KR20240089771A - 신규한 방법 - Google Patents

신규한 방법 Download PDF

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Publication number
KR20240089771A
KR20240089771A KR1020247016018A KR20247016018A KR20240089771A KR 20240089771 A KR20240089771 A KR 20240089771A KR 1020247016018 A KR1020247016018 A KR 1020247016018A KR 20247016018 A KR20247016018 A KR 20247016018A KR 20240089771 A KR20240089771 A KR 20240089771A
Authority
KR
South Korea
Prior art keywords
compound
formula
alkyl
fentanyl
compounds
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Pending
Application number
KR1020247016018A
Other languages
English (en)
Korean (ko)
Inventor
펭 리
알렌 에이 피엔베르그
그레첸 스나이더
로버트 이 데이비스
Original Assignee
인트라-셀룰라 써래피스, 인코퍼레이티드.
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by 인트라-셀룰라 써래피스, 인코퍼레이티드. filed Critical 인트라-셀룰라 써래피스, 인코퍼레이티드.
Publication of KR20240089771A publication Critical patent/KR20240089771A/ko
Pending legal-status Critical Current

Links

Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/495—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with two or more nitrogen atoms as the only ring heteroatoms, e.g. piperazine or tetrazines
    • A61K31/4985—Pyrazines or piperazines ortho- or peri-condensed with heterocyclic ring systems
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/30—Drugs for disorders of the nervous system for treating abuse or dependence
    • A61P25/36—Opioid-abuse
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D471/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00
    • C07D471/12—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00 in which the condensed system contains three hetero rings
    • C07D471/14—Ortho-condensed systems

Landscapes

  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Medicinal Chemistry (AREA)
  • Veterinary Medicine (AREA)
  • Public Health (AREA)
  • General Health & Medical Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Addiction (AREA)
  • Neurology (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • General Chemical & Material Sciences (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Neurosurgery (AREA)
  • Biomedical Technology (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Engineering & Computer Science (AREA)
  • Psychiatry (AREA)
  • Epidemiology (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Nitrogen Condensed Heterocyclic Rings (AREA)
  • Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
KR1020247016018A 2021-10-19 2022-10-14 신규한 방법 Pending KR20240089771A (ko)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
US202163262732P 2021-10-19 2021-10-19
US63/262,732 2021-10-19
PCT/US2022/078177 WO2023069880A1 (en) 2021-10-19 2022-10-14 Novel methods

Publications (1)

Publication Number Publication Date
KR20240089771A true KR20240089771A (ko) 2024-06-20

Family

ID=86058575

Family Applications (1)

Application Number Title Priority Date Filing Date
KR1020247016018A Pending KR20240089771A (ko) 2021-10-19 2022-10-14 신규한 방법

Country Status (10)

Country Link
US (1) US20240415832A1 (https=)
EP (1) EP4419523A4 (https=)
JP (1) JP2024539106A (https=)
KR (1) KR20240089771A (https=)
CN (1) CN118556058A (https=)
AU (1) AU2022368858A1 (https=)
CA (1) CA3235356A1 (https=)
IL (1) IL312165A (https=)
MX (1) MX2024004725A (https=)
WO (1) WO2023069880A1 (https=)

Families Citing this family (6)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
EP3898580A4 (en) 2018-12-17 2022-08-10 Intra-Cellular Therapies, Inc. SYNTHESIS OF CONDENSED GAMMA-CARBOLINES WITH SUBSTITUTED HETEROCYCLE
IL283963B2 (en) 2018-12-17 2025-01-01 Intra Cellular Therapies Inc Synthesis of condensed gamma-carbolines and converted heterocycles
WO2020132605A1 (en) 2018-12-21 2020-06-25 Intra-Cellular Therapies, Inc. Organic compounds
WO2024194263A1 (en) 2023-03-17 2024-09-26 Norwegian University Of Life Sciences Serotonin 5ht2a receptor antagonist for use in treating side effects resulting form mu opioid receptor agonist overdose
WO2026011136A1 (en) * 2024-07-03 2026-01-08 Intra-Cellular Therapies, Inc. Organic compounds
WO2026011166A1 (en) * 2024-07-03 2026-01-08 Intra-Cellular Therapies, Inc. Substituted heterocycles for use in the treatment of diseases involving the 5-ht2a receptor

Family Cites Families (6)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JP7223742B2 (ja) * 2017-07-26 2023-02-16 イントラ－セルラー・セラピーズ・インコーポレイテッド 有機化合物
US20220160704A2 (en) * 2018-08-08 2022-05-26 Torralva Medical Therapeutics Llc Compositions for opiate and opioid prevention and reversal, and methods of their use
WO2020132605A1 (en) * 2018-12-21 2020-06-25 Intra-Cellular Therapies, Inc. Organic compounds
CN118105390A (zh) * 2019-01-23 2024-05-31 细胞内治疗公司 治疗成瘾的方法
CA3139168A1 (en) * 2019-05-07 2020-11-12 Nirsum Laboratories, Inc. Opioid receptor antagonist prodrugs
EP4493560A4 (en) * 2022-03-14 2026-03-18 Intra Cellular Therapies Inc ORGANIC COMPOUNDS

Also Published As

Publication number Publication date
US20240415832A1 (en) 2024-12-19
JP2024539106A (ja) 2024-10-28
EP4419523A1 (en) 2024-08-28
CN118556058A (zh) 2024-08-27
MX2024004725A (es) 2024-05-10
CA3235356A1 (en) 2023-04-27
AU2022368858A1 (en) 2024-05-02
IL312165A (en) 2024-06-01
EP4419523A4 (en) 2025-09-17
WO2023069880A1 (en) 2023-04-27

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PA0105 International application

St.27 status event code: A-0-1-A10-A15-nap-PA0105

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R18-X000 Changes to party contact information recorded

St.27 status event code: A-3-3-R10-R18-oth-X000

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P11-X000 Amendment of application requested

St.27 status event code: A-2-2-P10-P11-nap-X000