CN118556058A - 新方法 - Google Patents

新方法 Download PDF

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Publication number
CN118556058A
CN118556058A CN202280084050.5A CN202280084050A CN118556058A CN 118556058 A CN118556058 A CN 118556058A CN 202280084050 A CN202280084050 A CN 202280084050A CN 118556058 A CN118556058 A CN 118556058A
Authority
CN
China
Prior art keywords
compound
formula
alkyl
fentanyl
opioid
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Pending
Application number
CN202280084050.5A
Other languages
English (en)
Chinese (zh)
Inventor
李鹏
A·A·芬博格
G·斯奈德
R·E·戴维斯
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Intra Cellular Therapies Inc
Original Assignee
Intra Cellular Therapies Inc
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Intra Cellular Therapies Inc filed Critical Intra Cellular Therapies Inc
Publication of CN118556058A publication Critical patent/CN118556058A/zh
Pending legal-status Critical Current

Links

Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/495—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with two or more nitrogen atoms as the only ring heteroatoms, e.g. piperazine or tetrazines
    • A61K31/4985—Pyrazines or piperazines ortho- or peri-condensed with heterocyclic ring systems
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/30—Drugs for disorders of the nervous system for treating abuse or dependence
    • A61P25/36—Opioid-abuse
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D471/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00
    • C07D471/12—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00 in which the condensed system contains three hetero rings
    • C07D471/14—Ortho-condensed systems

Landscapes

  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Medicinal Chemistry (AREA)
  • Veterinary Medicine (AREA)
  • Public Health (AREA)
  • General Health & Medical Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Addiction (AREA)
  • Neurology (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • General Chemical & Material Sciences (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Neurosurgery (AREA)
  • Biomedical Technology (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Engineering & Computer Science (AREA)
  • Psychiatry (AREA)
  • Epidemiology (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Nitrogen Condensed Heterocyclic Rings (AREA)
  • Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
CN202280084050.5A 2021-10-19 2022-10-14 新方法 Pending CN118556058A (zh)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
US202163262732P 2021-10-19 2021-10-19
US63/262,732 2021-10-19
PCT/US2022/078177 WO2023069880A1 (en) 2021-10-19 2022-10-14 Novel methods

Publications (1)

Publication Number Publication Date
CN118556058A true CN118556058A (zh) 2024-08-27

Family

ID=86058575

Family Applications (1)

Application Number Title Priority Date Filing Date
CN202280084050.5A Pending CN118556058A (zh) 2021-10-19 2022-10-14 新方法

Country Status (10)

Country Link
US (1) US20240415832A1 (https=)
EP (1) EP4419523A4 (https=)
JP (1) JP2024539106A (https=)
KR (1) KR20240089771A (https=)
CN (1) CN118556058A (https=)
AU (1) AU2022368858A1 (https=)
CA (1) CA3235356A1 (https=)
IL (1) IL312165A (https=)
MX (1) MX2024004725A (https=)
WO (1) WO2023069880A1 (https=)

Families Citing this family (6)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
EP3898580A4 (en) 2018-12-17 2022-08-10 Intra-Cellular Therapies, Inc. SYNTHESIS OF CONDENSED GAMMA-CARBOLINES WITH SUBSTITUTED HETEROCYCLE
IL283963B2 (en) 2018-12-17 2025-01-01 Intra Cellular Therapies Inc Synthesis of condensed gamma-carbolines and converted heterocycles
WO2020132605A1 (en) 2018-12-21 2020-06-25 Intra-Cellular Therapies, Inc. Organic compounds
WO2024194263A1 (en) 2023-03-17 2024-09-26 Norwegian University Of Life Sciences Serotonin 5ht2a receptor antagonist for use in treating side effects resulting form mu opioid receptor agonist overdose
WO2026011136A1 (en) * 2024-07-03 2026-01-08 Intra-Cellular Therapies, Inc. Organic compounds
WO2026011166A1 (en) * 2024-07-03 2026-01-08 Intra-Cellular Therapies, Inc. Substituted heterocycles for use in the treatment of diseases involving the 5-ht2a receptor

Family Cites Families (6)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JP7223742B2 (ja) * 2017-07-26 2023-02-16 イントラ－セルラー・セラピーズ・インコーポレイテッド 有機化合物
US20220160704A2 (en) * 2018-08-08 2022-05-26 Torralva Medical Therapeutics Llc Compositions for opiate and opioid prevention and reversal, and methods of their use
WO2020132605A1 (en) * 2018-12-21 2020-06-25 Intra-Cellular Therapies, Inc. Organic compounds
CN118105390A (zh) * 2019-01-23 2024-05-31 细胞内治疗公司 治疗成瘾的方法
CA3139168A1 (en) * 2019-05-07 2020-11-12 Nirsum Laboratories, Inc. Opioid receptor antagonist prodrugs
EP4493560A4 (en) * 2022-03-14 2026-03-18 Intra Cellular Therapies Inc ORGANIC COMPOUNDS

Also Published As

Publication number Publication date
US20240415832A1 (en) 2024-12-19
JP2024539106A (ja) 2024-10-28
EP4419523A1 (en) 2024-08-28
KR20240089771A (ko) 2024-06-20
MX2024004725A (es) 2024-05-10
CA3235356A1 (en) 2023-04-27
AU2022368858A1 (en) 2024-05-02
IL312165A (en) 2024-06-01
EP4419523A4 (en) 2025-09-17
WO2023069880A1 (en) 2023-04-27

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