KR20240073926A - 간 용적을 감소시키기 위한 레스메티롬 - Google Patents

간 용적을 감소시키기 위한 레스메티롬 Download PDF

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Publication number
KR20240073926A
KR20240073926A KR1020247013928A KR20247013928A KR20240073926A KR 20240073926 A KR20240073926 A KR 20240073926A KR 1020247013928 A KR1020247013928 A KR 1020247013928A KR 20247013928 A KR20247013928 A KR 20247013928A KR 20240073926 A KR20240073926 A KR 20240073926A
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KR
South Korea
Prior art keywords
resmetirome
larger
subject
precursor
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Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Pending
Application number
KR1020247013928A
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English (en)
Korean (ko)
Inventor
레베카 타웁
Original Assignee
마드리갈 파마슈티칼스 인코포레이티드
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Application filed by 마드리갈 파마슈티칼스 인코포레이티드 filed Critical 마드리갈 파마슈티칼스 인코포레이티드
Publication of KR20240073926A publication Critical patent/KR20240073926A/ko
Pending legal-status Critical Current

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Classifications

    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00Medicinal preparations containing organic active ingredients
    • A61K31/33Heterocyclic compounds
    • A61K31/395Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/495Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with two or more nitrogen atoms as the only ring heteroatoms, e.g. piperazine or tetrazines
    • A61K31/50Pyridazines; Hydrogenated pyridazines
    • A61K31/501Pyridazines; Hydrogenated pyridazines not condensed and containing further heterocyclic rings
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00Medicinal preparations containing organic active ingredients
    • A61K31/33Heterocyclic compounds
    • A61K31/395Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/53Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with three nitrogens as the only ring hetero atoms, e.g. chlorazanil, melamine
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P1/00Drugs for disorders of the alimentary tract or the digestive system
    • A61P1/16Drugs for disorders of the alimentary tract or the digestive system for liver or gallbladder disorders, e.g. hepatoprotective agents, cholagogues, litholytics

Landscapes

  • Health & Medical Sciences (AREA)
  • Veterinary Medicine (AREA)
  • Public Health (AREA)
  • General Health & Medical Sciences (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Animal Behavior & Ethology (AREA)
  • Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • General Chemical & Material Sciences (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Organic Chemistry (AREA)
  • Gastroenterology & Hepatology (AREA)
  • Epidemiology (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
KR1020247013928A 2021-09-27 2022-09-27 간 용적을 감소시키기 위한 레스메티롬 Pending KR20240073926A (ko)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
US202163248634P 2021-09-27 2021-09-27
US63/248,634 2021-09-27
PCT/US2022/044826 WO2023049491A1 (en) 2021-09-27 2022-09-27 Resmetirom for reducing liver volume

Publications (1)

Publication Number Publication Date
KR20240073926A true KR20240073926A (ko) 2024-05-27

Family

ID=83900064

Family Applications (1)

Application Number Title Priority Date Filing Date
KR1020247013928A Pending KR20240073926A (ko) 2021-09-27 2022-09-27 간 용적을 감소시키기 위한 레스메티롬

Country Status (13)

Country Link
US (2) US20240408102A1 (https=)
EP (2) EP4408428A1 (https=)
JP (1) JP2024536126A (https=)
KR (1) KR20240073926A (https=)
CN (1) CN118251221A (https=)
AR (1) AR127165A1 (https=)
AU (1) AU2022348966A1 (https=)
CA (1) CA3233319A1 (https=)
CL (1) CL2024000886A1 (https=)
IL (1) IL311670A (https=)
MX (1) MX2024003967A (https=)
TW (1) TW202337470A (https=)
WO (1) WO2023049491A1 (https=)

Cited By (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO2026005409A1 (ko) * 2024-06-25 2026-01-02 연세대학교 산학협력단 Usp10 억제제를 유효성분으로 포함하는, 간섬유증 또는 간섬유증 관련 질환의 예방 또는 치료용 조성물

Families Citing this family (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CN121443313A (zh) * 2023-06-08 2026-01-30 成都微芯药业有限公司 PPAR全激动剂联合THR-β激动剂在抗代谢相关疾病中的用途
WO2024263714A1 (en) * 2023-06-22 2024-12-26 Madrigal Pharmaceuticals, Inc. BIOMARKERS FOR TREATING LIVER DISORDERS WITH THR-β AGONISTS AND RELATED USES

Family Cites Families (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
AR092872A1 (es) 2012-09-17 2015-05-06 Madrigal Pharmaceuticals Inc Metodo para sintetizar analogos de la hormona tiroidea y polimorfos de los mismos
CA3111025C (en) * 2018-09-06 2023-10-31 Galmed Research And Development Ltd Combination therapy for the treatment of liver disease

Cited By (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO2026005409A1 (ko) * 2024-06-25 2026-01-02 연세대학교 산학협력단 Usp10 억제제를 유효성분으로 포함하는, 간섬유증 또는 간섬유증 관련 질환의 예방 또는 치료용 조성물

Also Published As

Publication number Publication date
TW202337470A (zh) 2023-10-01
EP4408428A1 (en) 2024-08-07
JP2024536126A (ja) 2024-10-04
CN118251221A (zh) 2024-06-25
US20260069598A1 (en) 2026-03-12
IL311670A (en) 2024-05-01
WO2023049491A1 (en) 2023-03-30
AR127165A1 (es) 2023-12-27
CA3233319A1 (en) 2023-03-30
AU2022348966A1 (en) 2024-04-11
EP4578499A3 (en) 2025-09-17
CL2024000886A1 (es) 2024-08-30
EP4578499A2 (en) 2025-07-02
MX2024003967A (es) 2024-06-03
US20240408102A1 (en) 2024-12-12

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Legal Events

Date Code Title Description
PA0105 International application

Patent event date: 20240425

Patent event code: PA01051R01D

Comment text: International Patent Application

PG1501 Laying open of application