)
  • Rheumatology (AREA)
  • Neurosurgery (AREA)
  • Epidemiology (AREA)
  • Transplantation (AREA)
  • Orthopedic Medicine & Surgery (AREA)
  • Hospice & Palliative Care (AREA)
  • Psychiatry (AREA)
  • Physical Education & Sports Medicine (AREA)
  • Dermatology (AREA)
  • Pain & Pain Management (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Plural Heterocyclic Compounds (AREA)
KR1020247018420A 2018-05-04 2018-05-04 S1p1 수용체 작용제의 부가 염 및 이의 결정 형태 및 약제학적 조성물 Pending KR20240094023A (ko)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
PCT/CN2018/085617 WO2019210511A1 (zh) 2018-05-04 2018-05-04 一种s1p1受体激动剂的加成盐及其晶型和药物组合物
KR1020207034174A KR102672632B1 (ko) 2018-05-04 2018-05-04 S1p1 수용체 작용제의 부가 염 및 이의 결정 형태 및 약제학적 조성물

Related Parent Applications (1)

Application Number Title Priority Date Filing Date
KR1020207034174A Division KR102672632B1 (ko) 2018-05-04 2018-05-04 S1p1 수용체 작용제의 부가 염 및 이의 결정 형태 및 약제학적 조성물

Publications (1)

Publication Number Publication Date
KR20240094023A true KR20240094023A (ko) 2024-06-24

Family

ID=68387039

Family Applications (2)

Application Number Title Priority Date Filing Date
KR1020247018420A Pending KR20240094023A (ko) 2018-05-04 2018-05-04 S1p1 수용체 작용제의 부가 염 및 이의 결정 형태 및 약제학적 조성물
KR1020207034174A Active KR102672632B1 (ko) 2018-05-04 2018-05-04 S1p1 수용체 작용제의 부가 염 및 이의 결정 형태 및 약제학적 조성물

Family Applications After (1)

Application Number Title Priority Date Filing Date
KR1020207034174A Active KR102672632B1 (ko) 2018-05-04 2018-05-04 S1p1 수용체 작용제의 부가 염 및 이의 결정 형태 및 약제학적 조성물

Country Status (13)

Country Link
US (3) US11512078B2 (https=)
EP (2) EP4353719B1 (https=)
JP (3) JP7275253B2 (https=)
KR (2) KR20240094023A (https=)
AU (1) AU2018421487B2 (https=)
CA (1) CA3099196A1 (https=)
ES (1) ES2978392T3 (https=)
IL (3) IL312512B2 (https=)
MX (1) MX2020011665A (https=)
NZ (1) NZ770323A (https=)
SG (1) SG11202010969UA (https=)
WO (1) WO2019210511A1 (https=)
ZA (1) ZA202007347B (https=)

Families Citing this family (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
NZ770323A (en) * 2018-05-04 2025-12-19 Suzhou Connect Biopharmaceuticals Ltd Addition salt of s1p1 receptor agonist and crystal form thereof, and pharmaceutical composition
WO2022099155A1 (en) * 2020-11-09 2022-05-12 Arena Pharmaceuticals, Inc. Methods of treating conditions related to the s1p1 receptor

Family Cites Families (7)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JP2005533058A (ja) * 2002-06-17 2005-11-04 メルク　エンド　カムパニー　インコーポレーテッド Ｅｄｇ受容体アゴニストとしての１−（（５−アリール−１，２，４−オキサジアゾール−３−イル）ベンジル）アゼチジン−３−カルボキシラートおよび１−（（５−アリール−１，２，４−オキサジアゾール−３−イル）ベンジル）ピロリジン−３−カルボキシラート
WO2004035538A1 (en) 2002-10-15 2004-04-29 Merck & Co., Inc. Process for making azetidine-3-carboxylic acid
CN103450171B (zh) 2013-09-22 2015-07-08 苏州康乃德生物医药有限公司 一种免疫调节化合物、其用途和包含其的药物组合物
CN105315266B (zh) * 2014-08-01 2019-10-01 苏州康乃德生物医药有限公司 1-{2-氟-4-[5-(4-异丁基苯基)-1,2,4-噁二唑-3-基]-苄基}-3-吖丁啶羧酸的晶型
CN105348276B (zh) 2014-08-22 2020-05-26 苏州康乃德生物医药有限公司 1-{2-氟-4-[5-(4-异丁基苯基)-1,2,4-噁二唑-3-基]-苄基}-3-吖丁啶羧酸的合成方法
CN112778290B (zh) 2017-01-11 2022-12-06 苏州康乃德生物医药有限公司 一种s1p1受体激动剂的加成盐及其晶型和药物组合物
NZ770323A (en) * 2018-05-04 2025-12-19 Suzhou Connect Biopharmaceuticals Ltd Addition salt of s1p1 receptor agonist and crystal form thereof, and pharmaceutical composition

Also Published As

Publication number Publication date
JP2025074350A (ja) 2025-05-13
ES2978392T3 (es) 2024-09-11
SG11202010969UA (en) 2020-12-30
IL278464A (https=) 2021-03-01
EP4353719B1 (en) 2025-12-24
JP2023062091A (ja) 2023-05-02
KR102672632B1 (ko) 2024-06-07
EP3792258A4 (en) 2021-10-06
EP3792258A1 (en) 2021-03-17
IL278464B1 (en) 2024-06-01
IL323665A (en) 2025-11-01
KR20210019999A (ko) 2021-02-23
US12202822B2 (en) 2025-01-21
MX2020011665A (es) 2021-01-20
US20210230152A1 (en) 2021-07-29
BR112020022429A2 (pt) 2021-02-09
US20250320200A1 (en) 2025-10-16
WO2019210511A1 (zh) 2019-11-07
IL278464B2 (en) 2024-10-01
IL312512A (en) 2024-07-01
JP2021532165A (ja) 2021-11-25
US20230050777A1 (en) 2023-02-16
EP4353719A1 (en) 2024-04-17
IL312512B2 (en) 2026-03-01
IL312512B1 (en) 2025-11-01
ZA202007347B (en) 2021-10-27
EP3792258B1 (en) 2024-02-07
AU2018421487B2 (en) 2024-09-12
JP7275253B2 (ja) 2023-05-17
JP7651198B2 (ja) 2025-03-26
AU2018421487A1 (en) 2020-12-17
CA3099196A1 (en) 2019-11-07
NZ770323A (en) 2025-12-19
US11512078B2 (en) 2022-11-29

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